메뉴 건너뛰기




Volumn 66, Issue 10, 2013, Pages 839-846

Lung cancer in never-smokers. Does smoking history matter in the era of molecular diagnostics and targeted therapy?

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CRIZOTINIB; DABRAFENIB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN RET; ROS1 PROTEIN; SCATTER FACTOR RECEPTOR; SELUMETINIB; UNCLASSIFIED DRUG; VEMURAFENIB;

EID: 84884959620     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2012-201296     Document Type: Review
Times cited : (31)

References (95)
  • 2
    • 34648815009 scopus 로고    scopus 로고
    • Lung cancer in never smokers - A different disease
    • DOI 10.1038/nrc2190, PII NRC2190
    • Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers-a different disease. Nat Rev Cancer 2007;7:778-90. (Pubitemid 47463669)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.10 , pp. 778-790
    • Sun, S.1    Schiller, J.H.2    Gazdar, A.F.3
  • 3
    • 33947502512 scopus 로고    scopus 로고
    • Lung cancer in never smokers: A review
    • DOI 10.1200/JCO.2006.06.8015
    • Subramanian J, Govindan R. Lung cancer in never smokers: a review. J Clin Oncol 2007.;25:561-70. (Pubitemid 350002964)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.5 , pp. 561-570
    • Subramanian, J.1    Govindan, R.2
  • 4
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57.
    • (2009) N Engl J Med , vol.361 , pp. 947-57
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 7
    • 84869462031 scopus 로고    scopus 로고
    • Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: A success story to usher in the second decade of molecular targeted therapy in oncology
    • Ou SHI, Bartlett CH, Mino-Kenudson M, et al. Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: A success story to usher in the second decade of molecular targeted therapy in oncology. Oncologist 2012;17:1351-75.
    • (2012) Oncologist , vol.17 , pp. 1351-75
    • Ou, S.H.I.1    Bartlett, C.H.2    Mino-Kenudson, M.3
  • 8
    • 85064289371 scopus 로고    scopus 로고
    • Targeting ROS1 with anaplastic lymphoma kinase inhibitors. A promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer
    • Chin LP, Soo RA, Soong R, et al. Targeting ROS1 with anaplastic lymphoma kinase inhibitors. A promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer. J Thorac Oncol 2012;17:1351-75.
    • (2012) J Thorac Oncol , vol.17 , pp. 1351-75
    • Chin, L.P.1    Soo, R.A.2    Soong, R.3
  • 9
    • 84857985225 scopus 로고    scopus 로고
    • RET, ROS1 and ALK fusions in lung cancer
    • Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med 2012;18:378-81.
    • (2012) Nat Med , vol.18 , pp. 378-81
    • Takeuchi, K.1    Soda, M.2    Togashi, Y.3
  • 10
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • Paik PK, Arcila ME, Fara M, et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 2011;29:2046-51.
    • (2011) J Clin Oncol , vol.29 , pp. 2046-51
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3
  • 11
    • 4944232647 scopus 로고    scopus 로고
    • Lung cancer: Intragenic ERBB2 kinase mutations in tumours
    • Stephens P, Hunter C, Bignell G, et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 2004;30;431:525-6.
    • (2004) Nature , vol.30 , Issue.431 , pp. 525-6
    • Stephens, P.1    Hunter, C.2    Bignell, G.3
  • 12
    • 84875937242 scopus 로고    scopus 로고
    • Genotyping and genomic profiling of non-small-cell lung cancer: Implications for current and future therapies
    • Li T, Kung HJ, Mack PC, et al. Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies. J Clin Oncol 2013.;31:1039-49.
    • (2013) J Clin Oncol , vol.31 , pp. 1039-49
    • Li, T.1    Kung, H.J.2    MacK, P.C.3
  • 13
    • 69549121734 scopus 로고    scopus 로고
    • Asian ethnicity is a favorable prognostic factor for overall survival in non-small cell lung cancer (NSCLC) and is independent of smoking status
    • Ou SHI, Ziogas A, Zell JA. Asian ethnicity is a favorable prognostic factor for overall survival in non-small cell lung cancer (NSCLC) and is independent of smoking status. J Thorac Oncol 2009;4:1083-93.
