Abundance of plasma antioxidant proteins confers tolerance to acute hypobaric hypoxia exposure

High Altitude Medicine and Biology

Volumn 14, Issue 3, 2013, Pages 289-297

  Padhy, Gayatri ^a   Sethy, Niroj Kumar ^a   Ganju, Lilly ^a   Bhargava, Kalpana ^a  

^a DEFENCE INSTITUTE OF PHYSIOLOGY AND ALLIED SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTANE; ANTIOXIDANT; APOLIPOPROTEIN A1; ARYLDIALKYLPHOSPHATASE; ARYLDIALKYLPHOSPHATASE 1; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; GLUTATHIONE PEROXIDASE 3; GUANINE NUCLEOTIDE BINDING PROTEIN; HAPTOGLOBIN; NITRATE; NITRITE; PREALBUMIN;

ALTITUDE ACCLIMATIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERVENTILATION; HYPOBARISM; HYPOXIA; IMMUNOBLOTTING; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; RAT; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION;

ALTITUDE; ANIMALS; ANOXIA; ANTIOXIDANTS; APOLIPOPROTEIN A-I; ARYLDIALKYLPHOSPHATASE; C-REACTIVE PROTEIN; COMPLEMENT C3; COMPLEMENT C4; DOWN-REGULATION; GLUTATHIONE PEROXIDASE; HAPTOGLOBINS; HYPERVENTILATION; LECTINS, C-TYPE; MALE; NITRATES; NITRITES; PREALBUMIN; PRESSURE; PROTEOMICS; RAB3 GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; UP-REGULATION;

EID: 84884771041     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2012.1095     Document Type: Article

References (51)

