Amyloid β-protein toxicity and oxidative stress in Alzheimer's disease

Cell and Tissue Research

Volumn 290, Issue 3, 1997, Pages 471-480

  Behl, C ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Alzheimer's disease; Amyloid protein; Antioxidants; Neuroprotection; Neurotoxicity; Oxidative stress

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT;

ALZHEIMER DISEASE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIOXIDANTS; BRAIN; DISEASE MODELS, ANIMAL; ESTROGENS; HUMANS; MODELS, BIOLOGICAL; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS;

EID: 0030728765     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050955     Document Type: Review

References (153)

1. Alzheimer A (1907) Über eine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift der Psychiatrie und der Psychisch-Gerichtlichen Medizin 64:146-148
2. Aguzzi A, Brandner S, Marino S, Steinbach JP (1996) Transgenic and knockout mice in the study of neurodegenerative diseases. J Mol Med 74:111-126
3. Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922
4. Aust SD, Morehouse LA, Thomas CE (1985) Role of metals in oxygen radical reactions. J Free Radic Biol Med 1:3-25
5. Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38:357-366
6. Beckmann JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite - the good, the bad, and the ugly. Am J Physiol 40:C1424-C1437
7. Beckmann JS, Chen J, Crow JP, Ye YZ (1994) Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration. Prog Brain Res 103:371-380
8. Behl C, Davis J, Cole GM, Schubert D (1992) Vitamin E protects nerve cells from amyloid β protein toxicity. Biochem Biophys Res Commun 186:944-952
9. Behl C, Davis JB, Klier FG, Schubert D (1994a) Amyloid β peptide induces necrosis rather than apoptosis. Brain Res 645:253-264
10. Behl C, Davis JB, Lesley R, Schubert D (1994b) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77:817-822
11. Behl C, Widmann M, Trapp T, Holsboer F (1995) 17-β estradiol protects from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 216:473-482
12. Behl C, Trapp T, Skutella T, Holsboer F (1997a) Protection against oxidative stress-induced neuronal cell death - a novel role for RU486. Eur J Neurosci 9:912-920
13. Behl C, Skutella T, Lezoualc'h F, Post A, Widmann M, Newton C, Holsboer F (1997b) Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol 51: 535-541
14. Blass JP (1993) Pathophysiology of the Alzheimer syndrome. Neurology 43:S25-S38
15. Blessed G, Tomlinson B, Roth M (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 114: 797-809
16. Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, Kobayashi Y, Marino S, Weissmann C, Aguzzi A (1996) Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 379:339-343
17. Braughler JM, Hall ED, Jacobson EJ, McCall JM, Means ED (1989) The 21-aminosteroids: potent inhibitors of lipid peroxidation for the treatment of central nervous system trauma and ischemia. Drugs of the Future 14:143-151
18. Brown RH (1995) Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell 80:687-692
19. Busciglio JA, Lorenzo A, Yankner BA (1992) Methodological variables in the assessment of β amyloid neurotoxicity. Neurobiol Aging 13:609-612
20. Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, Lippa C, Nixon RA (1995) Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron 14:671-680
21. Citron M, Westaway D, Xia W (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med 3:67-72
22. Clemens JA, Panetta JA (1994) Neuroprotection by antioxidants in models of global and focal ischemia. Ann NY Acad Sci 738:250-256
23. Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695
24. Cross AR, Jones OTG (1991) Enzymatic mechanisms of superoxide production. Biochim Biophys Acta 1057:281-298
25. Dalcanto MC (1996) Comparison of pathological alterations in ALS and a murine transgenic model - pathogenetic implications. Clin Neurosci 3:332-337
26. Davis JB, Maher P (1994) Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. Brain Res 652:169-173
27. Davis JB, McMurray HF, Schubert D (1992) The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes. Biochem Biophys Res Commun 189:1096-1100
28. Davis P (1994) Neuronal abnormalities, not amyloid, are the cause of dementia in Alzheimer disease. In: Terry RD, Katzman R, Bick KL (eds) Alzheimer Disease. Raven, New York, pp 327-333
29. Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, Yen SH, Aronson MK (1991) Identification of normal and pathological aging in prospectively studied non-demented elderly humans. Neurobiol Aging 13:179-189
