Strain differences of the ability to hydroxylate methotrexate in rats

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 122, Issue 3, 1999, Pages 331-336

  Kitamura, Shigeyuki ^a   Nakatani, Keiko ^a   Sugihara, Kazumi ^a   Ohta, Shigeru ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

7 Hydroxymethotrexate; Aldehyde oxidase; Benzaldehyde oxidase; Cytosolic hydroxylase; Methotrexate; Rat liver; Strain difference; Xanthine oxidase

Indexed keywords

ALDEHYDE OXIDASE; CHLORPROMAZINE; DISULFIRAM; ESTRADIOL; MENADIONE; METHOTREXATE; OXIPURINOL; OXYGENASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; LIVER CYTOSOL; LIVER MICROSOME METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; STRAIN DIFFERENCE; TISSUE DISTRIBUTION;

ALDEHYDE OXIDASE; ALDEHYDE OXIDOREDUCTASES; ANIMALS; CYTOSOL; HYDROXYLATION; METHOTREXATE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; RATS; RATS, INBRED STRAINS; SPECIES SPECIFICITY;

EID: 0033018175     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0742-8413(98)10134-2     Document Type: Article

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