Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Si, Youhui ^a   Liu, Xiuying ^a   Cheng, Min ^a   Wang, Maorong ^b   Gong, Qiaoling ^a   Yang, Yang ^a   Wang, Tianyi ^c   Yang, Wei ^a  

^a INSTITUTE OF PATHOGEN BIOLOGY   (China)

^b The 81st Hospital of PLA   (China)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN A2; CYCLIN B1; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH DIFFERENTIATION FACTOR 15; MESSENGER RNA; PROTEIN KINASE B; RAF PROTEIN; UVOMORULIN; GDF15 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC MARKER; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LINKAGE ANALYSIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN SECRETION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS CULTURE; VIRUS INHIBITION; VIRUS PATHOGENESIS; BIOSYNTHESIS; GENETICS; LIVER TUMOR; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

HEPATITIS C VIRUS;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH DIFFERENTIATION FACTOR 15; HEPATITIS C; HUMANS; LIVER NEOPLASMS;

EID: 79956338806     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019967     Document Type: Article

References (34)

1. Ray Kim W, (2002) Global epidemiology and burden of hepatitis C. Microbes Infect 4: 1219-1225.
2. Liu X, Wang T, Wakita T, Yang W, (2010) Systematic identification of microRNA and messenger RNA profiles in hepatitis C virus-infected human hepatoma cells. Virology 398: 57-67.
3. Bootcov MR, Bauskin AR, Valenzuela SM, Moore AG, Bansal M, et al. (1997) MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci U S A 94: 11514-11519.
4. Subramaniam S, Strelau J, Unsicker K, (2003) Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. J Biol Chem 278: 8904-8912.
5. Lee DH, Yang Y, Lee SJ, Kim KY, Koo TH, et al. (2003) Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. Cancer Res 63: 4648-4655.
6. Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, et al. (2007) Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med 13: 1333-1340.
7. Hsiao EC, Koniaris LG, Zimmers-Koniaris T, Sebald SM, Huynh TV, et al. (2000) Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol 20: 3742-3751.
8. Welsh JB, Sapinoso LM, Su AI, Kern SG, Wang-Rodriguez J, et al. (2001) Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res 61: 5974-5978.
9. Bauskin AR, Brown DA, Kuffner T, Johnen H, Luo XW, et al. (2006) Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer. Cancer Res 66: 4983-4986.
10. Boyle GM, Pedley J, Martyn AC, Banducci KJ, Strutton GM, et al. (2009) Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity. J Invest Dermatol 129: 383-391.
11. Brown DA, Breit SN, Buring J, Fairlie WD, Bauskin AR, et al. (2002) Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet 359: 2159-2163.
12. Wollert KC, Kempf T, Peter T, Olofsson S, James S, et al. (2007) Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome. Circulation 115: 962-971.
13. Wollert KC, Kempf T, Lagerqvist B, Lindahl B, Olofsson S, et al. (2007) Growth differentiation factor 15 for risk stratification and selection of an invasive treatment strategy in non ST-elevation acute coronary syndrome. Circulation 116: 1540-1548.
14. Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, et al. (2007) High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 13: 1096-1101.
15. Wan F, Miao X, Quraishi I, Kennedy V, Creek KE, et al. (2008) Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer. Int J Cancer 123: 32-40.
16. Heger J, Schiegnitz E, von Waldthausen D, Anwar MM, Piper HM, et al. (2010) Growth differentiation factor 15 acts anti-apoptotic and pro-hypertrophic in adult cardiomyocytes. J Cell Physiol 224: 120-126.
17. Senapati S, Rachagani S, Chaudhary K, Johansson SL, Singh RK, et al. (1293-1302).
18. Strelau J, Strzelczyk A, Rusu P, Bendner G, Wiese S, et al. (2009) Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci 29: 13640-13648.
19. Vanhara P, Lincova E, Kozubik A, Jurdic P, Soucek K, et al. (2009) Growth/differentiation factor-15 inhibits differentiation into osteoclasts-a novel factor involved in control of osteoclast differentiation. Differentiation 78: 213-222.
20. Tanno T, Noel P, Miller JL, (2010) Growth differentiation factor 15 in erythroid health and disease. Curr Opin Hematol 17: 184-190.
21. Tsai JF, Jeng JE, Chuang LY, Chang WY, Tsai JH, (1997) Urinary transforming growth factor beta1 levels in hepatitis C virus-related chronic liver disease: correlation between high levels and severity of disease. Hepatology 25: 1141-1146.
22. Roulot D, Durand H, Coste T, Rautureau J, Strosberg AD, et al. (1995) Quantitative analysis of transforming growth factor beta 1 messenger RNA in the liver of patients with chronic hepatitis C: absence of correlation between high levels and severity of disease. Hepatology 21: 298-304.
23. Roberts LR, Gores GJ, (2005) Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis 25: 212-225.
24. Branda M, Wands JR, (2006) Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma. Hepatology 43: 891-902.
25. He X, Zhu Z, Johnson C, Stoops J, Eaker AE, et al. (2008) PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma. Cancer Res 68: 5591-5598.
26. von Wichert G, Haeussler U, Greten FR, Kliche S, Dralle H, et al. (2005) Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells. Oncogene 24: 1284-1289.
27. Ha NC, Tonozuka T, Stamos JL, Choi HJ, Weis WI, (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell 15: 511-521.
28. Schmitz KJ, Wohlschlaeger J, Lang H, Sotiropoulos GC, Malago M, et al. (2008) Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 48: 83-90.
29. Lin W, Weinberg EM, Tai AW, Peng LF, Brockman MA, et al. (2008) HIV increases HCV replication in a TGF-beta1-dependent manner. Gastroenterology 134: 803-811.
30. Murata T, Ohshima T, Yamaji M, Hosaka M, Miyanari Y, et al. (2005) Suppression of hepatitis C virus replicon by TGF-beta. Virology 331: 407-417.
31. Komurian-Pradel F, Paranhos-Baccala G, Sodoyer M, Chevallier P, Mandrand B, et al. (2001) Quantitation of HCV RNA using real-time PCR and fluorimetry. J Virol Methods 95: 111-119.
32. Liu S, Yang W, Shen L, Turner JR, Coyne CB, et al. (2009) Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol 83: 2011-2014.
33. Barton GM, Medzhitov R, (2002) Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A 99: 14943-14945.
34. Yang W, Qiu C, Biswas N, Jin J, Watkins SC, et al. (2008) Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus. J Biol Chem 283: 8643-8653.