    • (2009) J Thorac Oncol , vol.4 , pp. 1083-93
    • Ou, S.H.I.1    Ziogas, A.2    Zell, J.A.3
  • 14
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008;455:1069-75.
    • (2008) Nature , vol.455 , pp. 1069-75
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3
  • 15
    • 84866434919 scopus 로고    scopus 로고
    • Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    • Govindan R, Ding L, Griffith M, et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 2012;150:1121-34.
    • (2012) Cell , vol.150 , pp. 1121-34
    • Govindan, R.1    Ding, L.2    Griffith, M.3
  • 16
    • 84868309107 scopus 로고    scopus 로고
    • The transcriptional landscape and mutational profile of lung adenocarcinoma
    • Seo JS, Ju YS, Lee WC, et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res 2012;22:2109-19.
    • (2012) Genome Res , vol.22 , pp. 2109-19
    • Seo, J.S.1    Ju, Y.S.2    Lee, W.C.3
  • 17
    • 84861976809 scopus 로고    scopus 로고
    • First-SIGNAL: First-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
    • Han JY, Park K, Kim SW, et al. First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol 2012;30:1122-8.
    • (2012) J Clin Oncol , vol.30 , pp. 1122-8
    • Han, J.Y.1    Park, K.2    Kim, S.W.3
  • 18
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009;361:958-67.
    • (2009) N Engl J Med , vol.361 , pp. 958-67
    • Rosell, R.1    Moran, T.2    Queralt, C.3
  • 19
    • 84863892117 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial
    • Janne PA, Wang X, Socinski MA, et al. Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial. J Clin Oncol 2012.;30:2063-9.
    • (2012) J Clin Oncol , vol.30 , pp. 2063-9
    • Janne, P.A.1    Wang, X.2    Socinski, M.A.3
  • 20
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-8.
    • (2010) Lancet Oncol , vol.11 , pp. 121-8
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 21
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362:2380-8.
    • (2010) N Engl J Med , vol.362 , pp. 2380-8
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 22
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011;12:735-42.
    • (2011) Lancet Oncol , vol.12 , pp. 735-42
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 23
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-46.
    • (2012) Lancet Oncol , vol.13 , pp. 239-46
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 24
    • 84866655838 scopus 로고    scopus 로고
    • LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations
    • (suppl; abstr LBA7500)
    • Yang JCH, Schuler MH, Yamamoto N, et al. LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. J Clin Oncol 2012;30(suppl; abstr LBA7500).
    • (2012) J Clin Oncol , pp. 30
    • Yang, J.C.H.1    Schuler, M.H.2    Yamamoto, N.3
  • 25
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
    • Yang JC, Shih JY, Su WC, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol 2012;13:539-48.
    • (2012) Lancet Oncol , vol.13 , pp. 539-48
    • Yang, J.C.1    Shih, J.Y.2    Su, W.C.3
  • 27
    • 51049116207 scopus 로고    scopus 로고
    • Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response
    • Wu JY, Wu SG, Yang CH, et al. Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. Clin Cancer Res 2008;14:4877-82.
    • (2008) Clin Cancer Res , vol.14 , pp. 4877-82
    • Wu, J.Y.1    Wu, S.G.2    Yang, C.H.3
  • 29
    • 84865701893 scopus 로고    scopus 로고
    • Clinicopathologic characteristics of 11 NSCLC patients with EGFR-exon 20 mutations
    • Lung-Iversen M, Kleinberg L, Fjellbirkeland L, et al. Clinicopathologic characteristics of 11 NSCLC patients with EGFR-exon 20 mutations. J Thorac Oncol 2012.;7:1471-3.
    • (2012) J Thorac Oncol , vol.7 , pp. 1471-3
    • Lung-Iversen, M.1    Kleinberg, L.2    Fjellbirkeland, L.3
  • 30
    • 84873821602 scopus 로고    scopus 로고
    • Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions
    • Oxnard GR, Lo PC, Nishino M, et al. Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions. J Thorac Oncol 2013;8:179-84.
