Dynamic whole-body PET parametric imaging: I. Concept, acquisition protocol optimization and clinical application

Physics in Medicine and Biology

Volumn 58, Issue 20, 2013, Pages 7391-7418

  Karakatsanis, Nicolas A ^a   Lodge, Martin A ^a   Tahari, Abdel K ^a   Zhou, Y ^a   Wahl, Richard L ^a   Rahmim, Arman ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUISITION PROTOCOLS; CLINICAL APPLICATION; CONTRAST TO NOISE RATIO; MONTE- CARLO SIMULATIONS; ORDINARY LEAST SQUARES; PHYSIOLOGICAL PARAMETERS; STANDARDIZED UPTAKE VALUES; TUMOR CHARACTERIZATION;

DIAGNOSIS; MONTE CARLO METHODS; POSITRON EMISSION TOMOGRAPHY; REGRESSION ANALYSIS; TUMORS;

PHYSIOLOGICAL MODELS;

ARTICLE; FOUR DIMENSIONAL COMPUTED TOMOGRAPHY; HUMAN; IMAGE PROCESSING; IMAGE QUALITY; METHODOLOGY; MONTE CARLO METHOD; POSITRON EMISSION TOMOGRAPHY; TIME; WHOLE BODY IMAGING; PROCEDURES;

FOUR-DIMENSIONAL COMPUTED TOMOGRAPHY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MONTE CARLO METHOD; PHANTOMS, IMAGING; POSITRON-EMISSION TOMOGRAPHY; TIME FACTORS; WHOLE BODY IMAGING;

EID: 84884634317     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/58/20/7391     Document Type: Article

References (87)

