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Volumn 38, Issue 11, 2013, Pages 1137-1146

Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats

Author keywords

hydroxy methylbutyrate (HMB); Dexamethasone; Glucocorticoid; Glucose tolerance; Insulin sensitivity; Metabolism; Supplementation

Indexed keywords

GLUCOSE BLOOD LEVEL;

EID: 84884478456     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2012-0456     Document Type: Article
Times cited : (17)

References (45)
  • 1
    • 84865364874 scopus 로고    scopus 로고
    • A costeffectiveness analysis of dexamethasone versus prednisone in pediatric acute asthma exacerbations
    • doi:10.1111/j.1553-2712.2012.01418.x. PMID:22849379
    • Andrews, A.L., Wong, K.A., Heine, D., and Scott Russell, W. 2012. A costeffectiveness analysis of dexamethasone versus prednisone in pediatric acute asthma exacerbations. Acad. Emerg. Med. 19(8): 943-948. doi:10.1111/j.1553-2712.2012.01418.x. PMID:22849379.
    • (2012) Acad. Emerg. Med , vol.19 , Issue.8 , pp. 943-948
    • Andrews, A.L.1    Wong, K.A.2    Heine, D.3    Scott, R.W.4
  • 2
    • 84863844871 scopus 로고    scopus 로고
    • β-Hydroxy- β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy
    • doi:10.1016/j.bbrc.2012.06.029. PMID:22705301
    • Aversa, Z., Alamdari, N., Castillero, E., Muscaritoli, M., Rossi Fanelli, F., and Hasselgren, P.O. 2012. β-Hydroxy- β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy. Biochem. Biophys. Res. Commun. 423(4): 739-743. doi:10.1016/j.bbrc.2012.06.029. PMID:22705301.
    • (2012) Biochem. Biophys. Res. Commun , vol.423 , Issue.4 , pp. 739-743
    • Aversa, Z.1    Alamdari, N.2    Castillero, E.3    Muscaritoli, M.4    Rossi, F.F.5    Hasselgren, P.O.6
  • 3
    • 79951673619 scopus 로고    scopus 로고
    • Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance
    • doi:10.1016/j.jnutbio.2010.02.001. PMID:20558053
    • Balage, M., Dupont, J., Mothe-Satney, I., Tesseraud, S., Mosoni, L., and Dardevet, D. 2011. Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. J. Nutr. Biochem. 22(3): 219-226. doi:10.1016/j.jnutbio.2010.02.001. PMID:20558053.
    • (2011) J. Nutr. Biochem , vol.22 , Issue.3 , pp. 219-226
    • Balage, M.1    Dupont, J.2    Mothe-Satney, I.3    Tesseraud, S.4    Mosoni, L.5    Dardevet, D.6
  • 4
    • 25144519685 scopus 로고    scopus 로고
    • Dietary toxicity of calcium beta-hydroxy-beta-methyl butyrate (CaHMB)
    • doi:10.1016/j.fct.2005.05.016. PMID: 16006030
    • Baxter, J.H., Carlos, J.L., Thurmond, J., Rehani, R.N., Bultman, J., and Frost, D. 2005. Dietary toxicity of calcium beta-hydroxy-beta-methyl butyrate (CaHMB). Food Chem. Toxicol. 43(12): 1731-1741. doi:10.1016/j.fct.2005.05.016. PMID: 16006030.
    • (2005) Food. Chem. Toxicol , vol.43 , Issue.12 , pp. 1731-1741
    • Baxter, J.H.1    Carlos, J.L.2    Thurmond, J.3    Rehani, R.N.4    Bultman, J.5    Frost, D.6
  • 5
    • 51649122773 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl betamethyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122)
    • doi:10.1007/s00520-008-0403-7. PMID:18293016
    • Berk, L., James, J., Schwartz, A., Hug, E., Mahadevan, A., Samuels, M., et al. 2008. A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl betamethyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122). Support Care Cancer, 16(10): 1179-1188. doi:10.1007/s00520-008-0403-7. PMID:18293016.
