Nfatc1 directs the endocardial progenitor cells to make heart valve primordium

Trends in Cardiovascular Medicine

Volumn 23, Issue 8, 2013, Pages 294-300

  Wu, Bingruo ^a   Baldwin, H Scott ^b,c   Zhou, Bin ^a,d  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Division of Cardiology   (United States)

^c Department of Cell and Developmental Biology ^*  (United States)

^d THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CELL STRUCTURE; ENDOCARDIUM; EPITHELIAL MESENCHYMAL TRANSITION; GENE LOCUS; HEART VALVE; MESENCHYME CELL; MORPHOGENESIS; NONHUMAN; PRIMORDIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; STEM CELL; TRANSCRIPTION REGULATION; VALVULAR HEART DISEASE;

ANIMALS; CELL DIFFERENTIATION; ENDOCARDIAL CUSHIONS; ENDOCARDIUM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART VALVES; MESODERM; MICE; MODELS, GENETIC; NFATC TRANSCRIPTION FACTORS; STEM CELLS; TRANSCRIPTION ELONGATION, GENETIC;

EID: 84884819690     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2013.04.003     Document Type: Review

References (48)

1. Abdul-Sater Z., Yehya A., Beresian J., Salem E., Kamar A., Baydoun S., et al. Two heterozygous mutations in NFATC1 in a patient with tricuspid atresia. PLoS One 2012, 7:e49532.
2. Aikawa E., Whittaker P., Farber M., Mendelson K., Padera R.F., Aikawa M., et al. Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering. Circulation 2006, 113:1344-1352.
3. Armstrong E.J., Bischoff J. Heart valve development: endothelial cell signaling and differentiation. Circulation Research 2004, 95:459-470.
4. Asagiri M., Sato K., Usami T., Ochi S., Nishina H., Yoshida H., et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. Journal of Experimental Medicine 2005, 202:1261-1269.
5. Baldwin H.S., Jensen K.L., Solursh M. Myogenic cytodifferentiation of the precardiac mesoderm in the rat. Differentiation 1991, 47:163-172.
6. Barnett J.V., Desgrosellier J.S. Early events in valvulogenesis: a signaling perspective. Birth Defects Research. Part C, Embryo Today: Reviews 2003, 69:58-72.
7. Beals C.R., Sheridan C.M., Turck C.W., Gardner P., Crabtree G.R. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 1997, 275:1930-1934.
8. Bushdid P.B., Osinska H., Waclaw R.R., Molkentin J.D., Yutzey K.E. NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circulation Research 2003, 92:1305-1313.
9. Chang C.P., Neilson J.R., Bayle J.H., Gestwicki J.E., Kuo A., Stankunas K., et al. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell 2004, 118:649-663.
10. Combs M.D., Yutzey K.E. Heart valve development: regulatory networks in development and disease. Circulation Research 2009, 105:408-421.
11. 2+, calcineurin, and NF-AT. Cell 1999, 96:611-614.
12. Crabtree G.R., Olson E.N. NFAT signaling: choreographing the social lives of cells. Cell 2002, 109(Suppl.):S67-S79.
13. de la Pompa J.L., Timmerman L.A., Takimoto H., Yoshida H., Elia A.J., Samper E., et al. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 1998, 392:182-186.
14. DeLaughter D.M., Saint-Jean L., Baldwin H.S., Barnett J.V. What chick and mouse models have taught us about the role of the endocardium in congenital heart disease. Birth Defects Research. Part A, Clinical and Molecular Teratology 2011, 91:511-525.
15. Delot E.C. Control of endocardial cushion and cardiac valve maturation by BMP signaling pathways. Molecular Genetics and Metabolism 2003, 80:27-35.
16. Effmann E.L. Development of the right and left pulmonary arteries. A microangiographic study in the mouse. Investigative Radiology 1982, 17:529-538.
17. Eisenberg L.M., Markwald R.R. Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circulation Research 1995, 77:1-6.
18. Emmel E.A., Verweij C.L., Durand D.B., Higgins K.M., Lacy E., Crabtree G.R. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 1989, 246:1617-1620.
19. Flanagan W.M., Corthesy B., Bram R.J., Crabtree G.R. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 1991, 352:803-807.
20. 2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell 2001, 105:863-875.
21. Hinton R.B., Yutzey K.E. Heart valve structure and function in development and disease. Annual Review of Physiology 2011, 73:29-46.
