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Volumn 13, Issue 5, 2013, Pages 651-656

Is autoimmunity or insulin resistance the primary driver of type 1 diabetes?

Author keywords

Accelerator hypothesis; Autoimmunity; Insulin resistance; Pathophysiology; T1D; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; HLA ANTIGEN; INSULIN;

EID: 84884578219     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-013-0407-7     Document Type: Article
Times cited : (16)

References (50)
  • 1
    • 50249216083 scopus 로고
    • Diabetes mellitus: Its differentiation into insulin-sensitive and insulin-insensitive types
    • 10.1016/S0140-6736(01)36134-2
    • Himsworth HP. Diabetes mellitus: Its differentiation into insulin-sensitive and insulin-insensitive types. Lancet. 1936;I:127-30.
    • (1936) Lancet , vol.1 , pp. 127-130
    • Himsworth, H.P.1
  • 2
    • 0001730479 scopus 로고
    • Insulin sensitive and insulin-insensitive types of diabetes mellitus
    • 1:CAS:528:DyaH3cXjtFCitg%3D%3D
    • Himsworth HP, Kerr RB. Insulin sensitive and insulin-insensitive types of diabetes mellitus. Clin Sci. 1939;4:119-52.
    • (1939) Clin Sci , vol.4 , pp. 119-152
    • Himsworth, H.P.1    Kerr, R.B.2
  • 3
    • 0014154256 scopus 로고
    • Insulin sensitivity and 131l-insulin metabolism in juvenile-type diabetics
    • Martin FIR, Stocks AE. Insulin sensitivity and 131l-insulin metabolism in juvenile-type diabetics. Aust Ann Med. 1967;76:289-96.
    • (1967) Aust Ann Med. , vol.76 , pp. 289-296
    • Martin, F.I.R.1    Stocks, A.E.2
  • 4
    • 0017599701 scopus 로고
    • Investigation of insulin sensitivity in treated subjects with ketosis prone diabetes mellitus
    • 403100 10.2337/diabetes.26.4.278 1:CAS:528:DyaE2sXhvVOitr0%3D
    • Ginsberg HN. Investigation of insulin sensitivity in treated subjects with ketosis prone diabetes mellitus. Diabetes. 1977;26:278-83.
    • (1977) Diabetes , vol.26 , pp. 278-283
    • Ginsberg, H.N.1
  • 5
    • 0017670714 scopus 로고
    • Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity
    • 925138 10.1210/jcem-45-5-1124 1:CAS:528:DyaE1cXkvVCluw%3D%3D
    • Harano Y, Ohgaku S, Hidaka H, Haneda K, Kikkawa R, Shigeta Y, et al. Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. J Clin Endocrinol Metab. 1977;45:1124-7.
    • (1977) J Clin Endocrinol Metab , vol.45 , pp. 1124-1127
    • Harano, Y.1    Ohgaku, S.2    Hidaka, H.3    Haneda, K.4    Kikkawa, R.5    Shigeta, Y.6
  • 6
    • 0019988894 scopus 로고
    • Insulin resistance is a prominent feature of insulin-dependent diabetes
    • Defronzo RA, Bendler R, Simonson D. Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes. 1982;37:795-801.
    • (1982) Diabetes , vol.37 , pp. 795-801
    • Defronzo, R.A.1    Bendler, R.2    Simonson, D.3
  • 8
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • 5318831 1:STN:280:DyaF28%2FgvF2isQ%3D%3D
    • Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes. 1965;14:619-33.
    • (1965) Diabetes , vol.14 , pp. 619-633
    • Gepts, W.1
  • 9
    • 0016261369 scopus 로고
    • Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
    • 4139522 10.1016/S0140-6736(74)90140-8 1:STN:280:DyaE2M%2FksVCgsA%3D%3D
    • Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974;2:1279-83.