1. Adams M, Turkington T, Wilson J and Wong T 2010 A systematic review of the factors affecting accuracy of SUV measurements Am. J. Roentgenol. 195 310-20
2. Bergstorm M, Eriksson L, Bohn C, Blomqvist G and Litton J 1983 Correction for scattered radiation in a ring detector positron camera by integral transformation of the projections J. Comput. Assist. Tomogr. 7 42-50 (Pubitemid 13189434)
3. Burger I, Burger C, Berthold T and Buck A 2011 Simplified quantification of FDG metabolism in tumors using the autoradiographic method is less dependent on the acquisition time than SUV Nucl. Med. Biol. 38 835-41
4. Castell F and Cook G 2008 Quantitative techniques in 18-FDG PET scanning in oncology Br. J. Cancer 98 1597-601 (Pubitemid 351684676)
5. Catana C, Guimaraes A R and Rosen B R 2013 PET and MR imaging: the odd couple or a match made in heaven J. Nucl. Med. 54 815-24
6. Dahlbom M, Hoffman E, Hoh C, Schiepers C, Rosenqvist G, Hawkins R and Phelps M 1992 Whole-body positron emission tomography: part I. Methods and performance characteristics J. Nucl. Med. 33 1191-9 PMID: 1597738
7. Dimitrakopoulou-Strauss A, Georgoulias V, Eisenhut M, Herth F, Koukouraki S, Macke H, Haberkorn U and Strauss L 2006 Quantitative assessment of SSTR2 expression in patients with non-small cell lung cancer using 68 Ga-DOTATOC PET and comparison with 18 F-FDG PET Eur. J. Nucl. Med. Mol. Imaging 33 823-30 (Pubitemid 43979691)
8. Dimitrakopoulou-Strauss A, Strauss L G and Burger C 2001a Quantitative PET studies in pretreated melanoma patients: a comparison of 6-[18F] fluoro-L-dopa with 18F-FDG and 15O-water using compartment and noncompartment analysis J. Nucl. Med. 42 248-56 PMID: 11216523 (Pubitemid 32150515)
9. Dimitrakopoulou-Strauss A, Strauss L, Burger C, Ruhl A, Irngartinger G, Stremmel W and Rudi J 2004 Prognostic aspects of 18F-FDG PET kinetics in patients with metastatic colorectal carcinoma receiving FOLFOX chemotherapy J. Nucl. Med. 45 1480-7 PMID: 15347714 (Pubitemid 47618501)
10. Dimitrakopoulou-Strauss A, Strauss L, Schwarzbach M, Burger C, Heichel T, Willeke F, Mechtersheimer G and Lehnert T 2001b Dynamic PET 18F-FDG studies in patients with primary and recurrent soft-tissue sarcomas: impact on diagnosis and correlation with grading J. Nucl. Med. 42 713-20 PMID: 11337565 (Pubitemid 32453458)
11. Dinges J, Nekolla S G and Bundschuh R A 2013 Motion artifacts in oncological and cardiac PET imaging PET Clin. 8 1-9
12. Effron B and Tibshirani R J 1993 An Introduction to the Bootstrap (CRC Monographs on Statistics and Applied Probability vol 57) (New York: Chapman and Hall/CRC Press)
13. Erlandsson K, Buvat I, Pretorius P H, Thomas B A and Hutton B F 2012 A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology Phys. Med. Biol. 57 R119-59
14. Facey K, Bradbury I, Laking G and Payne E 2007 Overview of the clinical effectiveness of positron emission tomography imaging in selected cancers Health Technol. Assess. 11 44
15. Freedman N M, Sundaram S K, Kurdziel K, Carrasquillo J A, Whatley M, Carson J M, Sellers D, Libutti S K, Yang J C and Bacharach S L 2003 Comparison of SUV and Patlak slope for monitoring of cancer therapy using serial PET scans Eur. J. Nucl. Med. 30 46-53 (Pubitemid 36692892)
16. Galli G, Indovina L, Calcagni M L, Mansi L and Giordano A 2013 The quantification with FDG as seen by a physician Nucl. Med. Biol. 40 720-30
17. Gonias P et al 2007 Validation of a GATE model for the simulation of the Siemens biographTM 6 PET scanner Nucl. Instrum. Methods Phys. Res. A 571 263-6 (Pubitemid 46136609)
18. Guo N, Zhu Z, Zheng K, Xing H, Li F, Chen X and Li Q 2012 Multi-bed position dynamic imaging and kinetic analysis of 68Ga-NOTA-PRGD2 in lung cancer patients J. Nucl. Med. 53 1253
19. Halpern B S, Dahlbom M, Quon A, Schiepers C, Waldherr C, Silverman D H, Ratib O and Czernin J 2004 Impact of patient weight and emission scan duration on PET/CT image quality and lesion detectability J. Nucl. Med. 45 797-801 PMID: 15136629 (Pubitemid 47618559)
