Contextual analysis of immunological response through whole-organ fluorescent imaging

Lymphatic Research and Biology

Volumn 11, Issue 3, 2013, Pages 121-127

  Woodruff, Matthew C ^a,b   Herndon, Caroline N ^b   Heesters, B A ^b,c   Carroll, Michael C ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE IMAGING; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGE RECONSTRUCTION; LYMPH NODE; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; OPTICS; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING; TISSUE SECTION; WHOLE ORGAN FLUORESCENT IMAGING;

ANIMALS; GREEN FLUORESCENT PROTEINS; IMAGING, THREE-DIMENSIONAL; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; REPRODUCIBILITY OF RESULTS; TIME-LAPSE IMAGING;

EID: 84884483679     PISSN: 15396851     EISSN: 15578585     Source Type: Journal    
DOI: 10.1089/lrb.2013.0011     Document Type: Article

References (32)

1. Miller MJ, Safrina O, Cahalan MD. Imaging the single cell dynamics of DC4+ T cell activation by dendritic cells in lymph nodes. J Exp Med 2004;200:847-856
2. Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 2004;427:154-159
3. Bajenoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, Germain RN. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 2006;25:989-1001
4. Carrasco YR, Batista FD. B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus in the lymph node. Immunity 2007;27:160-171
5. Allen CD, Okada T, Cyster JG. Germinal-center organization and cellular dynamics. Immunity 2007;27:190-202
6. Reese AJM. The effect of hypoxia on liver secretion studied by intravital fluorescence microscopy. Br J Exp Pathol 1960; 41:527-535
7. Reese AJ, Rimington C. Biliary and urinary excretion of porphyrins in the rate studied by intravital fluorescence microscopy. Br J Exp Pathol 1964;45:30-36
8. Atherton A, Born GVR. Quantitative investigation of the adhesiveness of circulating polymorphonuclear leucocytes to blood vessel walls. J Physiol 1972;222:447-474
9. Denk W, Strickler JH, Webb WW. Two-photon laser scanning fluorescence microscopy. Science 1990;248:73-76
10. Williams RM, Piston DW, Webb WW. Two-photon molecular excitation provides intrinsic 3-dimensional resolution for laser-based microscopy and microphotochemistry. FASEB J 1994;8:804-813
11. Bargatze RF, Jutila MA, Butcher EC. Distinct roles of Lselectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined. Immunity 1995;3:99-108
12. Slmen C, Mempel TR, Mazo IB, Von Andrian UH. Intravital microscopy; Visualizing immunity in context. Immunity 2004;21:315-329
13. Kilarski WW, Guc E. Teo JC, Oliver SR, Lund AW, Swartz MA. Intravital immunofluorescence for visualizing the microcirculatory and immune microenvironments in the mouse ear dermis. PLos One 2013;8
14. von Andrian UH. Intravital microscopy of the peripheral lymph node microcirculation in mice. Microcirculation 1996; 3:287-300
15. Stein JV, Cheng G, Stockton BM, Fors BP, Butcher EC, von Andrian UH. L-selectin-mediated leukocyte adhesion in vivo: Microvillous distribution determines tethering efficiency, but not rolling velocity. J Exp Med 1999;189:37-50
16. Lindquist RL, Shakhar G, Dudziak D, et al. Visualizing dendritic cell networks in vivo. Nat Immunol 2004;5:1243-1250
17. Gonzalez SF, Lukacs-Kornek V, Kuligowski MP, et al. Capture of influenza by medullary dendritic cells via SIGNR1 is essential for hlmoral immunity in draining lymph nodes. Nat Immunol 2010;11:427-434
18. Grigorova IL, Panteleev M, Cyster JG. Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. Proc Natl Acad Sci USA 2010;107:20447-20452
19. Textor J, Peixoto A, Henrickson SE, Sinn M, von Andrian UH, Westermann J. Defining the quantitative limits of intravital two-photon lymphocyte tracking. Proc Natl Acad Sci USA 2011;108:12401-12406
20. Gerber SA, Turner MJ, Lugade AA, Moran JP, Frelinger JG, Lord EM. Characterization of a lymph node within the mouse prostate: Detailed analysis using whole mount histology. Prostate 2005;63:105-116
21. He Y, Rajantie I, Pajusola K, et al. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005;65:4739-4746
22. Kotslma M, Parashurama N, Smith BR, Wo J, Ito K, Gambhir SS. Nondestructive, serial in vivo imaging of a tissue-flap using a tissue adhesion barrier: Applications for IVM imaging in the mammary fat pad and lymph node. IntraVital 2012;1:69-76
23. Erturk A, Becker K, Jahrling N, et al. Three-dimensional imaging of solvent-cleared organs using 3DISCO. Nat Protoc 2012;7:1983-1995
24. Paish EC, Green AR, Rakha EA, Macmillan RD, Maddison JR, Ellis IO. Three-dimensional reconstruction of sentinel lymph nodes with metastatic breast cancer indicates three distinct patterns of tumour growth. J Clin Pathol 2009;62: 617-623
25. Bin M, Lin Z, Winkelbach S, Lindenmaier W, Dittmar KEJ. Automatic registration of serial sections of mouse lymph node by using Image-Reg. Micron 2008;39:387-396
26. Miller MJ, Wei SH, Parker I, Cahalan MD. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 2002;296:1869-1873
27. Emmenlauer M, Ronneberger O, Ponti A, et al. XuvTools: Free, fast and reliable stitching of large 3D datasets. J Microscopy 2009;233:42-60
28. Gerner MY, Kastenmuller W, Ifrim I, Kabat J, Germain RN. Histocytometry: A method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes. Immunity 2012;37:364-376
29. Lambrecht MR, Sabatini DM, Carpenter AE. CellProfiler: Free, versatile software for automated biological image analysis. Biotechniques 2007;42:72-75
30. Murooka TT, Deruaz M, Marangoni F, et al. HIV-infected T cells are migratory vehicles for viral dissemination. Nature 2012;490:283-287
31. Henrickson SE, Mempel TR, Mazo IB, et al. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol 2008;9:282-291
32. Gray EE, Friend S, Suzuki K, Phan TG, Cyster JG. Subcapsular sinus macrophage fragmentation and CD169 + bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLos One 2012;7:e38258