메뉴 건너뛰기




Volumn 13, Issue 4, 2013, Pages 264-270

Negligible nuclear FOXP3 expression in breast cancer epithelial cells compared with FOXP3-positive T cells

Author keywords

Breast cancer cell lines; Epithelial tumor cells; Forkhead box protein 3; Immunohistochemistry; Tissue microarray

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3;

EID: 84884686329     PISSN: 15268209     EISSN: 19380666     Source Type: Journal    
DOI: 10.1016/j.clbc.2013.02.009     Document Type: Article
Times cited : (11)

References (35)
  • 1
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-6.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 2
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson A, Kretschmer K, Frampton GM, et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007;445:931-5.
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1    Kretschmer, K.2    Frampton, G.M.3
  • 3
    • 67649170980 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells: Differentiation, specification, subphenotypes
    • Feuerer M, Hill JA, Mathis D, et al. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009;10:689-95.
    • (2009) Nat Immunol , vol.10 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3
  • 4
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009;30:616-25.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 5
    • 44749092510 scopus 로고    scopus 로고
    • Regulatory T cells and treatment of cancer
    • Curiel TJ. Regulatory T cells and treatment of cancer. Curr Opin Immunol 2008;20:241-6.
    • (2008) Curr Opin Immunol , vol.20 , pp. 241-246
    • Curiel, T.J.1
  • 6
    • 44849100619 scopus 로고    scopus 로고
    • Is FOXP3 a bona fide marker for human regulatory T cells?
    • Roncarolo MG, Gregori S. Is FOXP3 a bona fide marker for human regulatory T cells? Eur J Immunol 2008;38:925-7.
    • (2008) Eur J Immunol , vol.38 , pp. 925-927
    • Roncarolo, M.G.1    Gregori, S.2
  • 7
    • 61449212006 scopus 로고    scopus 로고
    • Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells
    • Siegmund K, Ruckert B, Ouaked N, et al. Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells. J Immunol 2009;182:2124-30.
    • (2009) J Immunol , vol.182 , pp. 2124-2130
    • Siegmund, K.1    Ruckert, B.2    Ouaked, N.3
  • 8
    • 45949099261 scopus 로고    scopus 로고
    • Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: A caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells
    • Chen GY, Chen C, Wang L, et al. Cutting edge: broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells. J Immunol 2008;180:5163-6.
    • (2008) J Immunol , vol.180 , pp. 5163-5166
    • Chen, G.Y.1    Chen, C.2    Wang, L.3
  • 10
    • 78651098988 scopus 로고    scopus 로고
    • Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy
    • Ladoire S, Arnould L, Mignot G, et al. Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy. Breast Cancer Res Treat 2011;125:65-72.
    • (2011) Breast Cancer Res Treat , vol.125 , pp. 65-72
    • Ladoire, S.1    Arnould, L.2    Mignot, G.3
  • 11
    • 34250863911 scopus 로고    scopus 로고
    • FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER2/ErbB2 oncogene
    • Zuo T, Wang L, Morrison C, et al. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER2/ErbB2 oncogene. Cell 2007;129:1275-86.
    • (2007) Cell , vol.129 , pp. 1275-1286
    • Zuo, T.1    Wang, L.2    Morrison, C.3
  • 12
    • 64649088372 scopus 로고    scopus 로고
    • FOXP3 expression and overall survival in breast cancer
    • Merlo A, Casalini P, Carcangiu ML, et al. FOXP3 expression and overall survival in breast cancer. J Clin Oncol 2009;27:1746-52.
    • (2009) J Clin Oncol , vol.27 , pp. 1746-1752
    • Merlo, A.1    Casalini, P.2    Carcangiu, M.L.3
  • 13
    • 84867121868 scopus 로고    scopus 로고
    • FOXP3 expression in cancer cells and anthracyclines efficacy in patients with primary breast cancer treated with adjuvant chemotherapy in the phase III UNICANCER-PACS 01 trial
