-
1
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304:1497-500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
-
2
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350:2129-39.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
3
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers," and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004; 101:13306-11.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
-
4
-
-
19944426858
-
High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan
-
Huang SF, Liu HP, Li LH, Ku YC, Fu YN, Tsai HY, et al.High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Clin Cancer Res 2004; 10:8195-203.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8195-8203
-
-
Huang, S.F.1
Liu, H.P.2
Li, L.H.3
Ku, Y.C.4
Fu, Y.N.5
Tsai, H.Y.6
-
5
-
-
10844231985
-
Mutations of the epidermal growthfactor receptor gene inlung cancer: Biological and clinical implications
-
Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growthfactor receptor gene inlung cancer: biological and clinical implications. Cancer Res 2004; 64:8919-23.
-
(2004)
Cancer Res
, vol.64
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
Kuwano, H.4
Takahashi, T.5
Mitsudomi, T.6
-
6
-
-
35748941360
-
EGFR exon 20 insertion mutation in Japanese lung cancer
-
Sasaki H, Endo K, Takada M, Kawahara M, Kitahara N, Tanaka H, et al. EGFR exon 20 insertion mutation in Japanese lung cancer. Lung Cancer 2007; 58:324-8.
-
(2007)
Lung Cancer
, vol.58
, pp. 324-328
-
-
Sasaki, H.1
Endo, K.2
Takada, M.3
Kawahara, M.4
Kitahara, N.5
Tanaka, H.6
-
7
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005; 97:339-46.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
Nomura, M.4
Suzuki, M.5
Wistuba, I.I.6
-
8
-
-
51049116207
-
Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response
-
Wu JY, Wu SG, Yang CH, Gow CH, Chang YL, Yu CJ, et al. Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. Clin Cancer Res 2008; 14:4877-82.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4877-4882
-
-
Wu, J.Y.1
Wu, S.G.2
Yang, C.H.3
Gow, C.H.4
Chang, Y.L.5
Yu, C.J.6
-
9
-
-
33846444010
-
Response totreatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing
-
Sequist LV, Joshi VA, Janne PA, Muzikansky A, Fidias P, Meyerson M, et al. Response totreatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing. Oncologist 2007; 12:90-8.
-
(2007)
Oncologist
, vol.12
, pp. 90-98
-
-
Sequist, L.V.1
Joshi, V.A.2
Janne, P.A.3
Muzikansky, A.4
Fidias, P.5
Meyerson, M.6
-
10
-
-
37549061078
-
PF00299804, anirreversiblepan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
-
Engelman JA, Zejnullahu K, Gale CM, Lifshits E, Gonzales AJ, Shimamura T, et al. PF00299804, anirreversiblepan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res 2007; 67:11924-32.
-
(2007)
Cancer Res
, vol.67
, pp. 11924-11932
-
-
Engelman, J.A.1
Zejnullahu, K.2
Gale, C.M.3
Lifshits, E.4
Gonzales, A.J.5
Shimamura, T.6
-
11
-
-
28444478439
-
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
-
Greulich H, Chen TH, Feng W, Janne PA, Alvarez JV, Zappaterra M, et al. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med 2005; 2:e313.
-
(2005)
PLoS Med
, vol.2
-
-
Greulich, H.1
Chen, T.H.2
Feng, W.3
Janne, P.A.4
Alvarez, J.V.5
Zappaterra, M.6
-
12
-
-
79954574430
-
Characterizationofepidermalgrowth factor receptormutationsinnonsmall-cell lung cancer patients of African-American ancestry
-
Harada T, Lopez-Chavez A, Xi L, Raffeld M, Wang Y, Giaccone G. Characterizationofepidermalgrowth factor receptormutationsinnonsmall-cell lung cancer patients of African-American ancestry. Oncogene 2011; 30:1744-52.
-
(2011)
Oncogene
, vol.30
, pp. 1744-1752
-
-
Harada, T.1
Lopez-Chavez, A.2
Xi, L.3
Raffeld, M.4
Wang, Y.5
Giaccone, G.6
-
13
-
-
49149118719
-
BIBW2992, anirreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, et al. BIBW2992, anirreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008; 27:4702-11.