    • (2013) J Thorac Oncol , vol.8 , pp. 179-84
    • Oxnard, G.R.1    Lo, P.C.2    Nishino, M.3
  • 31
    • 84874024717 scopus 로고    scopus 로고
    • EGFR exon 20 insertion mutations in lung adenocarcinomas: Prevalence, molecular heterogeneity, and clinicopathologic characteristics
    • Arcila ME, Nafa K, Chaft JE, et al. EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics. Mol Cancer Ther 2013;12:220-9.
    • (2013) Mol Cancer Ther , vol.12 , pp. 220-9
    • Arcila, M.E.1    Nafa, K.2    Chaft, J.E.3
  • 32
    • 84871950516 scopus 로고    scopus 로고
    • How sensitive are epidermal growth factor receptor-tyrosine kinase inhibitors for squamous cell carcinoma of the lung harboring EGFR gene-sensitive mutations?
    • Hata A, Katakami N, Yoshioka H, et al. How sensitive are epidermal growth factor receptor-tyrosine kinase inhibitors for squamous cell carcinoma of the lung harboring EGFR gene-sensitive mutations? J Thorac Oncol 2013;8:89-95.
    • (2013) J Thorac Oncol , vol.8 , pp. 89-95
    • Hata, A.1    Katakami, N.2    Yoshioka, H.3
  • 33
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012;489:519-25.
    • (2012) Nature , vol.489 , pp. 519-25
  • 36
    • 33745981517 scopus 로고    scopus 로고
    • Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain
    • DOI 10.2353/jmoldx.2006.050132
    • Sonobe M, Manabe T, Wada H, et al. Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain. J Mol Diagn 2006;8:351-6. (Pubitemid 44063812)
    • (2006) Journal of Molecular Diagnostics , vol.8 , Issue.3 , pp. 351-356
    • Sonobe, M.1    Manabe, T.2    Wada, H.3    Tanaka, F.4
  • 37
    • 80052558779 scopus 로고    scopus 로고
    • Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers
    • Tomizawa K, Suda K, Onzato R, et al. Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers. Lung Cancer 2011;74:139-44.
    • (2011) Lung Cancer , vol.74 , pp. 139-44
    • Tomizawa, K.1    Suda, K.2    Onzato, R.3
  • 38
    • 82355191818 scopus 로고    scopus 로고
    • Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
    • Sequist LV, Heist RS, Shaw AT, et al. Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol 2011.;22:2616-24.
    • (2011) Ann Oncol , vol.22 , pp. 2616-24
    • Sequist, L.V.1    Heist, R.S.2    Shaw, A.T.3
  • 39
    • 84857929267 scopus 로고    scopus 로고
    • KIF5B-RET fusions in lung adenocarcinoma
    • Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med 2012;18:375-7.
    • (2012) Nat Med , vol.18 , pp. 375-7
    • Kohno, T.1    Ichikawa, H.2    Totoki, Y.3
  • 40
    • 84870317500 scopus 로고    scopus 로고
    • The introduction of systematic genomic testing for patients with non-small-cell lung cancer
    • Cardarella S, Ortiz TM, Joshi VA, et al. The introduction of systematic genomic testing for patients with non-small-cell lung cancer. J Thorac Oncol 2012.;7:1767-74.
    • (2012) J Thorac Oncol , vol.7 , pp. 1767-74
    • Cardarella, S.1    Ortiz, T.M.2    Joshi, V.A.3
  • 41
    • 84866360342 scopus 로고    scopus 로고
    • Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
    • Arcila ME, Chaft JE, Nafa K, et al. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res 2012;18:4910-18.
