Distinct plasma profile of polar neutral amino acids, leucine, and glutamate in children with autism spectrum disorders

Journal of Autism and Developmental Disorders

Volumn 42, Issue 5, 2012, Pages 827-836

  Tirouvanziam, Rabindra ^a,b   Obukhanych, Tetyana V ^a   Laval, Julie ^a,c   Aronov, Pavel A ^a   Libove, Robin ^a   Banerjee, Arpita Goswami ^a,d   Parker, Karen J ^a   O'Hara, Ruth ^a   Herzenberg, Leonard A ^a   Herzenberg, Leonore A ^a   Hardan, Antonio Y ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^d OXFORD HEALTH NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Blood; Glutamate; Leucine; Polar neutral amino acids; Predictive value

Indexed keywords

ASPARTIC ACID; GLUTAMIC ACID; ISOLEUCINE; LEUCINE;

AGE; AMINO ACID BLOOD LEVEL; ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; HUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL;

AMINO ACIDS, NEUTRAL; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; FEMALE; GLUTAMIC ACID; HUMANS; LEUCINE; MALE;

EID: 84863811998     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-011-1314-x     Document Type: Article

References (31)

1. Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011). Gastrointestinal flora and gastrointestinal status in children with autism-comparisons to typical children and correlation with autism severity. BMC Gastroenterology, 11, 22.
2. Ahearn, W. H., Castine, T., Nault, K., & Green, G. (2001). An assessment of food acceptance in children with autism or pervasive developmental disorder-not otherwise specified. Journal of Autism and Developmental Disorders, 31, 505-511. (Pubitemid 37486686)
3. Aldred, S., Moore, K. M., Fitzgerald, M., & Waring, R. H. (2003). Plasma amino acid levels in children with autism and their families. Journal of Autism and Developmental Disorders, 33, 93-97. (Pubitemid 36323144)
4. Altamura, C., Maes, M., Dai, J., & Meltzer, H. Y. (1995). Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression. European Neuropsychopharmacology, 5 (Suppl), 71-75. (Pubitemid 26017262)
5. Arnold, G. L., Hyman, S. L., Mooney, R. A., & Kirby, R. S. (2003). Plasma amino acids profiles in children with autism: Potential risk of nutritional deficiencies. Journal of Autism and Developmental Disorders, 33, 449-454. (Pubitemid 37127941)
6. Badawy, A. A., Morgan, C. J., & Turner, J. A. (2008). Application of the Phenomenex EZ: Faasttrade mark amino acid analysis kit for rapid gas-chromatographic determination of concentrations of plasma tryptophan and its brain uptake competitors. Amino Acids, 34, 587-596.
7. Banks, R. E., Stanley, A. J., Cairns, D. A., Barrett, J. H., Clarke, P., Thompson, D., et al. (2005). Influences of blood sample processing on low-molecular-weight proteome identified by surface-enhanced laser desorption/ionization mass spectrometry. Clinical Chemistry, 51, 1637-1649. (Pubitemid 41233099)
8. Bellodi, L., Erzegovesi, S., Bianchi, L., Lucini, V., Conca, R., & Lucca, A. (1997). Plasma tryptophan levels and tryptophan/neutral amino acid ratios in obsessive-compulsive patients with and without depression. Psychiatry Research, 69, 9-15. (Pubitemid 27139679)
9. Blaylock, R. L., & Strunecka, A. (2009). Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Current Medicinal Chemistry, 16, 157-170.
10. Courchesne, E., Carper, R., & Akshoomoff, N. (2003). Evidence of brain overgrowth in the first year of life in autism. JAMA, 290, 337-344. (Pubitemid 37430519)
11. Courchesne, E., Pierce, K., Schumann, C. M., Redcay, E., Buckwalter, J. A., Kennedy, D. P., et al. (2007). Mapping early brain development in autism. Neuron, 56, 399-413.
12. Fernell, E.,Karagiannakis,A., Edman, G.,Bjerkenstedt, L.,Wiesel, F. A., &Venizelos,N. (2007). Aberrant amino acid transport in fibroblasts from children with autism. Neuroscience Letters, 418, 82-86. (Pubitemid 46602699)
13. Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., et al. (2010). Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe, 16, 444-453.
14. Geschwind, D. H. (2009). Advances in autism. Annual Review of Medicine, 60, 367-380.
15. Hardan, A. Y., Minshew, N. J., Mallikarjuhn, M., & Keshavan, M. S. (2001). Brain volume in autism. Journal of Child Neurology, 16, 421-424. (Pubitemid 32631738)
16. Hawkins, R. A., O'kane, R. L., Simpson, I. A., & Vina, J. R. (2006). Structure of the blood-brain barrier and its role in the transport of amino acids. Journal of Nutrition, 136, 218S-226S.
17. Hazlett, H. C., Poe, M., Gerig, G., Smith, R. G., Provenzale, J., Ross, A., et al. (2005). Magnetic resonance imaging and head circumference study of brain size in autism: Birth through age 2 years. Archives of General Psychiatry, 62, 1366-1376. (Pubitemid 41746614)
18. Hyde, R., Taylor, P. M., & Hundal, H. S. (2003). Amino acid transporters: Roles in amino acid sensing and signalling in animal cells. Biochemical Journal, 373, 1-18. (Pubitemid 36819495)
19. Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 980-988. (Pubitemid 27272932)
20. Lepage, N., Mcdonald, N., Dallaire, L., & Lambert, M. (1997). Age-specific distribution of plasma amino acid concentrations in a healthy pediatric population. Clinical Chemistry, 43, 2397-2402. (Pubitemid 28022978)
21. Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., et al. (1989). Autism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185-212. (Pubitemid 19176529)
22. Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659-685. (Pubitemid 24309810)
23. Mohabbat, T., & Drew, B. (2008). Simultaneous determination of 33 amino acids and dipeptides in spent cell culture media by gas chromatography-flame ionization detection following liquid and solid phase extraction. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 862, 86-92.
24. Moreno-Fuenmayor, H., Borjas, L., Arrieta, A., Valera, V., & Socorro-Candanoza, L. (1996). Plasma excitatory amino acids in autism. Investigation Clinical, 37, 113-128.
25. Ratajczak, H. V. (2011). Theoretical aspects of autism: Biomarkers-a review. Journal of Immunotoxicology, 8, 80-94.
26. Rolf, L. H., Haarmann, F. Y., Grotemeyer, K. H., & Kehrer, H. (1993). Serotonin and amino acid content in platelets of autistic children. Acta Psychiatrica Scandinavica, 87, 312-316. (Pubitemid 23134638)
27. Scholl-Burgi, S., Haberlandt, E., Heinz-Erian, P., Deisenhammer, F., Albrecht, U., Sigl, S. B., et al. (2008). Amino acid cerebrospinal fluid/plasma ratios in children: Influence of age, gender, and antiepileptic medication. Pediatrics, 121, e920-e926.
28. Schreck, K. A., Williams, K., & Smith, A. F. (2004). A comparison of eating behaviors between children with and without autism. Journal of Autism and Developmental Disorders, 34, 433-438. (Pubitemid 39127718)
29. Shinohe, A., Hashimoto, K., Nakamura, K., Tsujii, M., Iwata, Y., Tsuchiya, K. J., et al. (2006). Increased serum levels of glutamate in adult patients with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30, 1472-1477. (Pubitemid 44634960)
30. Sumiyoshi, T., Anil, A. E., Jin, D., Jayathilake, K., Lee, M., & Meltzer, H. Y. (2004). Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: Relation to negative symptoms. The International Journal of Neuropsychopharmacology, 7, 1-8. (Pubitemid 38523801)
31. Tremolizzo, L., Difrancesco, J. C., Rodriguez-Menendez, V., Sirtori, E., Longoni, M., Cassetti, A., et al. (2006). Human platelets express the synaptic markers VGLUT1 and 2 and release glutamate following aggregation. Neuroscience Letters, 404, 262-265. (Pubitemid 44108439)