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Volumn 223, Issue 1, 2013, Pages 81-87

Genotoxicity evaluation of individual cigarette smoke toxicants using the in vitro γH2AX assay by High Content Screening

Author keywords

H2AX; Cigarette smoke; Genotoxicity; In vitro; Tobacco regulation

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; BENZO[A]PYRENE; CADMIUM CHLORIDE; CIGARETTE SMOKE; GAMMAH2AX PROTEIN; HISTONE H2AX; NITROSONORNICOTINE; TOBACCO SMOKE; UNCLASSIFIED DRUG;

EID: 84884584271     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.08.024     Document Type: Article
Times cited : (14)

References (50)
  • 1
    • 77955583308 scopus 로고    scopus 로고
    • The critical DNA damage by benzo(a)pyrene in lung tissues of smokers and approaches to preventing its formation
    • Alexandrov K., Rojas M., Satarug S. The critical DNA damage by benzo(a)pyrene in lung tissues of smokers and approaches to preventing its formation. Toxicol. Lett. 2010, 198:63-68.
    • (2010) Toxicol. Lett. , vol.198 , pp. 63-68
    • Alexandrov, K.1    Rojas, M.2    Satarug, S.3
  • 3
    • 77957946614 scopus 로고    scopus 로고
    • Use of the gammaH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines
    • Audebert M., Riu A., Jacques C., Hillenweck A., Jamin E.L., Zalko D., Cravedi J.P. Use of the gammaH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines. Toxicol. Lett. 2010, 199:182-192.
    • (2010) Toxicol. Lett. , vol.199 , pp. 182-192
    • Audebert, M.1    Riu, A.2    Jacques, C.3    Hillenweck, A.4    Jamin, E.L.5    Zalko, D.6    Cravedi, J.P.7
  • 4
    • 0038278508 scopus 로고    scopus 로고
    • An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
    • Brandon E.F., Raap C.D., Meijerman I., Beijnen J.H., Schellens J.H. An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicol. Appl. Pharmacol. 2003, 189:233-246.
    • (2003) Toxicol. Appl. Pharmacol. , vol.189 , pp. 233-246
    • Brandon, E.F.1    Raap, C.D.2    Meijerman, I.3    Beijnen, J.H.4    Schellens, J.H.5
  • 6
    • 80053564797 scopus 로고    scopus 로고
    • A novel application of the margin of exposure approach: segregation of tobacco smoke toxicants
    • Cunningham F.H., Fiebelkorn S., Johnson M., Meredith C. A novel application of the margin of exposure approach: segregation of tobacco smoke toxicants. Food Chem. Toxicol. 2011, 49:2921-2933.
    • (2011) Food Chem. Toxicol. , vol.49 , pp. 2921-2933
    • Cunningham, F.H.1    Fiebelkorn, S.2    Johnson, M.3    Meredith, C.4
  • 7
    • 84871191384 scopus 로고    scopus 로고
    • DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis
    • Darzynkiewicz Z., Zhao H., Halicka H.D., Rybak P., Dobrucki J., Wlodkowic D. DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis. Crit. Rev. Clin. Lab. Sci. 2012, 49:199-217.
    • (2012) Crit. Rev. Clin. Lab. Sci. , vol.49 , pp. 199-217
    • Darzynkiewicz, Z.1    Zhao, H.2    Halicka, H.D.3    Rybak, P.4    Dobrucki, J.5    Wlodkowic, D.6
  • 8
    • 0035897708 scopus 로고    scopus 로고
    • A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation
    • Easterbrook J., Fackett D., Li A.P. A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation. Chem. Biol. Interact. 2001, 134:243-249.