    • Ladoire S, Mignot G, Dalban C, et al. FOXP3 expression in cancer cells and anthracyclines efficacy in patients with primary breast cancer treated with adjuvant chemotherapy in the phase III UNICANCER-PACS 01 trial. Ann Oncol 2012;2:2552-61.
    • (2012) Ann Oncol , vol.2 , pp. 2552-2561
    • Ladoire, S.1    Mignot, G.2    Dalban, C.3
  • 14
    • 77952761024 scopus 로고    scopus 로고
    • Comment on "Cutting edge: Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice"
    • Wolf D, Wolf AM, Tzankov A. Comment on "Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice". J Immunol 2010;184:4051.
    • (2010) J Immunol , vol.184 , pp. 4051
    • Wolf, D.1    Wolf, A.M.2    Tzankov, A.3
  • 15
    • 70349466655 scopus 로고    scopus 로고
    • Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate
    • Wang L, Liu R, Li W, et al. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell 2009;16:336-46.
    • (2009) Cancer Cell , vol.16 , pp. 336-346
    • Wang, L.1    Liu, R.2    Li, W.3
  • 16
    • 77950876806 scopus 로고    scopus 로고
    • Foxp3 expression in p53-dependent DNA damage responses
    • Jung DJ, Jin DH, Hong SW, et al. Foxp3 expression in p53-dependent DNA damage responses. J Biol Chem 2010;285:7995-8002.
    • (2010) J Biol Chem , vol.285 , pp. 7995-8002
    • Jung, D.J.1    Jin, D.H.2    Hong, S.W.3
  • 17
    • 84857357926 scopus 로고    scopus 로고
    • FOXP3 and FOXP3-regulated micro-RNAs suppress SATB1 in breast cancer cells
    • McInnes N, Sadlon TJ, Brown CY, et al. FOXP3 and FOXP3-regulated micro-RNAs suppress SATB1 in breast cancer cells. Oncogene 2012;31:1045-54.
    • (2012) Oncogene , vol.31 , pp. 1045-1054
    • McInnes, N.1    Sadlon, T.J.2    Brown, C.Y.3
  • 18
    • 24644520560 scopus 로고    scopus 로고
    • Tissue microarray technology: Principles, pitfalls and perspectives-lessons learned from hematological malignancies
    • Tzankov A, Went P, Zimpfer A, et al. Tissue microarray technology: principles, pitfalls and perspectives-lessons learned from hematological malignancies. Exp Gerontol 2005;40:737-44.
    • (2005) Exp Gerontol , vol.40 , pp. 737-744
    • Tzankov, A.1    Went, P.2    Zimpfer, A.3
  • 19
    • 40849126992 scopus 로고    scopus 로고
    • Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma
    • Tzankov A, Meier C, Hirschmann P, et al. Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica 2008;93:193-200.
    • (2008) Haematologica , vol.93 , pp. 193-200
    • Tzankov, A.1    Meier, C.2    Hirschmann, P.3
  • 20
    • 28544433483 scopus 로고    scopus 로고
    • The expression of the regulatory T cellspecific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer
    • Wolf D, Wolf AM, Rumpold H, et al. The expression of the regulatory T cellspecific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res 2005;11:8326-31.
    • (2005) Clin Cancer Res , vol.11 , pp. 8326-8331
    • Wolf, D.1    Wolf, A.M.2    Rumpold, H.3
  • 21
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 22
    • 84859193457 scopus 로고    scopus 로고
    • Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+ tumor infiltrating lymphocytes in ductal and lobular breast cancers
    • Droeser R, Zlobec I, Kilic E, et al. Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+ tumor infiltrating lymphocytes in ductal and lobular breast cancers. BMC Cancer 2012;12:134.
    • (2012) BMC Cancer , vol.12 , pp. 134
    • Droeser, R.1    Zlobec, I.2    Kilic, E.3
  • 23
    • 55249095393 scopus 로고    scopus 로고
    • Hypoxiacontrols CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha
    • Ben Shoshan J, Maysel-Auslender S, Mor A, et al. Hypoxiacontrols CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol 2008;38:2412-8.
    • (2008) Eur J Immunol , vol.38 , pp. 2412-2418
    • Ben Shoshan, J.1    Maysel-Auslender, S.2    Mor, A.3
  • 24
    • 34247261531 scopus 로고    scopus 로고
    • Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    • Bates GJ, Fox SB, Han C, et al. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol 2006;24:5373-80.
