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Volumn 60, Issue , 2013, Pages 126-138

Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model

Author keywords

Afterdischarges; Antiepileptogenesis; Cortical focus theory; Depression; DTI; Electrical stimulation; Ethosuximide; Somatosensory cortex; WAG Rij rats

Indexed keywords

ETHOSUXIMIDE; SUCROSE;

EID: 84884713199     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.08.013     Document Type: Article
Times cited : (44)

References (58)
  • 1
    • 77951296488 scopus 로고    scopus 로고
    • Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy
    • Akman O., Demiralp T., Ates N., Onat F.Y. Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy. Epilepsy Res. 2010, 89:185-193.
    • (2010) Epilepsy Res. , vol.89 , pp. 185-193
    • Akman, O.1    Demiralp, T.2    Ates, N.3    Onat, F.Y.4
  • 2
    • 0036868692 scopus 로고    scopus 로고
    • The basis of anisotropic water diffusion in the nervous system - a technical review
    • Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed. 2002, 15:435-455.
    • (2002) NMR Biomed. , vol.15 , pp. 435-455
    • Beaulieu, C.1
  • 6
    • 0029077754 scopus 로고
    • Neuronal activities underlying the electroencephalogram and evoked potentials of sleeping and waking: implications for information processing
    • Coenen A.M. Neuronal activities underlying the electroencephalogram and evoked potentials of sleeping and waking: implications for information processing. Neurosci. Biobehav. Rev. 1995, 19:447-463.
    • (1995) Neurosci. Biobehav. Rev. , vol.19 , pp. 447-463
    • Coenen, A.M.1
  • 7
    • 0023247384 scopus 로고
    • The WAG/Rij rat model for absence epilepsy: age and sex factors
    • Coenen A.M.L., van Luijtelaar E.L.J.M. The WAG/Rij rat model for absence epilepsy: age and sex factors. Epilepsy Res. 1987, 1:297-301.
    • (1987) Epilepsy Res. , vol.1 , pp. 297-301
    • Coenen, A.M.L.1    van Luijtelaar, E.L.J.M.2
  • 8
    • 0345256499 scopus 로고    scopus 로고
    • Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats
    • Coenen A.M.L., van Luijtelaar E.L.J.M. Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats. Behav. Genet. 2003, 33:635-655.
    • (2003) Behav. Genet. , vol.33 , pp. 635-655
    • Coenen, A.M.L.1    van Luijtelaar, E.L.J.M.2
  • 10
    • 84882841597 scopus 로고    scopus 로고
    • Genetic models of absence epilepsy in the rat
    • Elsevier Academic Press, San Diego, CA, A. Pitkanen, P.A. Schwartzkroin, S.L. Moshe (Eds.)
    • Depaulis A., van Luijtelaar G. Genetic models of absence epilepsy in the rat. Models of Seizures and Epilepsy 2006, Elsevier Academic Press, San Diego, CA. A. Pitkanen, P.A. Schwartzkroin, S.L. Moshe (Eds.).
    • (2006) Models of Seizures and Epilepsy
    • Depaulis, A.1    van Luijtelaar, G.2
  • 11
    • 84875859244 scopus 로고    scopus 로고
    • Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy
    • Dezsi G., Ozturk E., Stanic D., Powell K.L., Blumenfeld H., O'Brien T.J., Jones N.C. Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy. Epilepsia 2013, 54:635-643.
    • (2013) Epilepsia , vol.54 , pp. 635-643
    • Dezsi, G.1    Ozturk, E.2    Stanic, D.3    Powell, K.L.4    Blumenfeld, H.5    O'Brien, T.J.6    Jones, N.C.7
  • 13
    • 67651121813 scopus 로고    scopus 로고
    • Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls
    • Edelbroek P.M., van der Heijden J., Stolk L.M. Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls. Ther. Drug Monit. 2009, 231:327-336.
    • (2009) Ther. Drug Monit. , vol.231 , pp. 327-336
    • Edelbroek, P.M.1    van der Heijden, J.2    Stolk, L.M.3
  • 14
    • 77952592440 scopus 로고    scopus 로고
    • Is epilepsy a preventable disorder? New evidence from animal models
    • Giblin K.A., Blumenfeld H. Is epilepsy a preventable disorder? New evidence from animal models. Neuroscientist 2010, 16:253-275.
