Chronic alcohol consumption increases the expression of uncoupling protein-2 and -4 in the brain

Alcoholism: Clinical and Experimental Research

Volumn 37, Issue 10, 2013, Pages 1650-1656

  Graw, Jan A ^a   von Haefen, Clarissa ^a   Poyraz, Deniz ^a   Möbius, Nadine ^a   Sifringer, Marco ^a   Spies, Claudia D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Apoptosis; Chronic Alcohol Consumption; Neurodegeneration; Uncoupling Proteins

Indexed keywords

CYTOCHROME C; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 4;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BRAIN LEVEL; BRAIN SLICE; CELL DEATH; CELL STRESS; CONTROLLED STUDY; DIETARY INTAKE; ENZYME RELEASE; GENE EXPRESSION; MALE; MITOCHONDRION; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY CHAIN;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

APOPTOSIS; CHRONIC ALCOHOL CONSUMPTION; NEURODEGENERATION; UNCOUPLING PROTEINS;

ALCOHOL DRINKING; ANIMALS; BRAIN; ETHANOL; GENE EXPRESSION REGULATION; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; RATS; RATS, WISTAR;

EID: 84884986577     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12144     Document Type: Article

References (51)

1. Andrews ZB, Diano S, Horvath TL (2005a) Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci 6:829-840.
2. Andrews ZB, Horvath B, Barnstable CJ, Elseworth J, Yang J, Beal MF, Roth RH, Matthews RT, Horvath TL (2005b) Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J Neurosci 25:184-191.
3. Armstrong RJ, Baker RA (2001) Neurodegeneration. A failure of neuroregeneration? Lancet 358:1174-1176.
4. Arsenijevic D, Clavel S, Sanchis D, Plamondon J, Huang Q, Ricquier D, Rouger L, Richard D (2007) Induction of UCP2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol 186:121-132.
5. Bailey SM, Patel VB, Young TA, Asayama K, Cunningham CC (2001) Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein status in rat liver. Alcohol Clin Exp Res 25:726-733.
6. Bhupanapadu Sunkesula SR, Swain U, Babu PP (2008) Cell death is associated with reduced base excision repair during chronic alcohol administration in adult rat brain. Neurochem Res 33:1117-1128.
7. Boveris A, Chance B (1973) The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 134:707-716.
8. Brand MD, Esteves TC (2005) Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab 2:85-93.
9. Cannon B, Shabalina IG, Kramarova TV, Petrovic N, Nedergaard J (2006) Uncoupling proteins: a role in protection against reactive oxygen species-or not? Biochim Biophys Acta 1757:449-458.
10. Cederbaum AI (2001) Introduction-Serial review: alcohol, oxidative stress and cell injury. Free Radic Biol Med 31:1524-1526.
11. Cohen G (1994) Enzymatic/nonenzymatic sources of oxyradicals and regulation of antioxidant defenses. Ann N Y Acad Sci 738:8-14.
12. Cortez-Pinto H, Zhi Lin H, Qi Yang S, Odwin Da Costa S, Diehl AM (1999) Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. Gastroenterology 116:1184-1193.
13. Couplan E, del Mar Gonzalez-Barroso M, Alves-Guerra MC, Ricquier D, Goubern M, Bouillaud F (2002) No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J Biol Chem 277:26268-26275.
14. Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, Horvath TL (2003) Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology 144:5014-5021.
15. Duval C, Nègre-Salvayre A, Dogilo A, Salvayre R, Pénicaud L, Casteilla L (2002) Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells. Biochem Cell Biol 80:757-764.
16. Echtay KS (2007) Mitochondrial uncoupling proteins-what is their physiological role? Free Radic Biol Med 43:1351-1371.
17. Haines B, Li PA (2012) Overexpression of mitochondrial uncoupling protein 2 inhibits inflammatory cytokines and activates cell survival factors after cerebral ischemia. PLoS One 7:e31739.
18. Harper C, Kril J, Daly J (1987) Are we drinking our neurons away? Br Med J 294:534-536.
19. Ho JW, Ho PW, Liu HF, So DH, Chan KH, Tse ZH, Kung MH, Ramsden DB, Ho SL (2012) UCP4 is a target effector of NF-κB c-Rel pro-survival pathway against oxidative stress. Free Radic Biol Med 53:383-394.
20. Hoang T, Smith MD, Jelokhandi-Niaraki M (2012) Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4 and UCP5. Biochemistry 51:4004-4014.
21. Hoek JB, Cahill A, Pastorino JG (2002) Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 122:2049-2063.
22. Horvarth TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, Elsworth JD, Sotonyi P, Roth RH, Dietrich EH, Matthews RT, Barnstable CJ, Redmond DE Jr (2003) Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology 144:2757-2760.
23. Horvath B, Spies C, Horvath G, Kox WJ, Miyamoto S, Barry S, Warden CH, Bechmann I, Diano S, Heemskerk J, Horvath TL (2002) Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochem Pharmacol 64:369-374.
