Expression of E-cadherin, Twist, and p53 and their prognostic value in patients with oral squamous cell carcinoma

Journal of Cancer Research and Clinical Oncology

Volumn 139, Issue 10, 2013, Pages 1735-1744

  Fan, Chi Chen ^a,b   Wang, Tao Yeuan ^a   Cheng, Yen An ^b   Jiang, Shih Sheng ^c   Cheng, Chien Wen ^c   Lee, Alan Yueh Luen ^c   Kao, Ting Yu ^b  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

E cadherin; EMT; Oral cancer; p53; Prognostic marker

Indexed keywords

PROTEIN P53; TRANSCRIPTION FACTOR TWIST; TUMOR MARKER; UVOMORULIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BENIGN TUMOR; BETEL NUT; CANCER MORTALITY; CANCER RECURRENCE; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DISEASE MARKER; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROGNOSTIC VALUE; SMOKING; TAIWAN; TISSUE LEVEL; TUMOR LOCALIZATION; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NUCLEAR PROTEINS; PROGNOSIS; RISK FACTORS; TUMOR SUPPRESSOR PROTEIN P53; TWIST TRANSCRIPTION FACTOR;

EID: 84884674443     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-013-1499-9     Document Type: Article

References (51)

1. Aamodt R, Bondi J, Andersen SN, Bakka A, Bukholm G, Bukholm IR (2010) The prognostic impact of protein expression of E-cadherin-catenin complexes differs between rectal and colon carcinoma. Gastroenterol Res Pract. doi: 10.1155/2010/616023
2. Bacic B, Haller H, Mrklic I, Kosta V, Caric A, Tomic S (2013) Prognostic role of E-cadherin in patients with advanced serous ovarian cancer. Arch Gynecol Obstet 287(6):1219-1224. doi: 10.1007/s00404-012-2684-9
3. Bettendorf O, Piffko J, Bankfalvi A (2004) Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy? Oral Oncol 40(2):110-119
4. Bondi J, Bukholm G, Nesland JM, Bakka A, Bukholm IR (2006) An increase in the number of adhesion proteins with altered expression is associated with an increased risk of cancer death for colon carcinoma patients. Int J Colorectal Dis 21(3):231-237. doi: 10.1007/s00384-005-0762-1
5. Brinkman BM, Wong DT (2006) Disease mechanism and biomarkers of oral squamous cell carcinoma. Curr Opin Oncol 18(3):228-233. doi: 10.1097/01.cco.0000219250.15041.f8
6. Brooks CL, Gu W (2003) Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 15(2):164-171
7. Cheng AN, Jiang SS, Fan CC, Lo YK, Kuo CY, Chen CH, Liu YL, Lee CC, Chen WS, Huang TS, Wang TY, Lee AY (2013) Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents. Cancer Lett 337(2):218-225. doi: 10.1016/j.canlet.2013.05.008
8. Davidson B, Gotlieb WH, Ben-Baruch G, Nesland JM, Bryne M, Goldberg I, Kopolovic J, Berner A (2000) E-cadherin complex protein expression and survival in ovarian carcinoma. Gynecol Oncol 79(3):362-371. doi: 10.1006/gyno.2000.5964
9. Dayan D, Vered M (2013) Is immuno-expression of E-cadherin really a prognostic factor in head and neck cancer? Oral Oncol 49(3):e5. doi: 10.1016/j.oraloncology.2012.10.007
10. Department-of-Health (ed) (2009) Cancer registry annual report in Taiwan. Department of Health, Taipei, Taiwan
11. Faleiro-Rodrigues C, Macedo-Pinto I, Pereira D, Lopes CS (2004) Prognostic value of E-cadherin immunoexpression in patients with primary ovarian carcinomas. Ann Oncol 15(10):1535-1542. doi: 10.1093/annonc/mdh387
12. Ho CM, Cheng WF, Lin MC, Chen TC, Huang SH, Liu FS, Chien CC, Yu MH, Wang TY, Hsieh CY (2010) Prognostic and predictive values of E-cadherin for patients of ovarian clear cell adenocarcinoma. Int J Gynecol Cancer 20(9):1490-1497. doi: 10.1111/IGC.0b013e3181e68a4d