20. Hamberg L, Hunter G, Alpert N, Choi N, Babich J and Fischman A 1994 The dose uptake ratio as an index of glucose metabolism: useful parameter or oversimplification? J. Nucl. Med. 35 1308-12 PMID: 8046485 (Pubitemid 24243143)
21. Haynor D R and Woods S D 1989 Resampling estimates of precision in emission tomography IEEE Trans. Med. Imaging 8 337-43 (Pubitemid 20642537)
22. Hofmann M, Pichler B, Scholkopf B and Beyer T 2009 Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques Eur. J. Nucl. Med. Mol. Imaging 36 S93-104
23. Hoh C K, Levin C S and Vera D R 2003 Whole body Patlak imaging J. Nucl. Med. 44 61
24. Ho-Shon K, Feng D, Hawkins A R, Meikle S, Fulham M and Li X 1996 Optimized sampling and parameter estimation for quantification in whole body PET IEEE Trans. Biomed. Eng. 43 1021-8 (Pubitemid 26318243)
25. Huang S 2000 Anatomy of SUV Nucl. Med. Biol. 27 643-6
26. Huang S, Phelps M E, Hoffman E J, Sideris K, Selin C and Kuhl D E 1980 Noninvasive determination of local cerebral metabolic rate of glucose in man Am. J. Physiol. Endocrinol. Metab. 238 E69-82 PMID: 6965568
27. Hunter G J, Hamberg L M, Alpert N M, Choi N C and Fischman A J 1996 Simplified measurement of deoxyglucose utilization rate J. Nucl. Med. 37 950-5 PMID: 8683318 (Pubitemid 126447127)
28. Hustinx R, Benard F and Alavi A 2002 Whole-body FDG-PET imaging in the management of patients with cancer Semin. Nucl. Med. 32 35-46 (Pubitemid 34112941)
29. Iatrou M, Manjeshwar R M, Ross S G, Thielemans K and Stearns C W 2006 3D implementation of scatter estimation in 3D PET IEEE Nuclear Science Symp. Conf. Record pp 2142-5 (Pubitemid 351164705)
30. Iatrou M, Ross S G, Manjeshwar R M and Stearns C W 2004 A fully 3D iterative image reconstruction algorithm incorporating data corrections IEEE Nuclear Science Symp. Conf. Record pp 2493-7 (Pubitemid 41148079)
31. Jan S et al 2011 GATE V6: a major enhancement of the GATE simulation platform enabling modeling of CT and radiotherapy Phys. Med. Biol. 56 881
32. Judenhofer M S et al 2008 Simultaneous PET-MRI: a new approach for functional and morphological imaging Nature Med. 14 459-65 (Pubitemid 351499385)
33. Kaneta T et al 2007 Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia Ann. Nucl. Med. 21 101-7 (Pubitemid 46495609)
34. Karakatsanis N, Lodge M, Mohy-ud-Din H, Tahari A, Zhou Y, Segars W, Wahl R and Rahmim A 2012a Enhanced whole-body PET parametric imaging using hybrid regression and thresholding driven by kinetic correlations NSS/MIC'12: IEEE Nuclear Science Symp. Medical Imaging Conf. Record pp 4017-27
35. Karakatsanis N, Lodge M, Zhou Y, Wahl R L and Rahmim A 2013a Dynamic whole body PET parametric imaging: II. Task-oriented statistical estimation Phys. Med. Biol. 58 7419-45
36. Karakatsanis N, Lodge M, Wahl R L and Rahmim A 2013b Direct 4D whole-body PET/CT parametric image reconstruction: concept and comparison vs. indirect parametric imaging J. Nucl. Med. 54 2133
37. Karakatsanis N, Lodge M, Zhou Y, Mhlanga J, Tahari A, Chaudhry M, Segars W, Wahl R and Rahmim A 2011 Dynamic multi-bed FDG PET imaging: feasibility and optimization NSS/MIC'11: IEEE Nuclear Science Symp. Medical Imaging Conf. Record pp 3863-70
38. Karakatsanis N, Lodge M, Zhou Y, Mhlanga J, Tahari A, Wahl R and Rahmim A 2012b Towards parametric whole-body FDG PET/CT imaging: potentials for enhanced tumor detectability J. Nucl. Med. 53 1236
39. Karakatsanis N, Loudos G and Nikita K 2009 A methodology for optimizing the acquisition time of a clinical PET scan using GATE NSS/MIC'09: IEEE Nuclear Science Symp. Medical Imaging Conf. Record pp 2896-901
40. Karakatsanis N et al 2006 A comparative evaluation of two commercial PET scanners using GATE Nucl. Instrum. Methods Phys. Res. A 569 368-72 (Pubitemid 44820454)
41. Karakatsanis N, Zhou Y, Lodge M, Casey M E, Wahl R L and Rahmim A 2013c Quantitative whole-body parametric PET imaging incorporating a generalized Patlak model NSS/MIC'13: IEEE Nuclear Science Symp. Medical Imaging Conf. Record at press
42. Keyes J W Jr 1995 SUV: standard uptake or silly useless value? J. Nucl. Med. 36 1836-9 PMID: 7562051