    • (2012) Clin Cancer Res , vol.18 , pp. 4910-18
    • Arcila, M.E.1    Chaft, J.E.2    Nafa, K.3
  • 42
    • 84877600056 scopus 로고    scopus 로고
    • Lung cancer harboring HER2 mutation: Epidemiological characteristics and therapeutic perspectives
    • supplement 9 ix403 (abstract number 1232)
    • Mazieres J, Peters S, Cortot A, et al. Lung cancer harboring HER2 mutation: epidemiological characteristics and therapeutic perspectives. Ann Oncol 2012;23: supplement 9 ix403 (abstract number 1232).
    • (2012) Ann Oncol , pp. 23
    • Mazieres, J.1    Peters, S.2    Cortot, A.3
  • 43
    • 84858002759 scopus 로고    scopus 로고
    • Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
    • De Grèvea J, Teugelsa E, Geersa C, et al. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer 2012;76:123-7.
    • (2012) Lung Cancer , vol.76 , pp. 123-7
    • De Grèvea, J.1    Teugelsa, E.2    Geersa, C.3
  • 44
    • 84884982613 scopus 로고    scopus 로고
    • Dacomitinib (PF-00299804), an irreversible pan-HER tyrosine kinase inhibitor (TKI), for first-line treatment of EGFR-mutant or HER2-mutant or -amplified lung cancers
    • September 28-October 2, Vienna, Austria. Abstract 1228
    • Janne PA, Kris M, Goldberg Z, et al. Dacomitinib (PF-00299804), an irreversible pan-HER tyrosine kinase inhibitor (TKI), for first-line treatment of EGFR-mutant or HER2-mutant or -amplified lung cancers. Presented at: European Society of Medical Oncology 2012 Congress; September 28-October 2, 2012; Vienna, Austria. Abstract 1228.
    • (2012) Presented At: European Society of Medical Oncology 2012 Congress
    • Janne, P.A.1    Kris, M.2    Goldberg, Z.3
  • 45
    • 77349091545 scopus 로고    scopus 로고
    • Biological and clinical significance of KRAS mutations in lung cancer: An oncogenic driver that contrasts with EGFR mutation
    • Suda K, Tomizawa K, Mitsudomi T. Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation. Cancer Metastasis Rev 2010;29:49-60.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 49-60
    • Suda, K.1    Tomizawa, K.2    Mitsudomi, T.3
  • 46
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • Riely GJ, Kris MG, Rosenbaum D, et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 2008.;14:5731-4.
    • (2008) Clin Cancer Res , vol.14 , pp. 5731-4
    • Riely, G.J.1    Kris, M.G.2    Rosenbaum, D.3
  • 47
    • 77955096407 scopus 로고    scopus 로고
    • KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small lung cancer: A meta-analysis of 22 studies
    • Mao C, Qiu LX, Liao RY, et al. KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small lung cancer: a meta-analysis of 22 studies. Lung Cancer 2010;69:272-8.
    • (2010) Lung Cancer , vol.69 , pp. 272-8
    • Mao, C.1    Qiu, L.X.2    Liao, R.Y.3
  • 48
    • 84863104686 scopus 로고    scopus 로고
    • Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status
    • An SJ, Chen ZH, Su J, et al. Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status. PLoS ONE 2012;7:e40109.
    • (2012) PLoS ONE , vol.7
    • An, S.J.1    Chen, Z.H.2    Su, J.3
  • 49
    • 84869224992 scopus 로고    scopus 로고
    • Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: Higher susceptibility of women to smoking-related KRAS-mutant cancers
    • Dogan S, Shen R, Ang DC, et al. Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. Clin Cancer Res 2012;18:6169-77.
    • (2012) Clin Cancer Res , vol.18 , pp. 6169-77
    • Dogan, S.1    Shen, R.2    Ang, D.C.3
  • 50
    • 84871720411 scopus 로고    scopus 로고
    • Selumetinib plus docetaxel for KRAS-mutated advanced non-small-cell lung cancer: A randomized, multicenter, placebo-controlled, phase 2 study
    • Janne PA, Shaw AT, Pereira JR, et al. Selumetinib plus docetaxel for KRAS-mutated advanced non-small-cell lung cancer: a randomized, multicenter, placebo-controlled, phase 2 study. Lancet Oncol 2013;14:38-47.
