메뉴 건너뛰기




Volumn 238, Issue 10, 2013, Pages 1147-1159

Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice

Author keywords

cell regeneration; maternal protein restriction; microarray; Reg1; streptozotocin

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; FEMALE; GENE SEQUENCE; GLUCOSE INTOLERANCE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN RESTRICTION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY CHAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; UPREGULATION; WESTERN BLOTTING;

EID: 84884662785     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213493715     Document Type: Article
Times cited : (14)

References (63)
  • 1
    • 33645868980 scopus 로고    scopus 로고
    • Ontogeny of regeneration of {beta}-cells in the neonatal rat after treatment with streptozotocin
    • Thyssen S,Arany E,Hill DJ.Ontogeny of regeneration of {beta}-cells in the neonatal rat after treatment with streptozotocin.Endocrinology. 2006;147:2346-56.
    • (2006) Endocrinology , vol.147 , pp. 2346-2356
    • Thyssen, S.1    Arany, E.2    Hill, D.J.3
  • 2
    • 0028062752 scopus 로고
    • Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity
    • Wang RN,Bouwens L,Kloppel G.Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity.Diabetologia. 1994;37:1088-96.
    • (1994) Diabetologia , vol.37 , pp. 1088-1096
    • Wang, R.N.1    Bouwens, L.2    Kloppel, G.3
  • 3
    • 77953794065 scopus 로고    scopus 로고
    • The effects of low protein during gestation on mouse pancreatic development and beta cell regeneration
    • Cox AR,Gottheil SK,Arany EJ,Hill DJ.The effects of low protein during gestation on mouse pancreatic development and beta cell regeneration.Pediatr Res. 2010;68:16-22.
    • (2010) Pediatr Res , vol.68 , pp. 16-22
    • Cox, A.R.1    Gottheil, S.K.2    Arany, E.J.3    Hill, D.J.4
  • 4
    • 0029991261 scopus 로고    scopus 로고
    • Beta-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period
    • Wang RN,Bouwens L,Kloppel G.Beta-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period.Diabetologia. 1996;39:548-57.
    • (1996) Diabetologia , vol.39 , pp. 548-557
    • Wang, R.N.1    Bouwens, L.2    Kloppel, G.3
  • 6
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y,Brown J,Martinez OI,Melton DA.Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.Nature. 2004;429:41-6.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 7
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • Teta M,Rankin MM,Long SY,Stein GM,Kushner JA.Growth and regeneration of adult beta cells does not involve specialized progenitors.Dev Cell. 2007;12:817-26.
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 11
    • 0026772772 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
    • Hales CN,Barker DJ.Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.Diabetologia. 1992;35:595-601.
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.N.1    Barker, D.J.2
  • 12
    • 0027529974 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
    • Barker DJ,Hales CN,Fall CH,Osmond C,Phipps K,Clark PM.Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth.Diabetologia. 1993;36:62-7.
    • (1993) Diabetologia , vol.36 , pp. 62-67
    • Barker, D.J.1    Hales, C.N.2    Fall, C.H.3    Osmond, C.4    Phipps, K.5    Clark, P.M.6
  • 13
    • 77649171913 scopus 로고    scopus 로고
    • Changes in islet microvasculature following streptozotocin-induced beta-cell loss and subsequent replacement in the neonatal rat
    • Nicholson JM,Arany EJ,Hill DJ.Changes in islet microvasculature following streptozotocin-induced beta-cell loss and subsequent replacement in the neonatal rat.Exp Biol Med (Maywood). 2010;235:189-98.
    • (2010) Exp Biol Med (Maywood) , vol.235 , pp. 189-198
    • Nicholson, J.M.1    Arany, E.J.2    Hill, D.J.3
  • 14
    • 79960907300 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival
    • Liu Z,Stanojevic V,Avadhani S,Yano T,Habener JF.Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival.Diabetologia. 2011;54:2067-76.
    • (2011) Diabetologia , vol.54 , pp. 2067-2076