    • (1974) Lancet , vol.2 , pp. 1279-1283
    • Bottazzo, G.F.1    Florin-Christensen, A.2    Doniach, D.3
  • 10
    • 0016177620 scopus 로고
    • HLA antigens and diabetes mellitus
    • 4137711 10.1016/S0140-6736(74)91201-X 1:STN:280:DyaE2M%2FhtVyhug%3D%3D
    • Nerup J et al. HLA antigens and diabetes mellitus. Lancet. 1974;2:864-6.
    • (1974) Lancet , vol.2 , pp. 864-866
    • Nerup, J.1
  • 11
    • 84865526149 scopus 로고    scopus 로고
    • Immunotherapy in T1D: A shorter but more winding road?
    • 22923646 10.2337/db12-0648 1:CAS:528:DC%2BC38XhtlantbzI A balanced and compelling appraisal of the difficulties that have met immunotherapy trials in their attempts to prevent T1D
    • •• Bonifacio E. Immunotherapy in T1D: a shorter but more winding road? Diabetes. 2012;61:2214-5. A balanced and compelling appraisal of the difficulties that have met immunotherapy trials in their attempts to prevent T1D.
    • (2012) Diabetes , vol.61 , pp. 2214-2215
    • Bonifacio, E.1
  • 12
    • 33746692515 scopus 로고    scopus 로고
    • Declassifying diabetes
    • 16821044 10.1007/s00125-006-0348-7 1:STN:280:DC%2BD28vnt1KhsQ%3D%3D
    • Gale EAM. Declassifying diabetes. Diabetologia. 2006;49:1989-95.
    • (2006) Diabetologia , vol.49 , pp. 1989-1995
    • Gale, E.A.M.1
  • 13
    • 0034932098 scopus 로고    scopus 로고
    • The accelerator hypothesis: Weight gain as the missing link between Type i and Type II diabetes
    • 11508279 10.1007/s001250100548 1:CAS:528:DC%2BD3MXks1OrtLg%3D
    • Wilkin TJ. The accelerator hypothesis: Weight gain as the missing link between Type I and Type II diabetes. Diabetologia. 2001;44:914-22.
    • (2001) Diabetologia , vol.44 , pp. 914-922
    • Wilkin, T.J.1
  • 14
    • 58449085511 scopus 로고    scopus 로고
    • Animal models of human type 1 diabetes
    • 10.1038/ni0209-129
    • von Herrath M, Nepom GT. Animal models of human type 1 diabetes. Nat Immunol. 2009;10:129-32.
    • (2009) Nat Immunol , vol.10 , pp. 129-132
    • Von Herrath, M.1    Nepom, G.T.2
  • 15
    • 34447129009 scopus 로고    scopus 로고
    • Changing perspectives in diabetes: Their impact on its classification
    • 17457564 10.1007/s00125-007-0665-5 1:STN:280:DC%2BD2szptFShuw%3D%3D
    • Wilkin TJ. Changing perspectives in diabetes: their impact on its classification. Diabetologia. 2007;50:1587-92.
    • (2007) Diabetologia , vol.50 , pp. 1587-1592
    • Wilkin, T.J.1
  • 16
    • 33744791161 scopus 로고    scopus 로고
    • Beta-cell autoantibodies in children with type 2 diabetes mellitus: Subgroup or misclassification?
    • 16449253 10.1136/adc.2005.088229 1:STN:280:DC%2BD283ot1Ghsg%3D%3D
    • Reinehr T, Schober E, Wiegand S, et al. Beta-cell autoantibodies in children with type 2 diabetes mellitus: Subgroup or misclassification? Arch Dis Child. 2006;91:473-7.
    • (2006) Arch Dis Child , vol.91 , pp. 473-477
    • Reinehr, T.1    Schober, E.2    Wiegand, S.3
  • 17
    • 0027500697 scopus 로고
    • Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a noninsulin-dependent onset of disease
    • 8425674 10.2337/diabetes.42.2.359 1:STN:280:DyaK3s7ks1ansA%3D%3D
    • Tuomi T, Groop LC, Zimmet PZ, et al. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a noninsulin-dependent onset of disease. Diabetes. 1993;42:359-62.