    • (2010) Neuroscientist , vol.16 , pp. 253-275
    • Giblin, K.A.1    Blumenfeld, H.2
  • 16
    • 6344226569 scopus 로고    scopus 로고
    • Sequential activation of microcircuits underlying somatosensory-evoked potentials in rat neocortex
    • Jellema T., Brunia C.H., Wadman W.J. Sequential activation of microcircuits underlying somatosensory-evoked potentials in rat neocortex. Neuroscience 2004, 129:283-295.
    • (2004) Neuroscience , vol.129 , pp. 283-295
    • Jellema, T.1    Brunia, C.H.2    Wadman, W.J.3
  • 17
    • 33846927830 scopus 로고    scopus 로고
    • Cambridge University Press
    • Jones E.G. The Thalamus 2007, Cambridge University Press. 2nd edition.
    • (2007) The Thalamus
    • Jones, E.G.1
  • 18
    • 0032835247 scopus 로고    scopus 로고
    • Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging
    • Jones D.K., Horsfield M.A., Simmons A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn. Reson. Med. 1999, 42(3):515-525.
    • (1999) Magn. Reson. Med. , vol.42 , Issue.3 , pp. 515-525
    • Jones, D.K.1    Horsfield, M.A.2    Simmons, A.3
  • 19
    • 37649011458 scopus 로고    scopus 로고
    • Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation
    • Jones N.C., Salzberg M.R., Kumar G., Couper A., Morris M.J., O'Brien T.J. Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation. Exp. Neurol. 2008, 209:254-260.
    • (2008) Exp. Neurol. , vol.209 , pp. 254-260
    • Jones, N.C.1    Salzberg, M.R.2    Kumar, G.3    Couper, A.4    Morris, M.J.5    O'Brien, T.J.6
  • 20
    • 0030862893 scopus 로고    scopus 로고
    • Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat
    • Kandel A., Buzsáki G. Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat. J. Neurosci. 1997, 17:6783-6797.
    • (1997) J. Neurosci. , vol.17 , pp. 6783-6797
    • Kandel, A.1    Buzsáki, G.2
  • 21
    • 84862804156 scopus 로고    scopus 로고
    • Connectivity of thalamo-cortical pathway in rat brain: combined diffusion spectrum imaging and functional MRI at 11.7T
    • Kim Y.B., Kalthoff D., Po C., Wiedermann D., Hoehn M. Connectivity of thalamo-cortical pathway in rat brain: combined diffusion spectrum imaging and functional MRI at 11.7T. NMR Biomed 2012, 10.1002/nbm.1815.
    • (2012) NMR Biomed
    • Kim, Y.B.1    Kalthoff, D.2    Po, C.3    Wiedermann, D.4    Hoehn, M.5
  • 22
    • 1842453277 scopus 로고    scopus 로고
    • Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy
    • Klein J.P., Khera D.S., Nersesyan H., Kimchi E.Y., Waxman S.G., Blumenfeld H. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res. 2004, 1000:102-109.
    • (2004) Brain Res. , vol.1000 , pp. 102-109
    • Klein, J.P.1    Khera, D.S.2    Nersesyan, H.3    Kimchi, E.Y.4    Waxman, S.G.5    Blumenfeld, H.6
  • 23
    • 33846200737 scopus 로고    scopus 로고
    • Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model
    • Kole M.H., Bräuer A.U., Stuart G.J. Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model. J. Physiol. 2007, 578(Pt 2):507-525.
    • (2007) J. Physiol. , vol.578 , Issue.PART 2 , pp. 507-525
    • Kole, M.H.1    Bräuer, A.U.2    Stuart, G.J.3
  • 24
    • 34547644482 scopus 로고    scopus 로고
    • Reticular nucleus-specific changes in α3 subunit protein at GABA synapses in genetically epilepsy-prone rats
    • Liu X.B., Cobble J., van Luijtelaar G., Jones E.G. Reticular nucleus-specific changes in α3 subunit protein at GABA synapses in genetically epilepsy-prone rats. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:12512-12517.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 12512-12517
    • Liu, X.B.1    Cobble, J.2    van Luijtelaar, G.3    Jones, E.G.4
  • 25
    • 0031908063 scopus 로고    scopus 로고
    • Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy
    • Loscher W., Honack D., Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J. Pharmacol. Exp. Ther. 1998, 284:474-479.
