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Volumn 62, Issue , 2013, Pages 238-245

Kaempferol induces chondrogenesis in ATDC5 cells through activation of ERK/BMP-2 signaling pathway

Author keywords

ATDC5 cells; BMP 2; Chondrogenesis; Kaempferol; MAP kinases

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; KAEMPFEROL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCALCIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; BMP2 PROTEIN, MOUSE; KAEMPFEROL DERIVATIVE; PROTEOGLYCAN; RUNX2 PROTEIN, MOUSE; SOX9 PROTEIN, MOUSE;

EID: 84884395349     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.034     Document Type: Article
Times cited : (25)

References (47)
  • 1
    • 35848958601 scopus 로고    scopus 로고
    • Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation
    • Adams S.L., Cohen A.J., Lassova L. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. J. Cell. Physiol. 2007, 213:635-641.
    • (2007) J. Cell. Physiol. , vol.213 , pp. 635-641
    • Adams, S.L.1    Cohen, A.J.2    Lassova, L.3
  • 2
    • 0036830491 scopus 로고    scopus 로고
    • The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    • Akiyama H., Chaboissier M.C., Martin J.F., Schedl A., de Crombrugghe B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes. Dev. 2002, 16:2813-2828.
    • (2002) Genes. Dev. , vol.16 , pp. 2813-2828
    • Akiyama, H.1    Chaboissier, M.C.2    Martin, J.F.3    Schedl, A.4    de Crombrugghe, B.5
  • 3
    • 79951923564 scopus 로고    scopus 로고
    • The bioflavonoid kaempferol is an abcg2 substrate and inhibits abcg2-mediated quercetin efflux
    • An G., Gallegos J., Morris M.E. The bioflavonoid kaempferol is an abcg2 substrate and inhibits abcg2-mediated quercetin efflux. Drug Metab. Dispos. 2011, 39:426-432.
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 426-432
    • An, G.1    Gallegos, J.2    Morris, M.E.3
  • 4
    • 33847653790 scopus 로고    scopus 로고
    • Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation
    • Bobick B.E., Thornhill T.M., Kulyk WM. Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation. J. Cell. Physiol. 2007, 211:233-243.
    • (2007) J. Cell. Physiol. , vol.211 , pp. 233-243
    • Bobick, B.E.1    Thornhill, T.M.2    Kulyk, W.M.3
  • 7
    • 79952532793 scopus 로고    scopus 로고
    • Stimulation of chondrogenesis in ATDC5 chondroprogenitor cells and hypertrophy in mouse by Genkwadaphnin
    • 5-9-15
    • Choi H.J., Nepal M., Park Y.R., Lee H.K., Oh S.R., Soh Y. Stimulation of chondrogenesis in ATDC5 chondroprogenitor cells and hypertrophy in mouse by Genkwadaphnin. Eur. J. Pharmacol. 2011, 65. 5-9-15.
    • (2011) Eur. J. Pharmacol. , vol.65
    • Choi, H.J.1    Nepal, M.2    Park, Y.R.3    Lee, H.K.4    Oh, S.R.5    Soh, Y.6
  • 8
    • 53649084494 scopus 로고    scopus 로고
    • A comparison of the effects of kaempferol and quercetin on cytokineinduced pro-inflammatory status of cultured human endothelial cells
    • Crespo I., Garcia-Mediavilla M.V., Gutierrez B., Sanchez-Campos S., Tunon M.J., Gonzalez-Gallego J. A comparison of the effects of kaempferol and quercetin on cytokineinduced pro-inflammatory status of cultured human endothelial cells. Br. J. Nutr. 2008, 100:968-976.
    • (2008) Br. J. Nutr. , vol.100 , pp. 968-976
    • Crespo, I.1    Garcia-Mediavilla, M.V.2    Gutierrez, B.3    Sanchez-Campos, S.4    Tunon, M.J.5    Gonzalez-Gallego, J.6
  • 11
    • 0033973655 scopus 로고    scopus 로고
    • All for one and one for all: condensations and the initiation of skeletal development