    • (1993) Diabetes , vol.42 , pp. 359-362
    • Tuomi, T.1    Groop, L.C.2    Zimmet, P.Z.3
  • 18
    • 0027990934 scopus 로고
    • Incidence of insulin-dependent diabetes mellitus in age groups over 30 years in Denmark
    • 7955989 10.1111/j.1464-5491.1994.tb00327.x 1:STN:280: DyaK2M%2FksVSnsw%3D%3D
    • Molbak AG, Christau B, Marner B, et al. Incidence of insulin-dependent diabetes mellitus in age groups over 30 years in Denmark. Diabetic Med. 1994;11:650-5.
    • (1994) Diabetic Med. , vol.11 , pp. 650-655
    • Molbak, A.G.1    Christau, B.2    Marner, B.3
  • 19
    • 0016578086 scopus 로고
    • Weight gain in infancy and subsequent development of diabetes mellitus in childhood
    • 53343 10.1016/S0140-6736(75)90250-0 1:STN:280:DyaE28%2FnsVWmtw%3D%3D
    • Baum JD, Ounsted M, Smith MA. Weight gain in infancy and subsequent development of diabetes mellitus in childhood. Lancet. 1975;2:866.
    • (1975) Lancet , vol.2 , pp. 866
    • Baum, J.D.1    Ounsted, M.2    Smith, M.A.3
  • 20
    • 0141786054 scopus 로고
    • Environmental factors and genetic interactions
    • W. Creutzfeld J. Kobberling J.V. Neel (eds) Springer-Verlag Berlin
    • Keen H, Jarrett RJ. Environmental factors and genetic interactions. In: Creutzfeld W, Kobberling J, Neel JV, editors. The genetics of diabetes mellitus. Berlin: Springer-Verlag; 1976. p. 203-14.
    • (1976) The Genetics of Diabetes Mellitus , pp. 203-214
    • Keen, H.1    Jarrett, R.J.2
  • 21
    • 0036897063 scopus 로고    scopus 로고
    • The rise of childhood type 1 diabetes in the 20th century
    • 12453886 10.2337/diabetes.51.12.3353 1:CAS:528:DC%2BD38Xptl2ntbw%3D
    • Gale EAM. The rise of childhood type 1 diabetes in the 20th century. Diabetes. 2002;51:3353-61.
    • (2002) Diabetes , vol.51 , pp. 3353-3361
    • Gale, E.A.M.1
  • 22
    • 0018860519 scopus 로고
    • Diabetes in offspring and siblings of juvenile- and maturity-onset-type diabetics
    • 6989842 10.1016/0021-9681(80)90042-9 1:STN:280:DyaL3c7ot1GhsA%3D%3D
    • Gottlieb MS. Diabetes in offspring and siblings of juvenile- and maturity-onset-type diabetics. J Chronic Dis. 1980;33:331-9.
    • (1980) J Chronic Dis. , vol.33 , pp. 331-339
    • Gottlieb, M.S.1
  • 23
    • 0024511641 scopus 로고
    • The Swedish childhood diabetes study: Results from a 9 year case register and a 1 year case-referent study indicating that type 1 (insulin-dependent) diabetes mellitus is associated with both type 2 (noninsulin-dependent) diabetes mellitus and autoimmune disorders
    • 2707516 10.1007/BF00265396 1:STN:280:DyaL1M3htFKmtg%3D%3D
    • Dahlquist G et al. The Swedish childhood diabetes study: results from a 9 year case register and a 1 year case-referent study indicating that type 1 (insulin-dependent) diabetes mellitus is associated with both type 2 (noninsulin-dependent) diabetes mellitus and autoimmune disorders. Diabetologia. 1989;32:2-6.
    • (1989) Diabetologia , vol.32 , pp. 2-6
    • Dahlquist, G.1
  • 24
    • 0024455574 scopus 로고
    • Autoimmunity: Attack, or defence?
    • 2491621 10.3109/08916938909043614 1:STN:280:DyaK3MzntVGhsA%3D%3D
    • Wilkin TJ. Autoimmunity: attack, or defence? Autoimmunity. 1989;3:57-73.
