Down regulation of e-cadherin (ECAD) - a predictor for occult metastatic disease in sentinel node biopsy of early squamous cell carcinomas of the oral cavity and oropharynx

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Huber, Gerhard F ^a   Züllig, Lena ^a   Soltermann, Alex ^a   Roessle, Matthias ^a   Graf, Nicole ^a   Haerle, Stephan K ^a   Studer, Gabriela ^a   Jochum, Wolfram ^b   Moch, Holger ^a   Stoeckli, Sandro J ^b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

E cadherin (ECAD); Head and neck squamous cell carcinoma (HNSCC); Immunohistochemistry; Oral cavity; Oropharynx; Sentinel node biopsy

Indexed keywords

UVOMORULIN; CADHERIN;

ACCURACY; ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CONTROLLED STUDY; DOWN REGULATION; EARLY CANCER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; OROPHARYNX CARCINOMA; PREDICTIVE VALUE; PROGNOSIS; PROTEIN EXPRESSION; REGIONAL METASTASIS; SENSITIVITY AND SPECIFICITY; SENTINEL LYMPH NODE BIOPSY; SQUAMOUS CELL CARCINOMA; TISSUE MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; MOUTH TUMOR; OROPHARYNX TUMOR; PATHOLOGY; RETROSPECTIVE STUDY;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CARCINOMA, SQUAMOUS CELL; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM STAGING; OROPHARYNGEAL NEOPLASMS; PROGNOSIS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SENTINEL LYMPH NODE BIOPSY;

EID: 79957864140     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-217     Document Type: Article

References (27)

1. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics CA Cancer J Clin. 1999, 49:8-31.
2. Grandi C, Alloisio M, Moglia D, Podrecca S, Sala L, Salvator P, Molinari R. Prognostic significance of lymphatic spread in head and neck carcinomas: therapeutic implications. Head Neck Surg 1985, 8(2):67-73. 10.1002/hed.2890080202, 4077553.
3. Crnic I, Christofori G. Novel technologies and recent advances in metastasis research. Int J Dev Biol 2004, 48(5-6):573-81. 10.1387/ijdb.041809ic, 15349832.
4. Stoeckli SJ. Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma of the Head and Neck. The Laryngoscope 2007, 117:1539-51. 10.1097/MLG.0b013e318093ee67, 17667135.
5. Goerkem M, Braun J, Stoeckli JS. Evaluation of clinical and histomorphological parameters as potential predictors of occult metastases in sentinel lymph nodes of early squamous cell carcinoma of the oral cavity. Annals of surgical oncology 2010, 17(2):227-235.
6. Chung MK, Min J-Y, So YK, Ko Y-H, Jeong H-S, Son Y-I, Baek C-H. Correlation between lymphatic vessel density and regional metastasis in squamous cell carcinoma of the tongue. Head Neck 2010, 32(4):445-51.
7. Cavallaro U, Christofori G. Cell adhesion and signaling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 2004, 118-32.
8. Brock MV, Gou M, Akiyama Y, Muller A, Wu TT, Montgomery E, Deasel M, Germonpré P, Rubinson L, Heitmiller RF, Yang SC, Forastiere AA, Baylin SB, Herman JG. Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res 2003, 9(8):2912-9.
9. Krishnadath KK, Tilanus HW, van Blankenstein M, Hop WC, Kremers ED, Dinjens WN, Bosman FT. Reduced expression of the cadherin-catenin complex in oesophageal adenocarcinoma correlates with poor prognosis. J Pathol 1997, 182(3):331-8. 10.1002/(SICI)1096-9896(199707)182:3<331::AID-PATH860>3.0.CO;2-D, 9349237.
10. Weinberg RA. The Biology of Cancer. 2009, Garland Science.
11. Zhai B, Yan HX, Liu SQ, Chen L, Wu MC, Wang HY. Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas. World J Gastroenterol 2008, 14(37):5665-73. 10.3748/wjg.14.5665, 2748200, 18837082.
12. Hirata T, Fukuse T, Naiki H, Wada H. Expression of E-cadherin and lymph node metastasis in resected non-small-cell lung cancer. Clin Lung Cancer 2001, 3(2):134-40. 10.3816/CLC.2001.n.024, 14659029.
13. Stoeckli SJ, Pfaltz M, Ross GL, Steinert HC, MacDonald DG, Wittekind C, Soutar DS. The second international conference on sentinel node biopsy in mucosal head and neck cancer. Ann Surg Oncol 2005, 12(11):919-24. 10.1245/ASO.2005.11.024, 16177861.
14. Ambrosch P, Brinck U. Detection of nodal micrometastases in head and neck cancer by serial sectioning and immunostaining. Oncology (Williston Park) 1996, 10(8):1221-6.
15. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP. Tissue microarrays for high-throughput molecular profiling of tumour specimens. Nat Med 1998, 4:844-7. 10.1038/nm0798-844, 9662379.
16. Hinterberger M, Reineke T, Storz M, Weder W, Vogt P, Moch H. D2-40 and calretinin - a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation. Mod Pathol 2007, 20(2):248-55. 10.1038/modpathol.3800736, 17361207.
17. Cueni LN, Hegyi I, Shin JW, Albinger-Hegyi A, Gruber S, Kunstfeld R, Moch H, Detmar M. Tumour lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol 2010, 177(2):1004-16. 10.2353/ajpath.2010.090703, 20616339.
18. Li K, He W, Lin N, Wang X, Fan QX. Downregulation of N-cadherin expression inhibits invasiveness, arrests cell cycle and induces cell apoptosis in esophageal squamous cell carcinoma. Cancer Invest 2010, 28(5):479-86. 10.3109/07357900903476745, 20014942.
19. Liu LK, Jiang XY, Zhou XX, Wang DM, Song XL, Jiang HB. Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome. Mod Pathol 2010, 23(2):213-24. 10.1038/modpathol.2009.160, 19915524.
20. Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010, 12(3):247-56. 2845545, 20173740.
21. Koensgen D, Freitag C, Klaman I, Dahl E, Mustea A, Chekerov R, Braicu I, Lichtenegger W, Sehouli J. Expression and localization of e-cadherin in epithelial ovarian cancer. Anticancer Res 2010, 30(7):2525-30.
22. Xie LQ, Bian LJ, Li Z, Li Y, Li ZX, Li B. Altered expression of E-cadherin by hepatocyte growth factor and effect on the prognosis of nasopharyngeal carcinoma. Ann Surg Oncol 2010, 17(7):1927-36. 10.1245/s10434-010-0922-6, 20131016.
23. Liu YN, Liu Y, Lee HJ, Hsu YH, Chen JH. Activated androgen receptor downregulates E-cadherin gene expression and promotes tumour metastasis. Mol Cell Biol 2008, 28(23):7096-108. 10.1128/MCB.00449-08, 2593382, 18794357.
24. Bryan RT, Tselepis C. Cadherin switching and bladder cancer. J Urol 2010, 184(2):423-31. 10.1016/j.juro.2010.04.016, 20620393.
25. Huber GF, Fritzsche FR, Züllig L, Storz M, Graf N, K Haerle S, Jochum W, Stoeckli SJ, Moch H. Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx. Int J Cancer 2010,
26. Huber GF, Albinger A, Soltermann A, Roessle M, Graf N, Haerle SK, Holzmann D, Moch H, Hegyi I. Expression patterns of Bmi-1 and p16 significantly correlate with overall, disease specific and recurrence free survival in oropharyngeal squamous cell carcinoma (OSCC). Cancer 2011,
27. Albinger-Hegyi A, Stoeckli SJ, Schmid S, Storz M, Iotzova G, Probst-Hensch NM, Rehrauer H, Tinguely M, Moch H, Hegyi I. Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC). Int J Cancer 2010, 126(11):2653-62.