    • (2001) Chem. Biol. Interact. , vol.134 , pp. 243-249
    • Easterbrook, J.1    Fackett, D.2    Li, A.P.3
  • 11
  • 12
    • 77958111676 scopus 로고    scopus 로고
    • Cadmium chloride, benzo[a]pyrene and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Covance laboratories, Harrogate UK in support of OECD draft Test Guideline 487
    • Fowler P., Whitwell J., Jeffrey L., Young J., Smith K., Kirkland D. Cadmium chloride, benzo[a]pyrene and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Covance laboratories, Harrogate UK in support of OECD draft Test Guideline 487. Mutat. Res. 2010, 702:171-174.
    • (2010) Mutat. Res. , vol.702 , pp. 171-174
    • Fowler, P.1    Whitwell, J.2    Jeffrey, L.3    Young, J.4    Smith, K.5    Kirkland, D.6
  • 13
    • 4143062086 scopus 로고    scopus 로고
    • Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke
    • Fowles J., Dybing E. Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob. Control 2003, 12:424-430.
    • (2003) Tob. Control , vol.12 , pp. 424-430
    • Fowles, J.1    Dybing, E.2
  • 14
    • 84866042698 scopus 로고    scopus 로고
    • GammaH2AX as a novel endpoint to detect DNA damage: Applications for the assessment of the in vitro genotoxicity of cigarette smoke
    • Garcia-Canton C., Anadon A., Meredith C. gammaH2AX as a novel endpoint to detect DNA damage: Applications for the assessment of the in vitro genotoxicity of cigarette smoke. Toxicol. In Vitro 2012, 26:1075-1086.
    • (2012) Toxicol. In Vitro , vol.26 , pp. 1075-1086
    • Garcia-Canton, C.1    Anadon, A.2    Meredith, C.3
  • 15
    • 84878473901 scopus 로고    scopus 로고
    • Metabolic characterization of cell systems used in in vitro toxicology testing: lung cell system BEAS-2B as a working example
    • Garcia-Canton C., Minet E., Anadon A., Meredith C. Metabolic characterization of cell systems used in in vitro toxicology testing: lung cell system BEAS-2B as a working example. Toxicol. In Vitro 2013, 27:1719-1727.
    • (2013) Toxicol. In Vitro , vol.27 , pp. 1719-1727
    • Garcia-Canton, C.1    Minet, E.2    Anadon, A.3    Meredith, C.4
  • 16
    • 84885869334 scopus 로고    scopus 로고
    • Assessment of the in vitro γH2AX assay by High Content Screening as a novel genotoxicity test
    • (in press)
    • Garcia-Canton C., Anadon A., Meredith C. Assessment of the in vitro γH2AX assay by High Content Screening as a novel genotoxicity test. Mutat. Res. 2013, (in press). 10.1016/j.mrgentox.2013.08.002.
    • (2013) Mutat. Res.
    • Garcia-Canton, C.1    Anadon, A.2    Meredith, C.3
  • 17
    • 0031010463 scopus 로고    scopus 로고
    • Use of bronchial epithelial cells expressing human cytochrome P450 for study on metabolism and genotoxicity of ochratoxin A
    • Grosse Y., Monje M.C., Mace K., Pfeifer A.M., Pfohl-leszkowicz A. Use of bronchial epithelial cells expressing human cytochrome P450 for study on metabolism and genotoxicity of ochratoxin A. In Vitro Toxicol. 1997, 10:93-102.
    • (1997) In Vitro Toxicol. , vol.10 , pp. 93-102
    • Grosse, Y.1    Monje, M.C.2    Mace, K.3    Pfeifer, A.M.4    Pfohl-leszkowicz, A.5
  • 18
    • 78349306291 scopus 로고    scopus 로고
    • Mechanisms in cadmium-induced carcinogenicity: recent insights
    • Hartwig A. Mechanisms in cadmium-induced carcinogenicity: recent insights. Biometals 2010, 23:951-960.
    • (2010) Biometals , vol.23 , pp. 951-960
    • Hartwig, A.1
  • 19
    • 0033535375 scopus 로고    scopus 로고
    • DNA adduct formation from tobacco-specific N-nitrosamines
    • Hecht S.S. DNA adduct formation from tobacco-specific N-nitrosamines. Mutat. Res. 1999, 424:127-142.