    • (1989) Autoimmunity , vol.3 , pp. 57-73
    • Wilkin, T.J.1
  • 25
    • 0003430697 scopus 로고
    • Autoantibodies and the physiological role of immunoglobulins
    • 10.1016/0167-5699(83)90169-X 1:CAS:528:DyaL2cXotlOltw%3D%3D
    • Grabar P. Autoantibodies and the physiological role of immunoglobulins. Immunol Today. 1983;4:337-40.
    • (1983) Immunol Today , vol.4 , pp. 337-340
    • Grabar, P.1
  • 26
    • 0016675949 scopus 로고
    • Auto-antibodies and immunological theories: An analytical review
    • 10.1016/0090-1229(75)90087-2
    • Hypothesis GP. Auto-antibodies and immunological theories: an analytical review. Clin Immunol Immunopathol. 1975;4:453-66.
    • (1975) Clin Immunol Immunopathol , vol.4 , pp. 453-466
    • Hypothesis, G.P.1
  • 28
    • 84873038379 scopus 로고    scopus 로고
    • β-cell failure in type 2 diabetes: A case of asking too much of too few?
    • 23349537 10.2337/db12-1326 1:CAS:528:DC%2BC3sXhvFOgurc%3D
    • Costes F, Langen R, Gurlo T, et al. β-cell failure in type 2 diabetes: A case of asking too much of too few? Diabetes. 2013;62:327-35.
    • (2013) Diabetes , vol.62 , pp. 327-335
    • Costes, F.1    Langen, R.2    Gurlo, T.3
  • 29
    • 67049159857 scopus 로고    scopus 로고
    • Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
    • 19481249 10.1016/S0140-6736(09)60568-7
    • Patterson CC, Dahlquist GG, Gyürüs E, et al. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet. 2009;373:2027-33.
    • (2009) Lancet , vol.373 , pp. 2027-2033
    • Patterson, C.C.1    Dahlquist, G.G.2    Gyürüs, E.3
  • 30
    • 0035432491 scopus 로고    scopus 로고
    • Glucose induces b-cell apoptosis via upregulation of the Fas receptor in human islets
    • 11473025 10.2337/diabetes.50.8.1683 1:CAS:528:DC%2BD3MXlslKntbY%3D
    • Maedler K et al. Glucose induces b-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes. 2001;50:1683-90.
    • (2001) Diabetes , vol.50 , pp. 1683-1690
    • Maedler, K.1
  • 31
    • 0033034807 scopus 로고    scopus 로고
    • Hyperglycaemia-induced β-cell apoptosis in pancreatic cells of Psammomys obesus during development of diabetes
    • 10102689 10.2337/diabetes.48.4.738 1:CAS:528:DyaK1MXitFCqt7w%3D
    • Donath MY et al. Hyperglycaemia-induced β-cell apoptosis in pancreatic cells of Psammomys obesus during development of diabetes. Diabetes. 1999;48:738-44.
    • (1999) Diabetes , vol.48 , pp. 738-744
    • Donath, M.Y.1
  • 32
    • 0842284799 scopus 로고    scopus 로고
    • Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • 14749276 10.2337/diabetes.53.2007.S119 1:CAS:528:DC%2BD2cXhtlGqtr8%3D
    • Robertson RP et al. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes. 2004;53 Suppl 1:S119-24.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1 , pp. 119-124
    • Robertson, R.P.1
  • 33
    • 0027976643 scopus 로고
    • A high weight gain in early life is associated with an increased risk of type 1(insulin-dependent) diabetes
    • 8150235 10.1007/BF00428783 1:STN:280:DyaK2c3gtVGntA%3D%3D
    • Johansson C et al. A high weight gain in early life is associated with an increased risk of type 1(insulin-dependent) diabetes. Diabetologia. 1994;37:91-4.
    • (1994) Diabetologia , vol.37 , pp. 91-94
    • Johansson, C.1
  • 34
    • 0343081526 scopus 로고    scopus 로고
    • Infant feeding, early weight gain and risk of type 1 diabetes
    • 10587826 10.2337/diacare.22.12.1961 1:STN:280:DC%2BD3c%2FlsFWgug%3D%3D
    • Hypponen E et al. Infant feeding, early weight gain and risk of type 1 diabetes. Diabetes Care. 1999;22:1961-5.
