Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2195-2199

  Ye, Xiaocong M ^a   Konradi, Andrei W ^a   Smith, Jenifer ^a   Xu, Ying Zi ^a   Dressen, Darren ^a   Garofalo, Albert W ^a   Marugg, Jennifer ^a   Sham, Hing L ^a   Truong, Anh P ^a   Jagodzinski, Jacek ^a   Pleiss, Michael ^a   Zhang, Hongbin ^a   Goldbach, Erich ^a   Sauer, John Michael ^a   Brigham, Elizabeth ^a   Bova, Michael ^a   Basi, Guriqbal S ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

Secretase; Secretase inhibitor; Alzheimer's disease; Amyloid precursor protein

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE INHIBITOR; PIPERIDINE DERIVATIVE; SULFONAMIDE; SULFONAMIDE PYRAZOLOPIPERIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; HUMANS; MICE; MODELS, MOLECULAR; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 77949491712     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.039     Document Type: Article

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