Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema

American Journal of Respiratory and Critical Care Medicine

Volumn 172, Issue 6, 2005, Pages 763-767

  Berger, Marc M ^b   Hesse, Christiane ^b   Dehnert, Christoph ^b   Siedler, Heike ^b   Kleinbongard, Petra ^b   Bardenheuer, Hubert J ^b   Kelm, Malte ^b   Bärtsch, Peter ^b   Haefeli, Walter E ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NONE

Author keywords

Edema; Endothelin; Endothelium; Hypoxia; Nitric oxide

Indexed keywords

ACETYLCHOLINE; ENDOTHELIN 1; NITRATE; NITRIC OXIDE; NITRITE; NITROPRUSSIDE SODIUM;

ADULT; ALTITUDE DISEASE; ARTICLE; BLOOD GAS ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GAS EXCHANGE; HEART RATE; HEMODYNAMIC PARAMETERS; HIGH ALTITUDE PULMONARY EDEMA; HUMAN; HYPOXIA; LUNG ARTERY PRESSURE; LUNG EDEMA; MALE; MEAN ARTERIAL PRESSURE; MOUNTAINEERING; PATHOGENESIS; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY;

ACETYLCHOLINE; ADULT; ALTITUDE SICKNESS; ANOXIA; BLOOD PRESSURE; DISEASE SUSCEPTIBILITY; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; NITRATES; NITRITES; NITROPRUSSIDE; PULMONARY ARTERY; PULMONARY EDEMA; PULMONARY GAS EXCHANGE; REGIONAL BLOOD FLOW; SINGLE-BLIND METHOD; VASODILATION; VASODILATOR AGENTS;

EID: 24944498766     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200504-654OC     Document Type: Article

References (34)