    • (1999) Mutat. Res. , vol.424 , pp. 127-142
    • Hecht, S.S.1
  • 20
    • 0002382629 scopus 로고    scopus 로고
    • Nitrosamines derived from nicotine and other tobacco alkaloids
    • Elsevier Science, Amsterdam, (Chapter 11), W.G. John, I.I.I. Peyton Jacob (Eds.)
    • Hecht S.S., Tricker A.R. Nitrosamines derived from nicotine and other tobacco alkaloids. Analytical Determination of Nicotine and Related Compounds and their Metabolites 1999, 421-488. Elsevier Science, Amsterdam, (Chapter 11). W.G. John, I.I.I. Peyton Jacob (Eds.).
    • (1999) Analytical Determination of Nicotine and Related Compounds and their Metabolites , pp. 421-488
    • Hecht, S.S.1    Tricker, A.R.2
  • 21
    • 84884551632 scopus 로고    scopus 로고
    • IARC,. IARC monographs on the evaluation of carcinogenic risk to humans. A review of human carcinogens: chemical agents and related occupations. Benzo[a]pyrene. 100F.
    • IARC, 2012a. IARC monographs on the evaluation of carcinogenic risk to humans. A review of human carcinogens: chemical agents and related occupations. Benzo[a]pyrene. 100F.
    • (2012)
  • 22
    • 84884571079 scopus 로고    scopus 로고
    • IARC. IARC monographs on the evaluation of carcinogenic risks to humans. A review of human carcinogens: personal habits and indoor combustions. N'-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). International Agency for Research on Cancer. 100E.
    • IARC, 2012b. IARC monographs on the evaluation of carcinogenic risks to humans. A review of human carcinogens: personal habits and indoor combustions. N'-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). International Agency for Research on Cancer. 100E.
    • (2012)
  • 23
    • 84884537630 scopus 로고    scopus 로고
    • IARC. IARC monographs on the evaluation of carcinogenic risk to humans. A review of human carcinogens: carcinogenic metals, arsenic, fibres and dust. Cadmium and Cadmium Compounds. 100C.
    • IARC, 2012c. IARC monographs on the evaluation of carcinogenic risk to humans. A review of human carcinogens: carcinogenic metals, arsenic, fibres and dust. Cadmium and Cadmium Compounds. 100C.
    • (2012)
  • 24
    • 84884553920 scopus 로고    scopus 로고
    • IARC, (accessed June 2013)
    • IARC TP53 Database 2013, http://p53.iarc.fr/ (accessed June 2013).
    • (2013) TP53 Database
  • 25
    • 84884546047 scopus 로고    scopus 로고
    • ICH. Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use S2(R1).
    • ICH, 2011. Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use S2(R1). http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S2_R1/Step4/S2R1_Step4.pdf.
    • (2011)
  • 28
    • 0025317906 scopus 로고
    • Metabolism and DNA single strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its analogues in primary culture of rat hepatocytes
    • Liu L.L., Alaoui-Jamali M.A., el A.N., Castonguay A. Metabolism and DNA single strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its analogues in primary culture of rat hepatocytes. Cancer Res. 1990, 50:1810-1816.
    • (1990) Cancer Res. , vol.50 , pp. 1810-1816
    • Liu, L.L.1    Alaoui-Jamali, M.A.2    el, A.N.3    Castonguay, A.4
  • 29
    • 33745793905 scopus 로고    scopus 로고
    • Cadmium concentration in tobacco (Nicotiana tabacum L.) from different countries and its relationship with other elements
    • Lugon-Moulin N., Martin F., Krauss M.R., Ramey P.B., Rossi L. Cadmium concentration in tobacco (Nicotiana tabacum L.) from different countries and its relationship with other elements. Chemosphere 2006, 63:1074-1086.