    • (2013) Lancet Oncol , vol.14 , pp. 38-47
    • Janne, P.A.1    Shaw, A.T.2    Pereira, J.R.3
  • 51
    • 84875943507 scopus 로고    scopus 로고
    • KRAS mutation: Should we test for it, and does it matter?
    • Roberts PJ, Stinchcombe TE. KRAS mutation: should we test for it, and does it matter? J Clin Oncol 2013;31:1112-21.
    • (2013) J Clin Oncol , vol.31 , pp. 1112-21
    • Roberts, P.J.1    Stinchcombe, T.E.2
  • 52
    • 84876416500 scopus 로고    scopus 로고
    • KRAS mutations as prognostic and predictive markers in non-small cell lung cancer
    • epublished ahead of print
    • Martin P, Leighl NB, Tsao MS, et al. KRAS mutations as prognostic and predictive markers in non-small cell lung cancer. J Thorac Oncol 2013; epublished ahead of print.
    • (2013) J Thorac Oncol
    • Martin, P.1    Leighl, N.B.2    Tsao, M.S.3
  • 53
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16.
    • (2011) N Engl J Med , vol.364 , pp. 2507-16
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 54
    • 80053014471 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
    • Marchetti A, Felicioni L, Malatesta S, et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J Clin Oncol 2011.;29:3574-9.
    • (2011) J Clin Oncol , vol.29 , pp. 3574-9
    • Marchetti, A.1    Felicioni, L.2    Malatesta, S.3
  • 55
    • 84855164491 scopus 로고    scopus 로고
    • Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer
    • Kobayashi M, Sonobe M, Takahashi T, et al. Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer. Anticancer Res 2011.;31:4619-24.
    • (2011) Anticancer Res , vol.31 , pp. 4619-24
    • Kobayashi, M.1    Sonobe, M.2    Takahashi, T.3
  • 56
    • 52149114884 scopus 로고    scopus 로고
    • The histopathology of BRAF-V600E-mutated lung adenocarcinoma
    • Yousem SA, Nikiforova M, Nikiforov Y. The histopathology of BRAF-V600E-mutated lung adenocarcinoma. Am J Surg Pathol 2008;32:1317-21.
    • (2008) Am J Surg Pathol , vol.32 , pp. 1317-21
    • Yousem, S.A.1    Nikiforova, M.2    Nikiforov, Y.3
  • 57
    • 84874581453 scopus 로고    scopus 로고
    • Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in primary lung adenocarcinoma Caucasian patients
    • Ilie M, Long E, Hofman V, et al. Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in primary lung adenocarcinoma Caucasian patients. Ann Oncol 2013;24:742-8.
    • (2013) Ann Oncol , vol.24 , pp. 742-8
    • Ilie, M.1    Long, E.2    Hofman, V.3
  • 58
    • 84866595717 scopus 로고    scopus 로고
    • A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib
    • Gautschi O, Pauli C, Strobel K, et al. A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib. J Thorac Oncol 2012;10: e23-4.
    • (2012) J Thorac Oncol , vol.10
    • Gautschi, O.1    Pauli, C.2    Strobel, K.3
  • 59
    • 84876419277 scopus 로고    scopus 로고
    • Molecular characterization of acquired resistance to the BRAF Inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer
    • epublished ahead of print
    • Rudin CM, Hong K, Streit M. Molecular characterization of acquired resistance to the BRAF Inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer. J Thorac Oncol 2013; epublished ahead of print.
    • (2013) J Thorac Oncol
    • Rudin, C.M.1    Hong, K.2    Streit, M.3
  • 60
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367:1694-703.
    • (2012) N Engl J Med , vol.367 , pp. 1694-703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 61
    • 69349083935 scopus 로고    scopus 로고
    • Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
    • Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res 2009;15:5216-23.
    • (2009) Clin Cancer Res , vol.15 , pp. 5216-23
    • Rodig, S.J.1    Mino-Kenudson, M.2    Dacic, S.3
  • 62
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009.;27:4247-53.