    • (2008) Support Care Cancer , vol.16 , Issue.10 , pp. 1179-1188
    • Berk, L.1    James, J.2    Schwartz, A.3    Hug, E.4    Mahadevan, A.5    Samuels, M.6
  • 6
    • 79953772897 scopus 로고    scopus 로고
    • The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass
    • doi:10.1016/j.jamcollsurg.2010.12.040. PMID:21463799
    • Breitman, I., Saraf, N., Kakade, M., Yellumahanthi, K., White, M., Hackett, J.A., et al. 2011. The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass. J. Am. Coll. Surg. 212(4): 617-627. doi:10.1016/j.jamcollsurg.2010.12.040. PMID:21463799.
    • (2011) J. Am. Coll. Surg , vol.212 , Issue.4 , pp. 617-627
    • Breitman, I.1    Saraf, N.2    Kakade, M.3    Yellumahanthi, K.4    White, M.5    Hackett, J.A.6
  • 7
    • 0015847114 scopus 로고
    • Quantitative determination of serum triglycerides by the use of enzymes
    • PMID:4703655
    • Bucolo, G., and David, H. 1973. Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem. 19(5): 476-482. PMID:4703655.
    • (1973) Clin. Chem , vol.19 , Issue.5 , pp. 476-482
    • Bucolo, G.1    David, H.2
  • 8
    • 33846658434 scopus 로고    scopus 로고
    • Beta-hydoxy-beta-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner
    • doi:10.1016/j.clnu.2006.05.007. PMID:17011676
    • Caperuto, E.C., Tomatieli, R.V., Colquhoun, A., Seelaender, M.C., and Costa Rosa, L.F. 2007. Beta-hydoxy-beta-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner. Clin. Nutr. 26(1): 117-122. doi:10.1016/j.clnu.2006.05.007. PMID:17011676.
    • (2007) Clin. Nutr , vol.26 , Issue.1 , pp. 117-122
    • Caperuto, E.C.1    Tomatieli, R.V.2    Colquhoun, A.3    Seelaender, M.C.4    Costa, R.L.F.5
  • 9
    • 35148898785 scopus 로고    scopus 로고
    • Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli
    • doi:10.1152/ajpendo.00314.2007. PMID:17609254
    • Eley, H.L., Russell, S.T., Baxter, J.H., Mukerji, P., and Tisdale, M.J. 2007. Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am. J. Physiol. Endocrinol. Metab. 293(4): E923-E931. doi:10.1152/ajpendo.00314.2007. PMID:17609254.
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.293 , Issue.4
    • Eley, H.L.1    Russell, S.T.2    Baxter, J.H.3    Mukerji, P.4    Tisdale, M.J.5
  • 10
    • 84867399092 scopus 로고    scopus 로고
    • Medical management of Cushing's disease: What is the future?
    • doi:10.1007/s11102-012-0397-5. PMID:22674211
    • Fleseriu, M., and Petersenn, S. 2012. Medical management of Cushing's disease: what is the future? Pituitary, 15(3): 330-341. doi:10.1007/s11102-012-0397-5. PMID:22674211.
    • (2012) Pituitary , vol.15 , Issue.3 , pp. 330-341
    • Fleseriu, M.1    Petersenn, S.2
  • 11
    • 79955469592 scopus 로고    scopus 로고
    • Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMbeta) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats
    • doi:10.1016/j.ghir.2010.12.006. PMID:21237681
    • Gerlinger-Romero, F., Guimaraes-Ferreira, L., Giannocco, G., and Nunes, M.T. 2011. Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMbeta) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats. Growth Horm. IGF Res. 21(2): 57-62. doi:10.1016/j.ghir.2010.12.006. PMID:21237681.