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 474-479
    • Loscher, W.1    Honack, D.2    Rundfeldt, C.3
  • 26
    • 80955178319 scopus 로고    scopus 로고
    • Electrical stimulation of the epileptic focus in absence epileptic WAG/Rij rats: assessment of local and network excitability
    • Lüttjohann A., Zhang S., de Peijper R., van Luijtelaar G. Electrical stimulation of the epileptic focus in absence epileptic WAG/Rij rats: assessment of local and network excitability. Neuroscience 2011, 188:125-134.
    • (2011) Neuroscience , vol.188 , pp. 125-134
    • Lüttjohann, A.1    Zhang, S.2    de Peijper, R.3    van Luijtelaar, G.4
  • 27
    • 0037083650 scopus 로고    scopus 로고
    • Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats
    • Meeren H.K., Pijn J.P., Van Luijtelaar E.L., Coenen A.M., Lopes da Silva F.H. Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J. Neurosci. 2002, 22:1480-1495.
    • (2002) J. Neurosci. , vol.22 , pp. 1480-1495
    • Meeren, H.K.1    Pijn, J.P.2    Van Luijtelaar, E.L.3    Coenen, A.M.4    Lopes da Silva, F.H.5
  • 30
    • 84873098807 scopus 로고    scopus 로고
    • The involvement of limbic structures in typical and atypical absence epilepsy
    • Onat F.Y., van Luijtelaar G., Nehlig A., Snead O.C. The involvement of limbic structures in typical and atypical absence epilepsy. Epilepsy Res. 2012, 103(2-3):111-123.
    • (2012) Epilepsy Res. , vol.103 , Issue.2-3 , pp. 111-123
    • Onat, F.Y.1    van Luijtelaar, G.2    Nehlig, A.3    Snead, O.C.4
  • 31
    • 0032860017 scopus 로고    scopus 로고
    • Typical absence seizures and their treatment
    • Panayiotopoulos C.P. Typical absence seizures and their treatment. Arch. Dis. Child. 1999, 81:351-355.
    • (1999) Arch. Dis. Child. , vol.81 , pp. 351-355
    • Panayiotopoulos, C.P.1
  • 32
    • 20344363931 scopus 로고    scopus 로고
    • Integrating intensity and feature nonrigid registration
    • Medical Image Computing and Computer-Assisted Intervention (MICCAI)
    • Papademetris X., Staib L.H., Jackowski A.P., Win L.Y., Schultz R.T., Duncan J.S. Integrating intensity and feature nonrigid registration. LNCS 2004, 3216, I:763-770.
    • (2004) LNCS , pp. 763-770
    • Papademetris, X.1    Staib, L.H.2    Jackowski, A.P.3    Win, L.Y.4    Schultz, R.T.5    Duncan, J.S.6
  • 34
    • 0242475139 scopus 로고    scopus 로고
    • Cellular interactions in the rat somatosensory thalamocortical system during normal and epileptic 5-9Hz oscillations
    • Pinault D. Cellular interactions in the rat somatosensory thalamocortical system during normal and epileptic 5-9Hz oscillations. J. Physiol. 2003, 552(Pt 3):881-905.
    • (2003) J. Physiol. , vol.552 , Issue.PART 3 , pp. 881-905
    • Pinault, D.1
  • 35
    • 67649908316 scopus 로고    scopus 로고
    • Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model
    • Polack P.O., Charpier S. Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. Epilepsia 2009, 50:1816-1820.
    • (2009) Epilepsia , vol.50 , pp. 1816-1820
    • Polack, P.O.1    Charpier, S.2
  • 36
    • 34250308414 scopus 로고    scopus 로고
    • Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence epilepsy
    • Polack P., Guillemain I., Hu E., Deransart C., Depaulis A., Charpier S. Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence epilepsy. J. Neurosci. 2007, 27:6590-6599.
    • (2007) J. Neurosci. , vol.27 , pp. 6590-6599
    • Polack, P.1    Guillemain, I.2    Hu, E.3    Deransart, C.4    Depaulis, A.5    Charpier, S.6
  • 37
    • 0018268297 scopus 로고
    • Behavioural despair in rats: a new model sensitive to antidepressant treatments
    • Porsolt R.D., Anton G., Blavet N., Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 1978, 47:379-391.
