Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas

Hematology/ Oncology and Stem Cell Therapy

Volumn 6, Issue 1, 2013, Pages 20-25

  Giatromanolaki, Alexandra ^a   Koukourakis, Michael I ^a   Pouliliou, Stamatia ^a   Gatter, Kevin C ^b   Pezzella, Francesco ^b   Harris, Adrian L ^b   Sivridis, Efthimios ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE 5; LIGHT CHAIN 3A PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; FOLLICULAR LYMPHOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; LYMPHOID HYPERPLASIA; MAJOR CLINICAL STUDY; MOLECULAR PATHOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 84884677650     PISSN: 16583876     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hemonc.2013.02.001     Document Type: Article

References (32)

1. Anonymous. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project. Blood 1997:89(11):3909-18.
2. Horning SJ, Rosenberg SA. The natural history of initially untreated low-grade non-Hodgkin's lymphomas. N Engl J Med 1984;311(23):1471-5.
3. Coiffier B. Diffuse large cell lymphoma. Curr Opin Oncol 2001;13(5):325-34.
4. Anderson JR, Armitage JO, Weisenburger DD. Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin's Lymphoma Classification Project. Ann Oncol 1998;9(7):717-20.
5. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000;403(6769):503-11.
6. Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002;346(25):1937-47.
7. Savage KJ, Monti S, Kutok JL, et al. The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 2003;102(12):3871-9.
8. Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B-cell lymphoma. Proc Natl Acad Sci USA 2003;100(17):9991-6.
9. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000;290(5497):1717-21.
10. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004;306(5698):990-5.
11. Levine B. Cell biology: autophagy and cancer. Nature 2007;446(7137):745- 7.
12. Sivridis E, Koukourakis MI, Zois CE, et al. LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. Am J Pathol 2010;176(5):2477-89.
13. Sivridis E, Giatromanolaki A, Zois C, Koukourakis MI. The "stone-like" pattern of autophagy in human epithelial tumors and tumor-like lesions: an approach to the clinical outcome. Autophagy 2010;6:830-3.
14. Giatromanolaki A, Koukourakis MI, Harris AL, Polychronidis A, Gatter KC, Sivridis E. Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas. J Clin Pathol 2010;63(10):867-72.
15. Sivridis E, Giatromanolaki A, Liberis V, Koukourakis MI. Autophagy in endometrial carcinomas and prognostic relevance of "stone-like" structures (SLS}: What is destined for the atypical endometrial hyperplasia? Autophagy 2011;7(1):74-82.
16. Sivridis E, Giatromanolaki A, Karpathiou G, Karpouzis A, Kouskoukis C, Koukourakis MI. LC3A-positive "stone-like" structures in cutaneous squamous cell carcinomas. Am J Dermatopathol 2011;33(3):285-90.
17. Mizushima N, Ohsumi Y, Yoshimori T Autophagosome formation in mammalian cells. Cell Struct Funct 2002;27(6):421-9.
18. Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19(21):5720-8.
19. Hirota K, Semenza GL. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 2006;59(1):15-26.
20. Semenza GL, Jiang BH, Leung SW, et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996;271(51):32529-37.
21. Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumors and survival. Br J Cancer 2001;85(6):881-90.
22. Turley H, Scott PA, Watts VM, Bicknell R, Harris AL, Gatter KC. Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1. J Pathol 1998;186(3):313-8.
23. Koukourakis MI, Giatromanolaki A, Sivridis E. Tumour and Angiogenesis Research Group. Lactate dehydrogenase isoenzymes 1 and 5: differential expression by neoplastic and stromal cells in nonsmall cell lung cancer and other epithelial malignant tumors. Tumour Biol 2003;24(4):199-202.
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193(1):265-75.
25. Watanabe K, Ichinose S, Hayashizaki K, Tsubata T. Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation. Biochem Biophys Res Commun 2008;374(2):274-81.
26. Miller BC, Zhao Z, Stephenson LM, Cadwell K, et al. The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy 2008;4(3):309-14.
27. Khan WN. B cell receptor and BAFF receptor signaling regulation of B cell homeostasis. J Immunol 2009;183(6):3561-7.
28. Sato K, Tsuchihara K, Fujii S, et al. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res 2007;67(20):9677-84.
29. Rzymski T, Milani M, Pike L, et al. Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 2010;29(31):4424-35.
30. Nakagawa I, Amano A, Mizushima N, et al. Autophagy defends cells against invading group A Streptococcus. Science 2004;306(5698):1037-40.
31. Jia L, Dourmashkin RR, Allen PD, Gray AB, Newland AC, Kelsey SM. Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br J Haematol 1997;98(3):673-85.
32. Younes A. Therapeutic activity of mTOR inhibitors in mantle cell lymphoma: clues but no clear answers. Autophagy 2008;4(5):707-9.