Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model

Epilepsia

Volumn 49, Issue 7, 2008, Pages 1160-1168

  Vinogradova, Lyudmila V ^a   Van Rijn, Clementina M ^b  

^a INSTITUTE OF HIGHER NERVOUS ACTIVITY AND NEUROPHYSIOLOGY   (Russian Federation)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Antiepileptic drugs; Audiogenic seizure; Epilepsy; Kindling; Levetiracetam; Rat

Indexed keywords

ETIRACETAM; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; AUDIOGENIC KINDLING; AUDITORY STIMULATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DRUG MECHANISM; DRUG POTENCY; EXPERIMENTAL MODEL; FEMALE; GENETIC SUSCEPTIBILITY; KINDLING; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SEIZURE; STATISTICAL SIGNIFICANCE; TONIC CLONIC SEIZURE;

ACOUSTIC STIMULATION; ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY, TONIC-CLONIC; FEMALE; INJECTIONS, INTRAPERITONEAL; KINDLING, NEUROLOGIC; PIRACETAM; RATS; TIME FACTORS;

EID: 47249088211     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01594.x     Document Type: Article

References (37)

1. Ben-Ari Y 2005) Seizures beget seizures. Epilepsia 46 (Suppl. 8 1 5.
2. Bouwman BM, van Rijn CM 2004) Effects of levetiracetam on spike and wave discharges in WAG/Rij rats. Seizure 13 : 591 594.
3. Brandt C, Glien M, Gastens AM, Fedrowitz M, Bethmann K, Volk HA, Potschka H, Löscher W 2007) Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats. Neuropharmacology 53 : 207 221.
4. Browning RA 1986) Neuroanatomical localization of structures responsible for seizures in the GEPR: lesion studies. Life Sci 39 : 857 867.
5. Dedeurwaerdere S, Boon P, De Smedt T, Claeys P, Raedt R, Bosman T, Van Hese P, Van Maele G, Vonck K 2005) Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood. Seizure 14 : 403 411.
6. Faingold CL, Randall ME 1995) Pontine reticular formation neurons exhibit a premature and precipitous increase in acoustic responses prior to audiogenic seizures in genetically epilepsy-prone rats. Brain Res 704 : 218 226.
7. Faingold CL 1999) Neuronal networks in the genetically epilepsy-prone rats. Adv Neurol 79 : 311 321.
8. Faingold CL, Randall ME 1999) Neurons in the deep layers of superior colliculus play a critical role in the neuronal network for audiogenic seizures: mechanisms for production of wild running behavior. Brain Res 815 : 250 258.
9. Feng H-J, Faingold CL 2002) Repeated generalized audiogenic seizures induce plastic changes on acoustically evoked neuronal firing in the amygdala. Brain Res 932 : 61 69.
10. Friedman D, French JA 2006) Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures. Neurology 66 : 590 591.
11. Fuks B, Gillard M, Michel PH, Lynch B, Vertongen P, Leprince P, Klitgaard H, Chatelain P 2003) Localization and proaffinity labelling of the levetiracetam binding site in rat brain and certain cell lines. Eur J Pharmacol 478 : 11 19.
12. Garcia-Cairasco N, Terra VC, Doretto MC 1993) Midbrain substrates of audiogenic seizures in rats. Behav Brain Res 58 : 57 67.
13. Garcia-Cairasco N, Wakamatsu H, Oliveira JAC, Gomes ELT, Del Bel EA, Mello LEAM 1996) Neuroethological and morphological (neo-Timm staining) correlates of limbic recruitment during the development of audiogenic kindling in seizures susceptible Wistar rats. Epilepsy Res 26 : 177 192.
14. Glien M, Brandt C, Potschka H, Loscher W 2002) Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy. Epilepsia 43 : 350 357.
15. Goddard G, McIntyre D, Leech C 1969) A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 25 : 295 330.