    • (2011) Growth Horm. IGF Res , vol.21 , Issue.2 , pp. 57-62
    • Gerlinger-Romero, F.1    Guimaraes-Ferreira, L.2    Giannocco, G.3    Nunes, M.T.4
  • 12
    • 42949098384 scopus 로고    scopus 로고
    • Dexamethasone treatment in vivo counteracts the functional pancreatic islet alterations caused by malnourishment in rats
    • doi:10.1016/j.metabol.2007.12.004. PMID:18442623
    • Giozzet, V.A., Rafacho, A., Boschero, A.C., Carneiro, E.M., and Bosqueiro, J.R. 2008. Dexamethasone treatment in vivo counteracts the functional pancreatic islet alterations caused by malnourishment in rats. Metabolism, 57(5): 617-624. doi:10.1016/j.metabol.2007.12.004. PMID:18442623.
    • (2008) Metabolism , vol.57 , Issue.5 , pp. 617-624
    • Giozzet, V.A.1    Rafacho, A.2    Boschero, A.C.3    Carneiro, E.M.4    Bosqueiro, J.R.5
  • 13
    • 77954938902 scopus 로고    scopus 로고
    • The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp
    • doi:10.1210/jc.2010-0288. PMID:20484475
    • Guerrero-Romero, F., Simental-Mendia, L.E., Gonzalez-Ortiz, M., Martinez-Abundis, E., Ramos-Zavala, M.G., Hernandez-Gonzalez, S.O., et al. 2010. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J. Clin. Endocrinol. Metab. 95(7): 3347-3351. doi:10.1210/jc.2010-0288. PMID:20484475.
    • (2010) J. Clin. Endocrinol. Metab , vol.95 , Issue.7 , pp. 3347-3351
    • Guerrero-Romero, F.1    Simental-Mendia, L.E.2    Gonzalez-Ortiz, M.3    Martinez-Abundis, E.4    Ramos-Zavala, M.G.5    Hernandez-Gonzalez, S.O.6
  • 14
    • 42949140834 scopus 로고    scopus 로고
    • Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity
    • doi:10.1016/j.physbeh.2008.01.002. PMID:18262211
    • Jocken, J.W., and Blaak, E.E. 2008. Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity. Physiol. Behav. 94(2): 219-230. doi:10.1016/j.physbeh.2008.01.002. PMID:18262211.
    • (2008) Physiol. Behav , vol.94 , Issue.2 , pp. 219-230
    • Jocken, J.W.1    Blaak, E.E.2
  • 15
    • 0034456568 scopus 로고    scopus 로고
    • Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
    • doi:10.1210/jc.85.7.2402. PMID:10902785
    • Katz, A., Nambi, S.S., Mather, K., Baron, A.D., Follmann, D.A., Sullivan, G., et al. 2000. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab. 85(7): 2402-2410. doi:10.1210/jc.85.7.2402. PMID:10902785.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , Issue.7 , pp. 2402-2410
    • Katz, A.1    Nambi, S.S.2    Mather, K.3    Baron, A.D.4    Follmann, D.A.5    Sullivan, G.6
  • 16
    • 84865687594 scopus 로고    scopus 로고
    • Effect of inhaled glucocorticoids in childhood on adult height
    • doi:10.1056/NEJMoa1203229. PMID:22938716
    • Kelly, H.W., Sternberg, A.L., Lescher, R., Fuhlbrigge, A.L., Williams, P., Zeiger, R.S., et al. 2012. Effect of inhaled glucocorticoids in childhood on adult height. N. Engl. J. Med. 367(10): 904-912. doi:10.1056/NEJMoa1203229. PMID:22938716.