13. Huber GF, Zullig L, Soltermann A, Roessle M, Graf N, Haerle SK, Studer G, Jochum W, Moch H, Stoeckli SJ (2011) Down regulation of E-cadherin (ECAD) - a predictor for occult metastatic disease in sentinel node biopsy of early squamous cell carcinomas of the oral cavity and oropharynx. BMC Cancer 11(217):211-218. doi: 10.1186/1471-2407-11-217
14. Hung KF, Chang CS, Liu CJ, Lui MT, Cheng CY, Kao SY (2006) Differential expression of E-cadherin in metastatic lesions comparing to primary oral squamous cell carcinoma. J Oral Pathol Med 35(10):589-594. doi: 10.1111/j.1600-0714.2006.00474.x
15. Hung JJ, Yang MH, Hsu HS, Hsu WH, Liu JS, Wu KJ (2009) Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer. Thorax 64(12):1082-1089. doi: 10.1136/thx.2009.115691
16. Iwatsuki M, Mimori K, Yokobori T, Ishi H, Beppu T, Nakamori S, Baba H, Mori M (2010) Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 101(2):293-299. doi: 10.1111/j.1349-7006.2009. 01419.x
17. Kim NH, Kim HS, Li XY, Lee I, Choi HS, Kang SE, Cha SY, Ryu JK, Yoon D, Fearon ER, Rowe RG, Lee S, Maher CA, Weiss SJ, Yook JI (2011) A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol 195(3):417-433. doi: 10.1083/jcb.201103097
18. Koensgen D, Freitag C, Klaman I, Dahl E, Mustea A, Chekerov R, Braicu I, Lichtenegger W, Sehouli J (2010) Expression and localization of E-cadherin in epithelial ovarian cancer. Anticancer Res 30(7):2525-2530
19. Kwok WK, Ling MT, Lee TW, Lau TC, Zhou C, Zhang X, Chua CW, Chan KW, Chan FL, Glackin C, Wong YC, Wang X (2005) Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res 65(12):5153-5162. doi: 10.1158/0008-5472.can-04-3785
20. Lim J, Kim JH, Paeng JY, Kim MJ, Hong SD, Lee JI, Hong SP (2005) Prognostic value of activated Akt expression in oral squamous cell carcinoma. J Clin Pathol 58(11):1199-1205. doi: 10.1136/jcp.2004.024786
21. Lim SO, Kim H, Jung G (2010) p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. FEBS Lett 584(11):2231-2236. doi: 10.1016/j.febslet.2010.04.006
22. Liu LK, Jiang XY, Zhou XX, Wang DM, Song XL, Jiang HB (2010) Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome. Mod Pathol 23(2):213-224. doi: 10.1038/modpathol.2009.160
23. Lydiatt WM, Shah JP, Hoffman HT (2001) AJCC stage groupings for head and neck cancer: should we look at alternatives? A report of the head and neck sites task force. Head Neck 23(8):607-612
24. Martin TA, Goyal A, Watkins G, Jiang WG (2005) Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol 12(6):488-496. doi: 10.1245/aso.2005.04.010
25. Mignogna MD, Fedele S, Lo Russo L (2004) The world cancer report and the burden of oral cancer. Eur J Cancer Prev 13(2):139-142
26. Moore SR, Johnson NW, Pierce AM, Wilson DF (2000) The epidemiology of mouth cancer: a review of global incidence. Oral Dis 6(2):65-74
27. Muller PA, Vousden KH, Norman JC (2011) p53 and its mutants in tumor cell migration and invasion. J Cell Biol 192(2):209-218. doi: 10.1083/jcb.201009059
28. Nijkamp MM, Span PN, Hoogsteen IJ, van der Kogel AJ, Kaanders JH, Bussink J (2011) Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients. Radiother Oncol 99(3):344-348. doi: 10.1016/j.radonc.2011.05.066
29. Parkin DM, Pisani P, Ferlay J (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80(6):827-841
30. Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7(6):415-428. doi: 10.1038/nrc2131
31. Ren D, Wang M, Guo W, Zhao X, Tu X, Huang S, Zou X, Peng X (2013) Wild-type p53 suppresses the epithelial-mesenchymal transition and stemness in PC-3 prostate cancer cells by modulating miR145. Int J Oncol 42(4):1473-1481. doi: 10.3892/ijo.2013.1825