16. Gower AJ, Noyer M, Verloes R, Gobert J, Wulfert E 1992) Ucb L059, a novel anti-convulsant drug: pharmacological profile in animals. Eur J Neurosci 222 : 193 203.
17. Gower AJ, Hirsch E, Boehrer A, Noyer M, Marescaux C 1995) Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy. Epilepsy Res 22 : 207 213.
18. Gu J, Lynch BA, Anderson D, Klitgaard H, Lu S, Elashoff M, Ebert U, Potschka H, Loscher W 2004) The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats. Eur J Neurosci 19 : 334 345.
19. Hirsch E, Danober L, Simler S, Pereira de Vasconcelos A, Maton B, Nehlig A, Marescaux C, Vergnes M 1997) The amygdala is critical for seizure propagation from brainstem to forebrain. Neuroscience 77 : 975 984.
20. Ji-qun C, Ishihara K, Nagayama T, Serikawa T, Sasa M 2005) Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): differentiation of levetiracetam from conventional antiepileptic drugs. Epilepsia 46 : 1362 1370.
21. Jobe PC, Picchioni AL, Chin L 1973) Role of brain norepinephrine in audiogenic seizures in the rat. J Pharmacol Exp Ther 184 : 1 10.
22. Klitgaard H, Matagne A, Gobert J, Wulfert E 1998) Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur J Pharmacol 353 : 191 206.
23. Krushinsky LV 1949) News in investigations of experimental epilepsy. Usp Sovrem Biol 28 : 108 133.
24. Krushinsky VL, Molodkina LN, Fless DA, Dobrokhotova LP, Steshenko AP, Semiokhina AF, Zorina ZA, Romanova LG 1970) The functional state of the brain during sonic stimulation. In Welch BL, Welch AS (Eds) Physiological effects of noise. Plenum Press, New York, pp. 159 183.
25. Loscher W, Honack D 1993) Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats. Eur J Pharmacol 232 : 147 158.
26. Loscher W, Honack D, Rundfeldt C 1998) Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J Pharmacol Exp Ther 284 : 474 479.
27. Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B 2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA 101 : 9861 9866.
28. Marescaux C, Vergnes M, Kiesmann M, Depaulis A, Micheletti G, Varter GM 1987) Kindling of audiogenic seizures in Wistar rats: an EEG study. Exp Neurol 97 : 160 168.
29. Naritoku DK, Mecozzi LB, Aiello MT, Faingold CL 1992) Repetition of audiogenic seizures in genetically epilepsy-prone rats induces cortical epileptiform activity and additional seizure behaviors. Exp Neurol 115 : 317 324.
30. N'Gouermo P, Faingold CL 1998) Periaqueductal gray neurons exhibit increased responsiveness associated with audiogenic seizures in the genetically epilepsy-prone rats. Neuroscience 84 : 619 625.
31. Noyer M, Gillard M, Matagne A, Henichart J-P, Wulfert E 1995) The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes. Eur J Pharmacol 286 : 137 146.
32. Racine RJ 1972) Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 32 : 281 294.
33. Romanova LG, Zorina ZA, Korochkin LI 1993) A genetic, physiological and biochemical investigation of audiogenic seizures is rats. Behav Genet 23 : 483 489.
34. Stratton SC, Large LH, Cox B, Davies G, Hagan RM 2003) Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model. Epilepsy Res 53 : 95 106.
35. Vinogradova LV, Kuznetsova GD, Shatskova AB, van Rijn CM 2005) Vigabatrin in low doses selectively suppresses the clonic component of audiogenically kindled seizures. Epilepsia 46 : 800 810.
36. Vinogradova LV, Vinogradov VY, Kuznetsova GD 2006) Unilateral cortical spreading depression is an early marker of audiogenic kindling in awake rats. Epilepsy Res 71 : 64 75.
37. Yan HD, Ji-qun C, Ishihara K, Nagayama T, Serikawa T, Sasa M 2005) Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rats (SER). Epilepsia 46 : 1170 1177.