Aldehyde oxidase 1 (AOX1) in human liver cytosols: Quantitative characterization of AOX1 expression level and activity relationships

Drug Metabolism and Disposition

Volumn 41, Issue 10, 2013, Pages 1797-1804

  Fu, Cexiong ^a   Di, Li ^a   Han, Xiaogang ^a   Soderstrom, Cathy ^a   Snyder, Mark ^b   Troutman, Matthew D ^a   Obach, R Scott ^a   Zhang, Hui ^a  

^a PFIZER INC   (United States)

^b SCIENION AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE OXIDASE; ALDEHYDE OXIDASE 1; CARBAZERAN; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG; ZONIPORIDE;

ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; DISSOCIATION; DONOR; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER CYTOSOL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION;

ADULT; AGED; ALDEHYDE OXIDASE; CHROMATOGRAPHY, LIQUID; CYTOSOL; FEMALE; HUMANS; LIVER; MALE; MIDDLE AGED; PEPTIDE MAPPING; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84884692206     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.053082     Document Type: Article

References (36)

1. Al-Salmy HS (2001) Individual variation in hepatic aldehyde oxidase activity. IUBMB Life 51:249-253.
2. Améen C, Lindén D, Larsson BM, Mode A, Holmäng A, and Oscarsson J (2004) Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver. Am J Physiol Endocrinol Metab 287:E1039-E1048. (Pubitemid 39491944)
3. Anderson L and Hunter CL (2006) Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol Cell Proteomics 5:573-588.
4. Buckley DB and Klaassen CD (2007) Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metab Dispos 35:121-127. (Pubitemid 46036485)
5. Carr SA and Anderson L (2008) Protein quantitation through targeted mass spectrometry: the way out of biomarker purgatory? Clin Chem 54:1749-1752.
6. Dalvie D, Zhang C, Chen W, Smolarek T, Obach RS, and Loi CM (2010) Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences. Drug Metab Dispos 38:641-654.
7. Di L, Whitney-Pickett C., Umland J. P., Zhang H., Zhang X., Gebhard D. F., Lai Y., Federico J.J., 3rd, Davidson R. E., and Smith R. et al. (2011) Development of a new permeability assay using low-efflux MDCKII cells. J Pharm Sci 100 (11):4974-85
8. Diamond S, Boer J, Maduskuie Jr TP, Falahatpisheh N, Li Y, and Yeleswaram S (2010) Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications. Drug Metab Dispos 38:1277-1285.
9. Fernández Ocaña M, James IT, Kabir M, Grace C, Yuan G, Martin SW, and Neubert H (2012) Clinical pharmacokinetic assessment of an anti-MAdCAM monoclonal antibody therapeutic by LC-MS/MS. Anal Chem 84:5959-5967.
10. Franconi F, Brunelleschi S, Steardo L, and Cuomo V (2007) Gender differences in drug responses. Pharmacol Res 55:81-95. (Pubitemid 46186037)
11. Garattini E, Fratelli M, and Terao M (2008) Mammalian aldehyde oxidases: genetics, evolution and biochemistry. Cell Mol Life Sci 65:1019-1048.
12. Garattini E and Terao M (2011) Increasing recognition of the importance of aldehyde oxidase in drug development and discovery. Drug Metab Rev 43:374-386.
13. Hartmann T, Terao M, Garattini E, Teutloff C, Alfaro JF, Jones JP, and Leimkühler S (2012) The impact of single nucleotide polymorphisms on human aldehyde oxidase. Drug Metab Dispos 40:856-864.
14. Heikkinen AT, Friedlein A, Lamerz J, Jakob P, Cutler P, Fowler S, Williamson T, Tolando R, Lave T, and Parrott N (2012) Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog. Pharm Res 29:1832-1842.
15. Hunt CM, Westerkam WR, and Stave GM (1992) Effect of age and gender on the activity of human hepatic CYP3A. Biochem Pharmacol 44:275-283.
16. Itoh K, Maruyama H, Adachi M, Hoshino K, Watanabe N, and Tanaka Y (2007) Lack of dimer formation ability in rat strains with low aldehyde oxidase activity. Xenobiotica 37: 709-716. (Pubitemid 47057125)