    • (1999) Diabetes Care , vol.22 , pp. 1961-1965
    • Hypponen, E.1
  • 35
    • 0034686954 scopus 로고    scopus 로고
    • Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes
    • 10968443 10.1016/S0140-6736(00)02612-X 1:STN:280:DC%2BD3cvjvVyrtA%3D%3D
    • Bruining GJ. Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes. Lancet. 2000;356:655-6.
    • (2000) Lancet , vol.356 , pp. 655-656
    • Bruining, G.J.1
  • 36
    • 67649196774 scopus 로고    scopus 로고
    • Birth weight, early weight gain, and subsequent risk of type 1 diabetes: Systematic review and meta-analysis
    • 19363100 10.1093/aje/kwp065 The most comprehensive evidence available that children who develop T1D are heavier from early life than their peers who do not
    • • Harder T et al. Birth weight, early weight gain, and subsequent risk of type 1 diabetes: Systematic review and meta-analysis. Am J Epidemiol. 2009;169:1428-36. The most comprehensive evidence available that children who develop T1D are heavier from early life than their peers who do not.
    • (2009) Am J Epidemiol , vol.169 , pp. 1428-1436
    • Harder, T.1
  • 37
    • 33744787063 scopus 로고    scopus 로고
    • The great weight gain experiment, accelerators, and their implications for autoantibodies in diabetes
    • 16714715 10.1136/adc.2006.094037 1:STN:280:DC%2BD283ot1GhtQ%3D%3D
    • Wilkin TJ. The great weight gain experiment, accelerators, and their implications for autoantibodies in diabetes. Arch Dis Child. 2006;91:456-8.
    • (2006) Arch Dis Child , vol.91 , pp. 456-458
    • Wilkin, T.J.1
  • 38
    • 33750102667 scopus 로고    scopus 로고
    • The accelerator hypothesis
    • J. Bantle G. Slama (eds) Nestle International Workshops Karger 10.1159/000094447
    • Wilkin TJ. The accelerator hypothesis. In: Bantle JP, Slama G, editors. Nutritional management of diabetes mellitus and dysmetabolic syndrome. Karger: Nestle International Workshops; 2006. p. 139-53.
    • (2006) Nutritional Management of Diabetes Mellitus and Dysmetabolic Syndrome , pp. 139-153
    • Wilkin, T.J.1
  • 39
    • 44649106439 scopus 로고    scopus 로고
    • Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis
    • 18540866 10.1111/j.1399-5448.2007.00343.x
    • Wilkin TJ. Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis. Pediatric Diabetes. 2008;9:23-32.
    • (2008) Pediatric Diabetes. , vol.9 , pp. 23-32
    • Wilkin, T.J.1
  • 40
    • 67650450153 scopus 로고    scopus 로고
    • The accelerator hypothesis: A review of the evidence for insulin resistance as the basis for type 1 as well as type 2 diabetes
    • 10.1038/ijo.2009.97
    • Wilkin TJ. The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type 1 as well as type 2 diabetes. Int J Obesity. 2009;33(7):16-26.
    • (2009) Int J Obesity , vol.33 , Issue.7 , pp. 16-26
    • Wilkin, T.J.1
  • 41
    • 84861712514 scopus 로고    scopus 로고
    • The convergence of type 1 and type 2 diabetes in childhood: The accelerator hypothesis
    • 22059423 10.1111/j.1399-5448.2011.00831.x 1:STN:280: DC%2BC38znt1SrsA%3D%3D The most recent update of the accelerator hypothesis and the role of insulin resistance in T1D
    • • Wilkin TJ. The convergence of type 1 and type 2 diabetes in childhood: the accelerator hypothesis. Pediatric Diabetes. 2012;13:334-9. The most recent update of the accelerator hypothesis and the role of insulin resistance in T1D.
