Initial evaluation of dynamic human imaging using18F-FRP170 as a new PET tracer for imaging hypoxia

Annals of Nuclear Medicine

Volumn 21, Issue 2, 2007, Pages 101-107

  Kaneta, Tomohiro ^a   Takai, Yoshihiro ^a   Iwata, Ren ^a   Hakamatsuka, Takashi ^a   Yasuda, Hiroyasu ^a   Nakayama, Katsutoshi ^a   Ishikawa, Yoichi ^a   Watanuki, Shoichi ^a   Furumoto, Shozo ^a   Funaki, Yoshihito ^a   Nakata, Eiko ^a   Jingu, Keiichi ^a   Tsujitani, Michihiko ^b   Ito, Masatoshi ^a   Fukuda, Hiroshi ^a   Takahashi, Shoki ^a   Yamada, Shogo ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b POLA CHEMICAL INDUSTRIES INC   (Japan)

Author keywords

FRP170; Hypoxia; Nitroimidazole; PET; RP170

Indexed keywords

1 [2 FLUORO 1 (HYDROXYMETHYL)ETHOXY]METHYL 2 NITROIMIDAZOLE F 18; 2 (2 NITRO 1 IMIDAZOLYLMETHOXY) 1,3 PROPANEDIOL; FLUORINE 18; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; DRUG DISTRIBUTION; HUMAN; HYPOXIA; IMAGING; LUNG CANCER; MALE; PRIORITY JOURNAL; WHOLE BODY IMAGING;

EID: 33947666080     PISSN: 09147187     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033987     Document Type: Article

References (21)

1. Nunn A, Linder K, Strauss HW. Nitroimidazoles and imaging hypoxia. Eur J Nucl Med 1995; 22: 265-280.
2. Chapman JD, Franko AJ, Sharplin J. A marker for hypoxic cells in tumours with potential clinical applicability. Br J Cancer 1981; 43: 546-550.
3. Koh WJ, Bergman KS, Rasey JS, Peterson LM, Evans ML, Graham MM, et al. Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography. Int J Radiat Oncol Biol Phys 1995; 33: 391-398.
4. 18F]fluoromisonidazole: a pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys 1996; 36: 417-428.
5. Sasai K, Shibamoto Y, Takahashi M, Abe M, Wang J, Zhou L, et al. A new, potent 2-nitroimidazole nucleoside hypoxic cell radiosensitizer, RP170. Jpn J Cancer Res 1989; 80: 1113-1118.
6. Murayama C, Suzuki A, Sato C, Tanabe Y, Miyata Y, Shoji T, et al. Radiosensitization by 2-nitroimidazole nucleoside analog RP-170: radiosensitizing effects under both intravenous and oral administration. Int J Radiat Oncol Biol Phys 1992; 22: 557-560.
7. Murayama C, Suzuki A, Suzuki T, Miyata Y, Sakaguchi M, Tanabe Y, et al. Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl) ethoxy]methyl-2-nitroimidazole (RP-170). Int J Radiat Oncol Biol Phys 1989; 17: 575-581.
8. Yang DJ, Wallace S, Cherif A, Li C, Gretzer MB, Kim EE, et al. Development of F-18-labeled fluoroerythronitroimidazole as a PET agent for imaging tumor hypoxia. Radiology 1995; 194: 795-800.
9. 18F]FENI), a potential agent for imaging hypoxic tissues by PET. J Label Compd Radiopharm 2000; 43: 785-793.
10. 18F-FRP170. J Nucl Med 2002; 43: 109-116.
11. Fujiwara T, Watanuki S, Yamamoto S, Miyake M, Seo S, Itoh M, et al. Performance evaluation of a large axial field-of-view PET scanner: SET-2400W. Ann Nucl Med 1997; 11: 307-313.
12. Brown JM, Workman P. Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole. Radiat Res 1980; 82: 171-190.
13. 18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography. Br J Cancer 2004; 90: 2232-2242.
14. 18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia. J Nucl Med 1999; 40: 1072-1079.
15. 3H-labelling and preliminary biological evaluation of a novel 2-nitroimidazole marker of tissue hypoxia. J Label Compd Radiopharm 1999; 42: 3-16.
16. 18F-fluoroazomycin arabinoside. J Nucl Med 2005; 46: 106-113.
17. 18F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy. J Nucl Med 2005; 46: 253-260.
18. Lehtio K, Eskola O, Viljanen T, Oikonen V, Gronroos T, Sillanmaki L, et al. Imaging perfusion and hypoxia with PET to predict radiotherapy response in head-and-neck cancer. Int J Radiat Oncol Biol Phys 2004; 59: 971-982.
19. 18F]FRP-170 injection for imaging hypoxia by PET]. KAKU IGAKU (Jpn J Nucl Med) 2005; 42: 1-10.
20. Graziano MJ, Henck JW, Meierhenry EF, Gough AW. Neurotoxicity of misonidazole in rats following intravenous administration. Pharmacol Res 1996; 33: 307-318.
21. 18)F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression. Eur J Nucl Med Mol Imaging 2003; 30: 695-704.