메뉴 건너뛰기




Volumn 6, Issue 6, 2012, Pages 1367-1370

Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression

Author keywords

bcl xl; HepG2; pten; Resveratrol

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL XL; RESVERATROL;

EID: 84868547837     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1077     Document Type: Article
Times cited : (10)

References (30)
  • 2
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • DOI 10.1038/nrd2060, PII NRD2060
    • Baur JA and Sinclair DA: Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5: 493-506, 2006. (Pubitemid 44136961)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.6 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 3
    • 80052079930 scopus 로고    scopus 로고
    • Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells
    • Santandreu FM, Valle A, Oliver J and Roca P: Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells. Cell Physiol Biochem 28: 219-228, 2011.
    • (2011) Cell Physiol Biochem , vol.28 , pp. 219-228
    • Santandreu, F.M.1    Valle, A.2    Oliver, J.3    Roca, P.4
  • 4
    • 77949367262 scopus 로고    scopus 로고
    • Evaluation of anti-invasion effect of resveratrol and related methoxy analogues on human hepatocarcinoma cells
    • Weng CJ, Wu CF, Huang HW, Wu CH, Ho CT and Yen GC: Evaluation of anti-invasion effect of resveratrol and related methoxy analogues on human hepatocarcinoma cells. J Agric Food Chem 58: 2886-2894, 2010.
    • (2010) J Agric Food Chem , vol.58 , pp. 2886-2894
    • Weng, C.J.1    Wu, C.F.2    Huang, H.W.3    Wu, C.H.4    Ho, C.T.5    Yen, G.C.6
  • 5
    • 42449140345 scopus 로고    scopus 로고
    • Effects of resveratrol on growth inhibition and gap-junctional intercellular communication of HepG2 cells
    • In Chinese
    • Yan F, Tian XM and Ma XD: Effects of resveratrol on growth inhibition and gap-junctional intercellular communication of HepG2 cells. Nan Fang Yi Ke Da Xue Xue Bao 26: 963-966, 2006 (In Chinese).
    • (2006) Nan Fang Yi Ke da Xue Xue Bao , vol.26 , pp. 963-966
    • Yan, F.1    Tian, X.M.2    Ma, X.D.3
  • 6
    • 0032535055 scopus 로고    scopus 로고
    • Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor
    • Ciolino HP, Daschner PJ and Yeh GC: Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res 58: 5707-5712, 1998. (Pubitemid 29006410)
    • (1998) Cancer Research , vol.58 , Issue.24 , pp. 5707-5712
    • Ciolino, H.P.1    Daschner, P.J.2    Yeh, G.C.3
  • 7
    • 60549098942 scopus 로고    scopus 로고
    • Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway
    • Wang GL, Fu YC, Xu WC, Feng YQ, Fang SR and Zhou XH: Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway. Biochem Biophys Res Commun 380: 644-649, 2009.
    • (2009) Biochem Biophys Res Commun , vol.380 , pp. 644-649
    • Wang, G.L.1    Fu, Y.C.2    Xu, W.C.3    Feng, Y.Q.4    Fang, S.R.5    Zhou, X.H.6
  • 8
    • 77950832747 scopus 로고    scopus 로고
    • Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways
    • Lu CC and Chen JK: Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways. J Cell Physiol 223: 343-351, 2010.
    • (2010) J Cell Physiol , vol.223 , pp. 343-351
    • Lu, C.C.1    Chen, J.K.2
  • 9
    • 79251543646 scopus 로고    scopus 로고
    • Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-κB-mediated mechanism
    • Yu HB, Zhang HF, Zhang X, et al: Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-κB-mediated mechanism. Hepatogastroenterology 57: 1241-1246, 2010.
