Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen

Developmental Dynamics

Volumn 240, Issue 5, 2011, Pages 1303-1310

  Zhu, Jianjian ^a   Mackem, Susan ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Digit patterning; Limb development; Sonic hedgehog

Indexed keywords

EOMESODERMIN; MITOGENIC AGENT; MORPHOGEN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN;

ARTICLE; CONTROLLED STUDY; FINGER MALFORMATION; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC MARKER; MOUSE; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; BODY PATTERNING; EXTREMITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; IN SITU HYBRIDIZATION; LIMB BUDS; MICE; MICE, MUTANT STRAINS; MITOGENS;

ERINACEIDAE;

EID: 79955014681     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22637     Document Type: Article

References (24)

1. Bastida MF, Sheth R, Ros MA. 2009. A BMP-Shh negative-feedback loop restricts Shh expression during limb development. Development 136: 3779-3789.
2. Bouldin CM, Gritli-Lindeb A, Ahn S, Harfe BD. 2010. Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A 107: 5489-5494.
3. Brunet LJ, McMahon JA, McMahon AP, Harland RM. 1998. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280: 1455-1457.
4. Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407-413.
5. Hancock SN, Agulnik SI, Silver LM, Papaioannou VE. 1999. Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin. Mech Dev 81: 205-208.
6. Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. 2004. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118: 517-528.
7. Kwon GS, Hadjantonakis AK. 2007. Eomes:GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo. Genesis 45: 208-217.
8. Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP. 2001. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105: 599-612.
9. Li Y, Zhang HM, Litingtung Y, Chiang C. 2006. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A 103: 6548-6553.
10. Logan M, Martin JF, Nagy A, Lobe C, Olson EN, Tabin C. 2002. Expression of cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33: 77-80.
11. Nahmad M, Stathopoulos A. 2009. Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc. PLoS Biol 7: e1000202.
12. Nakamura E, Nguyen MT, Mackem S. 2006. Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn 235: 2603-2612.
13. Nguyen MT, Zhu J, Nakamura E, Bao X, Mackem S. 2009. Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud. Dev Dyn 238: 467-474.
14. Parr BA, McMahon AP. 1995. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374: 350-353.
15. Saunders T, Howard M. 2009. When it pays to rush: interpreting morphogen gradients prior to steady-state. Phys Biol 6: e046020.
16. Scherz PJ, McGlinn E, Nissim S, Tabin CJ. 2007. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Dev Biol 308: 343-354.
17. Suzuki T, Takeuchi J, Koshiba-Takeuchi K, Ogura T. 2004. Tbx genes specify posterior digit identity through Shh and BMP signaling. Dev Cell 6: 43-53.
18. Tabin CJ, McMahon AP. 2008. Developmental biology. Grasping limb patterning. Science 321: 350-352.
19. Towers M, Mahood R, Yin Y, Tickle C. 2008. Integration of growth and specification in chick wing digit-patterning. Nature 452: 882-886.
20. Towers M, Tickle C. 2009. Growing models of vertebrate limb development. Development 136: 179-190.
21. Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X. 2005. Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development 132: 4235-4245.
22. Yang Y, Niswander L. 1995. Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 80: 939-947.
23. Zeller R. 2004. It takes time to make a pinky: unexpected insights into how SHH patterns vertebrate digits. Sci. STKE 259: pe53.
24. Zhu J, Nakamura E, Nguyen M-T, Bao X, Akiyama H, Mackem S. 2008. Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. Dev Cell 14: 624-632.