1. Ahmad Y, Shukla D, Garg I, Sharma NK, Saxena S, Malhotra VK, and Bhargava K. (2011). Identification of haptoglobin and apolipoprotein A-I as biomarkers for high altitude pulmonary edema. Funct Integr Genomics 11:407-417.
2. Ali SS, Hsiao M, Zhao HW, Dugan LL, Haddad GG, and Zhou D. (2012). Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage. PLoS One 7:e36801.
3. Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, and La Du BN. (1998). Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest 101:1581-1590.
4. Baik SC, Kim KM, Song SM, et al. (2004). Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Helicobacter pylori strain 26695. J Bacteriol 186:949-955.
5. Bailey DM, Dehnert C, Luks AM, et al. (2010). High-altitude pulmonary hypertension is associated with a free radicalmediated reduction in pulmonary nitric oxide bioavailability. J Physiol 588:4837-4847.
6. Bailey DM, Evans KA, James PE, et al. (2009). Altered free radical metabolism in acute mountain sickness: Implications for dynamic cerebral autoregulation and blood-brain barrier function. J Physiol 587:73-85.
7. Berger MM, Hesse C, Dehnert C, et al. (2005). Hypoxia impairs systemic endothelial function in individuals prone to highaltitude pulmonary edema. Am J Respir Crit Care Med 172: 763-767.
8. Bierl C, Voetsch B, Jin RC, Handy DE, and Loscalzo J. (2004). Determinants of human plasma glutathione peroxidase (GPx- 3) expression. J Biol Chem 279:26839-26845.
9. Boretti FS, Buehler PW, D'Agnillo F, et al. (2009). Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest 119:2271-2280.
10. Brown DE, Beall CM, Strohl KP, and Mills PS. (2006). Exhaled nitric oxide decreases upon acute exposure to high-altitude hypoxia. Am J Hum Biol 18:196-202.
11. Busch T, Ba rtsch P, Pappert D, et al. (2001). Hypoxia decreases exhaled nitric oxide in mountaineers susceptible to high-altitude pulmonary edema. Am J Respir Crit Care Med 163:368-373.
12. Dosek A, Ohno H, Acs Z, Taylor AW, and Radak Z. (2007). High altitude and oxidative stress. Respir Physiol Neurobiol 158:128-131.
13. Erzurum SC, Ghosh S, Janocha AJ, et al. (2007). Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc Natl Acad Sci USA 104:17593-17598.
14. Fuhrman B, Gantman A, and Aviram M. (2010). Paraoxonase 1 (PON1) deficiency in mice is associated with reduced expression of macrophage SR-BI and consequently the loss of HDL cytoprotection against apoptosis. Atherosclerosis 211:61-68.
15. Gaillard T, Parthasarathy S, and Osei K. (2011). HDL dysfunctionality (Paraoxonase) is worse in nondiabetic, postmenopausal African American than in white women. Diabetes Care 34:e19.
16. Gelfi C, De Palma S, Ripamonti M, et al. (2004). New aspects of altitude adaptation in Tibetans: A proteomic approach. FASEB J 18:612-614.
17. Guzy RD, and Schumacker PT. (2006). Oxygen sensing by mitochondria at complex III: The paradox of increased reactive oxygen species during hypoxia. Exp Physiol 91:807-819.
18. Hackett PH, and Roach RC. (2004). High altitude cerebral edema. High Alt Med Biol 5:136-146.
19. Hohenhaus E, Paul A, McCullough RE, Kucherer H, and Bartsch P. (1995). Ventilatory and pulmonary vascular response to hypoxia and susceptibility to high altitude pulmonary oedema. Eur Respir J 8:1825-1833.
20. Jacobs JM, Adkins JN, Qian WJ, Liu T, Shen Y, Camp DG, 2nd, and Smith RD. (2005). Utilizing human blood plasma for proteomic biomarker discovery. J Proteome Res 4:1073-1085.
21. Jefferson JA, Simoni J, Escudero E, et al. (2004). Increased oxidative stress following acute and chronic high altitude exposure. High Alt Med Biol 5:61-69.
22. Jin RC, Mahoney CE, Coleman Anderson L, et al. (2011). Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation 123:1963-1973.
23. Levett DZ, Fernandez BO, Riley HL, et al. (2011). The role of nitrogen oxides in human adaptation to hypoxia. Sci Rep 1:109.
24. Levy AP. (2003). Genetics of diabetic cardiovascular disease: Identification of a major susceptibility gene. Acta Diabetol 40: S330-333.
25. Loscalzo J. (2001). Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res 88:756-762.
26. Lundberg JO, Weitzberg E, and Gladwin MT. (2008). The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7:156-167.
27. Moraga FA, Flores A, Serra J, Esnaola C, and Barriento C. (2007). Ginkgo biloba decreases acute mountain sickness in people ascending to high altitude at Ollague (3696 m) in northern Chile. Wilderness Environ Med 18:251-257.
28. Peng YJ, Yuan G, Ramakrishnan D, et al. (2006). Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol 577:705-716.
29. Pialoux V, Hanly PJ, Foster GE, et al. (2009). Effects of exposure to intermittent hypoxia on oxidative stress and acute hypoxic ventilatory response in humans. Am J Respir Crit Care Med 180:1002-1009.
30. Pimenova T, Pereira CP, Gehrig P, Buehler PW, Schaer DJ, and Zenobi R. (2010). Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin. J Proteome Res 9:4061-4070.
31. Pidgeon GP, Tamosiuniene R, Chen G, Leonard I, Belton O, Bradford A, and Fitzgerald DJ. (2004). Intravascular thrombosis after hypoxia-induced pulmonary hypertension: Regulation by cyclooxygenase-2. Circulation 110:2701-2707.
32. Precourt LP, Amre D, Denis MC, Lavoie JC, Delvin E, Seidman E, and Levy E. (2011). The three-gene paraoxonase family: Physiologic roles, actions and regulation. Atherosclerosis 214: 20-36.
33. Purushothaman J, Suryakumar G, Shukla D, et al. (2008). Modulatory effects of seabuckthorn (Hippophae rhamnoides L.) in hypobaric hypoxia induced cerebral vascular injury. Brain Res Bull 77:246-252.
34. Quaye IK, Ababio G, and Amoah AG. (2006). Haptoglobin 2-2 phenotype is a risk factor for type 2 diabetes in Ghana. J Atheroscler Thromb 13:90-94.
35. Rochu D, Chabriere E, and Masson P. (2007). Human paraoxonase: A promising approach for pre-treatment and therapy of organophosphorus poisoning. Toxicology 233:47-59.
36. Rozenberg O, Rosenblat M, Coleman R, Shih DM, and Aviram M. (2003). Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: Studies in PON1- knockout mice. Free Radic Biol Med 34:774-784.
37. Salvatore A, Cigliano L, Bucci EM, et al. (2007). Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithincholesterol acyl-transferase. Biochemistry 46:11158-11168.
38. Schaer DJ, and Alayash AI. (2010). Clearance and control mechanisms of hemoglobin from cradle to grave. Antioxid Redox Signal 12:181-184.
39. Schlossmacher P, Hasselmann M, Meyer N, Kara F, Delabranche X, Kummerlen C, and Ingenbleek Y. (2002). The prognostic value of nutritional and inflammatory indices in critically ill patients with acute respiratory failure. Clin Chem Lab Med 40:1339-1343.
40. Sharp FR, and Bernaudin M. (2004). HIF1 and oxygen sensing in the brain. Nat Rev Neurosci 5:437-448.
41. Takaoka Y, Ohta M, Miyakawa K, Nakamura O, Suzuki M, Takahashi K, Yamamura K, and Sakaki Y. (2004). Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Val30Met. Am J Pathol 164:337-345.
42. Teppema LJ, and Dahan A. (2010). The ventilatory response to hypoxia in mammals: Mechanisms, measurement, and analysis. Physiol Rev 90:675-754.
43. Tseng CF, Lin CC, Huang HY, Liu HC, and Mao SJ. (2004). Antioxidant role of human haptoglobin. Proteomics 4:2221-2228.
44. Tward A, Xia YR, Wang XP, et al. (2002). Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation 106:484-490.
45. Vascotto C, Salzano AM, D'Ambrosio C, et al. (2007). Oxidized transthyretin in amniotic fluid as an early marker of preeclampsia. J Proteome Res 6:160-170.
46. Voetsch B, Jin RC, Bierl C, et al. (2007). Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: A novel risk factor for arterial ischemic stroke among young adults and children. Stroke 38:41-49.
47. Vij AG, Dutta R, and Satija NK. (2005). Acclimatization to oxidative stress at high altitude. High Alt Med Biol 6:301-310.
48. Watanabe J, Grijalva V, Hama S, et al. (2009). Hemoglobin and its scavenger protein haptoglobin associate with apoA-1- containing particles and influence the inflammatory properties and function of high density lipoprotein. J Biol Chem 284: 18292-18301.
49. Weil JV. (2004). Sleep at high altitude. High Alt Med Biol 5:180-189.
50. Wilson MH, Newman S, and Imray CH. (2009). The cerebral effects of ascent to high altitudes. Lancet Neurol 8:175-191.
51. Zhang Q, and Kelly JW. (2003). Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions. Biochemistry 42:8756-8761.