    • (2012) Pediatric Diabetes , vol.13 , pp. 334-339
    • Wilkin, T.J.1
  • 42
    • 0038222568 scopus 로고    scopus 로고
    • Temporal changes in the frequencies of HLA genotypes in patients with type i diabetes - Indication of an increased environmental pressure?
    • 12687342 1:STN:280:DC%2BD3s7mvVKmug%3D%3D
    • Hermann R, Knip M, Veijola R. Temporal changes in the frequencies of HLA genotypes in patients with type I diabetes - indication of an increased environmental pressure? Diabetologia. 2003;46:420-5.
    • (2003) Diabetologia , vol.46 , pp. 420-425
    • Hermann, R.1    Knip, M.2    Veijola, R.3
  • 43
    • 7644230152 scopus 로고    scopus 로고
    • The rising incidence of type 1 diabetes is associated with a reduced contribution from high-risk HLA haplotypes
    • 15530631 10.1016/S0140-6736(04)17357-1
    • Gillespie KM, Bain SC, Barnett AH. The rising incidence of type 1 diabetes is associated with a reduced contribution from high-risk HLA haplotypes. Lancet. 2004;364:1699-700.
    • (2004) Lancet , vol.364 , pp. 1699-1700
    • Gillespie, K.M.1    Bain, S.C.2    Barnett, A.H.3
  • 44
    • 33646376936 scopus 로고    scopus 로고
    • SEARCH for Diabetes in Youth Study Group. Testing the accelerator hypothesis: Body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes
    • 16443875 10.2337/diacare.29.02.06.dc05-1339
    • Dabelea D, D'Agostino Jr RB, Mayer-Davis EJ. SEARCH for Diabetes in Youth Study Group. Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes. Diabetes Care. 2006;29:290-4.
    • (2006) Diabetes Care , vol.29 , pp. 290-294
    • Dabelea, D.1    D'Agostino, Jr.R.B.2    Mayer-Davis, E.J.3
  • 45
    • 38149011472 scopus 로고    scopus 로고
    • Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)
    • Bingley PJ, Mahon JL, Gale EA. Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetes Care. 2008;3:146-50.
    • (2008) Diabetes Care , vol.3 , pp. 146-150
    • Bingley, P.J.1    Mahon, J.L.2    Gale, E.A.3
  • 46
    • 0346599403 scopus 로고    scopus 로고
    • An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
    • An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet. 1997;17:399-403.
    • (1997) Nat Genet , vol.17 , pp. 399-403
  • 47
    • 84859524893 scopus 로고    scopus 로고
    • Autoimmune polyendocrine syndrome type 1: An extensive longitudinal study in Sardinian patients
    • 22344197 10.1210/jc.2011-2461 1:CAS:528:DC%2BC38Xlslygu7s%3D
    • Meloni A, Willcox N, Meager A, et al. Autoimmune polyendocrine syndrome type 1: an extensive longitudinal study in Sardinian patients. J Clin Endocrinol Metab. 2012;97:1114-24.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1114-1124
    • Meloni, A.1    Willcox, N.2    Meager, A.3
  • 48
    • 33744808591 scopus 로고    scopus 로고
    • Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients
    • 16552513 10.1007/s00251-006-0088-3 1:CAS:528:DC%2BD28XltFyit7o%3D
    • Turunen JA, Wessman M, Forsblom C, et al. Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients. Immunogenetics. 2006;58:331-8.
    • (2006) Immunogenetics , vol.58 , pp. 331-338
    • Turunen, J.A.1    Wessman, M.2    Forsblom, C.3
  • 50
    • 33744787063 scopus 로고    scopus 로고
    • The great weight gain experiment, accelerators and their implications for autoantibodies in diabetes
    • 10.1136/adc.2006.094037 1:STN:280:DC%2BD283ot1GhtQ%3D%3D
    • Wilkin TJ. The great weight gain experiment, accelerators and their implications for autoantibodies in diabetes. Arch Disease in Childhood. 2006;91:456-8.
    • (2006) Arch Disease in Childhood. , vol.91 , pp. 456-458
    • Wilkin, T.J.1


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