    • (1978) Eur. J. Pharmacol. , vol.47 , pp. 379-391
    • Porsolt, R.D.1    Anton, G.2    Blavet, N.3    Jalfre, M.4
  • 38
    • 77955340670 scopus 로고    scopus 로고
    • Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy
    • Russo E., Citraro R., Scicchitano F., De Fazio S., Di Paola E.D., Constanti A., De Sarro G. Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. Epilepsia 2010, 51:1560-1569.
    • (2010) Epilepsia , vol.51 , pp. 1560-1569
    • Russo, E.1    Citraro, R.2    Scicchitano, F.3    De Fazio, S.4    Di Paola, E.D.5    Constanti, A.6    De Sarro, G.7
  • 39
    • 80052405638 scopus 로고    scopus 로고
    • Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity
    • Russo E., Citraro R., Scicchitano F., Urzono A., Marra R., Rispoli V., De Sarro G. Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity. Behav. Brain Res. 2011, 225:373-376.
    • (2011) Behav. Brain Res. , vol.225 , pp. 373-376
    • Russo, E.1    Citraro, R.2    Scicchitano, F.3    Urzono, A.4    Marra, R.5    Rispoli, V.6    De Sarro, G.7
  • 40
    • 27944505126 scopus 로고    scopus 로고
    • Behavioral characteristics of WAG/Rij rats susceptible and non-susceptible to audiogenic seizures
    • Sarkisova K.Y., Kulikov M.A. Behavioral characteristics of WAG/Rij rats susceptible and non-susceptible to audiogenic seizures. Behav. Brain Res. 2006, 166:9-18.
    • (2006) Behav. Brain Res. , vol.166 , pp. 9-18
    • Sarkisova, K.Y.1    Kulikov, M.A.2
  • 41
    • 79956004450 scopus 로고    scopus 로고
    • The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression
    • Sarkisova K., van Luijtelaar G. The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2011, 35:854-876.
    • (2011) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.35 , pp. 854-876
    • Sarkisova, K.1    van Luijtelaar, G.2
  • 42
    • 0041886973 scopus 로고    scopus 로고
    • Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy
    • Sarkisova K.Y., Midzianovskaia I.S., Kulikov M.A. Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy. Behav. Brain Res. 2003, 144:211-226.
    • (2003) Behav. Brain Res. , vol.144 , pp. 211-226
    • Sarkisova, K.Y.1    Midzianovskaia, I.S.2    Kulikov, M.A.3
  • 43
    • 76249112247 scopus 로고    scopus 로고
    • Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms
    • Sarkisova K.Y., Kuznetsova G.D., Kulikov M.A., van Luijtelaar G. Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms. Epilepsia 2010, 51:146-160.
    • (2010) Epilepsia , vol.51 , pp. 146-160
    • Sarkisova, K.Y.1    Kuznetsova, G.D.2    Kulikov, M.A.3    van Luijtelaar, G.4
  • 44
    • 0742271178 scopus 로고    scopus 로고
    • The influence of strain and housing on two types of spike-wave discharges in rats
    • Schridde U., van Luijtelaar G. The influence of strain and housing on two types of spike-wave discharges in rats. Genes Brain Behav. 2004, 3:1-7.
    • (2004) Genes Brain Behav. , vol.3 , pp. 1-7
    • Schridde, U.1    van Luijtelaar, G.2
  • 45
    • 64049086568 scopus 로고    scopus 로고
    • Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges
    • Shaw F.Z., Chuang S.H., Shieh K.R., Wang Y.J. Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges. Neuroscience 2009, 160:382-393.
    • (2009) Neuroscience , vol.160 , pp. 382-393
    • Shaw, F.Z.1    Chuang, S.H.2    Shieh, K.R.3    Wang, Y.J.4
  • 46
    • 0023028195 scopus 로고
    • Anti-seizure and antiepileptogenic effects of vigabatrin
    • Shin C., Rigsbee L.C., McNamara J.O. Anti-seizure and antiepileptogenic effects of vigabatrin. Brain Res. 1986, 398:370-374.