43. Kim C K and Gupta N C 1996 Dependency of standardized uptake values of fluorine-18 fluorodeoxyglucose on body size: comparison of body surface area correction and lean body mass correction Nucl. Med. Commun. 17 890
44. Kim C K, Gupta N C, Chandramouli B and Alavi A 1994 Standardized uptake values of FDG: body surface area correction is preferable to body weight correction J. Nucl. Med. 35 164-7 PMID: 8271040 (Pubitemid 24018461)
45. Kubota K, Itoh M, Ozaki K, Ono S, Tashiro M, Yamaguchi K, Akaizawa T, Yamada K and Fukuda H 2001 Advantage of delayed wholebody FDG-PET imaging for tumour detection Eur. J. Nucl. Med. Mol. Imaging 28 696-703
46. Leskinen-Kallio S, Nagren K, Lehikoinen P, Ruotsalainen U, Teras M and Joensuu H 1992 Carbon-11-methionine and PET is an effective method to image head and neck cancer J. Nucl. Med. 33 691-5 PMID: 1569477
47. Moser E, Stadlbauer A, Windischberger C, Quick H and Ladd M E 2008 Magnetic resonance imaging methodology Eur. J. Nucl. Med. Mol. Imaging 36 S30-41
48. Nakamoto Y, Chin B B, Cohade C, Osman M, Tatsumi M and Wahl R L 2004 PET/CT artifacts caused by bowel motion Nucl. Med. Commun. 25 221-5 (Pubitemid 38393511)
49. Nehmeh S A 2013 Respiratory motion correction strategies in thoracic PET-CT imaging PET Clin. 8 29-36
50. Nekolla S G, Dinges J and Rischpler C 2013 Clinical impact of cardiac-gated PET imaging PET Clin. 8 69-79
51. Ng J, Azuma K, Kelley C, Pencek R, Radikova Z, Laymon C, Price J, Goodpaster B and Kelley D 2012 PET imaging reveals distinctive roles for different regional adipose tissue deposits in systemic glucose metabolism in nonobase humans Am. J. Physiol. Endocrinal. Metab. 303 E1134-41
52. Okazumi S, Dimitrakopoulou-Strauss A, Schwarzbach M H and Strauss L G 2009 Quantitative, dynamic 18F-FDG-PET for the evaluation of soft tissue sarcomas: relation to differential diagnosis, tumor grading and prediction of prognosis Hellenic J. Nucl. Med. 12 223-8 PMID: 19936332
53. Ollinger J M 1996 Model-based scatter correction for fully 3D PET Phys. Med. Biol. 41 153-76 (Pubitemid 26035737)
54. Patlak C and Blasberg R 1985 Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations J. Cereb. Blood Flow Metab. 5 584-90 (Pubitemid 16218234)
55. Patlak C, Blasberg R and Fenstermacher J 1983 Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data J. Cereb. Blood Flow Metab. 3 1-7 (Pubitemid 13129630)
56. Pichler B J, Kolb A, Nagele T and Schlemmer H P 2010 PET/MRI: paving the way for the next generation of clinical multimodality imaging applications J. Nucl. Med. 51 333-6
57. Qiao H, Bai J, Chen Y and Tian J 2007 Kidney modeling for FDG excretion with PET Int. J. Biomed. Imaging 2007 632-4 (Pubitemid 47116868)
58. Rahmim A, Tang J and Zaidi H 2013 Four-dimensional image reconstruction strategies in cardiac-gated and respiratory-gated PET imaging PET Clin. 8 51-67
59. Rousset O, Rahmim A, Alavi A and Zaidi H 2007 Partial volume correction strategies in PET PET Clin. 2 235-49
60. Sadato N, Tsuchida T, Nakaumra S, Waki A, Uematsu H, Takahashi N, Hayashi N, Yonekura Y and Ishii Y 1998 Non-invasive estimation of the net influx constant using the standardized uptake value for quantification of FDG uptake of tumours Eur. J. Nucl. Med. Mol. Imaging 25 559-64 (Pubitemid 28297829)
61. Sakellios N, Rubio J L, Karakatsanis N, Kontaxakis G, Loudos G, Santos A, Nikita K S and Majewski S 2006 GATE simulations for small animal SPECT/PET using voxelized phantoms and rotating-head detectors NSS/MIC'06: IEEE Nuclear Science Symp. Medical Imaging Conf. vol 4 pp 2000-3 (Pubitemid 351164672)
62. Seemann M D 2005 Whole-body PET/MRI: the future in oncological imaging Technol. Cancer Res. Treat. 4 577-82 PMID: 16173829 (Pubitemid 41446811)
63. Segars W, Sturgeon G, Mendonca S, Grimes J and Tsui B 2010 4D XCAT phantom for multimodality imaging research J. Med. Phys. 37 4902
64. Sokoloff L, Reivich M, Kennedy C, Des Rosiers M H, Patlak C S, Pettigrew K D, Sakurada O and Shinohara M 1977 The (C-14) deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat J. Neurochem. 28 897-916 (Pubitemid 8098854)
65. Soret M, Bacharach S and Buvat I 2007 Partial volume effect in PET tumor imaging J. Nucl. Med. 48 932-45 (Pubitemid 46909922)