24. Horvath TL, Warden CH, Hajos M, Lombardi A, Goglia F, Diano S (1999) Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J Neurosci 19:10417-10427.
25. Kim-Han JS, Reichert SA, Quick KL, Dugan LL (2001) BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production. J Neurochem 79:658-668.
26. Lieber CS, DeCarli LM (1989) Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcohol 24:197-211.
27. Liu D, Chan SL, Souza-Pinto NC, Slevin JR, Wersto RP, Zhan M, Mustafa K, de Cabo R, Mattson MP (2006) Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med 8:389-414.
28. Liu Y, Chen L, Xu X, Vicaut E, Sercombe R (2009) Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. BMC Physiol 9:17.
29. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408.
30. Mantle D, Preedy VR (1999) Free radicals as mediators of alcohol toxicity. Adverse Drug React Toxicol Rev 18:235-252.
31. Mao W, Yu XX, Zhong A, Li W, Brush J, Sherwood SW, Adams SH, Pan G (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett 443:326-330.
32. Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi S, Warden CH, Castilho RF, Melcher T, Gonzalez-Zulueta M, Nikolich K, Wieloch T (2003) Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med 9:1062-1068.
33. Mattiasson G, Sullivan PG (2006) The emerging functions of UCP2 in health, disease, and therapeutics. Antioxid Redox Signal 8:1-38.
34. Montoliu C, Vallés S, Renau-Piqueras J, Guerri C (1994) Ethanol-induced oxygen radical formation and lipid peroxydation in rat brain: effect of chronic alcohol consumption. J Neurochem 63:1855-1862.
35. Nicholls DG, Locke RM (1984) Thermogenic mechanisms in brown fat. Physiol Rev 64:1-64.
36. Ouyang YB, Giffard RG (2001) Cellular neuroprotective mechanism in cerebral ischemia: Bcl-2 family proteins and protection of mitochondrial function. Cell Calcium 36:303-311.
37. Pawlak R, Skrzypiec A, Sulkowski S, Buczko W (2002) Ethanol-induced neurotoxicity is counterbalanced by increased cell proliferation in mouse dentate gyrus. Neurosci Lett 327:83-86.
38. Pecqueur C, Alves-Guerra MC, Gelly C, Levi-Meyrueis C, Couplan E, Collins S, Ricquier D, Bouillaud F, Miroux B (2001) Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J Biol Chem 276:8705-8712.
39. Pfefferbaum A, Lim KO, Zipursky RB, Mathalon DH, Rosenbloom MJ, Lane B, Ha CN, Sullivan EV (1992) Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol Clin Exp Res 16:1078-1089.
40. Rashid A, Wu TC, Huang CC, Chen CH, Lin HZ, Yang SQ, Lee FY, Diehl AM (1999) Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 29:1131-1138.
41. Richard D, Clavel S, Huang Q, Sanchis D, Ricquier D (2001) Uncoupling protein 2 in the brain: distribution and function. Biochem Soc Trans 29:812-817.
42. Richard D, Rivest R, Huang Q, Bouillaud F, Sanchis D, Champigny O, Ricquier D (1998) Distribution of the uncoupling protein 2 mRNA in the mouse brain. J Comp Neurol 397:549-560.
43. Roberts BJ, Shoaf SE, Jeong KS, Song BJ (1994) Induction of CYP2E1 in liver, kidney, brain and intestine during chronic alcohol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochem Biophys Res Commun 205:1064-1071.
44. Sanchis D, Fleury C, Chomiki N, Goubern M, Huang Q, Neverova M, Gregoire F, Easlick J, Raimbault S, Levi-Meyrueis C, Miroux B, Collins S, Seldin M, Richard D, Warden C, Bouillaud F, Ricquier D (1998) BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J Biol Chem 273:34611-34615.
45. Skulachev VP (1998) Uncoupling: new approaches to an old problem of bioenergetics. Biochim Biophys Acta 1363:100-124.
46. Smorodchenko A, Rupprecht A, Sarilova I, Ninnemann O, Bräuer AU, Franke K, Schumacher S, Techritz S, Nitsch R, Schuelke M, Pohl EE (2009) Comparative analysis of uncoupling 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta 1788:2309-2319.
47. Sullivan PG, Dube C, Dorenbos K, Steward O, Baram T (2003) Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol 53:711-717.
48. Voehringer DW, Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, Herzenberg LA, Steinman L, Herzenberg LA (2000) Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc Natl Acad Sci USA 97:2680-2685.
49. Vogler S, Pahnke J, Rousset S, Ricquier D, Moch H, Miroux B, Ibrahim SM (2006) Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis. Am J Pathol 168:1570-1575.
50. Yadav S, Pandey A, Shukla A, Talwelker SS, Kumar A, Pant AB, Parmar D (2011) miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2. J Biol Chem 286:37347-37357.
51. Yu XX, Mao W, Zhong A, Schow P, Brush J, Sherwood SW, Adams SH, Pan G (2000) Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB J 14:1611-1618.