Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.

Pharmaceutical research

Volumn 29, Issue 7, 2012, Pages 1832-1842

  Heikkinen, Aki T ^a   Friedlein, Arno ^b   Lamerz, Jens ^b   Jakob, Peter ^b   Cutler, Paul ^b   Fowler, Stephen ^b   Williamson, Tara ^b   Tolando, Roberto ^b   Lave, Thierry ^b   Parrott, Neil ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P 450 CYP2B11 (DOG); CYTOCHROME P 450 CYP3A12 (CANINE); CYTOCHROME P-450 CYP2B11 (DOG); CYTOCHROME P-450 CYP3A12 (CANINE); CYTOCHROME P450; STEROID MONOOXYGENASE; UNSPECIFIC MONOOXYGENASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMISTRY; DOG; ENZYMOLOGY; INTESTINE; LIVER; MASS SPECTROMETRY; METABOLISM; MICROSOME; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; INTESTINES; LIVER; MASS SPECTROMETRY; MICROSOMES; MOLECULAR SEQUENCE DATA; STEROID HYDROXYLASES;

EID: 85027949767     PISSN: None     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0707-7     Document Type: Article

References (0)