Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades

Journal of Cellular Biochemistry

Volumn 108, Issue 4, 2009, Pages 998-1011

  Misra, Uma Kant ^a   Pizzo, Salvatore Vincent ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

8 CPT 2 O Me cAMP and cancer cell proliferation; cAMP dependent; cAMP mediated cellular proliferation; EPAC and B Raf ERK signaling; EPAC and mTOR signaling; EPAC and prostate cancer; PKA independent cellular proliferation

Indexed keywords

ANTIPORTER; B RAF KINASE; CYCLIC AMP DERIVATIVE; EXCHANGE PROTEIN ACTIVATED BY CAMP 1; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; RHEB PROTEIN; S6 KINASE; TUBERIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN SYNTHESIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION; THEOPHYLLINE;

EID: 70350490057     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22333     Document Type: Article

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