    • Liu, Z.1    Stanojevic, V.2    Avadhani, S.3    Yano, T.4    Habener, J.F.5
  • 15
    • 84863947350 scopus 로고    scopus 로고
    • Combinatorial human progenitor cell transplantation optimizes islet regeneration through secretion of paracrine factors
    • Bell GI,Meschino MT,Hughes-Large JM,Broughton HC,Xenocostas A,Hess DA.Combinatorial human progenitor cell transplantation optimizes islet regeneration through secretion of paracrine factors.Stem Cells Dev. 2012;21:1863-76.
    • (2012) Stem Cells Dev , vol.21 , pp. 1863-1876
    • Bell, G.I.1    Meschino, M.T.2    Hughes-Large, J.M.3    Broughton, H.C.4    Xenocostas, A.5    Hess, D.A.6
  • 16
    • 0033305240 scopus 로고    scopus 로고
    • A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-II
    • Petrik J,Reusens B,Arany E,Remacle C,Coelho C,Hoet JJ,Hill DJ.A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-II.Endocrinology. 1999;140:4861-73.
    • (1999) Endocrinology , vol.140 , pp. 4861-4873
    • Petrik, J.1    Reusens, B.2    Arany, E.3    Remacle, C.4    Coelho, C.5    Hoet, J.J.6    Hill, D.J.7
  • 17
    • 0036596396 scopus 로고    scopus 로고
    • Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets
    • Boujendar S,Reusens B,Merezak S,Ahn MT,Arany E,Hill D,Remacle C.Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets.Diabetologia. 2002;45:856-66.
    • (2002) Diabetologia , vol.45 , pp. 856-866
    • Boujendar, S.1    Reusens, B.2    Merezak, S.3    Ahn, M.T.4    Arany, E.5    Hill, D.6    Remacle, C.7
  • 18
    • 0042920727 scopus 로고    scopus 로고
    • Taurine supplementation of a low protein diet fed to rat dams normalizes the vascularization of the fetal endocrine pancreas
    • Boujendar S,Arany E,Hill D,Remacle C,Reusens B.Taurine supplementation of a low protein diet fed to rat dams normalizes the vascularization of the fetal endocrine pancreas.J Nutr. 2003;133:2820-5.
    • (2003) J Nutr , vol.133 , pp. 2820-2825
    • Boujendar, S.1    Arany, E.2    Hill, D.3    Remacle, C.4    Reusens, B.5
  • 20
    • 34548291991 scopus 로고    scopus 로고
    • Overexpression of ErbB2 in the exocrine pancreas induces an inflammatory response but not increased proliferation
    • Algul H,Wagner M,Lesina M,Schmid RM.Overexpression of ErbB2 in the exocrine pancreas induces an inflammatory response but not increased proliferation.Int J Cancer. 2007;121:1410-16.
    • (2007) Int J Cancer , vol.121 , pp. 1410-1416
    • Algul, H.1    Wagner, M.2    Lesina, M.3    Schmid, R.M.4
  • 21
    • 0842328003 scopus 로고    scopus 로고
    • Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
    • Green K,Brand MD,Murphy MP.Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes.Diabetes. 2004;53:S110-18.
    • (2004) Diabetes , vol.53
    • Green, K.1    Brand, M.D.2    Murphy, M.P.3
  • 22
    • 75149194772 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities
    • Sivitz WI,Yorek MA.Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Antioxid Redox Signal. 2010;12:537-77.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 537-577
    • Sivitz, W.I.1    Yorek, M.A.2
  • 24
    • 0029944843 scopus 로고    scopus 로고
    • Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia
    • Zenilman ME,Perfetti R,Swinson K,Magnuson T,Shuldiner AR.Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia.Surgery. 1996;119:576-84.
    • (1996) Surgery , vol.119 , pp. 576-584
    • Zenilman, M.E.1    Perfetti, R.2    Swinson, K.3    Magnuson, T.4    Shuldiner, A.R.5
  • 26
    • 33751055997 scopus 로고    scopus 로고
    • Altered pancreatic morphology in the offspring of pregnant rats given reduced dietary protein is time and gender specific
    • Chamson-Reig A,Thyssen SM,Arany E,Hill DJ.Altered pancreatic morphology in the offspring of pregnant rats given reduced dietary protein is time and gender specific.J Endocrinol. 2006;191:83-92.
    • (2006) J Endocrinol , vol.191 , pp. 83-92
    • Chamson-Reig, A.1    Thyssen, S.M.2    Arany, E.3    Hill, D.J.4
  • 27