    • (2010) Hepatogastroenterology , vol.57 , pp. 1241-1246
    • Yu, H.B.1    Zhang, H.F.2    Zhang, X.3
  • 10
    • 78650173217 scopus 로고    scopus 로고
    • Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells
    • Parekh P, Motiwale L, Naik N and Rao KV: Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells. Exp Toxicol Pathol 63: 167-173, 2011.
    • (2011) Exp Toxicol Pathol , vol.63 , pp. 167-173
    • Parekh, P.1    Motiwale, L.2    Naik, N.3    Rao, K.V.4
  • 11
    • 78650512503 scopus 로고    scopus 로고
    • Resveratrol, a phytoestrogen found in red wine, down-regulates protein S expression in HepG2 cells
    • Hiroto Y, Tadokoro K, Tsuda T, et al: Resveratrol, a phytoestrogen found in red wine, down-regulates protein S expression in HepG2 cells. Thromb Res 127: e1-7, 2011.
    • (2011) Thromb Res , vol.127
    • Hiroto, Y.1    Tadokoro, K.2    Tsuda, T.3
  • 12
    • 33845297465 scopus 로고    scopus 로고
    • Resveratrol induces HepG2 cell apoptosis by depolarizing mitochondrial membrane
    • In Chinese
    • Ma XD, Yan F, Ma AD and Wang HJ: Resveratrol induces HepG2 cell apoptosis by depolarizing mitochondrial membrane. Nan Fang Yi Ke Da Xue Xue Bao 26: 406-408, 413, 2006 (In Chinese).
    • (2006) Nan Fang Yi Ke da Xue Xue Bao , vol.26
    • Ma, X.D.1    Yan, F.2    Ma, A.D.3    Wang, H.J.4
  • 13
    • 69549097739 scopus 로고    scopus 로고
    • Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: Implications for a mechanism of lifespan prolongation and cancer protection
    • Zhou R, Fukui M, Choi HJ and Zhu BT: Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection. Br J Pharmacol 158: 462-474, 2009.
    • (2009) Br J Pharmacol , vol.158 , pp. 462-474
    • Zhou, R.1    Fukui, M.2    Choi, H.J.3    Zhu, B.T.4
  • 15
    • 79959712087 scopus 로고    scopus 로고
    • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health
    • Chappell WH, Steelman LS, Long JM, et al: Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget 2: 135-164, 2011.
    • (2011) Oncotarget , vol.2 , pp. 135-164
    • Chappell, W.H.1    Steelman, L.S.2    Long, J.M.3
  • 16
    • 7044249212 scopus 로고    scopus 로고
    • PTEN regulatory functions in tumor suppression and cell biology
    • Chu EC and Tarnawski AS: PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit 10: RA235-241, 2004. (Pubitemid 39424480)
    • (2004) Medical Science Monitor , vol.10 , Issue.10
    • Chu, E.C.1    Tarnawski, A.S.2
  • 18
    • 79551542888 scopus 로고    scopus 로고
    • PTEN level in tumor suppression: How much is too little?
    • Carracedo A, Alimonti A and Pandolfi PP: PTEN level in tumor suppression: how much is too little? Cancer Res 71: 629-633, 2011.
    • (2011) Cancer Res , vol.71 , pp. 629-633
    • Carracedo, A.1    Alimonti, A.2    Pandolfi, P.P.3
  • 19
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams JM and Cory S: The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998. (Pubitemid 28406819)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 20
    • 33748754286 scopus 로고    scopus 로고
    • Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak
    • DOI 10.1210/en.2006-0502
    • Castilla C, Congregado B, Chinchon D, Torrubia FJ, Japon MA and Saez C: Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak. Endocrinology 147: 4960-4967, 2006. (Pubitemid 44402203)
    • (2006) Endocrinology , vol.147 , Issue.10 , pp. 4960-4967