    • (2012) N. Engl. J. Med , vol.367 , Issue.10 , pp. 904-912
    • Kelly, H.W.1    Sternberg, A.L.2    Lescher, R.3    Fuhlbrigge, A.L.4    Williams, P.5    Zeiger, R.S.6
  • 17
    • 78650172783 scopus 로고    scopus 로고
    • Effects of betahydroxy-beta-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats
    • doi:10.1007/s13105-010-0037-3. PMID:20725872
    • Kovarik, M., Muthny, T., Sispera, L., and Holecek, M. 2010. Effects of betahydroxy-beta-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats. J. Physiol. Biochem. 66(4): 311-319. doi:10.1007/s13105-010-0037-3. PMID:20725872.
    • (2010) J. Physiol. Biochem , vol.66 , Issue.4 , pp. 311-319
    • Kovarik, M.1    Muthny, T.2    Sispera, L.3    Holecek, M.4
  • 18
    • 84862248713 scopus 로고    scopus 로고
    • Bax/Bcl-2 protein expression ratio and leukocyte function are related to reduction of Walker-256 tumor growth after beta-hydroxy-beta-methylbutyrate (HMB) administration in Wistar rats
    • doi:10.1080/01635581.2012.647229. PMID: 22242972
    • Kuczera, D., Paro de Oliveira, H.H., Fonseca Guimaraes Fde, S., de Lima, C., Alves, L., Machado, A.F., et al. 2012. Bax/Bcl-2 protein expression ratio and leukocyte function are related to reduction of Walker-256 tumor growth after beta-hydroxy-beta-methylbutyrate (HMB) administration in Wistar rats. Nutr. Cancer, 64(2): 286-293. doi:10.1080/01635581.2012.647229. PMID: 22242972.
    • (2012) Nutr. Cancer , vol.64 , Issue.2 , pp. 286-293
    • Kuczera, D.1    de Oliveira, H.H.P.2    Fonseca, G.F.S.3    de Lima, C.4    Alves, L.5    Machado, A.F.6
  • 19
    • 67849128552 scopus 로고    scopus 로고
    • Lipolysis and lipid mobilization in human adipose tissue
    • doi:10.1016/j.plipres.2009.05.001. PMID:19464318
    • Lafontan, M., and Langin, D. 2009. Lipolysis and lipid mobilization in human adipose tissue. Prog. Lipid Res. 48(5): 275-297. doi:10.1016/j.plipres.2009.05.001. PMID:19464318.
    • (2009) Prog. Lipid Res , vol.48 , Issue.5 , pp. 275-297
    • Lafontan, M.1    Langin, D.2
  • 20
    • 0014738371 scopus 로고
    • Determination of glycogen in small tissue samples
    • PMID:5413312
    • Lo, S., Russell, J.C., and Taylor, A.W. 1970. Determination of glycogen in small tissue samples. J. Appl. Physiol. 28(2): 234-236. PMID:5413312.
    • (1970) J. Appl. Physiol , vol.28 , Issue.2 , pp. 234-236
    • Lo, S.1    Russell, J.C.2    Taylor, A.W.3
  • 21
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • doi:10.1007/BF00280883. PMID:3899825
    • Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., and Turner, R.C. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7): 412-419. doi:10.1007/BF00280883. PMID:3899825.
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 22
    • 65249171425 scopus 로고    scopus 로고
    • Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects
    • doi: 10.1210/er.2008-0027. PMID:19240267
    • Møller, N., and Jørgensen, J.O. 2009. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr. Rev. 30(2): 152-177. doi: 10.1210/er.2008-0027. PMID:19240267.
    • (2009) Endocr. Rev , vol.30 , Issue.2 , pp. 152-177
    • Møller, N.1    Jørgensen, J.O.2
  • 23
    • 4644237871 scopus 로고    scopus 로고
    • Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteers
    • doi:10.1038/oby.2003.90. PMID:12740452
    • Nicod, N., Giusti, V., Besse, C., and Tappy, L. 2003. Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteers. Obes. Res. 11(5): 625-631. doi:10.1038/oby.2003.90. PMID:12740452.