30. Duff K, Eckman C, Zehr C (1996) Increased anyloid-β42(43) in brains of mice expressing mutant presenilin I. Nature 383: 710-713
31. Dyrks T, Dyrks E, Hartmann T, Masters C, Beyreuther K (1992) Amyloidogenicity of β/A4 and β/A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. J Biol Chem 267:18210-18217
32. Eanes ED, Glenner GG (1968) X-ray diffraction studies on amyloid filaments. J Histochem Cytochem 16:673-677
33. Ebadi M, Srinivasan SK, Baxi MD (1996) Oxidative stress and antioxidant therapy in Parkinson's disease. Prog Neurobiol 48:1-19
34. Finch CE, Marchalonis JJ (1996) Evolutionary perspectives on amyloid and inflammatory features of Alzheimer disease. Neurobiol Aging 17:809-815
35. Frautschy SA, Baird A, Cole GM (1991) Effects of injected Alzheimer β-amyloid cores in rat brain. Proc Natl Acad Sci USA 88:8362-8366
36. Fridovich I (1978) The biology of oxygen radicals. Science 201: 875-880
37. Friedlich AL, Butcher LL (1994) Involvement of free oxygen radicals in beta-amyloidoses: an hypothesis. Neurobiol Aging 15:443-455
38. Fröhlich L, Riederer P (1995) Free radical mechanisms in dementia of Alzheimer type and the potential for antioxidative treatment. Arzneimittelforschung 45:443-446
39. Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA (1994) Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 269:13623-13628
40. Games D, Adams D, Alessandrini R (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V7I7F β-amyloid precursor protein. Nature 373:523-527
41. Giovanelli L, Casamenti F, Scali C, Bartolini L, Pepeu G (1995) Differential effects of amyloid peptides β-(1-40) and β-(25-35) injections into the rat nucleus basalis. Neuroscience 66:781-792
42. Glenner GG (1988) Alzheimer's disease: its proteins and genes. Cell 52:307-308
43. Glenner GG, Wong CW (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885-890
44. Good PF, Werner P, Hsu A, Olanow CW, Perl DP (1996) Evidence of neuronal oxidative damage in Alzheimer's disease. Am J Pathol 149:21-28
45. Goodmann Y, Bruce AJ, Cheng B, Mattson MP (1996) Estrogen attenuates and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β peptide toxicity in hippocampal neurons. J Neurochem 66:1836-1844
46. Green PS, Bishop J, Simpkins JW (1997) 17α-Estradiol exerts neuroprotective effects on SK-N-SH cells. J Neurosci 17:511-515
47. Gsell W, Conrad R, Hickethier M, Sofic E, Fröhlich L, Wichart I, Jellinger K, Moll G, Rasmayr G, Beckmann H, Riederer P (1995) Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type. J Neurochem 64:1216-1223
48. Gurney ME, Pu H, Chiu AY, Dal Canto MC (1994) Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation (comments). Science 264:1772-1775
49. Gutteridge JM (1994) Hydroxyl radicals, iron, oxidative stress, and neurodegeneration. Ann N Y Acad Sci 738:201-213
50. Hall ED, Braughler JM (1989) Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic Biol Med 6:303-313
51. Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine, 2nd edn. Oxford University Press, Oxford
52. Halliwell B, Gutteridge JMC, Cross CE (1992) Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 119:598-620
53. Hardy J (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20:154-159
54. Hardy J, Allsop D (1991) Amyloid deposition as the central event in the etiology of Alzheimer's disease. Trends Pharmacol Sci 12: 383-388
55. Harris ME, Hensley K, Butterfield A, Leedle RA, Carney JM (1995) Direct evidence of oxidative injury produced by the Alzheimer's β-amyloid peptide (1-40) in cultured hippocampal neurons. Exp Neurol 131:193-202
56. Henderson VW, Paganini-Hill A, Emanuel CK, Dunn ME, Buckwalter JG (1994) Estrogen replacement therapy in older women. Arch Neurol 51:896-900
57. Hensley K, Carney JM, Mattson MP, Aksenova M, Harris M, Wu JF, Floyd RA, Butterfield DA (1994) A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci USA 91:3270-3274
58. Higgins LS, Holtzman DM, Rabin J, Mobley WC, Cordell B (1994) Transgenic mouse brain histopathology resembles early Alzheimer's disease. Ann Neurol 35:598-607
59. Honjo H, Tanak K, Kashiwagi T, Urabe M, Okada H, Hayashi M, Hayashi K (1995) Senile dementia - Alzheimer's type and estrogen. Horm Metab Res 27:204-207
60. Hoyer S (1994) Age as a risk factor for sporadic dementia of the Alzheimer type? Ann NY Acad Sci 719:248-256