22. Horsley V., Aliprantis A.O., Polak L., Glimcher L.H., Fuchs E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell 2008, 132:299-310.
23. Hurle J.M., Colvee E., Blanco A.M. Development of mouse semilunar valves. Anatomy and Embryology 1980, 160:83-91.
24. Jain R., Engleka K.A., Rentschler S.L., Manderfield L.J., Li L., Yuan L., et al. Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. Journal of Clinical Investigation 2011, 121:422-430.
25. Krug E.L., Runyan R.B., Markwald R.R. Protein extracts from early embryonic hearts initiate cardiac endothelial cytodifferentiation. Developmental Biology 1985, 112:414-426.
26. Laforest B., Andelfinger G., Nemer M. Loss of Gata5 in mice leads to bicuspid aortic valve. Journal of Clinical Investigation 2011, 121:2876-2887.
27. Laforest B., Nemer M. GATA5 interacts with GATA4 and GATA6 in outflow tract development. Developmental Biology 2011, 358:368-378.
28. Lin C.J., Lin C.Y., Chen C.H., Zhou B., Chang C.P. Partitioning the heart: mechanisms of cardiac septation and valve development. Development 2012, 139:3277-3299.
29. Lin C.Y., Lin C.J., Chen C.H., Chen R.M., Zhou B., Chang C.P. The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development. Journal of Molecular and Cellular Cardiology 2012, 52:1096-1102.
30. Nemer G., Nemer M. Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Development 2002, 129:4045-4055.
31. Paff G.H., Boucek R.J., Gutten G.S. Ventricular blood pressures and competency of valves in the early embryonic chick heart. Anatomical Record 1965, 151:119-123.
32. Person A.D., Klewer S.E., Runyan R.B. Cell biology of cardiac cushion development. International Review of Cytology 2005, 243:287-335.
33. Phoon C.K., Ji R.P., Aristizabal O., Worrad D.M., Zhou B., Baldwin H.S., et al. Embryonic heart failure in NFATc1-/- mice: novel mechanistic insights from in utero ultrasound biomicroscopy. Circulation Research 2004, 95:92-99.
34. Ranger A.M., Grusby M.J., Hodge M.R., Gravallese E.M., de la Brousse F.C., Hoey T., et al. The transcription factor NF-ATc is essential for cardiac valve formation. Nature 1998, 392:186-190.
35. Ranger A.M., Hodge M.R., Gravallese E.M., Oukka M., Davidson L., Alt F.W., et al. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 1998, 8:125-134.
36. Rao A. Signaling to gene expression: calcium, calcineurin and NFAT. Nature Immunology 2009, 10:3-5.
37. Rao A., Luo C., Hogan P.G. Transcription factors of the NFAT family: regulation and function. Annual Review of Immunology 1997, 15:707-747.
38. Runyan R.B., Markwald R.R. Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissue. Developmental Biology 1983, 95:108-114.
39. Schroeder J.A., Jackson L.F., Lee D.C., Camenisch T.D. Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. Journal of Molecular Medicine 2003, 81:392-403.
40. Shibasaki F., Price E.R., Milan D., McKeon F. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 1996, 382:370-373.
41. Thompson R.P., Sumida H., Abercrombie V., Satow Y., Fitzharris T.P., Okamoto N. Morphogenesis of human cardiac outflow. Anatomical Record 1985, 213:578-586.
42. Tsuda T., Wang H., Timpl R., Chu M.L. Fibulin-2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels, and coronary vessels. Developmental Dynamics 2001, 222:89-100.
43. von Gise A., Pu W.T. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circulation Research 2012, 110:1628-1645.
44. Webb S., Brown N.A., Anderson R.H. Formation of the atrioventricular septal structures in the normal mouse. Circulation Research 1998, 82:645-656.
45. Wu B., Wang Y., Lui W., Langworthy M., Tompkins K.L., Hatzopoulos A.K., et al. Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circulation Research 2011, 109:183-192.
46. Yehya A., Souki R., Bitar F., Nemer G. Differential duplication of an intronic region in the NFATC1 gene in patients with congenital heart disease. Genome 2006, 49:1092-1098.
47. Zhou B., Cron R.Q., Wu B., Genin A., Wang Z., Liu S., et al. Regulation of the murine Nfatc1 gene by NFATc2. Journal of Biological Chemistry 2002, 277:10704-10711.
48. Zhou B., Wu B., Tompkins K.L., Boyer K.L., Grindley J.C., Baldwin H.S. Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development 2005, 132:1137-1146.