    • (2003) Obes. Res , vol.11 , Issue.5 , pp. 625-631
    • Nicod, N.1    Giusti, V.2    Besse, C.3    Tappy, L.4
  • 24
    • 0033934852 scopus 로고    scopus 로고
    • beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors
    • PMID:10917905
    • Nissen, S., Sharp, R.L., Panton, L., Vukovich, M., Trappe, S., and Fuller, J.C., Jr. 2000. beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors. J. Nutr. 130(8): 1937-1945. PMID:10917905.
    • (2000) J. Nutr , vol.130 , Issue.8 , pp. 1937-1945
    • Nissen, S.1    Sharp, R.L.2    Panton, L.3    Vukovich, M.4    Trappe, S.5    Fuller Jr., J.C.6
  • 25
    • 0032834829 scopus 로고    scopus 로고
    • Insufficient adaptive capability of pancreatic endocrine function in dexamethasone-treated ageing rats
    • doi:10.1677/joe.0.1620425. PMID:10467234
    • Novelli, M., De Tata, V., Bombara, M., Lorenzini, A., Masini, M., Pollera, M., et al. 1999. Insufficient adaptive capability of pancreatic endocrine function in dexamethasone-treated ageing rats. J. Endocrinol. 162(3): 425-432. doi:10.1677/joe.0.1620425. PMID:10467234.
    • (1999) J. Endocrinol , vol.162 , Issue.3 , pp. 425-432
    • Novelli, M.1    de Tata, V.2    Bombara, M.3    Lorenzini, A.4    Masini, M.5    Pollera, M.6
  • 26
    • 44949245770 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factorkappaB expression
    • doi:10.1016/j.nutres.2008.04.006. PMID:19083450
    • Nunes, E.A., Kuczera, D., Brito, G.A., Bonatto, S.J., Yamazaki, R.K., Tanhoffer, R.A., et al. 2008. Beta-hydroxy-beta-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factorkappaB expression. Nutr. Res. 28(7): 487-493. doi:10.1016/j.nutres.2008.04.006. PMID:19083450.
    • (2008) Nutr. Res , vol.28 , Issue.7 , pp. 487-493
    • Nunes, E.A.1    Kuczera, D.2    Brito, G.A.3    Bonatto, S.J.4    Yamazaki, R.K.5    Tanhoffer, R.A.6
  • 27
    • 33745501028 scopus 로고    scopus 로고
    • The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target
    • doi:10.1016/j.tips.2006.05.008. PMID:16766048
    • Offermanns, S. 2006. The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target. Trends Pharmacol. Sci. 27(7): 384-390. doi:10.1016/j.tips.2006.05.008. PMID:16766048.
    • (2006) Trends Pharmacol. Sci , vol.27 , Issue.7 , pp. 384-390
    • Offermanns, S.1
  • 28
    • 33749005926 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis response to sustained stress after major burn injury in children
    • doi:10.1097/01.BCR.0000238098.43888.07. PMID:16998409
    • Palmieri, T.L., Levine, S., Schonfeld-Warden, N., O'Mara, M.S., and Greenhalgh, D.G. 2006. Hypothalamic-pituitary-adrenal axis response to sustained stress after major burn injury in children. J. Burn Care Res. 27(5): 742-748. doi:10.1097/01.BCR.0000238098.43888.07. PMID:16998409.
    • (2006) J. Burn Care Res , vol.27 , Issue.5 , pp. 742-748
    • Palmieri, T.L.1    Levine, S.2    Schonfeld-Warden, N.3    O'Mara, M.S.4    Greenhalgh, D.G.5
  • 29
    • 79951851521 scopus 로고    scopus 로고
    • beta-Hydroxy-beta-methylbutyrate (HMbeta) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway
    • doi:10.1186/1743-7075-8-11. PMID:21345206
    • Pimentel, G.D., Rosa, J.C., Lira, F.S., Zanchi, N.E., Ropelle, E.R., Oyama, L.M., et al. 2011. beta-Hydroxy-beta-methylbutyrate (HMbeta) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway. Nutr. Metab. (Lond.), 8(1): 11. doi:10.1186/1743-7075-8-11. PMID:21345206.
