Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in Québec

Environmental Health Perspectives

Volumn 110, Issue 4, 2002, Pages 411-417

  Sandau, Courtney D ^a,d   Ayotte, Pierre ^b   Dewailly, Éric ^b   Duffe, Jason ^c   Norstrom, Ross J ^a,c  

^a CARLETON UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c ENVIRONMENT CANADA   (Canada)

^d NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

Hydroxylated metabolites; Pentachlorophenol; Polychlorinated biphenyls; Retinol; Thyroxine; Umbilical cord plasma

Indexed keywords

PENTACHLOROPHENOL; PHENOL DERIVATIVE; POLYCHLORINATED BIPHENYL; POLYCHLORINATED BIPHENYL DERIVATIVE; STYRENE DERIVATIVE; THYROID HORMONE;

ARTICLE; BLOOD SAMPLING; CANADA; CHLORINATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; ENVIRONMENTAL EXPOSURE; FISHERMAN; FOOD CONTAMINATION; HUMAN; HYDROXYLATION; MARINE ENVIRONMENT; METABOLITE; NERVE CELL DIFFERENTIATION; NEWBORN; POPULATION RESEARCH; PRIORITY JOURNAL; SEASHORE; UMBILICAL CORD BLOOD; URBAN POPULATION;

EID: 0036230329     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.02110411     Document Type: Article

References (59)

1. Prenatal exposure to polychlorinated biphenyls: Effects on birth size and gestational age
2. The effect of intrauterine PCB exposure on visual recognition memory
3. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children
4. Evidence for PCBs as neurodevelopmental toxicants in humans
5. Impact of PCBs on thyroid hormone directed brain development
6. The role of thyroid and growth hormones in neurogenesis
7. The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain
8. Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein
9. Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs
10. Interaction of chlorinated phenols with thyroxine binding sites of human transthyretin, albumin and thyroid binding globulin
11. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro
12. Analysis of hydroxylated metabolites of PCBs (OH-PCBs) and other chlorinated phenolic compounds in whole blood from Canadian Inuit
13. Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish Men
14. In vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons
15. Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: A novel pathway explaining the estrogenic activity of PCBs
16. Methyl sulfone and hydroxylated metabolites of polychlorinated biphenyls
17. Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin
18. Study on the mechanism of interference of 3,4,3′,4′-tetra-chlorobiphenyl with the plasma retinol-binding proteins in rodents
19. Hydroxylated polychlorinated biphenyls: Placental transfer and effects on thyroxine in the foetal mouse
20. Hydroxylated polychlorinated biphenyls: Distribution in the pregnant mouse
21. In vitro and in vivo interactions of organohalogens with the endocrine system-the role of metabolites and implications for human health
22. Reduction of thyroxine uptake into cerebrospinal fluid and rat brain by hexachlorobenzene and pentachlorophenol
23. Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants
24. Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development
25. Prenatal exposure of Canadian children to polychlorinated biphenyls and mercury
26. Lead, mercury, and organochlorine compound levels in cord blood in Quebec, Canada
27. Inuit exposure to organochlorines through the aquatic food chain in Arctic Quebec
28. Sea-bird egg consumption as a major source of PCB exposure for communities living along the Gulf of St. Lawrence
29. Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography. Composition of technical Aroclor- and Clophen-PCB mixtures. Fresenius′ Z
30. Selective retention of hydroxylated PCB metabolites in blood
31. Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transthyretin: A possible metabolite of octachlorostyrene?
32. Pentachlorophenol in the UK environment II: Human exposure and an assessment of pathways
33. Hexachlorobenzene and its metabolism
34. The pharmacokinetics and metabolism of pentachlorophenol in rats
35. Pharmacokinetics of pentachlorophenol in man
36. Impaired in-vitro lymphocyte responses in patients with elevated pentachlorophenol (PCP) blood levels
37. Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats
38. Investigation of liver binding of pentachlorophenol based upon measurement of protein adducts
39. Reproductive and endocrine function in rams exposed to the organochlorine pesticides lindane and pentachlorophenol from conception
40. Effects of pentachlorophenol and hydroxylated polychlorinated biphenyls on thyroid hormone conjugation in a rat and human hepatoma cell line
41. Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin
42. Hydroxylated and methylsulfonyl polychlorinated biphenyl metabolites in albatrosses from Midway Atoll, North Pacific Ocean
43. Analytical Chemistry of Hydroxylated Metabolites of PCBs and Other Halogenated Phenolic Compounds in Blood and Their Relationship to Thyroid Hormone and Retinol Homeostasis in Humans and Polar Bears
44. Microsomal hydroxylation of specifically deuterated monosubstituted benzenes. Evidence for direct aromatic hydroxylation
45. Metabolism of chlorobenzene with hepatic microsomes and solubilized cytochrome P-450 systems
46. Non-arene oxide aromatic ring hydroxylation of 2,2′,5,5′-tetrachlorobiphenyl as the major metabolic pathway catalyzed by phenobarbitol-induced rat liver microsomes
47. Complete PCB congener distributions for 17 Aroclor mixtures determined by 3 HRGC systems optimized for comprehensive, quantitative, congener specific analysis
48. Hydroxylation-induced migration: The NIH shift
49. Metabolism in vitro of 3,4,3′,4′-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450
50. Examination of the estrogenicity of 2,4,6,2′,6′-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2′,6′-pentachloro-4-biphenylol (HO-PCB 104), and a further 2,4,6,2′,4′,6′-hexachlorobiphenyl (PCB 155)
51. Maternal and neonatal plasma transthyretin (prealbumin) concentrations and birth weight of newborn infants
52. Halogenated biphenyl transport by blood components
53. Effects of pentachlorophenol (PCP) on the pituitary and thyroidal hormone regulation in the rat
54. Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats
55. Binding of a 3,3′,4,4′-tetrachlorobiphenyl (CB-77) metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice
56. Vulnerability of the developing brain to thyroid abnormalities: Environmental insults to the thyroid system
57. Thyroxine secretion rates during pregnancy in the rat
58. The role of thyroid hormones in prenatal and neonatal neurological development-current perspectives