    • Castilla, C.1    Congregado, B.2    Chinchon, D.3    Torrubia, F.J.4    Japon, M.A.5    Saez, C.6
  • 21
    • 48349109825 scopus 로고    scopus 로고
    • Bcl-XL and Bcl-2 expression in bilharzial squamous cell carcinoma of the urinary bladder: Which protein is prognostic?
    • Hameed DA, Abdel Raheem AM, Mosad E, Hammouda HM, Kamel NA and Abdel Aziz MA: Bcl-XL and Bcl-2 expression in bilharzial squamous cell carcinoma of the urinary bladder: which protein is prognostic? Urology 72: 374-378, 2008.
    • (2008) Urology , vol.72 , pp. 374-378
    • Hameed, D.A.1    Abdel Raheem, A.M.2    Mosad, E.3    Hammouda, H.M.4    Kamel, N.A.5    Abdel Aziz, M.A.6
  • 23
    • 30844472024 scopus 로고    scopus 로고
    • An improved synthesis of resveratrol
    • DOI 10.1080/14786410500059532, PII Q41X81X2217
    • Farina A, Ferranti C and Marra C: An improved synthesis of resveratrol. Nat Prod Res 20: 247-252, 2006. (Pubitemid 43102143)
    • (2006) Natural Product Research , vol.20 , Issue.3 , pp. 247-252
    • Farina, A.1    Ferranti, C.2    Marra, C.3
  • 24
    • 70449533072 scopus 로고    scopus 로고
    • Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae
    • Trantas E, Panopoulos N and Ververidis F: Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae. Metab Eng 11: 355-366, 2009.
    • (2009) Metab Eng , vol.11 , pp. 355-366
    • Trantas, E.1    Panopoulos, N.2    Ververidis, F.3
  • 26
    • 33749482264 scopus 로고    scopus 로고
    • Resveratrol is rapidly metabolized in athymic (Nu/Nu) mice and does not inhibit human melanoma xenograft tumor growth
    • Niles RM, Cook CP, Meadows GG, Fu YM, McLaughlin JL and Rankin GO: Resveratrol is rapidly metabolized in athymic (nu/nu) mice and does not inhibit human melanoma xenograft tumor growth. J Nutr 136: 2542-2546, 2006. (Pubitemid 44521610)
    • (2006) Journal of Nutrition , vol.136 , Issue.10 , pp. 2542-2546
    • Niles, R.M.1    Cook, C.P.2    Meadows, G.G.3    Fu, Y.-M.4    McLaughlin, J.L.5    Rankin, G.O.6
  • 27
    • 20344371723 scopus 로고    scopus 로고
    • Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats
    • DOI 10.1002/mnfr.200500003
    • Wenzel E, Soldo T, Erbersdobler H and Somoza V: Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Mol Nutr Food Res 49: 482-494, 2005. (Pubitemid 40780395)
    • (2005) Molecular Nutrition and Food Research , vol.49 , Issue.5 , pp. 482-494
    • Wenzel, E.1    Soldo, T.2    Erbersdobler, H.3    Somoza, V.4
  • 28
    • 79958099432 scopus 로고    scopus 로고
    • Results of a phase i pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer
    • Nguyen AV, Martinez M, Stamos MJ, et al: Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res 1: 25-37, 2009.
    • (2009) Cancer Manag Res , vol.1 , pp. 25-37
    • Nguyen, A.V.1    Martinez, M.2    Stamos, M.J.3
  • 30
    • 33750513819 scopus 로고    scopus 로고
    • Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation
    • DOI 10.1016/j.bbagen.2006.09.010, PII S0304416506002868
    • Notas G, Nifli AP, Kampa M, Vercauteren J, Kouroumalis E and Castanas E: Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest and NOS activation. Biochim Biophys Acta 1760: 1657-1666, 2006. (Pubitemid 44667277)
    • (2006) Biochimica et Biophysica Acta - General Subjects , vol.1760 , Issue.11 , pp. 1657-1666
    • Notas, G.1    Nifli, A.-P.2    Kampa, M.3    Vercauteren, J.4    Kouroumalis, E.5    Castanas, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.