17. Kawakami H, Ohtsuki S, Kamiie J, Suzuki T, Abe T, and Terasaki T (2011) Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection. J Pharm Sci 100:341-352.
18. Kitamura S, Nakatani K, Sugihara K, and Ohta S (1999) Strain differences of the ability to hydroxylate methotrexate in rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 122:331-336. (Pubitemid 29127132)
19. Klecker RW, Cysyk RL, and Collins JM (2006) Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors. Bioorg Med Chem 14:62-66. (Pubitemid 41635468)
20. Knight TR, Choudhuri S, and Klaassen CD (2007) Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice. Toxicol Sci 100:513-524. (Pubitemid 350131378)
21. Kocarek TA, Duanmu Z, Fang HL, and Runge-Morris M (2008) Age- and sex-dependent expression of multiple murine hepatic hydroxysteroid sulfotransferase (SULT2A) genes. Biochem Pharmacol 76:1036-1046.
22. Lamba V, Lamba J, Yasuda K, Strom S, Davila J, Hancock ML, Fackenthal JD, Rogan PK, Ring B, and Wrighton SA, et al. (2003) Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 307:906-922. (Pubitemid 37494207)
23. Li H, Kundu TK, and Zweier JL (2009) Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite. J Biol Chem 284:33850 -33858.
24. Li N, Nemirovskiy OV, Zhang Y, Yuan H, Mo J, Ji C, Zhang B, Brayman TG, Lepsy C, and Heath TG, et al. (2008) Absolute quantification of multidrug resistance-associated protein 2 (MRP2/ABCC2) using liquid chromatography tandem mass spectrometry. Anal Biochem 380:211-222.
25. Moriwaki Y, Yamamoto T, Takahashi S, Tsutsumi Z, and Hada T (2001) Widespread cellular distribution of aldehyde oxidase in human tissues found by immunohistochemistry staining. Histol Histopathol 16:745-753. (Pubitemid 32700384)
26. Neumeier M, Weigert J, Schäffler A, Weiss TS, Schmidl C, Büttner R, Bollheimer C, Aslanidis C, Schölmerich J, and Buechler C (2006) Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biophys Res Commun 350:731-735. (Pubitemid 44547907)
27. Pryde DC, Dalvie D, Hu Q, Jones P, Obach RS, and Tran TD (2010) Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem 53:8441-8460.
28. Rashidi MR, Smith JA, Clarke SE, and Beedham C (1997) In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. Drug Metab Dispos 25:805-813. (Pubitemid 27318599)
29. Sakamoto A, Matsumaru T, Ishiguro N, Schaefer O, Ohtsuki S, Inoue T, Kawakami H, and Terasaki T (2011) Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry with nano-liquid chromatography. J Pharm Sci 100:4037-4043.
30. Sato Y, Nagata M, Kawamura A, Miyashita A, and Usui T (2012) Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities. Xenobiotica 42:823-829.
31. Schwarz G, Mendel RR, and Ribbe MW (2009) Molybdenum cofactors, enzymes and pathways. Nature 460:839-847.
32. Seibert C, Davidson BR, Fuller BJ, Patterson LH, Griffiths WJ, and Wang Y (2009) Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry. J Proteome Res 8:1672-1681.
33. Sugihara K, Kitamura S, Tatsumi K, Asahara T, and Dohi K (1997) Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver. Biochem Mol Biol Int 41:1153-1160. (Pubitemid 27232074)
34. Watanabe K, Matsunaga T, Narimatsu S, Yamamoto I, and Yoshimura H (1992) Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice. Res Commun Chem Pathol Pharmacol 78:373-376. (Pubitemid 23009190)
35. Weigert J, Neumeier M, Bauer S, Mages W, Schnitzbauer AA, Obed A, Gröschl B, Hartmann A, Schäffler A, and Aslanidis C, et al. (2008) Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release. FEBS Lett 582:2965-2972.
36. Williamson BL, Purkayastha S, Hunter CL, Nuwaysir L, Hill J, Easterwood L, and Hill J (2011) Quantitative protein determination for CYP induction via LC-MS/MS. Proteomics 11:33-41.