61. Hoyer S, Henneberg N, Knapp S, Lannert H, Martin E (1996) Brain glucose metabolism is controlled by amplification and desensitization of the neuronal insulin receptor. Ann N Y Acad Sci 777:374-379
62. Hsiao K, Baker HF, Crow TJ, Poulter M, Owen F, Terwilliger JD, Westaway D, Ott J, Prusiner SB (1989) Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome. Nature 338:342-345
63. Hsiao K, Borchelt DR, Olson K (1995) Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15:1203-1218
64. Ingold KU, Webb AC, Witter D, Burton GW, Metcalf TA, Muller DPR (1987) Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Arch Biochem Biophys 259:224-225
65. Iversen LL, Mortishire-Smith RJ, Pollack SJ, Shearman MS (1995) The toxicity in vitro of β-amyloid protein. Biochem J 311:1-16
66. Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE (1994) Estrogen regulates metablism of Alzheimer amyloid beta precursor protein. J Biol Chem 269:13065-13068
67. Kaltschmidt B, Bäuerle PA, Kaltschmidt C (1993) Potential involvement of the transcription factor NF-κB in neurological disorders. Mol Aspects Med 14:171-190
68. Kang J, Lemaire H-G, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaupt G, Beyreuther K, Muller-Hill B (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736
69. Koh J, Yang LL, Cotman CW (1990) β Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res 533:315-320
70. Kosik KS, Greenberg SM (1994) Tau protein and Alzheimer disease. In: Terry RD, Katzman R, Bick KL (eds) Alzheimer Disease. Raven, New York, pp 335-344
71. Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA (1991) An in vivo model for the neurodegenerative effects of β amyloid and protection by substance P. Proc Natl Acad Sci USA 88:7247-7251
72. Lafon-Cazal M, Pietri S, Culcasi M, Bockaert J (1993) NMDA-dependent superoxide production and neurotoxicity. Nature 364:535-537
73. Lamb BT (1995) Making models for Alzheimer's disease. Nat Gen 9:4-6
74. Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD (1993) Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice. Nat Gen 5:22-30
75. LeWitt PA (1993) Neuroprotection by anti-oxidant strategies in Parkinson's disease. Eur Neurol 33 [Suppl 1]:24-30
76. Lezoualc'h F, Behl C (1997a) Transcription factor NF-κB: friend or foe of neurons? Mol Psychiatry (in press)
77. Lezoualc'h F, Behl C (1997b) Activation of the transcription factor NF-κB is a common signal induced by β-amyloid, amylin and hydrogen peroxide. Alzheimer's Research 3:43-50
78. Lezoualc'h F, Skutella T, Widmann M, Behl C (1996) Melatonin prevents oxidative stress-indueed cell death in hippocampal cells. Neuroreport 7:2071-2077
79. Liu G-T, Zhang T-M, Wang B-E, Wang Y-W (1992) Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43:147-152
80. Lohr JB (1991) Oxygen radicals and neuropsychiatrie illness. Arch Gen Psychiatry 48:1097-1106
81. Lorenzo A, Yankner BA (1994) Beta amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc Natl Acad Sei USA 91:12243-12247
82. Lorenzo A, Razzaboni B, Weir C, Yankner BA (1994) Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756-750
83. London JA, Biegel D, Pachter JS (1996) Neurocytopathic effects of beta-amyloid-stimulated monocytes - a potential mechanism for central nervous system damage in Alzheimer disease. Proc Natl Acad Sci USA 93:4147-4152
84. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel R (1992) β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12:376-389
85. Mattson MP, Tomaselli KJ, Rydel RE (1993) Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF. Brain Res 621:35-49
86. May PC, Gitter BD, Waters DC, Simmons LK, Becker GW, Small JS, Robison PM (1992) β-Amyloid peptide in vitro toxicity: lot-to-lot variability. Neurobiol Aging 13:605-607
87. May PC, Boggs LN, Fuson KS (1993) Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicity. J Neurochem 61:2330-2333
88. McCord JM (1985) Oxygen-derived free radicals in post-ischemic tissue injury. N Engl J Med 312:159-163
89. McGeer PL, McGeer EG (1995) The inflammatory response system of brain - implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev 21:195-218
90. Mecocci P, MacGarvey U, Beal MF (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36:747-750
91. Meda L, Cassatella MA, Szendrei GI, Otvos L, Baron P, Villalba M, Ferrari D, Rossi F Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 347:647-650
92. Melhorn RJ, Cole G (1985) The free radical theory of aging: a critical review. Adv Free Radic Biol Med 1:165-223