    • Hall B.K., Miyake T. All for one and one for all: condensations and the initiation of skeletal development. Bioessays 2000, 22:138-147.
    • (2000) Bioessays , vol.22 , pp. 138-147
    • Hall, B.K.1    Miyake, T.2
  • 12
    • 33846003498 scopus 로고    scopus 로고
    • Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis
    • Hinoi E., Takarada T., Fujimori S., Wang L., Iemata M., Uno K. Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis. Bone 2007, 40:337-344.
    • (2007) Bone , vol.40 , pp. 337-344
    • Hinoi, E.1    Takarada, T.2    Fujimori, S.3    Wang, L.4    Iemata, M.5    Uno, K.6
  • 13
    • 78349236990 scopus 로고    scopus 로고
    • Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells.
    • Huang W.W., Chiu Y.J., Fan M.J., Lu H.F., Yeh H.F., Li K.H., Chen P.Y., Chung J.G., Yang J.S. Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells. Mol. Nutr. Food. Res. 2010, 54:1585-1595.
    • (2010) Mol. Nutr. Food. Res. , vol.54 , pp. 1585-1595
    • Huang, W.W.1    Chiu, Y.J.2    Fan, M.J.3    Lu, H.F.4    Yeh, H.F.5    Li, K.H.6    Chen, P.Y.7    Chung, J.G.8    Yang, J.S.9
  • 14
    • 41549160315 scopus 로고    scopus 로고
    • Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    • Junttila M.R., Li S.P., Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. Faseb. J. 2008, 22:954-965.
    • (2008) Faseb. J. , vol.22 , pp. 954-965
    • Junttila, M.R.1    Li, S.P.2    Westermarck, J.3
  • 15
    • 75749093933 scopus 로고    scopus 로고
    • Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells
    • Kang J.W., Kim J.H., Song K., Kim S.H., Yoon J.H., Kim K.S. Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. Phytother. Res. 2010, 24:77-S82.
    • (2010) Phytother. Res. , vol.24
    • Kang, J.W.1    Kim, J.H.2    Song, K.3    Kim, S.H.4    Yoon, J.H.5    Kim, K.S.6
  • 16
    • 0033014044 scopus 로고    scopus 로고
    • Regulation of chondrocyte differentiation by Cbfa1
    • Kim I.S., Otto F., Zabel B., Mundlos S. Regulation of chondrocyte differentiation by Cbfa1. Mech. Dev. 1999, 80:159-170.
    • (1999) Mech. Dev. , vol.80 , pp. 159-170
    • Kim, I.S.1    Otto, F.2    Zabel, B.3    Mundlos, S.4
  • 17
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 18
    • 33744764558 scopus 로고    scopus 로고
    • PTHrP and skeletal development
    • Kronenberg H.M. PTHrP and skeletal development. Ann. NY. Acad. Sci. 2006, 1068:1-13.
    • (2006) Ann. NY. Acad. Sci. , vol.1068 , pp. 1-13
    • Kronenberg, H.M.1
  • 19
    • 42249108334 scopus 로고    scopus 로고
    • Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK
    • Kuang D., Zhao X., Xiao G., Ni J., Feng Y., Wu R. Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK. Basic. Res. Cardiol. 2008, 103:265-273.
    • (2008) Basic. Res. Cardiol. , vol.103 , pp. 265-273
    • Kuang, D.1    Zhao, X.2    Xiao, G.3    Ni, J.4    Feng, Y.5    Wu, R.6
  • 21
    • 0030899814 scopus 로고    scopus 로고
    • SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1 (II) collagen gene
    • Lefebvre V., Huang W., Harley V.R., Goodfellow P.N., de Crombrugghe B. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1 (II) collagen gene. Mol. Cell. Biol. 1997, 17:2336-2346.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2336-2346
    • Lefebvre, V.1    Huang, W.2    Harley, V.R.3    Goodfellow, P.N.4    de Crombrugghe, B.5
  • 22
    • 0032189223 scopus 로고    scopus 로고
    • A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the typeII collagen gene