1. Maggiorini M, Melot C, Pierre S, Pfeiffer F, Greve I, Sartori C, Lepori M, Hauser M, Scherrer U, Naeije R. High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 2001;103:2078-2083.
2. Hopkins SR, Garg J, Bolar DS, Balouch J, Levin DL. Pulmonary blood flow heterogeneity during hypoxia and high-altitude pulmonary edema. Am J Respir Crit Care Med 2005;171:83-87.
3. Bärtsch P, Maggiorini M, Ritter M, Noti C, Vock P, Oelz O. Prevention of high-altitude pulmonary edema by nifedipine. N Engl J Med 1991;325:1284-1289.
4. Bärtsch P. High altitude pulmonary edema. Respiration (Herrlisheim) 1997;64:435-443.
5. Grünig E, Mereles D, Hildebrandt W, Swenson ER, Kübler W, Kücherer H, Bärtsch P. Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema. J Am Coll Cardiol 2000;35:980-987.
6. Blitzer ML, Loh E, Roddy MA, Stamler JS, Creager MA. Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans. J Am Coll Cardiol 1996;28:591-596.
7. Busch T, Bärtsch P, Pappert D, Grünig E, Hildebrandt W, Elser H, Falke KJ, Swenson ER. Hypoxia decreases exhaled nitric oxide in mountaineers susceptible to high-altitude pulmonary edema. Am J Respir Crit Care Med 2001;163:368-373.
8. Duplain H, Sartori C, Lepori M, Egli M, Allemann Y, Nicod P, Scherrer U. Exhaled nitric oxide in high-altitude pulmonary edema: role in the regulation of pulmonary vascular tone and evidence for a role against inflammation. Am J Respir Crit Care Med 2000;162:221-224.
9. Swenson ER, Maggiorini M, Mongovin S, Gibbs JS, Greve I, Mairbäurl H, Bärtsch P. Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor. JAMA 2002;287:2228-2235.
10. Berg JT, Deem S, Kerr ME, Swenson ER. Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forces. Am J Physiol Heart Circ Physiol 2000;279:H2947-H2953.
11. Vaughan DJ, Brogan TV, Kerr ME, Deem S, Luchtel DL, Swenson ER. Contributions of nitric oxide synthase isozymes to exhaled nitric oxide and hypoxic pulmonary vasoconstriction in rabbit lungs. Am J Physiol Lung Cell Mol Physiol 2003;284:L834-L843.
12. Berger MM, Hesse C, Dehnert C, Siedler H, Kleinbongard P, Gharini P, Bardenheuer HJ, Keim M, Bärtsch P, Haefeli WE. Hypoxia impairs endothelial function in individuals susceptible to high-altitude pulmonary oedema (HAPE): the missing link in the pathogenesis of HAPE [abstract]? High Alt Med Biol 2004;5:476.
13. Scherrer U, Vollenweider L, Delabays A, Savcic M, Eichenberger U, Kleger GR, Fikrle A, Ballmer PE, Nicod P, Bärtsch P. Inhaled nitric oxide for high-altitude pulmonary edema. N Engl J Med 1996;334:624-629.
14. Benjamin N, Calver A, Collier J, Robinson B, Vallance P, Webb D. Measuring forearm blood flow and interpreting the responses to drugs and mediators. Hypertension 1995;25:918-923.
15. Haefeli WE, Linder L, Lüscher TF. Quinaprilat induces arterial vasodilation mediated by nitric oxide in humans. Hypertension 1997;30:912-917.
16. Yock PG, Popp RL. Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation 1984;70:657-662.
17. Kleinbongard P, Rassaf T, Dejam A, Kerber S, Keim M. Griess method for nitrite measurement of aqueous and protein-containing samples. Methods Enzymol 2002;359:158-168.
18. Gharini PDA, Lauer T, Matern S, Keim M, Kleinbongard P. A simple method to measure nitrite and nitrate in urine measurement of the end product of NO-metabolisms pathway in urine through vanadium chloride and Griess. Marburg, Germany: AOL Verlag Marburg; 2002.
19. Shaw SG, Schmid M, Casty A. Critical factors in the radioimmunoassay of endothelin-1, endothelin-3, and big endothelin-1 in human plasma. Anal Biochem 2000;278:143-149.
20. Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323:22-27.
21. Heitzer T, Just H, Munzel T. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 1996;94:6-9.
22. Lauer T, Preik M, Rassaf T, Strauer BE, Deussen A, Feelisch M, Keim M. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci USA 2001;98:12814-12819.
23. Kamper AM, Paul LC, Blauw GJ. Prostaglandins are involved in acetylcholine- and 5-hydroxytryptamine-induced, nitric oxide-mediated vasodilatation in human forearm. J Cardiovasc Pharmacol 2002;40:922-929.
24. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-142.
25. Kelm M. Nitric oxide metabolism and breakdown. Biochim Biophys Acta 1999;1411:273-289.
26. Zhao L, Mason NA, Strange JW, Walker H, Wilkins MR. Beneficial effects of phosphodiesterase 5 inhibition in pulmonary hypertension are influenced by natriuretic peptide activity. Circulation 2003;107:234-237.
27. Ghofrani HA, Reichenberger F, Kohstall MG, Mrosek EH, Seeger T, Olschewski H, Seeger W, Grimminger F. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med 2004;141:169-177.
28. Richalet JP, Gratadour P, Robach P, Pham I, Dechaux M, Joncquiert-Latarjet A, Mollard P, Brugniaux J, Cornolo J. Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am J Respir Crit Care Med 2005;171:275-281.
29. Maggiorini M, Brunner-La Rocca HP, Bärtsch P, Fischler M, Böhm T, Bloch KE, Mairbäurl H. Dexamethasone and tadalafil prophylaxis prevents both excessive pulmonary constriction and high altitude pulmonary edema in susceptible subjects [abstract]. Eur Respir J 2004;24:110s.
30. Morganti A, Giussani M, Sala C, Gazzano G, Marana I, Pierini A, Savoia MT, Ohio F, Cogo A, Zanchetti A. Effects of exposure to high altitude on plasma endothelin-1 levels in normal subjects. J Hypertens 1995;13:859-865.
31. Schiffrin EL, Touyz RM. Vascular biology of endothelin. J Cardiovasc Pharmacol 1998;32:82-813.
32. Johnson W, Nohria A, Garrett L, Fang JC, Igo J, Katai M, Ganz P, Creager MA. Contribution of endothelin to pulmonary vascular tone under normoxic and hypoxic conditions. Am J Physiol Heart Circ Physiol 2002;283:H568-H575.
33. Sato K, Rodman DM, McMurtry IF. Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs. Am J Physiol 1999;276:L571-L581.
34. Ivy D, McMurtry IF, Yanagisawa M, Gariepy CE, Le Cras TD, Gebb SA, Morris KG, Wiseman RC, Abman SH. Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 2001;280:L1040-L1048.