Synergistic anti-proliferative effect of resveratrol and etoposide on human hepatocellular and colon cancer cell lines

European Journal of Pharmacology

Volumn 718, Issue 1-3, 2013, Pages 34-40

  Amiri, Fatemehsadat ^a   Zarnani, Amir Hassan ^a,b   Zand, Hamid ^c   Koohdani, Fariba ^d   Jeddi Tehrani, Mahmood ^b   Vafa, Mohammadreza ^a  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cytotoxicity; Etoposide; HCT 116; HepG2; p53; Resveratrol

Indexed keywords

ETOPOSIDE; PROTEIN P53; RESVERATROL;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

CYTOTOXICITY; ETOPOSIDE; HCT-116; HEPG2; P53; RESVERATROL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG SYNERGISM; ETOPOSIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; STILBENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84884924798     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.09.020     Document Type: Article

References (32)

1. J.K. Aluyen, Q.N. Ton, T. Tran, A.E. Yang, H.B. Gottlieb, and R.A. Bellanger Resveratrol: potential as anticancer agent Journal of Dietary Supplements 9 2012 45 56
2. V.P. Androutsopoulos, K.C. Ruparelia, A. Papakyriakou, H. Filippakis, A.M. Tsatsakis, and D.A. Spandidos Anticancer effects of the metabolic products of the resveratrol analog, DMU-212: structural requirements for potency European Journal of Medicinal Chemistry 46 2011 2586 2595
3. M. Athar, J.H. Back, L. Kopelovich, D.R. Bickers, and A.L. Kim Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms Archives of Biochemistry and Biophysics 486 2009 95 102
4. S.J. Baek, L.C. Wilson, and T.E. Eling Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53 Carcinogenesis 23 2002 425 434 (Pubitemid 34257622)
5. B. Blechacz, and L. Mishra Hepatocellular carcinoma biology. Recent results in cancer research Fortschritte der Krebsforschung 190 2013 1 20
6. A. Borriello, D. Bencivenga, I. Caldarelli, A. Tramontano, A. Borgia, A. Pirozzi, A. Oliva, and F.D. Ragione Resveratrol and cancer treatment: is hormesis a yet unsolved matter? Current Pharmaceutical Design 2013
7. M. Casanova, M. Massimino, A. Ferrari, F. Spreafico, L. Piva, J. Coppa, R. Luksch, G. Cefalo, M. Terenziani, D. Polastri, F.F. Bellani, and V. Mazzaferro Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors Pediatric Hematology and Oncology 22 2005 189 198 (Pubitemid 40604863)
8. S.C. Gupta, R. Kannappan, S. Reuter, J.H. Kim, and B.B. Aggarwal Chemosensitization of tumors by resveratrol Annals of the New York Academy of Sciences 1215 2011 150 160
9. J.T. Hwang, D.W. Kwak, S.K. Lin, H.M. Kim, Y.M. Kim, and O.J. Park Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway Annals of the New York Academy of Sciences 1095 2007 441 448
10. K. In, J. Park, and H. Park Resveratrol at high doses acts as an apoptotic inducer in endothelial cells Cancer Research and Treatment 38 2006 48 53
11. M. Jang, L. Cai, G.O. Udeani, K.V. Slowing, C.F. Thomas, C.W. Beecher, H.H. Fong, N.R. Farnsworth, A.D. Kinghorn, R.G. Mehta, R.C. Moon, and J.M. Pezzuto Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science (New York) 275 1997 218 220 (Pubitemid 127696281)
12. M.E. Juan, I. Alfaras, and J.M. Planas Colorectal cancer chemoprevention by trans-resveratrol Pharmacological Research 65 2012 584 591
13. N.O. Karpinich, M. Tafani, R.J. Rothman, M.A. Russo, and J.L. Farber The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c Journal of Biological Chemistry 277 2002 16547 16552 (Pubitemid 34967670)
14. N.O. Karpinich, M. Tafani, T. Schneider, M.A. Russo, and J.L. Farber The course of etoposide-induced apoptosis in Jurkat cells lacking p53 and Bax Journal of Cellular Physiology 208 2006 55 63 (Pubitemid 43848989)