    • (1986) Brain Res. , vol.398 , pp. 370-374
    • Shin, C.1    Rigsbee, L.C.2    McNamara, J.O.3
  • 47
    • 0034831096 scopus 로고    scopus 로고
    • The EthoVision video tracking system - a tool for behavioral phenotyping of transgenic mice
    • Spink A.J., Tegelenbosch R.A., Buma M.O., Noldus L.P. The EthoVision video tracking system - a tool for behavioral phenotyping of transgenic mice. Physiol. Behav. 2001, 73:731-744.
    • (2001) Physiol. Behav. , vol.73 , pp. 731-744
    • Spink, A.J.1    Tegelenbosch, R.A.2    Buma, M.O.3    Noldus, L.P.4
  • 48
    • 33646376290 scopus 로고
    • Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient
    • Stejskal E., Tanner J. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J. Chem. Phys. 1965, 42:288-292.
    • (1965) J. Chem. Phys. , vol.42 , pp. 288-292
    • Stejskal, E.1    Tanner, J.2
  • 50
    • 34848863343 scopus 로고    scopus 로고
    • The properties of reticular thalamic neuron GABA(A) IPSCs of absence epilepsy rats lead to enhanced network excitability
    • Tóth T.I., Bessaïh T., Leresche N., Crunelli V. The properties of reticular thalamic neuron GABA(A) IPSCs of absence epilepsy rats lead to enhanced network excitability. Eur. J. Neurosci. 2007, 26:1832-1844.
    • (2007) Eur. J. Neurosci. , vol.26 , pp. 1832-1844
    • Tóth, T.I.1    Bessaïh, T.2    Leresche, N.3    Crunelli, V.4
  • 51
    • 79957819551 scopus 로고    scopus 로고
    • The prevention of behavioral consequences of idiopathic generalized epilepsy: evidence from rodent models
    • van Luijtelaar G. The prevention of behavioral consequences of idiopathic generalized epilepsy: evidence from rodent models. Neurosci. Lett. 2011, 497:177-184.
    • (2011) Neurosci. Lett. , vol.497 , pp. 177-184
    • van Luijtelaar, G.1
  • 52
    • 0022546002 scopus 로고
    • Two types of electrocortical paroxysms in an inbred strain of rats
    • van Luijtelaar E.L., Coenen A.M. Two types of electrocortical paroxysms in an inbred strain of rats. Neurosci. Lett. 1986, 70:393-397.
    • (1986) Neurosci. Lett. , vol.70 , pp. 393-397
    • van Luijtelaar, E.L.1    Coenen, A.M.2
  • 53
    • 33747872325 scopus 로고    scopus 로고
    • Global and focal aspects of absence epilepsy: the contribution of genetic models
    • van Luijtelaar G., Sitnikova E. Global and focal aspects of absence epilepsy: the contribution of genetic models. Neurosci. Biobehav. Rev. 2006, 30(7):983-1003.
    • (2006) Neurosci. Biobehav. Rev. , vol.30 , Issue.7 , pp. 983-1003
    • van Luijtelaar, G.1    Sitnikova, E.2
  • 55
    • 79958025263 scopus 로고    scopus 로고
    • On the origin and suddenness of absences in genetic absence models
    • van Luijtelaar G., Sitnikova E., Littjohann A. On the origin and suddenness of absences in genetic absence models. Clin. EEG Neurosci. 2011, 42:83-97.
    • (2011) Clin. EEG Neurosci. , vol.42 , pp. 83-97
    • van Luijtelaar, G.1    Sitnikova, E.2    Littjohann, A.3
  • 57
    • 4544363934 scopus 로고    scopus 로고
    • Simultaneous high-performance liquid chromatographic analysis of pregabalin, gabapentin and vigabatrin in human serum by precolumn derivatization with o-phtaldialdehyde and fluorescence detection
    • Vermeij T.A., Edelbroek P.M. Simultaneous high-performance liquid chromatographic analysis of pregabalin, gabapentin and vigabatrin in human serum by precolumn derivatization with o-phtaldialdehyde and fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2004, 810:297-303.
    • (2004) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.810 , pp. 297-303
    • Vermeij, T.A.1    Edelbroek, P.M.2
  • 58
    • 47249088211 scopus 로고    scopus 로고
    • Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model
    • Vinogradova L.V., van Rijn C.M. Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model. Epilepsia 2008, 49:1160-1168.
    • (2008) Epilepsia , vol.49 , pp. 1160-1168
    • Vinogradova, L.V.1    van Rijn, C.M.2


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