Steady-State Metabolite Concentrations Reflect a Balance between Maximizing Enzyme Efficiency and Minimizing Total Metabolite Load

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Tepper, Naama ^a   Noor, Elad ^b   Amador Noguez, Daniel ^c   Haraldsdóttir, Hulda S ^d   Milo, Ron ^b   Rabinowitz, Josh ^c   Liebermeister, Wolfram ^e   Shlomi, Tomer ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c PRINCETON UNIVERSITY   (United States)

^d UNIVERSITY OF ICELAND   (Iceland)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME;

ARTICLE; BACTERIAL METABOLISM; CHEMICAL REACTION; CLOSTRIDIUM ACETOBUTYLICUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; ESCHERICHIA COLI; FLOW KINETICS; MATHEMATICAL COMPUTING; METABOLIC PARAMETERS; METABOLITE; METABOLITE CONCENTRATION; NONHUMAN; STEADY STATE; THERMODYNAMICS;

CLOSTRIDIUM ACETOBUTYLICUM; COMPUTATIONAL BIOLOGY; ENZYMES; ESCHERICHIA COLI; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; MODELS, BIOLOGICAL; THERMODYNAMICS;

EID: 84884659937     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075370     Document Type: Article

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