    • (2009) J Clin Oncol , vol.27 , pp. 4247-53
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 63
    • 79955467025 scopus 로고    scopus 로고
    • Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component
    • Yoshida A, Tsuta K, Watanabe SI, et al. Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component. Lung Cancer 2011;72:309-15.
    • (2011) Lung Cancer , vol.72 , pp. 309-15
    • Yoshida, A.1    Tsuta, K.2    Watanabe, S.I.3
  • 64
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 65
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study
    • Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012;10:1011-19.
    • (2012) Lancet Oncol , vol.10 , pp. 1011-19
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3
  • 66
    • 84865431278 scopus 로고    scopus 로고
    • Results of a global phase II study with crizotinib in ALK-positive NSCLC
    • (suppl; abstr 7533)
    • Kim DW, Ahn MJ, Shi Y, et al. Results of a global phase II study with crizotinib in ALK-positive NSCLC. J Clin Oncol 2012;30(suppl; abstr 7533).
    • (2012) J Clin Oncol , pp. 30
    • Kim, D.W.1    Ahn, M.J.2    Shi, Y.3
  • 67
    • 84872569905 scopus 로고    scopus 로고
    • Phase III study of crizotinib vs pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive NSCLC (PROFILE 1007.)
    • LBA1
    • Shaw AT, Kim DY, Nagakawa K, et al. Phase III study of crizotinib vs pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive NSCLC (PROFILE 1007.). Ann Oncol 2012;23(Suppl 9):LBA1.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Shaw, A.T.1    Kim, D.Y.2    Nagakawa, K.3
  • 69
    • 84859794344 scopus 로고    scopus 로고
    • ROS1 as a 'druggable' receptor tyrosine kinase: Lessons learned from inhibiting the ALK pathway
    • Ou SH, Jam J, Yen Y, et al. ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway. Expert Rev Anticancer Ther 2012;2:447-56.
    • (2012) Expert Rev Anticancer Ther , vol.2 , pp. 447-56
    • Ou, S.H.1    Jam, J.2    Yen, Y.3
  • 70
    • 82355161909 scopus 로고    scopus 로고
    • Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers
    • Li C, Fang R, Sun Y, et al. Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers. PLoS ONE 2011;6:e28204.
    • (2011) PLoS ONE , vol.6
    • Li, C.1    Fang, R.2    Sun, Y.3
  • 71
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • Bergethon K, Shaw AT, Ou SHI, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 2012;30:863-70.
    • (2012) J Clin Oncol , vol.30 , pp. 863-70
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.I.3
  • 72
    • 84865089246 scopus 로고    scopus 로고
    • Analysis of receptor tyrosine kinase ROS1-Positive tumors in non-small cell lung cancer: Identification of a FIG-ROS1 fusion
    • Rimkunas VM, Crosby KE, Li D, et al. Analysis of receptor tyrosine kinase ROS1-Positive tumors in non-small cell lung cancer: Identification of a FIG-ROS1 fusion. Clin Cancer Res 2012;18:4449-57.
    • (2012) Clin Cancer Res , vol.18 , pp. 4449-57
    • Rimkunas, V.M.1    Crosby, K.E.2    Li, D.3
  • 73
    • 84865441368 scopus 로고    scopus 로고
    • Identifying and targeting ROS1 gene fusions in non-small cell lung cancer
    • Davies KD, Le AT, Theodoro MF, et al. Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. Clin Cancer Res 2012;18:4570-9.
    • (2012) Clin Cancer Res , vol.18 , pp. 4570-9
    • Davies, K.D.1    Le, A.T.2    Theodoro, M.F.3
  • 74
    • 84871181092 scopus 로고    scopus 로고
    • Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions
    • Suehara Y, Arcila M, Wang L, et al. Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. Clin Cancer Res 2012;18:6599-608.
    • (2012) Clin Cancer Res , vol.18 , pp. 6599-608
    • Suehara, Y.1    Arcila, M.2    Wang, L.3
  • 75
    • 84868309107 scopus 로고    scopus 로고
    • The transcriptional landscape and mutational profile of lung adenocarcinoma
    • Seo JS, Ju YS, Lee WC, et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Geonome Res 2012;22:2109-19.