15. K.A. Lee, Y.J. Lee, J.O. Ban, Y.J. Lee, S.H. Lee, M.K. Cho, H.S. Nam, J.T. Hong, and J.H. Shim The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1 International Journal of Molecular Medicine 30 2012 21 27
16. G. Li, P. Rivas, R. Bedolla, D. Thapa, R.L. Reddick, R. Ghosh, and A.P. Kumar Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis Cancer Prevention Research (Philadelphia) 6 2013 27 39
17. M. Mahyar-Roemer, and K. Roemer p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents Oncogene 20 2001 3387 3398 (Pubitemid 32588987)
18. K. Mizumoto, R.J. Rothman, and J.L. Farber Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide Molecular Pharmacology 46 1994 890 895 (Pubitemid 24364101)
19. W. Mo, X. Xu, L. Xu, F. Wang, A. Ke, X. Wang, and C. Guo Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell Pancreatology 11 2011 601 609
20. S. Nikoo, M. Ebtekar, M. Jeddi-Tehrani, A. Shervin, M. Bozorgmehr, S. Kazemnejad, and A.H. Zarnani Effect of menstrual blood-derived stromal stem cells on proliferative capacity of peripheral blood mononuclear cells in allogeneic mixed lymphocyte reaction Journal of Obstetrics and Gynaecology Research 38 2012 804 809
21. M.H. Pan, C.S. Lai, J.C. Wu, and C.T. Ho Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds Molecular Nutrition and Food Research 55 2011 32 45
22. H. Sadamori, T. Yagi, K. Shigeyasu, Y. Umeda, M. Sugihara, N. Yokomichi, T. Ohara, N. Nishida, T. Nagasaka, A. Goel, and T. Fujiwara Advanced hepatocellular carcinoma with lymph node metastases showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy: Report of a case Hepatology Research 2013
23. M. Shahbazi, M. Jeddi-Tehrani, M. Zareie, A. Salek-Moghaddam, M.M. Akhondi, M. Bahmanpoor, M.R. Sadeghi, and A.H. Zarnani Expression profiling of vitamin D receptor in placenta, decidua and ovary of pregnant mice Placenta 32 2011 657 664
24. Stagos, D., Amoutzias, G.D., Matakos, A., Spyrou, A., Tsatsakis, A.M., Kouretas, D., Chemoprevention of liver cancer by plant polyphenols. Food and Chemical Toxicology 50, pp. 2155-2170.
25. D. Su, Y. Cheng, M. Liu, D. Liu, H. Cui, B. Zhang, S. Zhou, T. Yang, and Q. Mei Comparision of piceid and resveratrol in antioxidation and antiproliferation activities in vitro PloS One 8 2013 e54505
26. J. Vanamala, L. Reddivari, S. Radhakrishnan, and C. Tarver Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways BMC Cancer 10 2010 238
27. G. Wang, H. Chen, M. Huang, N. Wang, J. Zhang, Y. Zhang, G. Bai, W.F. Fong, M. Yang, and X. Yao Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells Cancer Letters 241 2006 102 109
28. G. Wang, X. Guo, H. Chen, T. Lin, Y. Xu, Q. Chen, J. Liu, J. Zeng, X.K. Zhang, and X. Yao A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells Bioorganic and Medicinal Chemistry Letters 22 2012 2114 2118
29. H. Wang, H. Zhang, L. Tang, H. Chen, C. Wu, M. Zhao, Y. Yang, X. Chen, and G. Liu Resveratrol inhibits TGF-beta1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis Toxicology 303C 2013 139 146
30. W. Wang, J.N. Gallant, S.I. Katz, N.G. Dolloff, C.D. Smith, J. Abdulghani, J.E. Allen, D.T. Dicker, B. Hong, A. Navaraj, and W.S. El-Deiry Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents Cancer Biology and Therapy 12 2011 229 238
31. Z. Wang, W. Li, X. Meng, and B. Jia Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1 Clinical and Experimental Pharmacology and Physiology 39 2012 227 232
32. M. Zheng, R. Chen, H. Zhong, Q. Lin, X. Wang, Z. Zhao, and L. Xie Side-effects of resveratrol in HepG2 cells: reduced pten and increased bcl-xl mRNA expression Molecular Medicine Reports 6 2012 1367 1370