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz Y,Montminy MR,Stein R,Leonard J,Gamer LW,Wright CV,Teitelman G.Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.Development. 1995;121:11-18.
    • (1995) Development , vol.121 , pp. 11-18
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3    Leonard, J.4    Gamer, L.W.5    Wright, C.V.6    Teitelman, G.7
  • 29
    • 2342608007 scopus 로고    scopus 로고
    • Transcription factors in islet development and physiology: role of PDX-1 in beta-cell function
    • Melloul D.Transcription factors in islet development and physiology: role of PDX-1 in beta-cell function.Ann N Y Acad Sci. 2004;1014:28-37.
    • (2004) Ann N Y Acad Sci , vol.1014 , pp. 28-37
    • Melloul, D.1
  • 30
    • 0037341252 scopus 로고    scopus 로고
    • Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
    • Stoffers DA,Desai BM,DeLeon DD,Simmons RA.Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat.Diabetes. 2003;52:734-40.
    • (2003) Diabetes , vol.52 , pp. 734-740
    • Stoffers, D.A.1    Desai, B.M.2    DeLeon, D.D.3    Simmons, R.A.4
  • 31
    • 45549097738 scopus 로고    scopus 로고
    • Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1
    • Park JH,Stoffers DA,Nicholls RD,Simmons RA.Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.J Clin Invest. 2008;118:2316-2324.
    • (2008) J Clin Invest , vol.118 , pp. 2316-2324
    • Park, J.H.1    Stoffers, D.A.2    Nicholls, R.D.3    Simmons, R.A.4
  • 32
    • 0032525981 scopus 로고    scopus 로고
    • Beta cell specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
    • Ahlgren U,Jonsson J,Jonsson L,Simu K,Edlund H.Beta cell specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.Genes Dev. 1998;12:1763-8.
    • (1998) Genes Dev , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3    Simu, K.4    Edlund, H.5
  • 33
    • 23344432499 scopus 로고    scopus 로고
    • Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure
    • Simmons RA,Suponitsky-Kroyter I,Selak MA.Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure.J Biol Chem. 2005;280:28785-91.
    • (2005) J Biol Chem , vol.280 , pp. 28785-28791
    • Simmons, R.A.1    Suponitsky-Kroyter, I.2    Selak, M.A.3
  • 34
    • 67749108294 scopus 로고    scopus 로고
    • Early low protein diet aggravates unbalance between antioxidant enzymes leading to islet dysfunction
    • Theys N,Clippe A,Bouckenooghe T,Reusens B,Remacle C.Early low protein diet aggravates unbalance between antioxidant enzymes leading to islet dysfunction.PLoS One. 2009;4:e6110-e6110.
    • (2009) PLoS One , vol.4
    • Theys, N.1    Clippe, A.2    Bouckenooghe, T.3    Reusens, B.4    Remacle, C.5
  • 36
    • 0344033667 scopus 로고    scopus 로고
    • Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats
    • Peterside IE,Selak MA,Simmons RA.Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats.Am J Physiol Endocrinol Metab. 2003;285:E1258-66.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Peterside, I.E.1    Selak, M.A.2    Simmons, R.A.3
  • 37
    • 41849120416 scopus 로고    scopus 로고
    • The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation
    • Reusens B,Sparre T,Kalbe L,Bouckenooghe T,Theys N,Kruhoffer M,Orntoft TF,Nerup J,Remacle C.The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation.Diabetologia. 2008;51:836-45.
    • (2008) Diabetologia , vol.51 , pp. 836-845
    • Reusens, B.1    Sparre, T.2    Kalbe, L.3    Bouckenooghe, T.4    Theys, N.5    Kruhoffer, M.6    Orntoft, T.F.7    Nerup, J.8    Remacle, C.9
  • 39
    • 73449129321 scopus 로고    scopus 로고
    • Gestational protein restriction in mice has pronounced effects on gene expression in newborn offspring's liver and skeletal muscle; protective effect of taurine
    • Mortensen OH,Olsen HL,Frandsen L,Nielsen PE,Nielsen FC,Grunnet N,Quistorff B.Gestational protein restriction in mice has pronounced effects on gene expression in newborn offspring's liver and skeletal muscle; protective effect of taurine.Pediatr Res. 2010;67:47-53.
    • (2010) Pediatr Res , vol.67 , pp. 47-53
    • Mortensen, O.H.1    Olsen, H.L.2    Frandsen, L.3    Nielsen, P.E.4    Nielsen, F.C.5    Grunnet, N.6    Quistorff, B.7