93. Mooradian AD (1993) Antioxidant properties of steroids. J Steroid Biochem Mol Biol 45:509-511
94. Moran PM, Higgins LS, Cordell B, Moser PC (1995) Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human β-amyloid precursor protein. Proc Natl Acad Sci USA 92:5341-5345
95. Morris JC, McKeel DW Jr, Storandt M, Rubin EH, Price JL, Grant EA, Ball MJ, Berg L Very mild Alzheimer's disease: informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology 41:469-478
96. Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2:1547-1558
97. Nakano M, Sugioka K, Naito I, Takehoshi S, Niki E (1987) Novel and potent antioxidants on membrane phospholipid peroxidation: 2-hydroxy estrone and 2-hydroxy estradiol. Biochem Biophys Res Commun 142:919-924
98. Olanow CW (1993) A radical hypothesis for neurodegeneration. Trends Neurosci 16:439-444
99. Pappolla MA, Omar RA, Kim KS, Robakis NK (1992) Immunhistochemical evidence of antioxidant stress in Alzheimer's disease. Am J Pathol 140:621-628
100. Parthasarathy S, Steinberg D, Witztum JL (1992) The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Annu Rev Med 43:219-225
101. Parthasarathy S, Morales AJ, Murphy AA (1994) Antioxidant: a new role for RU486 and related compounds. J Clin Invest 94:1990-1995
102. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991) In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 563:311-314
103. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW (1993) Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state. J Neurosci 13:1676-1687
104. Podlisny MB, Stephenson DT, Frosch MP, Tolan DR, Lieberburg I, Clemens JA, Selkoe DJ (1993) Microinjection of synthetic amyloid β-protein in monkey cerebral cortex fails to produce acute neurotoxicity. Am J Pathol 142:17-24
105. Quon D, Wang Y, Catalane R, Scardina JM, Murakami K, Cordell B (1991) Formation of β-amyloid protein deposits in brains of transgenic mice. Nature 352:239-241
106. Reiter RJ (1995) Functional pleiotropy of the neurohormone melatonin: antioxidant protection and neuroendocrine regulation. Front Neuroendocrinol 16:383-415
107. Rifici VA, Khachadurian AK (1992) The inhibition of low-density lipoprotein oxidation by 17-β estradiol. Metabolism 41:1110-1114
108. Ripps ME, Huntley GW, Hof PR, Morrison JH, Gordon JW (1995) Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 92:689-693
109. Rogers J, Cooper NR, Webster S, Schultz J, McGeer PL, Styren SD, Civin WH, Brachova L, Bradt B, Ward P, Lieberburg I (1992) Complement activation by β-amyloid in Alzheimer disease. Proc Natl Acad Sci USA 89:10016-10020
110. Roher AE, Ball MJ, Bhave SV, Wakade AR (1991) β-Amyloid from Alzheimer's disease brain inhibits sprouting and survival of sympathetic neurons. Biochem Biophys Res Commun 174: 572-579
111. Sagara Y, Dargusch R, Klier FG, Schubert D, Behl C (1996) Increased antioxidant enzyme activity in amyloid β protein resistant cells. J Neurosci 16:497-505
112. Sandbrink R, Hartmann T, Masters CL, Beyreuther K (1996) Genes contributing to Alzheimer's disease. Mol Psychiatry 1:27-40
113. Sandhu FA, Salim M, Zain SB (1991) Expression of the human β-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice. J Biol Chem 266:21331-21334
114. Sano M, Ernesto C, Thomas RG (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. N Engl J Med 336:1216-1222
115. Schreck R, Rieber P, Baeuerle PA (1991) Reactive oxygen intermediates are apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J 10: 2247-2258
116. Schubert D (1994) The structure and function of Alzheimer's amyloid beta proteins. RG Landes, Austin
117. Schubert D, Kimura H, Maher P (1992) Growth factors and vitamin E modify neuronal glutamate toxicity. Proc Natl Acad USA 89:8264-8267
118. Schubert D, Behl C, Lesley R, Brack A, Dargusch R, Sagara Y, Kimura H (1995) Amyloid peptides are toxic via a common oxidative mechanism. Proc Natl Acad Sci USA 92:1989-1993
119. Schweers O, Mandelkow E-M, Biernat J, Mandelkow E (1995) Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments. Proc Natl Acad Sci USA 92:8463-8467
120. Selkoe DJ (1993) Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci 16:403-409
121. Selkoe DJ (1994) Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol 10:373-403
122. Sendtner M, Thoenen H (1994) Oxidative stress and motoneuron disease. Curr Biol 4:1036-1039
123. Shearman MS, Ragan CI, Iversen LL (1994) Inhibition of PC12 cell redox activity is a specific early indicator of the mechanism of beta-amyloid-mediated cell death. Proc Natl Acad Sci USA 91:1470-1474
