C-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer

Oncogene

Volumn 33, Issue 36, 2014, Pages 4508-4520

  Fiore, L S ^a   Ganguly, S S ^a   Sledziona, J ^a   Cibull, M L ^a   Wang, C ^a   Richards, D L ^a   Neltner, J M ^a   Beach, C ^a   McCorkle, J R ^a,c   Kaetzel, D M ^b   Plattner, R ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Arg; c Abl; cathepsin; metastasis suppressor; NM23 H1

Indexed keywords

4 METHYL N (3 (4 METHYLIMIDAZOL 1 YL) 5 (TRIFLUOROMETHYL)PHENYL) 3 ((4 PYRIDIN 3 YLPYRIMIDIN 2 YL)AMINO)BENZAMIDE; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; ABELSON KINASE; ANTINEOPLASTIC AGENT; CATHEPSIN; NUCLEOSIDE DIPHOSPHATE KINASE NM23; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LYSOSOME; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; CATHEPSINS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; LYSOSOMES; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASMS, EXPERIMENTAL; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES;

EID: 84884967609     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.399     Document Type: Article

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