siRNA screen for genes that affect Junín virus entry uncovers voltage-gated calcium channels as a therapeutic target

Science Translational Medicine

Volumn 5, Issue 204, 2013, Pages

  Lavanya, Madakasira ^a   Cuevas, Christian D ^a   Thomas, Monica ^a   Cherry, Sara ^a   Ross, Susan R ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GABAPENTIN; NIFEDIPINE; SMALL INTERFERING RNA; VERAPAMIL; VIRUS GLYCOPROTEIN; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ARENAVIRUS; ARFRP1 GENE; ARGENTINE HEMORRHAGIC FEVER; ARTICLE; CELL FUSION; CLDN2 GENE; CONTROLLED STUDY; CSDC2 GENE; DHX15 GENE; DRUG DOSE COMPARISON; DRUG TARGETING; GENE; GENE SILENCING; GENETIC SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; JUNIN VIRUS; KSR2 GENE; LTBP2 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOTYPING; RNA INTERFERENCE; SSU72 GENE; TREATMENT OUTCOME; VESICULAR STOMATITIS VIRUS; VIRUS ENTRY; VIRUS INHIBITION; VIRUS STRAIN;

AMINES; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL FUSION; CELL LINE, TUMOR; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; GENE KNOCKDOWN TECHNIQUES; HIGH-THROUGHPUT SCREENING ASSAYS; HOST-PATHOGEN INTERACTIONS; HUMANS; JUNIN VIRUS; MICE; MOLECULAR TARGETED THERAPY; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, TRANSFERRIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; VERO CELLS; VIRUS INTERNALIZATION;

EID: 84884697070     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006827     Document Type: Article

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