Central mechanisms of menthol-induced analgesia

Journal of Pharmacology and Experimental Therapeutics

Volumn 343, Issue 3, 2012, Pages 661-672

  Pan, Rong ^a   Tian, Yuzhen ^a   Gao, Ruby ^a   Li, Haitao ^a,b   Zhao, Xianguo ^c   Barrett, James E ^a   Hu, Huijuan ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c PharmaOn LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; MENTHOL; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ALLODYNIA; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BRAIN LEVEL; DRUG MECHANISM; DRUG RECEPTOR BINDING; HYPERALGESIA; INFLAMMATORY PAIN; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NOCICEPTIVE PAIN; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SPINAL CORD DORSAL HORN; SYNAPTIC TRANSMISSION; TANDEM MASS SPECTROMETRY;

ACTION POTENTIALS; ANALGESIA; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA-A RECEPTOR AGONISTS; MALE; MASS SPECTROMETRY; MENTHOL; MICE; MICE, INBRED STRAINS; NEURALGIA; PAIN MEASUREMENT; PAIN THRESHOLD; POSTERIOR HORN CELLS; RECEPTORS, GABA-A; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS; VOLTAGE-GATED SODIUM CHANNELS;

EID: 84869230595     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.196717     Document Type: Article

References (38)

1. v1.2 channel current decay by (+)- and (-)-isradipine. Br J Pharmacol 133:959-966.
2. Bianchi BR, Zhang XF, Reilly RM, Kym PR, Yao BB, and Chen J (2012) Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels. J Pharmacol Exp Ther 341:360-368.
3. Borhani Haghighi A, Motazedian S, Rezaii R, Mohammadi F, Salarian L, Pourmokhtari M, Khodaei S, Vossoughi M, and Miri R (2010) Cutaneous application of menthol 10% solution as an abortive treatment of migraine without aura: a randomised, double-blind, placebo-controlled, crossed-over study. Int J Clin Pract 64:451-456.
4. Coderre TJ and Melzack R (1992) The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. J Neurosci 12:3665-3670.
5. Colburn RW, Lubin ML, Stone DJ Jr, Wang Y, Lawrence D, D'Andrea MR, Brandt MR, Liu Y, Flores CM, and Qin N (2007) Attenuated cold sensitivity in TRPM8 null mice. Neuron 54:379-386. (Pubitemid 46671410)
6. Córdova MM, Werner MF, Silva MD, Ruani AP, Pizzolatti MG, and Santos AR (2011) Further antinociceptive effects of myricitrin in chemical models of overt nociception in mice. Neurosci Lett 495:173-177.
7. Filipović B, Matak I, Bach-Rojecky L, and Lacković Z (2012) Central action of peripherally applied botulinum toxin type A on pain and dural protein extravasation in rat model of trigeminal neuropathy. PLoS One 7:e29803.
8. Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A, and Ghelardini C (2002) Menthol: a natural analgesic compound. Neurosci Lett 322:145-148. (Pubitemid 34230540)
9. Gao YJ, Xu ZZ, Liu YC, Wen YR, Decosterd I, and Ji RR (2010) The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. Pain 148:309-319.
10. Gaudioso C, Hao J, Martin-Eauclaire MF, Gabriac M, and Delmas P (2012) Menthol pain relief through cumulative inactivation of voltage-gated sodium channels. Pain 153:473-484.
11. Gentry C, Stoakley N, Andersson DA, and Bevan S (2010) The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol Pain 6:4.
12. Green BG and McAuliffe BL (2000) Menthol desensitization of capsaicin irritation. Evidence of a short-term anti-nociceptive effect. Physiol Behav 68:631-639. (Pubitemid 30182463)
13. Haeseler G, Maue D, Grosskreutz J, Bufler J, Nentwig B, Piepenbrock S, Dengler R, and Leuwer M (2002) Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol. Eur J Anaesthesiol 19:571-579. (Pubitemid 34855560)