-
(2008)
Oncogene
, vol.27
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
Kubo, S.4
Takahashi, M.5
Chirieac, L.R.6
-
14
-
-
33847371736
-
Alleledependent variation in the relative cellular potency of distinct EGFR inhibitors
-
Yuza Y, Glatt KA, Jiang J, Greulich H, Minami Y, Woo MS, et al. Alleledependent variation in the relative cellular potency of distinct EGFR inhibitors. Cancer Biol Ther 2007; 6:661-7.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 661-667
-
-
Yuza, Y.1
Glatt, K.A.2
Jiang, J.3
Greulich, H.4
Minami, Y.5
Woo, M.S.6
-
15
-
-
79952267022
-
Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced Malignant solid tumors
-
Janne PA, Boss DS, Camidge DR, Britten CD, Engelman JA, Garon EB, et al. Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumors. Clin Cancer Res 2011; 17:1131-9.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1131-1139
-
-
Janne, P.A.1
Boss, D.S.2
Camidge, D.R.3
Britten, C.D.4
Engelman, J.A.5
Garon, E.B.6
-
16
-
-
77954584507
-
Neratinib, an irreversible pan-erbb receptor tyrosine kinase inhibitor: Results of a phase II trial in patients with advanced non-small-cell lung cancer
-
Sequist LV, Besse B, Lynch TJ, Miller VA, Wong KK, Gitlitz B, et al. Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer. J Clin Oncol 2010; 28:3076-83.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3076-3083
-
-
Sequist, L.V.1
Besse, B.2
Lynch, T.J.3
Miller, V.A.4
Wong, K.K.5
Gitlitz, B.6
-
17
-
-
34250161814
-
Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-akt-positive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL trial
-
Cappuzzo F, Ligorio C, Janne PA, Toschi L, Rossi E, Trisolini R, et al. Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial. J Clin Oncol 2007; 25:2248-55.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2248-2255
-
-
Cappuzzo, F.1
Ligorio, C.2
Janne, P.A.3
Toschi, L.4
Rossi, E.5
Trisolini, R.6
-
18
-
-
24944497744
-
Mutationsintheepidermal growth factor receptorand in KRAS are predictive and prognostic indicators in patients with nonsmall-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, et al. Mutationsintheepidermal growth factor receptorand in KRAS are predictive and prognostic indicators in patients with nonsmall-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005; 23:5900-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
Goddard, A.D.4
Heldens, S.L.5
Herbst, R.S.6
-
19
-
-
69349088824
-
Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomesinpreviously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials
-
Jackman DM, Miller VA, Cioffredi LA, Yeap BY, Janne PA, Riely GJ, et al. Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomesinpreviously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials. Clin Cancer Res 2009; 15:5267-73.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5267-5273
-
-
Jackman, D.M.1
Miller, V.A.2
Cioffredi, L.A.3
Yeap, B.Y.4
Janne, P.A.5
Riely, G.J.6
-
20
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, Grunberg SM, Spira A, Janne PA, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008; 26: 2442-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
Grunberg, S.M.4
Spira, A.5
Janne, P.A.6
-
21
-
-
20244388126
-
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
-
Mitsudomi T, Kosaka T, Endoh H, Horio Y, Hida T, Mori S, et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 2005; 23: 2513-20.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2513-2520
-
-
Mitsudomi, T.1
Kosaka, T.2
Endoh, H.3
Horio, Y.4
Hida, T.5
Mori, S.6
-
22
-
-
21044445279
-
Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer
-
Chou TY, Chiu CH, Li LH, Hsiao CY, Tzen CY, Chang KT, et al. Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer. Clin Cancer Res 2005; 11: 3750-7.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3750-3757
-
-
Chou, T.Y.1
Chiu, C.H.2
Li, L.H.3
Hsiao, C.Y.4
Tzen, C.Y.5
Chang, K.T.6
-
23
-
-
84855310079
-
Costa DBEGFR exon20insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications
-
Yasuda H, Kobayashi S, Costa DB. EGFR exon20insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol 2012; 13:e23-31.
-
(2012)
Lancet Oncol
, vol.13
-
-
Yasuda, H.1
Kobayashi, S.2
-
24
-
-
23844544647
-
Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
-
Pan Q, Pao W, Ladanyi M. Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas. J Mol Diagn 2005; 7:396-403.
-
(2005)
J Mol Diagn
, vol.7
, pp. 396-403
-
-
Pan, Q.1
Pao, W.2
Ladanyi, M.3
-
25
-
-
78651071913
-
Detection of KRAS and BRAF mutations in colorectal carcinoma roles for high-sensitivity locked nucleic acid-PCR sequencing and broad-spectrum mass spectrometry genotyping
-
Arcila M, Lau C, Nafa K, Ladanyi M. Detection of KRAS and BRAF mutations in colorectal carcinoma roles for high-sensitivity locked nucleic acid-PCR sequencing and broad-spectrum mass spectrometry genotyping. J Mol Diagn 2011; 13:64-73.