32. Richmond PJ, Karayiannakis AJ, Nagafuchi A, Kaisary AV, Pignatelli M (1997) Aberrant E-cadherin and alpha-catenin expression in prostate cancer: correlation with patient survival. Cancer Res 57(15):3189-3193
33. Rosivatz E, Becker I, Specht K, Fricke E, Luber B, Busch R, Hofler H, Becker KF (2002) Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 161(5):1881-1891. doi: 10.1016/s0002-9440(10)64464-1
34. Shibata K, Kajiyama H, Ino K, Terauchi M, Yamamoto E, Nawa A, Nomura S, Kikkawa F (2008) Twist expression in patients with cervical cancer is associated with poor disease outcome. Ann Oncol 19(1):81-85. doi: 10.1093/annonc/mdm344
35. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2(6):442-454. doi: 10.1038/nrc822
36. Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139(5):871-890. doi: 10.1016/j.cell.2009.11.007
37. Tseng RC, Lee SH, Hsu HS, Chen BH, Tsai WC, Tzao C, Wang YC (2010) SLIT2 attenuation during lung cancer progression deregulates beta-catenin and E-cadherin and associates with poor prognosis. Cancer Res 70(2):543-551. doi: 10.1158/0008-5472.can-09-2084
38. Ueda G, Sunakawa H, Nakamori K, Shinya T, Tsuhako W, Tamura Y, Kosugi T, Sato N, Ogi K, Hiratsuka H (2006) Aberrant expression of beta- and gamma-catenin is an independent prognostic marker in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 35(4):356-361. doi: 10.1016/j.ijom.2005.07.023
39. Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HF, Oosterhof GO, Debruyne FM, Schalken JA (1994) Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 54(14):3929-3933
40. van Oort IM, Tomita K, van Bokhoven A, Bussemakers MJ, Kiemeney LA, Karthaus HF, Witjes JA, Schalken JA (2007) The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study. Prostate 67(13):1432-1438. doi: 10.1002/pros.20626
41. Vousden KH, Lu X (2002) Live or let die: the cell's response to p53. Nat Rev Cancer 2(8):594-604. doi: 10.1038/nrc864
42. Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, Yuan A, Lin CW, Yang SC, Chan WK, Li KC, Hong TM, Yang PC (2009) p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat Cell Biol 11(6):694-704. doi: 10.1038/ncb1875
43. Wu DW, Lee MC, Wang J, Chen CY, Cheng YW, Lee H (2013) DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer. Oncogene. doi: 10.1038/onc.2013.107
44. Yang MH, Wu KJ (2008) TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell cycle (Georgetown, TX) 7(14):2090-2096
45. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA (2004) Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117(7):927-939. doi: 10.1016/j.cell.2004.06.006
46. Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 10(3):295-305. doi: 10.1038/ncb1691
47. Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL, Wu JC (2009) Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology (Baltimore, MD) 50(5):1464-1474. doi: 10.1002/hep.23221
48. Yu Q, Zhang K, Wang X, Liu X, Zhang Z (2010) Expression of transcription factors snail, slug, and twist in human bladder carcinoma. J Exp Clin Cancer Res 29:119. doi: 10.1186/1756-9966-29-119
49. Yuen HF, Chua CW, Chan YP, Wong YC, Wang X, Chan KW (2007) Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer. Histopathology 50(5):648-658. doi: 10.1111/j.1365-2559.2007.02665.x
50. Zhao Z, Ge J, Sun Y, Tian L, Lu J, Liu M, Zhao Y (2012) Is E-cadherin immunoexpression a prognostic factor for head and neck squamous cell carcinoma (HNSCC)? A systematic review and meta-analysis. Oral Oncol 48(9):761-767. doi: 10.1016/j.oraloncology.2012.02.024
51. Zhou YN, Xu CP, Han B, Li M, Qiao L, Fang DC, Yang JM (2002) Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival. WJG 8(6):987-993.