    • (2012) Geonome Res , vol.22 , pp. 2109-19
    • Seo, J.S.1    Ju, Y.S.2    Lee, W.C.3
  • 76
    • 84875224942 scopus 로고    scopus 로고
    • ROS1-rearranged lung cancer. A clinicopathologic and molecular study of 15 surgical cases
    • Yoshida A, Kohno T, Tsuta K, et al. ROS1-rearranged lung cancer. A clinicopathologic and molecular study of 15 surgical cases. Am J Surg Pathol 2013.;37:554-62.
    • (2013) Am J Surg Pathol , vol.37 , pp. 554-62
    • Yoshida, A.1    Kohno, T.2    Tsuta, K.3
  • 78
    • 84865092224 scopus 로고    scopus 로고
    • Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement
    • (suppl; abstract 7508)
    • Shaw AT, Camidge DR, Engelman JA, et al. Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement. J Clin Oncol 2012;30 (suppl; abstract 7508).
    • (2012) J Clin Oncol , pp. 30
    • Shaw, A.T.1    Camidge, D.R.2    Engelman, J.A.3
  • 79
    • 78650412305 scopus 로고    scopus 로고
    • Targeting RET receptor tyrosine kinase activation in cancer
    • Phay JE, Shah MH. Targeting RET receptor tyrosine kinase activation in cancer. Clin Cancer Res 2010;16:5936-41.
    • (2010) Clin Cancer Res , vol.16 , pp. 5936-41
    • Phay, J.E.1    Shah, M.H.2
  • 80
    • 84862776857 scopus 로고    scopus 로고
    • Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
    • Lipson D, Capelletti M, Yelensky R, et al. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med 2012;18:382-4.
    • (2012) Nat Med , vol.18 , pp. 382-4
    • Lipson, D.1    Capelletti, M.2    Yelensky, R.3
  • 81
    • 84862812241 scopus 로고    scopus 로고
    • Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers
    • Li F, Feng Y, Fang R, et al. Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers. Cell Res 2012;22:928-31.
    • (2012) Cell Res , vol.22 , pp. 928-31
    • Li, F.1    Feng, Y.2    Fang, R.3
  • 82
    • 84870748688 scopus 로고    scopus 로고
    • RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer
    • Wang R, Hu H, Pan Y, et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol 2012.;30:4352-9.
    • (2012) J Clin Oncol , vol.30 , pp. 4352-9
    • Wang, R.1    Hu, H.2    Pan, Y.3
  • 83
    • 84876033073 scopus 로고    scopus 로고
    • KIF5B-RET fusions in Chinese patients with non-small cell lung cancer
    • epublish ahead of print
    • Cai W, Su C, Fan L, et al. KIF5B-RET fusions in Chinese patients with non-small cell lung cancer. Cancer 2013; [epublish ahead of print].
    • (2013) Cancer
    • Cai, W.1    Su, C.2    Fan, L.3
  • 84
    • 84878858856 scopus 로고    scopus 로고
    • Response to cabozantinib in patients with RET fusion-positive lung adenocarcinomas
    • Epub ahead of print
    • Drilon A, Wang L, Hasanovic A, et al. Response to cabozantinib in patients with RET fusion-positive lung adenocarcinomas. Cancer Discov 2013; [Epub ahead of print].
    • (2013) Cancer Discov
    • Drilon, A.1    Wang, L.2    Hasanovic, A.3
  • 85
    • 84877686704 scopus 로고    scopus 로고
    • Ponatinib (AP24534) is a novel potent inhibitor of oncogenic RET mutants associated with thyroid cancer
    • Epub ahead of print
    • De Falco V, Buonocore P, Muthu M, et al. Ponatinib (AP24534) is a novel potent inhibitor of oncogenic RET mutants associated with thyroid cancer. J Clin Endocrinol Metab 2013; [Epub ahead of print].