  • 40
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S,Drinkgern J,Tiedge M.Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.Free Radic Biol Med. 1996;20:463-6.
    • (1996) Free Radic Biol Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 41
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
    • Tiedge M,Lortz S,Drinkgern J,Lenzen S.Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells.Diabetes. 1997;46:1733-42.
    • (1997) Diabetes , vol.46 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 42
    • 0036420517 scopus 로고    scopus 로고
    • How mitochondrial damage affects cell function
    • James AM,Murphy MP.How mitochondrial damage affects cell function.J Biomed Sci. 2002;9:475-87.
    • (2002) J Biomed Sci , vol.9 , pp. 475-487
    • James, A.M.1    Murphy, M.P.2
  • 44
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: a unifying mechanism
    • Brownlee M.The pathobiology of diabetic complications: a unifying mechanism.Diabetes. 2005;54:1615-25.
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 45
    • 23344432499 scopus 로고    scopus 로고
    • Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure
    • Simmons RA,Suponitsky-Kroyter I,Selak MA.Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure.J Biol Chem. 2005;280:28785-91.
    • (2005) J Biol Chem , vol.280 , pp. 28785-28791
    • Simmons, R.A.1    Suponitsky-Kroyter, I.2    Selak, M.A.3
  • 47
    • 34547572645 scopus 로고    scopus 로고
    • Nkx2.2 regulates beta-cell function in the mature islet
    • Doyle MJ,Sussel L.Nkx2.2 regulates beta-cell function in the mature islet.Diabetes. 2007;56:1999-2007.
    • (2007) Diabetes , vol.56 , pp. 1999-2007
    • Doyle, M.J.1    Sussel, L.2
  • 52
    • 0028889787 scopus 로고
    • Increased expression of a regenerating (reg) gene protein in neonatal rat pancreas treated with streptozotocin
    • Ohno T,Ishii C,Kato N,Ito Y,Shimizu M,Tomono S,Murata K,Kawazu S.Increased expression of a regenerating (reg) gene protein in neonatal rat pancreas treated with streptozotocin.Endocr J. 1995;42:649-53.
    • (1995) Endocr J , vol.42 , pp. 649-653
    • Ohno, T.1    Ishii, C.2    Kato, N.3    Ito, Y.4    Shimizu, M.5    Tomono, S.6    Murata, K.7    Kawazu, S.8
  • 56
    • 33745851489 scopus 로고    scopus 로고
    • Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas
    • Lu Y,Ponton A,Okamoto H,Takasawa S,Herrera PL,Liu JL.Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas.Am J Physiol Endocrinol Metab. 2006;291:E50-8.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Lu, Y.1    Ponton, A.2    Okamoto, H.3    Takasawa, S.4    Herrera, P.L.5    Liu, J.L.6
  • 58
    • 18244377210 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway
    • Moon RT.Wnt/beta-catenin pathway.Sci STKE. 2005;2005:cm1-cm1.
    • (2005) Sci STKE , vol.2005
    • Moon, R.T.1
  • 59
    • 0033995119 scopus 로고    scopus 로고
    • Proteolysis and the cell cycle: with this RING I do thee destroy
    • Tyers M,Jorgensen P.Proteolysis and the cell cycle: with this RING I do thee destroy.Curr Opin Genet Dev. 2000;10:54-64.
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 54-64
    • Tyers, M.1    Jorgensen, P.2
  • 61
    • 0036894357 scopus 로고    scopus 로고
    • Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice
    • Unno M,Nata K,Noguchi N,Narushima Y,Akiyama T,Ikeda T,Nakagawa K,Takasawa S,Okamoto H.Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice.Diabetes. 2002;51 Suppl 3:S478-83.
    • (2002) Diabetes , vol.51 , Issue.SUPPL.
    • Unno, M.1    Nata, K.2    Noguchi, N.3    Narushima, Y.4    Akiyama, T.5    Ikeda, T.6    Nakagawa, K.7    Takasawa, S.8    Okamoto, H.9
  • 62
    • 54549083394 scopus 로고    scopus 로고
    • Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells
    • Mueller CM,Zhang H,Zenilman ME.Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells.J Surg Res. 2008;150:137-43.
    • (2008) J Surg Res , vol.150 , pp. 137-143
    • Mueller, C.M.1    Zhang, H.2    Zenilman, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.