Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events

Oncogene

Volumn 32, Issue 39, 2013, Pages 4683-4693

  Higgs, M R ^a,c   Lerat, H ^a   Pawlotsky, Jean Michel ^a,b  

^a INSERM U955   (France)

^b Hǒ Pital Henri Mondor ^*  (France)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

c Myc; DNA damage; hepatitis C virus; hepatocellular carcinoma; NS5A protein; oxidative stress

Indexed keywords

BETA CATENIN; MYC PROTEIN; NONSTRUCTURAL PROTEIN 5A; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENETIC DAMAGE; HEPATITIS C; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; OPEN READING FRAME; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; ANIMALS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL NUCLEUS; CELL TRANSFORMATION, VIRAL; DNA DAMAGE; DNA, MITOCHONDRIAL; FEMALE; GENES, MYC; HEPACIVIRUS; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; NEOPLASM PROTEINS; OPEN READING FRAMES; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTEIN INTERACTION MAPPING; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; MURINAE;

EID: 84884907504     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.484     Document Type: Article

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