Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1155-1163

  Tsakiri, Eleni N ^a   Iliaki, Kalliopi K ^a   Höhn, Annika ^b   Grimm, Stefanie ^b   Papassideri, Issidora S ^a   Grune, Tilman ^b   Trougakos, Ioannis P ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Advanced glycation end products; Aging; Cathepsin; Drosophila; Free radicals; Lipofuscin; Lysosome; Proteasome

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALBUMIN; CATHEPSIN B; CATHEPSIN D; FRUCTOSE; GLUCOSE; LIPOFUSCIN; PEPTIDASE; PROTEASOME; PROTEASOME PEPTIDASE; RIBOSE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CULTURE MEDIUM; DIET; DROSOPHILA; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HEMOLYMPH; IN VIVO STUDY; LIFESPAN; LOCOMOTION; LONGEVITY; LYSOSOME; MALE; MUSCLE TISSUE; NERVOUS TISSUE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; SENESCENCE; UPREGULATION;

DROSOPHILA MELANOGASTER;

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCTS; AGE; AGING; ALS; AUTOPHAGY-LYSOSOME SYSTEM; BOVINE SERUM ALBUMIN; BSA; C-L; CASPASE-LIKE; CATHEPSIN; CHYMOTRYPSIN-LIKE; CML; CT-L; DROSOPHILA; FRC; FREE RADICALS; FRUCTOSE; GAPDH; GLC; GLUCOSE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; LF; LIPOFUSCIN; LYSOSOME; N(Ε)-(CARBOXYMETHYL)LYSINE; PN; PROTEASOME; PROTEOSTASIS NETWORK; RAGE; REACTIVE OXYGEN SPECIES; RECEPTOR FOR AGES; RIB; RIBOSE; ROS; T-L; TRYPSIN-LIKE; UBIQUITIN-PROTEASOME SYSTEM; UPS;

AGING; ALBUMINS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CATHEPSIN B; CATHEPSIN D; CATHEPSIN L; DIET; DROSOPHILA MELANOGASTER; FRUCTOSE; GLUCOSE; GLYCOSYLATION; GLYCOSYLATION END PRODUCTS, ADVANCED; LIPOFUSCIN; LONGEVITY; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN FOLDING; RIBOSE; RNA INTERFERENCE; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84884940660     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.08.186     Document Type: Article

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