    • (2011) Nutr. Metab. (Lond.) , vol.8 , Issue.1 , pp. 11
    • Pimentel, G.D.1    Rosa, J.C.2    Lira, F.S.3    Zanchi, N.E.4    Ropelle, E.R.5    Oyama, L.M.6
  • 30
    • 64749109569 scopus 로고    scopus 로고
    • Niacin stimulates adiponectin secretion through the GPR109A receptor
    • doi:10.1152/ajpendo.91004.2008. PMID:19141678
    • Plaisance, E.P., Lukasova, M., Offermanns, S., Zhang, Y., Cao, G., and Judd, R.L. 2009. Niacin stimulates adiponectin secretion through the GPR109A receptor. Am. J. Physiol Endocrinol Metab. 296(3): E549-E558. doi:10.1152/ajpendo.91004.2008. PMID:19141678.
    • (2009) Am. J. Physiol Endocrinol Metab , vol.296 , Issue.3
    • Plaisance, E.P.1    Lukasova, M.2    Offermanns, S.3    Zhang, Y.4    Cao, G.5    Judd, R.L.6
  • 31
    • 77956538059 scopus 로고    scopus 로고
    • Effect of HMB supplementation on body composition, fitness, hormonal profile and muscle damage indices
    • doi:10.1515/JPEM.2010.23.7.641. PMID:20857835
    • Portal, S., Eliakim, A., Nemet, D., Halevy, O., and Zadik, Z. 2010. Effect of HMB supplementation on body composition, fitness, hormonal profile and muscle damage indices. J. Pediatr. Endocrinol. Metab. 23(7): 641-650. doi:10.1515/JPEM.2010.23.7.641. PMID:20857835.
    • (2010) J. Pediatr. Endocrinol. Metab , vol.23 , Issue.7 , pp. 641-650
    • Portal, S.1    Eliakim, A.2    Nemet, D.3    Halevy, O.4    Zadik, Z.5
  • 32
    • 34548173724 scopus 로고    scopus 로고
    • Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets
    • doi:10.1139/Y07-037. PMID:17632589
    • Rafacho, A., Roma, L.P., Taboga, S.R., Boschero, A.C., and Bosqueiro, J.R. 2007. Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets. Can. J. Physiol. Pharmacol. 85(5): 536-545. doi:10.1139/Y07-037. PMID:17632589.
    • (2007) Can. J. Physiol. Pharmacol , vol.85 , Issue.5 , pp. 536-545
    • Rafacho, A.1    Roma, L.P.2    Taboga, S.R.3    Boschero, A.C.4    Bosqueiro, J.R.5
  • 33
    • 41149165411 scopus 로고    scopus 로고
    • Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance
    • doi:10.1097/MPA.0b013e31815ba826. PMID:18362843
    • Rafacho, A., Giozzet, V.A., Boschero, A.C., and Bosqueiro, J.R. 2008. Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance. Pancreas, 36(3): 284-293. doi:10.1097/MPA.0b013e31815ba826. PMID:18362843.
    • (2008) Pancreas , vol.36 , Issue.3 , pp. 284-293
    • Rafacho, A.1    Giozzet, V.A.2    Boschero, A.C.3    Bosqueiro, J.R.4
  • 34
    • 78649309853 scopus 로고    scopus 로고
    • The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment
    • doi:10.1111/j.1748-1716.2010.02146.x. PMID:20456283
    • Rafacho, A., Quallio, S., Ribeiro, D.L., Taboga, S.R., Paula, F.M., Boschero, A.C., et al. 2010. The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment. Acta Physiol. (Oxf.), 200(3): 223-235. doi:10.1111/j.1748-1716.2010.02146.x. PMID:20456283.