-
(2011)
J Mol Diagn
, vol.13
, pp. 64-73
-
-
Arcila, M.1
Lau, C.2
Nafa, K.3
Ladanyi, M.4
-
26
-
-
84857087591
-
Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: Lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations
-
Rekhtman N, Paik PK, Arcila ME, Tafe LJ, Oxnard GR, Moreira AL, et al. Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations. Clin Cancer Res 2012; 18: 1167-76.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1167-1176
-
-
Rekhtman, N.1
Paik, P.K.2
Arcila, M.E.3
Tafe, L.J.4
Oxnard, G.R.5
Moreira, A.L.6
-
27
-
-
78651079558
-
A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer
-
Su Z, Dias-Santagata D, Duke M, Hutchinson K, Lin YL, Borger DR, et al. A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer. J Mol Diagn 2011; 13:74-84.
-
(2011)
J Mol Diagn
, vol.13
, pp. 74-84
-
-
Su, Z.1
Dias-Santagata, D.2
Duke, M.3
Hutchinson, K.4
Lin, Y.L.5
Borger, D.R.6
-
28
-
-
79551563284
-
International association for the study of lung cancer/ American thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
-
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/ american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011; 6:244-85.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 244-285
-
-
Travis, W.D.1
Brambilla, E.2
Noguchi, M.3
Nicholson, A.G.4
Geisinger, K.R.5
Yatabe, Y.6
-
29
-
-
80053189298
-
Predicting the functional impact of protein mutations: Application to cancer genomics
-
Reva B, Antipin Y, Sander C. Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Res 2011; 39:e118.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Reva, B.1
Antipin, Y.2
Sander, C.3
-
30
-
-
84856823963
-
Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling
-
Chaft JE, Arcila ME, Paik PK, Lau C, Riely GJ, Pietanza MC, et al. Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma- rationale for comprehensive mutation profiling. Mol Cancer Ther 2012; 11:485-91.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 485-491
-
-
Chaft, J.E.1
Arcila, M.E.2
Paik, P.K.3
Lau, C.4
Riely, G.J.5
Pietanza, M.C.6
-
31
-
-
84858201603
-
EGFR exon 19 insertions: A new family of sensitizing EGFR mutations in lung adenocarcinoma
-
He M, Capelletti M, Nafa K, Yun CH, Arcila ME, Miller VA, et al. EGFR exon 19 insertions: a new family of sensitizing EGFR mutations in lung adenocarcinoma. Clin Cancer Res 2012; 18:1790-7.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1790-1797
-
-
He, M.1
Capelletti, M.2
Nafa, K.3
Yun, C.H.4
Arcila, M.E.5
Miller, V.A.6
-
32
-
-
84866360342
-
Prevalence, clinicopathologic associations and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
-
Arcila ME, Chaft JE, Nafa K, Roy-Chowdhuri S, Lau C, Zaidinski M, et al. Prevalence, clinicopathologic associations and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res 2012; 18:4910-8.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4910-4918
-
-
Arcila, M.E.1
Chaft, J.E.2
Nafa, K.3
Roy-Chowdhuri, S.4
Lau, C.5
Zaidinski, M.6
-
33
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, Grunberg SM, Spira A, Janne PA, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008; 26: 2442-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
Grunberg, S.M.4
Spira, A.5
Janne, P.A.6
-
34
-
-
33750381018
-
Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L
-
Asahina H, Yamazaki K, Kinoshita I, Yokouchi H, Dosaka-Akita H, Nishimura M. Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L. Lung Cancer 2006; 54:419-22.
-
(2006)
Lung Cancer
, vol.54
, pp. 419-422
-
-
Asahina, H.1
Yamazaki, K.2
Kinoshita, I.3
Yokouchi, H.4
Dosaka-Akita, H.5
Nishimura, M.6
-
35
-
-
78651339071
-
EGFR mutation detection in NSCLC- assessment of diagnostic application and recommendations of the german panel for mutation testing in NSCLC
-
Penzel R, Sers C, Chen Y, Lehmann-Muhlenhoff U, MerkelbachBruse S, Jung A, et al. EGFR mutation detection in NSCLC- assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC. Virchows Archiv 2011; 458:95-8.
-
(2011)
Virchows Archiv
, vol.458
, pp. 95-98
-
-
Penzel, R.1
Sers, C.2
Chen, Y.3
Lehmann-Muhlenhoff, U.4
MerkelbachBruse, S.5
Jung, A.6
|