Synthesis, biological evaluation, and molecular docking studies of 2,5-substituted-1,4-benzoquinone as novel urease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 16, 2012, Pages 4889-4894

  You, Zhong Lu ^a   Xian, Dong Mei ^a   Zhang, Mei ^a   Cheng, Xiao Shan ^a   Li, Xiao Fang ^a  

^a LIAONING NORMAL UNIVERSITY   (China)

Author keywords

Benzoquinone; Crystal structure; Inhibition; Molecular docking; Urease

Indexed keywords

1,4 BENZOQUINONE DERIVATIVE; 2,5 BIS(2 MORPHOLINO 4 YLETHYLAMINO)[1,4]BENZOQUINONE; 2,5 BIS(2 PHENYLAMINOETHYLAMINO)[1,4]BENZOQUINONE; 2,5 BISCYCLOHEXYLAMINO[1,4]BENZOQUINONE; 2,5 BISCYCLOPENTYLAMINO[1,4]BENZOQUINONE; 2,5 BISCYCLOPROPYLAMINO[1,4]BENZOQUINONE; 2,5 BISISOPROPYLAMINO[1,4]BENZOQUINONE; UNCLASSIFIED DRUG; UREASE; UREASE INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; HELICOBACTER PYLORI; IC 50; MOLECULAR DOCKING; NONHUMAN; SIMULATION;

BENZOQUINONES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HELICOBACTER PYLORI; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; UREASE;

HELICOBACTER PYLORI;

EID: 84864453908     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.002     Document Type: Article

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