Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis

Toxicological Sciences

Volumn 68, Issue 1, 2002, Pages 51-58

  Watson, Rebecca E ^a   Goodman, Jay I ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

B6C3F1; C3H He; C57BL 6; Carcinogenesis; CpG islands; DNA methylation; GC rich regions; Liver; Non CpG methylation; Phenobarbital; Susceptibility; Tumorigenesis

Indexed keywords

CARCINOGEN; CYSTEINE; CYTOSINE; DNA; DNA METHYLTRANSFERASE; DRINKING WATER; GUANINE; PHENOBARBITAL; PRIMER DNA; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE; GUANOSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; CPG ISLAND; DNA METHYLATION; DNA STRUCTURE; GC RICH SEQUENCE; GENE AMPLIFICATION; GENE EXPRESSION; GENOTOXICITY; HYPOTHESIS; LIVER TUMOR; MALE; MOLECULAR RECOGNITION; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEIC ACID ANALYSIS; POLYMERASE CHAIN REACTION; PROTEIN DEGRADATION; REGULATORY MECHANISM; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; TUMOR PROMOTION; ANIMAL; C3H MOUSE; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; COCARCINOGENESIS; COMPARATIVE STUDY; DRUG EFFECT; GENETIC PREDISPOSITION; GENETICS; LIVER; RAT; SPECIES DIFFERENCE;

ANIMAL; CARCINOGENS; COCARCINOGENESIS; COMPARATIVE STUDY; CYTOSINE; DNA; DNA METHYLATION; GENETIC PREDISPOSITION TO DISEASE; GUANOSINE; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PHENOBARBITAL; POLYMERASE CHAIN REACTION; RATS; SPECIES SPECIFICITY; ANIMALS;

ANIMALIA; RODENTIA;

EID: 0035996058     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/68.1.51     Document Type: Article

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