    • (2006) J Clin Oncol , vol.24 , pp. 5373-5380
    • Bates, G.J.1    Fox, S.B.2    Han, C.3
  • 25
    • 56649102194 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: A potential therapeutic target
    • Bohling SD, Allison KH. Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target. Mod Pathol 2008;21:1527-32.
    • (2008) Mod Pathol , vol.21 , pp. 1527-1532
    • Bohling, S.D.1    Allison, K.H.2
  • 26
    • 76749138150 scopus 로고    scopus 로고
    • The predictive value of HLA class I tumor cell expression and presence of intratumoral Tregs for chemotherapy in patients with early breast cancer
    • De Kruijf EM, Van Nes JG, Sajet A, et al. The predictive value of HLA class I tumor cell expression and presence of intratumoral Tregs for chemotherapy in patients with early breast cancer. Clin Cancer Res 2010;16:1272-80.
    • (2010) Clin Cancer Res , vol.16 , pp. 1272-1280
    • De Kruijf, E.M.1    Van Nes, J.G.2    Sajet, A.3
  • 27
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    • Fontenot JD, Rasmussen JP, Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005;22:329-41.
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3
  • 28
    • 58249089749 scopus 로고    scopus 로고
    • Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    • Salama P, Phillips M, Grieu F, et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009;27:186-92.
    • (2009) J Clin Oncol , vol.27 , pp. 186-192
    • Salama, P.1    Phillips, M.2    Grieu, F.3
  • 29
    • 77951217044 scopus 로고    scopus 로고
    • High frequency of tumor-infiltrating FOXP3 (+) regulatory T cells predicts improved survival in mismatch repairproficient colorectal cancer patients
    • Frey DM, Droeser RA, Viehl CT, et al. High frequency of tumor-infiltrating FOXP3 (+) regulatory T cells predicts improved survival in mismatch repairproficient colorectal cancer patients. Int J Cancer 2010;126:2635-43.
    • (2010) Int J Cancer , vol.126 , pp. 2635-2643
    • Frey, D.M.1    Droeser, R.A.2    Viehl, C.T.3
  • 30
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-9.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 31
    • 33845590308 scopus 로고    scopus 로고
    • Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients
    • Petersen RP, Campa MJ, Sperlazza J, et al. Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients. Cancer 2006;107:2866-72.
    • (2006) Cancer , vol.107 , pp. 2866-2872
    • Petersen, R.P.1    Campa, M.J.2    Sperlazza, J.3
  • 32
    • 34548590227 scopus 로고    scopus 로고
    • Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    • Hinz S, Pagerols-Raluy L, Oberg HH, et al. Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res 2007;67:8344-50.
    • (2007) Cancer Res , vol.67 , pp. 8344-8350
    • Hinz, S.1    Pagerols-Raluy, L.2    Oberg, H.H.3
  • 33
    • 42349092708 scopus 로고    scopus 로고
    • The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells
    • Ebert LM, Tan BS, Browning J, et al. The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells. Cancer Res 2008;68:3001-9.
    • (2008) Cancer Res , vol.68 , pp. 3001-3009
    • Ebert, L.M.1    Tan, B.S.2    Browning, J.3
  • 34
    • 76249088097 scopus 로고    scopus 로고
    • Cutting edge: Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
    • Kim J, Lahl K, Hori S, et al. Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 2009;183:7631-4.
    • (2009) J Immunol , vol.183 , pp. 7631-7634
    • Kim, J.1    Lahl, K.2    Hori, S.3
  • 35
    • 79954815112 scopus 로고    scopus 로고
    • An evaluation of the clinical significance of FOXP3 (+) infiltrating cells in human breast cancer
    • Mahmoud SM, Paish EC, Powe DG, et al. An evaluation of the clinical significance of FOXP3 (+) infiltrating cells in human breast cancer. Breast Cancer Res Treat 2011;127:99-108.
    • (2011) Breast Cancer Res Treat , vol.127 , pp. 99-108
    • Mahmoud, S.M.1    Paish, E.C.2    Powe, D.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.