    • (2006) Chemosphere , vol.63 , pp. 1074-1086
    • Lugon-Moulin, N.1    Martin, F.2    Krauss, M.R.3    Ramey, P.B.4    Rossi, L.5
  • 30
    • 0027299878 scopus 로고
    • The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens
    • Lynch A.M., Parry J.M. The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens. Mutat. Res. 1993, 287:71-86.
    • (1993) Mutat. Res. , vol.287 , pp. 71-86
    • Lynch, A.M.1    Parry, J.M.2
  • 32
    • 0001285525 scopus 로고    scopus 로고
    • Drug metabolism and carcinogen activation studies with human genetically engineered cells
    • Academic Press, London, J.V. Castell, M.J. Gomez-Lechon (Eds.)
    • Mace K., Offord E.A., Pfeifer A.M.A. Drug metabolism and carcinogen activation studies with human genetically engineered cells. In Vitro Methods in Pharmaceutical Research 1997, 433-456. Academic Press, London. J.V. Castell, M.J. Gomez-Lechon (Eds.).
    • (1997) In Vitro Methods in Pharmaceutical Research , pp. 433-456
    • Mace, K.1    Offord, E.A.2    Pfeifer, A.M.A.3
  • 34
    • 78751566518 scopus 로고    scopus 로고
    • Short tandem repeat profiling: part of an overall strategy for reducing the frequency of cell misidentification
    • Nims R.W., Sykes G., Cottrill K., Ikonomi P., Elmore E. Short tandem repeat profiling: part of an overall strategy for reducing the frequency of cell misidentification. In Vitro Cell Dev. Biol. Anim. 2010, 46:811-819.
    • (2010) In Vitro Cell Dev. Biol. Anim. , vol.46 , pp. 811-819
    • Nims, R.W.1    Sykes, G.2    Cottrill, K.3    Ikonomi, P.4    Elmore, E.5
  • 35
    • 79960819794 scopus 로고    scopus 로고
    • The complexity of tobacco and tobacco smoke
    • Perfetti T.A., Rodgman A. The complexity of tobacco and tobacco smoke. Contrib. Tob. Res. 2011, 24:215-232.
    • (2011) Contrib. Tob. Res. , vol.24 , pp. 215-232
    • Perfetti, T.A.1    Rodgman, A.2
  • 37
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
    • Petitjean A., Mathe E., Kato S., Ishioka C., Tavtigian S.V., Hainaut P., Olivier M. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum. Mutat. 2007, 28:622-629.
    • (2007) Hum. Mutat. , vol.28 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3    Ishioka, C.4    Tavtigian, S.V.5    Hainaut, P.6    Olivier, M.7
  • 38
    • 0023944920 scopus 로고
    • Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes
    • Reddel R.R., Ke Y., Gerwin B.I., McMenamin M.G., Lechner J.F., Su R.T., Brash D.E., Park J.B., Rhim J.S., Harris C.C. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 1988, 48:1904-1909.
    • (1988) Cancer Res. , vol.48 , pp. 1904-1909
    • Reddel, R.R.1    Ke, Y.2    Gerwin, B.I.3    McMenamin, M.G.4    Lechner, J.F.5    Su, R.T.6    Brash, D.E.7    Park, J.B.8    Rhim, J.S.9    Harris, C.C.10
  • 39
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 40
    • 0036053805 scopus 로고    scopus 로고
    • Implementation of the 3Rs (refinement, reduction, and replacement): validation and regulatory acceptance considerations for alternative toxicological test methods
    • Schechtman L.M. Implementation of the 3Rs (refinement, reduction, and replacement): validation and regulatory acceptance considerations for alternative toxicological test methods. ILAR J. 2002, 43(Suppl.):S85-S94.
    • (2002) ILAR J. , vol.43 , Issue.SUPPL.