66. Spinks T J and Bastin J E 2008 Quantitative accuracy in cardiac studies with the GE discovery RX PET/CT scanner IEEE Nuclear Science Symp. Conf. Record pp 3697-701
67. Strauss L, Klippel S, Pan L, Schonleben K, Haberkorn U and Dimitrakopoulou-Strauss A 2007 Assessment of quantitative FDG PET data in primary colorectal tumors: which parameters are important with respect to tumor detection? Eur. J. Nucl. Med. Mol. Imaging 34 868-77 (Pubitemid 46798955)
68. Strauss L, Koczan D, Klippel S, Pan L, Cheng C, Willis S, Haberkorn U and Dimitrakopoulou-Strauss A 2008 Impact of angiogenesis-related gene expression on the tracer kinetics of 18F-FDG in colorectal tumors J. Nucl. Med. 49 1238-44
69. Strother S C, Casey M E and Hoffman E J 1990 Measuring PET scanner sensitivity: relating countrates to image signal-to-noise ratios using equivalents counts IEEE Trans. Nucl. Sci. 37 783-8 (Pubitemid 20713969)
70. Sugawara Y, Zasadny K R, Grossman H B, Francis I R, Clarke M F and Wahl R L 1999 Germ cell tumor: differentiation of viable tumor, mature teratoma, and necrotic tissue with FDG PET and kinetic modeling Radiology 211 249-56 PMID: 10189480 (Pubitemid 29161760)
71. Sundaram S K, Freedman N M T, Carrasquillo J A, Carson J M, Whatley M, Libutti S K, Sellers D and Bacharach S L 2004 Simplified kinetic analysis of tumor 18F-FDG uptake: a dynamic approach J. Nucl. Med. 45 1328-33 (Pubitemid 47618531)
72. Tang J, Kuwabara H, Wong D F and Rahmim A 2010 Direct 4D reconstruction of parametric images incorporating anato-functional joint entropy Phys. Med. Biol. 55 4261-72
73. Thielemans K, Tsoumpas C, Mustafovic S, Beisel T, Aguiar P, Dikaios N and Jacobson M W 2012 STIR: software for tomographic image reconstruction release 2 Phys. Med. Biol. 57 867
74. Torizuka T, Tamaki N, Inokuma T, Magata Y, Sasayama S, Yonekura Y, Tanaka A, Yamaoka Y, Yamamoto K and Konishi J 1995 In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDG-PET J. Nucl. Med. 36 1811-7 PMID: 7562048
75. Townsend D 2008 Positron emission tomography/computed tomography Semin. Nucl. Med. 38 152-66 (Pubitemid 351466916)
76. Tsoumpas C, Turkheimer F and Thielemans K 2008 Study of the direct and indirect parametric estimation methods of linear models in dynamic positron emission tomography Med. Phys. 35 1299 (Pubitemid 351457497)
77. Wahl R L and Buchanan J W 2002 Principles and Practice of Positron Emission Tomography (Philadelphia, PA: Lippincott Williams & Wilkins)
78. Wahl R L, Jacene H, Kasamon Y and Lodge M A 2009 From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors J. Nucl. Med. 50 122S-50S
79. Wang G, Fu L and Qi J 2008 Maximum a posteriori reconstruction of the Patlak parametric image from sinograms in dynamic PET Phys. Med. Biol. 53 593-604 (Pubitemid 351496207)
80. Wang G and Qi J 2010 Acceleration of the direct reconstruction of linear parametric images using nested algorithms Phys. Med. Biol. 55 1505-17
81. Weber W A, Ziegler S I, Thödtmann R, Hanauske A R and Schwaiger M 1999 Reproducibility of metabolic measurements in malignant tumors using FDG PET J. Nucl. Med. 40 1771-7 PMID: 10565769 (Pubitemid 29523568)
82. Wollenweber S D 2002 Parameterization of a model-based 3-D PET scatter correction IEEE Trans. Nucl. Sci. 49 722-7 (Pubitemid 35311892)
83. Wong W H and Hicks K 1994 A clinically practical method to acquire parametric images of unidirectional metabolic rates and blood spaces J. Nucl. Med. 35 1206-12 PMID: 8014684 (Pubitemid 24204125)
84. Zasadny K R and Wahl R L 1993 Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction Radiology 189 847-50 PMID: 8234714 (Pubitemid 23354506)
85. Zasadny K R and Wahl R L 1996 Enhanced FDG-PET tumor imaging with correlation-coefficient filtered influx-constant images J. Nucl. Med. 37 371-4 PMID: 8667078 (Pubitemid 26150918)
86. Zhou Y, Rahmim A, Lodge M, Jacene H, Pili R, Wong D F and Wahl R L 2010a Feasibility of parametric imaging in multi-bed dynamic human FDG PET J. Nucl. Med. 51 127
87. Zhou Y, Ye W, Brasic J and Wong D 2010b Multi-graphical analysis of dynamic PET Neuroimage 49 2947-57