124. Sies H (1993) Strategies of antioxidant defense. Eur J Biochem 215:213-219
125. Simpkins JW, Singh M, Bishop J (1994) The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease. Neurobiol Aging [Suppl 15]:195-197
126. Singer TP, Ramsay PR (1995) Monoamine oxidases: old friends hold many surprises. FASEB J 9:605-610
127. Sipe JD (1992) Amyloidosis. Annu Rev Biochem 61:947-975
128. Smith CD, Carney JM, Starke-Reed PE, Oliver CN, Stadtman ER, Floyd RA, Markesbery WR (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzheimer disease. Proc Natl Acad Sci USA 88:10540-10543
129. Smith MA, Siedlak SL, Richey PL, Mulvihill P, Ghiso I, Frangione B, Tagliavini F, Giaccone G, Bugiani O, Praprotnik D, Kalaria RN, Perry G (1995a) Tau protein directly interacts with the amyloid beta-protein precursor - implications for Alzheimer's disease. Nature Med 1:365-369
130. Smith MA, Sayre LM, Monnier VM, Perry G (1995b) Radical AGEing in Alzheimer's disease. Trends Neurosci 18:172-176
131. Smith MA, Rudnicka-Nawrot M, Richey PL, Praprotnik D, Mulvihill P, Miller CA, Sayre LM, Perry G (1995c) Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. J Neurochem 64:2660-2666
132. Snow AD, Sekiguchi R, Nochlin D, Fraser P, Kimata K, Mizutani A, Arai M, Schreier WA, Morgan DG (1994) An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar Aβ-amyloid in rat brain. Neuron 12:219-234
133. Subbarao KV, Richardson JS, Ang LC (1990) Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J Neurochem 55:342-345
134. Subbiah MTR, Kessel B, Agrawal M, Rajan R, Abplanalp W, Rymaszewski (1993) Antioxidant potential of specific estrogens and lipid peroxidation. J Clin Endocrinol Metab 77:1095-1097
135. Sugioka K, Shimosegawa Y, Nakano M (1987) Estrogens as natural antioxidants of membrane phospholipid peroxidation. FEBS Lett 210:37-39
136. Tang M-X, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R (1996) Effect of oestrogen during menopause on risk and age of onset of Alzheimer's disease. Lancet 348:429-432
137. Terry RD, Masliah E, Salmon DP, Butters N, De Teresa R, Hill R, Hansen LA, Katman R (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580
138. Terry RD, Katzmann R, Bick KL (eds) (1994) Alzheimer's disease. Raven, New York
139. Toran-Allerand CD, Hashimoto K, Greenough WT, Saltarelli M (1983) Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro. III. Effects of estrogen on dendritic differentiation. Brain Res Dev Brain Res 7:97-101
140. Tuszynski MH, Sang H, Yoshida K, Gage FH (1991) Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann Neurol 30:625-636
141. Westermark P, Wernstedt C, Wilander E, Sletten K (1986) A novel peptide in the calcitonin gene-related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 140:827-831
142. Weyler W, Hsu Y-PP, Breakefield XO (1990) Biochemistry and genetics of monoaminooxidase. Pharmacol Ther 47:391-417
143. Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle AW, Delon MR (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215:1237-1239
144. Winkler J, Connor DJ, Frautschy SA, Behl C, Waite JJ, Cole GM, Thai LJ (1994) Lack of long-term effects after β-amyloid protein injections in rat brain. Neurobiol Aging 15:601-607
145. Wirak DO, Bayney R, Ramabhadan TV, Fracasso RP, Hart JT, Hauer PE, Hsiau P, Pekar SK, Scangos GA, Trapp BD, Unterbeck AJ (1991) Deposits of amyloid β protein in the central nervous system of transgenic mice. Science 253:323-325
146. Wisniewski KE, Wisniewski HM, Wen GY (1985) Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 17:278-282
147. Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt A (1996) RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382:685-691
148. Yankner BA (1992) Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging 13:615-616
149. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245:417-429
150. Yankner BA, Duffy LK, Kirschner DA (1990a) Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250:279-282
151. Yankner BA, Caceres A, Duffy LK (1990b) Nerve growth factor potentiates the neurotoxicity of β-amyloid. Proc Natl Acad Sci USA 87:9020-9023
152. Yoshikawa K, Aizawa T, Hayashi Y (1992) Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359:64-66
153. Zhao W, Richardson JS, Mombourquette MJ, Weil JA (1995) An in vitro EPR study of the free radical scavenging actions of the lazaroid antioxidants U-74500A and U-7851F. Free Radic Biol Med 19:21-30