    • (2013) J Clin Endocrinol Metab
    • De Falco, V.1    Buonocore, P.2    Muthu, M.3
  • 86
    • 78650451788 scopus 로고    scopus 로고
    • Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
    • Weiss J, Sos ML, Seidel D, et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med 2010;2:62ra93.
    • (2010) Sci Transl Med , vol.2
    • Weiss, J.1    Sos, M.L.2    Seidel, D.3
  • 87
    • 84870336531 scopus 로고    scopus 로고
    • FGFR1 amplification in squamous cell carcinoma of the lung
    • Heist RS, Mino-Kenudson M, Sequist LV, et al. FGFR1 amplification in squamous cell carcinoma of the lung. J Thorac Oncol 2012;7:1775-80.
    • (2012) J Thorac Oncol , vol.7 , pp. 1775-80
    • Heist, R.S.1    Mino-Kenudson, M.2    Sequist, L.V.3
  • 88
    • 84874888512 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 gene amplification Is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer
    • Kim HR, Kim DJ, Kang DR, et al. Fibroblast growth factor receptor 1 gene amplification Is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. J Clin Oncol 2012;31:731-7.
    • (2012) J Clin Oncol , vol.31 , pp. 731-7
    • Kim, H.R.1    Kim, D.J.2    Kang, D.R.3
  • 89
    • 79958112619 scopus 로고    scopus 로고
    • Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer
    • Dutt A, Ramos AH, Hammerman PS, et al. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS One 2011;6:e20351.
    • (2011) PLoS One , vol.6
    • Dutt, A.1    Ramos, A.H.2    Hammerman, P.S.3
  • 90
    • 84871217393 scopus 로고    scopus 로고
    • Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models
    • Zhang J, Zhang L, Su X, et al. Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. Clin Cancer Res. 2012;18:6658-67.
    • (2012) Clin Cancer Res. , vol.18 , pp. 6658-67
    • Zhang, J.1    Zhang, L.2    Su, X.3
  • 91
    • 63849163410 scopus 로고    scopus 로고
    • Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
    • Cappuzzo F, Marchetti A, Skokan M, et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol 2009;27:1667-74.
    • (2009) J Clin Oncol , vol.27 , pp. 1667-74
    • Cappuzzo, F.1    Marchetti, A.2    Skokan, M.3
  • 92
    • 77649308276 scopus 로고    scopus 로고
    • High MET gene copy number leads to shorter survival inpatients with non-small cell lung cancer
    • Go H, Jeon YK, Park HL, et al. High MET gene copy number leads to shorter survival inpatients with non-small cell lung cancer. J Thorac Oncol 2010;5:305-13.
    • (2010) J Thorac Oncol , vol.5 , pp. 305-13
    • Go, H.1    Jeon, Y.K.2    Park, H.L.3
  • 93
    • 79955458487 scopus 로고    scopus 로고
    • Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
    • Ou SHI, Kwak E, Siwak-Tapp C, et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol 2011;6:942-6.
    • (2011) J Thorac Oncol , vol.6 , pp. 942-6
    • Ou, S.H.I.1    Kwak, E.2    Siwak-Tapp, C.3
  • 94
    • 84876412641 scopus 로고    scopus 로고
    • MET and EGFR mutations is identified in ALK-rearranged pulmonary adenocarcinoma. Molecular analysis of 25 ALK-positive cases
    • epublish ahead of print
    • MET and EGFR mutations is identified in ALK-rearranged pulmonary adenocarcinoma. Molecular analysis of 25 ALK-positive cases. J Thorac Oncol 2013, [epublish ahead of print].
    • (2013) J Thorac Oncol
  • 95
    • 80555139776 scopus 로고    scopus 로고
    • Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's lung cancer mutation consortium (LCMC)
    • (suppl; abstract 7506.)
    • Kris MG, Johnson BE, Kwiatkowski DJ, et al. Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: the NCI's Lung Cancer Mutation Consortium (LCMC). J Clin Oncol 2011;29, (suppl; abstract 7506.).
    • (2011) J Clin Oncol , pp. 29
    • Kris, M.G.1    Johnson, B.E.2    Kwiatkowski, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.