14. Hatem S, Attal N, Willer JC, and Bouhassira D (2006) Psychophysical study of the effects of topical application of menthol in healthy volunteers. Pain 122:190-196.
15. Higashi Y, Kiuchi T, and Furuta K (2010) Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study. Clin Ther 32:34-43.
16. Hu HJ, Alter BJ, Carrasquillo Y, Qiu CS, and Gereau RW 4th (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. J Neurosci 27:13181-13191. (Pubitemid 350220481)
17. Hu HJ, Bhave G, and Gereau RW 4th (2002) Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia. J Neurosci 22:7444-7452. (Pubitemid 35386344)
18. Hu HJ, Carrasquillo Y, Karim F, Jung WE, Nerbonne JM, Schwarz TL, and Gereau RW 4th (2006) The kv4.2 potassium channel subunit is required for pain plasticity. Neuron 50:89-100.
19. Huang LY (1989) Calcium channels in isolated rat dorsal horn neurones, including labelled spinothalamic and trigeminothalamic cells. J Physiol 411:161-177.
20. Hunskaar S and Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30:103-114. (Pubitemid 17094194)
21. Jiang X, Ory DS, and Han X (2007) Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine. Rapid Commun Mass Spectrom 21:141-152. (Pubitemid 46095472)
22. Karashima Y, Damann N, Prenen J, Talavera K, Segal A, Voets T, and Nilius B (2007) Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci 27:9874-9884. (Pubitemid 47403994)
23. Klein AH, Sawyer CM, Carstens MI, Tsagareli MG, Tsiklauri N, and Carstens E (2010) Topical application of L-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats. Behav Brain Res 212:179-186.
24. Knowlton WM, Bifolck-Fisher A, Bautista DM, and McKemy DD (2010) TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain 150:340-350.
25. Koltzenburg M, Wall PD, and McMahon SB (1999) Does the right side know what the left is doing? Trends Neurosci 22:122-127. (Pubitemid 29151805)
26. Latremoliere A and Woolf CJ (2009) Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10:895-926.
27. Lee KS and Tsien RW (1983) Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature 302:790-794. (Pubitemid 13125114)
28. McKemy DD, Neuhausser WM, and Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416:52-58. (Pubitemid 34215395)
29. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, et al. (2002) A TRP channel that senses cold stimuli and menthol. Cell 108:705-715. (Pubitemid 34241429)
30. Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, Fleetwood-Walker SM, and Mitchell R (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16:1591-1605. (Pubitemid 44233290)
31. Shibata M, Ohkubo T, Takahashi H, and Inoki R (1989) Modified formalin test: characteristic biphasic pain response. Pain 38:347-352. (Pubitemid 19251258)
32. Su L, Wang C, Yu YH, Ren YY, Xie KL, and Wang GL (2011) Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain. BMC Neurosci 12:120.
33. Swandulla D, Carbone E, Schäfer K, and Lux HD (1987) Effect of menthol on two types of Ca currents in cultured sensory neurons of vertebrates. Pflugers Arch 409:52-59. (Pubitemid 17096631)
34. 2+ stores potentiates sensory synaptic transmission. J Neurosci 24:762-771.
35. Wasner G, Naleschinski D, Binder A, Schattschneider J, McLachlan EM, and Baron R (2008) The effect of menthol on cold allodynia in patients with neuropathic pain. Pain Med 9:354-358. (Pubitemid 351467891)
36. A receptor with the intravenous agent, propofol. Eur J Pharmacol 590:120-126.
37. Xiao B, Dubin AE, Bursulaya B, Viswanath V, Jegla TJ, and Patapoutian A (2008) Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci 28:9640-9651.
38. Zhang XB, Jiang P, Gong N, Hu XL, Fei D, Xiong ZQ, Xu L, and Xu TL (2008) A-type GABA receptor as a central target of TRPM8 agonist menthol. PLoS One 3:e3386.