    • (2010) Acta Physiol. (Oxf.) , vol.200 , Issue.3 , pp. 223-235
    • Rafacho, A.1    Quallio, S.2    Ribeiro, D.L.3    Taboga, S.R.4    Paula, F.M.5    Boschero, A.C.6
  • 35
    • 79953272271 scopus 로고    scopus 로고
    • Morphofunctional alterations in endocrine pancreas of short- and long-term dexamethasone-treated rats
    • doi:10.1055/s-0030-1269896. PMID:21225543
    • Rafacho, A., Abrantes, J.L., Ribeiro, D.L., Paula, F.M., Pinto, M.E., Boschero, A.C., et al. 2011. Morphofunctional alterations in endocrine pancreas of short- and long-term dexamethasone-treated rats. Horm. Metab. Res. 43(4): 275-281. doi:10.1055/s-0030-1269896. PMID:21225543.
    • (2011) Horm. Metab. Res , vol.43 , Issue.4 , pp. 275-281
    • Rafacho, A.1    Abrantes, J.L.2    Ribeiro, D.L.3    Paula, F.M.4    Pinto, M.E.5    Boschero, A.C.6
  • 36
    • 1642375575 scopus 로고    scopus 로고
    • Supplementation with a combination of betahydroxy- beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters
    • doi:10.1177/014860710402800265. PMID:15080599
    • Rathmacher, J.A., Nissen, S., Panton, L., Clark, R.H., Eubanks May, P., Barber, A.E., et al. 2004. Supplementation with a combination of betahydroxy- beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters. JPEN J. Parenter. Enteral Nutr. 28(2): 65-75. doi:10.1177/014860710402800265. PMID:15080599.
    • (2004) JPEN J. Parenter. Enteral Nutr , vol.28 , Issue.2 , pp. 65-75
    • Rathmacher, J.A.1    Nissen, S.2    Panton, L.3    Clark, R.H.4    Eubanks, M.P.5    Barber, A.E.6
  • 37
    • 43549100794 scopus 로고    scopus 로고
    • Efeitos da administração de dexametasona in vivo sobre glicemia, insulinemia e substratos circulantes são dependentes do tempo de tratamento
    • Santos, C.L., Rafacho, A., and Bosqueiro, J.R. 2007. Efeitos da administração de dexametasona in vivo sobre glicemia, insulinemia e substratos circulantes são dependentes do tempo de tratamento. Biosci. J. 23(3): 101-110.
    • (2007) Biosci. J , vol.23 , Issue.3 , pp. 101-110
    • Santos, C.L.1    Rafacho, A.2    Bosqueiro, J.R.3
  • 38
    • 84884470729 scopus 로고    scopus 로고
    • Steroid-induced diabetes: Is it just unmasking of type 2 diabetes?
    • article ID 910905. doi:10.5402/2012/910905. PMID:22830041
    • Simmons, L.R., Molyneaux, L., Yue, D.K., and Chua, E.L. 2012. Steroid-induced diabetes: is it just unmasking of type 2 diabetes? ISRN Endocrinol. 2012, article ID 910905. doi:10.5402/2012/910905. PMID:22830041.
    • (2012) ISRN Endocrinol
    • Simmons, L.R.1    Molyneaux, L.2    Yue, D.K.3    Chua, E.L.4
  • 39
    • 9244227105 scopus 로고    scopus 로고
    • Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate
    • doi: 10.1158/0008-5472.CAN-04-1760. PMID:15574784
    • Smith, H.J., Wyke, S.M., and Tisdale, M.J. 2004. Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate. Cancer Res. 64(23): 8731-8735. doi: 10.1158/0008-5472.CAN-04-1760. PMID:15574784.
