Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 356-364

  Samala, Ganesh ^a   Devi, Parthiban Brindha ^a   Nallangi, Radhika ^a   Yogeeswari, Perumal ^a   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Cytotoxicity; Pantothenate synthetase; Tuberculosis

Indexed keywords

3 PHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[4,3 C]PYRIDINE DERIVATIVE; ENZYME INHIBITOR; PANTOTHENATE SYNTHETASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS;

CYTOTOXICITY; PANTOTHENATE SYNTHETASE; TUBERCULOSIS;

ANIMALS; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MICE; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884662100     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.036     Document Type: Article

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