    • Schechtman, L.M.1
  • 41
    • 0035916368 scopus 로고    scopus 로고
    • Genotoxic ability of cadmium, chromium and nickel salts studied by kinetochore staining in the cytokinesis-blocked micronucleus assay
    • Seoane A.I., Dulout F.N. Genotoxic ability of cadmium, chromium and nickel salts studied by kinetochore staining in the cytokinesis-blocked micronucleus assay. Mutat. Res. 2001, 490:99-106.
    • (2001) Mutat. Res. , vol.490 , pp. 99-106
    • Seoane, A.I.1    Dulout, F.N.2
  • 42
    • 80052632678 scopus 로고    scopus 로고
    • Genotoxicity screening via the gammaH2AX by flow assay
    • Smart D.J., Ahmedi K.P., Harvey J.S., Lynch A.M. Genotoxicity screening via the gammaH2AX by flow assay. Mutat. Res. 2011, 715:25-31.
    • (2011) Mutat. Res. , vol.715 , pp. 25-31
    • Smart, D.J.1    Ahmedi, K.P.2    Harvey, J.S.3    Lynch, A.M.4
  • 43
    • 0034665139 scopus 로고    scopus 로고
    • Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Su T., Bao Z., Zhang Q.Y., Smith T.J., Hong J.Y., Ding X. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 2000, 60:5074-5079.
    • (2000) Cancer Res. , vol.60 , pp. 5074-5079
    • Su, T.1    Bao, Z.2    Zhang, Q.Y.3    Smith, T.J.4    Hong, J.Y.5    Ding, X.6
  • 44
    • 75749130671 scopus 로고    scopus 로고
    • Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks
    • Svetlova M.P., Solovjeva L.V., Tomilin N.V. Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks. Mutat. Res. 2010, 685:54-60.
    • (2010) Mutat. Res. , vol.685 , pp. 54-60
    • Svetlova, M.P.1    Solovjeva, L.V.2    Tomilin, N.V.3
  • 45
    • 77956029024 scopus 로고    scopus 로고
    • A personal perspective on high-content screening (HCS): from the beginning
    • Taylor D.L. A personal perspective on high-content screening (HCS): from the beginning. J. Biomol. Screen. 2010, 15:720-725.
    • (2010) J. Biomol. Screen. , vol.15 , pp. 720-725
    • Taylor, D.L.1
  • 46
    • 0142219722 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of cadmium carcinogenesis
    • Waisberg M., Joseph P., Hale B., Beyersmann D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003, 192:95-117.
    • (2003) Toxicology , vol.192 , pp. 95-117
    • Waisberg, M.1    Joseph, P.2    Hale, B.3    Beyersmann, D.4
  • 47
    • 0018290965 scopus 로고
    • Mutagenic effects of cadmium on mammalian oocyte chromosomes
    • Watanabe T., Shimada T., Endo A. Mutagenic effects of cadmium on mammalian oocyte chromosomes. Mutat. Res. 1979, 67:349-356.
    • (1979) Mutat. Res. , vol.67 , pp. 349-356
    • Watanabe, T.1    Shimada, T.2    Endo, A.3
  • 49
    • 84884586031 scopus 로고    scopus 로고
    • WHO. The Scientific Basis of Tobacco Product Regulation. WHO Technical Report Series, no. 951.
    • WHO, 2008. The Scientific Basis of Tobacco Product Regulation. WHO Technical Report Series, no. 951. http://www.who.int/tobacco/global_interaction/tobreg/publications/9789241209519.pdf.
    • (2008)
  • 50
    • 35548981393 scopus 로고    scopus 로고
    • CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Zhang X., D'Agostino J., Wu H., Zhang Q.Y., von W.L., Murphy S.E., Ding X. CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. J. Pharmacol. Exp. Ther. 2007, 323:570-578.
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , pp. 570-578
    • Zhang, X.1    D'Agostino, J.2    Wu, H.3    Zhang, Q.Y.4    von, W.L.5    Murphy, S.E.6    Ding, X.7


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