    • (2004) Cancer Res , vol.64 , Issue.23 , pp. 8731-8735
    • Smith, H.J.1    Wyke, S.M.2    Tisdale, M.J.3
  • 40
    • 11244259394 scopus 로고    scopus 로고
    • Attenuation of proteasomeinduced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss
    • PMID:15665304
    • Smith, H.J., Mukerji, P., and Tisdale, M.J. 2005. Attenuation of proteasomeinduced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss. Cancer Res. 65(1): 277-283. PMID:15665304.
    • (2005) Cancer Res , vol.65 , Issue.1 , pp. 277-283
    • Smith, H.J.1    Mukerji, P.2    Tisdale, M.J.3
  • 41
    • 0001072302 scopus 로고
    • The production and release of glycerol by adipose tissue incubated in vitro
    • PMID:13996476
    • Vaughan, M. 1962. The production and release of glycerol by adipose tissue incubated in vitro. J. Biol. Chem. 237: 3354-3358. PMID:13996476.
    • (1962) J. Biol. Chem , vol.237 , pp. 3354-3358
    • Vaughan, M.1
  • 42
    • 9444242665 scopus 로고    scopus 로고
    • Five stages of evolving beta-cell dysfunction during progression to diabetes
    • doi:10.2337/diabetes.53.suppl_3.S16. PMID:15561905
    • Weir, G.C., and Bonner-Weir, S. 2004. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes, 53(Suppl. 3): S16-S21. doi:10.2337/diabetes.53.suppl_3.S16. PMID:15561905.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Weir, G.C.1    Bonner-Weir, S.2
  • 43
    • 84859805774 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats
    • doi:10.1186/1550-2783-9-18. PMID:22512917
    • Wilson, J.M., Grant, S.C., Lee, S.R., Masad, I.S., Park, Y.M., Henning, et al. 2012. Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats. J. Int. Soc. Sports Nutr. 9(1): 18. doi:10.1186/1550-2783-9-18. PMID:22512917.
    • (2012) J. Int. Soc. Sports Nutr , vol.9 , Issue.1 , pp. 18
    • Wilson, J.M.1    Grant, S.C.2    Lee, S.R.3    Masad, I.S.4    Park, Y.M.5    Henning6
  • 44
    • 79954445776 scopus 로고    scopus 로고
    • HMB supplementation: Clinical and athletic performance-related effects and mechanisms of action
    • doi:10.1007/s00726-010-0678-0. PMID:20607321
    • Zanchi, N.E., Gerlinger-Romero, F., Guimaraes-Ferreira, L., de Siqueira Filho, M.A., Felitti, V., Lira, F.S., et al. 2011. HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. Amino Acids, 40(4): 1015-1025. doi:10.1007/s00726-010-0678-0. PMID:20607321.
    • (2011) Amino Acids , vol.40 , Issue.4 , pp. 1015-1025
    • Zanchi, N.E.1    Gerlinger-Romero, F.2    Guimaraes-Ferreira, L.3    de Siqueira, F.M.A.4    Felitti, V.5    Lira, F.S.6
  • 45
    • 84869085167 scopus 로고    scopus 로고
    • The possible role of leucine in modulating glucose homeostasis under distinct catabolic conditions
    • doi:10.1016/j.mehy.2012.09.018. PMID:23079398
    • Zanchi, N.E., Guimaraes-Ferreira, L., Siqueira-Filho, M.A., Gabriel Camporez, J.P., Nicastro, H., Seixas Chaves, D.F., et al. 2012. The possible role of leucine in modulating glucose homeostasis under distinct catabolic conditions. Med. Hypotheses, 79(6): 883-888. doi:10.1016/j.mehy.2012.09.018. PMID:23079398.
    • (2012) Med. Hypotheses , vol.79 , Issue.6 , pp. 883-888
    • Zanchi, N.E.1    Guimaraes-Ferreira, L.2    Siqueira-Filho, M.A.3    Gabriel, C.J.P.4    Nicastro, H.5    Seixas, C.D.F.6


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