Human NK Cell Subset Functions Are Differentially Affected by Adipokines

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Huebner, Lena ^a,b   Engeli, Stefan ^a   Wrann, Christiane D ^c   Goudeva, Lilia ^a   Laue, Tobias ^a   Kielstein, Heike ^d  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; CD56 ANTIGEN; GAMMA INTERFERON; GRANZYME A; LEPTIN RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADIPOCYTE CONDITIONED MEDIUM; ADIPOGENESIS; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION;

3T3-L1 CELLS; ADIPOKINES; ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMALS; CULTURE MEDIA; FLOW CYTOMETRY; GRANZYMES; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; MICE; OBESITY; SPECIES SPECIFICITY; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84884732976     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075703     Document Type: Article

References (44)

1. Caballero B, (2007) The global epidemic of obesity: An overview. Epidemiol Rev 29: 1-5.
2. Ogden CL, Carroll MD, McDowell MA, Flegal KM, (2007) Obesity among adults in the united states-no statistically significant chance since 2003-2004. NCHS data brief (1): 1-8.
3. Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB, (2002) Overweight and obesity as determinants of cardiovascular risk: The framingham experience. Arch Intern Med 162: 1867-1872.
4. Calle EE, Kaaks R, (2004) Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4: 579-591.
5. Falagas ME, Kompoti M, (2006) Obesity and infection. Lancet Infect Dis 6: 438-446.
6. Dixit VD, (2008) Adipose-immune interactions during obesity and caloric restriction: Reciprocal mechanisms regulating immunity and health span. J Leukoc Biol 84: 882-892.
7. Fantuzzi G, (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115: 911-919.
8. Kershaw EE, Flier JS, (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-2556.
9. Trayhurn P, (2005) Adipose tissue in obesity-an inflammatory issue. Endocrinology 146: 1003-1005.
10. Wolf AM, Wolf D, Rumpold H, Enrich B, Tilg H, (2004) Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun 323: 630-635.
11. Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian J, Spurlock ME, (2004) Adiponectin differentially regulates cytokines in porcine macrophages. Biochem Biophys Res Commun 316: 924-929.
12. La Cava A, Matarese G, (2004) The weight of leptin in immunity. Nat Rev Immunol 4: 371-379.
13. Moschen AR, Kaser A, Enrich B, Mosheimer B, Theurl M, et al. (2007) Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J Immunol 178: 1748-1758.
14. Lago F, Dieguez C, Gomez-Reino J, Gualillo O, (2007) The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev 18: 313-325.
15. Trayhurn P, Wood IS, (2004) Adipokines: Inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92: 347-355.
16. Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, et al. (2010) Role of leptin in the activation of immune cells. Mediators Inflamm 2010: 568343.
17. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, et al. (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110: 1093-1103.
18. Lautenbach A, Wrann CD, Jacobs R, Muller G, Brabant G, et al. (2009) Altered phenotype of NK cells from obese rats can be normalized by transfer into lean animals. Obesity 17: 1848-1855.
19. Nave H, Mueller G, Siegmund B, Jacobs R, Stroh T, et al. (2008) Resistance of janus kinase-2 dependent leptin signaling in natural killer (NK) cells: A novel mechanism of NK cell dysfunction in diet-induced obesity. Endocrinology 149: 3370-3378.
20. Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S, (2008) Functions of natural killer cells. Nat Immunol 9: 503-510.
21. Lanier LL, (2008) Up on the tightrope: Natural killer cell activation and inhibition. Nat Immunol 9: 495-502.
22. Kim KY, Kim JK, Han SH, Lim JS, Kim KI, et al. (2006) Adiponectin is a negative regulator of NK cell cytotoxicity. J Immunol 176: 5958-5964.
23. Housa D, Housova J, Vernerova Z, Haluzik M, (2006) Adipocytokines and cancer. Physiol Res 55: 233-244.
24. Wabitsch M, Brenner RE, Melzner I, Braun M, Moller P, et al. (2001) Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 25: 8-15.
25. Gregoire FM, Smas CM, Sul HS, (1998) Understanding adipocyte differentiation. Physiol Rev 78: 783-809.
26. Poulos SP, Dodson MV, Hausman GJ, (2010) Cell line models for differentiation: Preadipocytes and adipocytes. Exp Biol Med 235: 1185-1193.
27. Zhong J, Krawczyk SA, Chaerkady R, Huang H, Goel R, et al. (2010) Temporal profiling of the secretome during adipogenesis in humans. J Proteome Res 9: 5228-5238.
28. Cooper MA, Fehniger TA, Caligiuri MA, (2001) The biology of human natural killer-cell subsets. Trends Immunol 22: 633-640.
29. Corazza N, Kassahn D, Jakob S, Badmann A, Brunner T, (2009) TRAIL-induced apoptosis: Between tumor therapy and immunopathology. Annals N Y Acad Sci 1171: 50-58.
30. Takeda K, Smyth MJ, Cretney E, Hayakawa Y, Yamaguchi N, et al. (2001) Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol 214: 194-200.
31. Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, et al. (2007) Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med 204: 667-680.
32. Falschlehner C, Schaefer U, Walczak H, (2009) Following TRAIL's path in the immune system. Immunology 127: 145-154.
33. Wrann CD, Laue T, Hübner L, Kuhlmann S, Jacobs R, et al. (2012) Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions. Am J Physiol Endocrinol Metab. 302(1): E108-E116.
34. De Maria A, Bozzano F, Cantoni C, Moretta L, (2011) Revisiting human natural killer cell subset function revealed cytolytic CD56(dim)CD16+ NK cells as rapid producers of abundant IFN-gamma on activation. Proc Natl Acad Sci USA 108: 728-732.
35. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, et al. (2008) Dynamics of fat cell turnover in humans. Nature 453: 783-787.
36. Arner P, Spalding KL, (2010) Fat cell turnover in humans. Biochem Biophys Res Commun 396: 101-104.
37. Bluher M, (2009) Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes 117: 241-250.
38. McLaughlin T, Deng A, Yee G, Lamendola C, Reaven G, et al. (2010) Inflammation in subcutaneous adipose tissue: Relationship to adipose cell size. Diabetologia 53: 369-377.
39. Rosenow A, Arrey TN, Bouwman FG, Noben JP, Wabitsch M, et al. (2010) Identification of novel human adipocyte secreted proteins by using SGBS cells. J Proteome Res 9: 5389-5401.
40. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271.
41. Zhao Y, Sun R, You L, Gao C, Tian Z, (2003) Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem Biophys Res Commun 300: 247-252.
42. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, et al. (2013) Genomic responses in mouse models poorly mimic human infl{ligature}ammatory diseases. PNAS 110 (9): 3507-3512.
43. Lynch LA, O'Connell JM, Kwasnik AK, Cawood TJ, O'Farrelly C, et al. (2009) Are natural killer cells protecting the metabolically healthy obese patient? Obesity 17: 601-605.
44. O'Shea D, Cawood TJ, O'Farrelly C, Lynch L, (2010) Natural killer cells in obesity: Impaired function and increased susceptibility to the effects of cigarette smoke. PloS One 5: e8660.