    • Lefebvre V., Li P., de Crombrugghe B. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the typeII collagen gene. EMBO J. 1998, 17:5718-5733.
    • (1998) EMBO J. , vol.17 , pp. 5718-5733
    • Lefebvre, V.1    Li, P.2    de Crombrugghe, B.3
  • 23
    • 33846640446 scopus 로고    scopus 로고
    • Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)
    • Loizzo M.R., Said A., Tundis R., Rashed K., Statti G.A., Hufner A., Menichini F. Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae). Phytother. Res. 2007, 21:32-36.
    • (2007) Phytother. Res. , vol.21 , pp. 32-36
    • Loizzo, M.R.1    Said, A.2    Tundis, R.3    Rashed, K.4    Statti, G.A.5    Hufner, A.6    Menichini, F.7
  • 24
    • 33645337383 scopus 로고    scopus 로고
    • Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling
    • Longobardi L., O'Rear L., Aakula S., Johnstone B., Shimer K., Chytil A. Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling. J. Bone. Miner. Res. 2006, 21:626-636.
    • (2006) J. Bone. Miner. Res. , vol.21 , pp. 626-636
    • Longobardi, L.1    O'Rear, L.2    Aakula, S.3    Johnstone, B.4    Shimer, K.5    Chytil, A.6
  • 25
    • 62649152321 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction
    • Marfe G., Tafani M., Indelicato M., Sinibaldi-Salimei P., Reali V., Pucci B., Fini M., Russo M.A. Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. J. Cell. Biochem. 2009, 106:643-650.
    • (2009) J. Cell. Biochem. , vol.106 , pp. 643-650
    • Marfe, G.1    Tafani, M.2    Indelicato, M.3    Sinibaldi-Salimei, P.4    Reali, V.5    Pucci, B.6    Fini, M.7    Russo, M.A.8
  • 26
    • 0034851475 scopus 로고    scopus 로고
    • Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants
    • Miean K.H., Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J. Agric. Food. Chem. 2001, 49:3106-3112.
    • (2001) J. Agric. Food. Chem. , vol.49 , pp. 3106-3112
    • Miean, K.H.1    Mohamed, S.2
  • 27
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina E., Wenzel H.M., Kreschel C., Karp S., Gaffield W., McMahon A.P., Vortkamp A. BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 2001, 128:4523-4534.
    • (2001) Development , vol.128 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 28
    • 0036744820 scopus 로고    scopus 로고
    • Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation
    • Minina E., Kreschel C., Naski M.C., Ornitz D.M., Vortkamp A. Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev. Cell. 2002, 3:439-449.
    • (2002) Dev. Cell. , vol.3 , pp. 439-449
    • Minina, E.1    Kreschel, C.2    Naski, M.C.3    Ornitz, D.M.4    Vortkamp, A.5
  • 29
    • 77954818547 scopus 로고    scopus 로고
    • The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
    • Mylonis I., Lakka A., Tsakalof A., Simos G. The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions. Biochem. Biophys. Res. Commun. 2010, 398:74-78.
    • (2010) Biochem. Biophys. Res. Commun. , vol.398 , pp. 74-78
    • Mylonis, I.1    Lakka, A.2    Tsakalof, A.3    Simos, G.4
  • 30
    • 3142759375 scopus 로고    scopus 로고
    • P21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells
    • Nakajima M., Negishi Y., Tanaka H., Kawashima K. P21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells. Biochem. Biophys. Res. Commun. 2004, 320:1069-1075.
    • (2004) Biochem. Biophys. Res. Commun. , vol.320 , pp. 1069-1075
    • Nakajima, M.1    Negishi, Y.2    Tanaka, H.3    Kawashima, K.4
  • 31
    • 0037059614 scopus 로고    scopus 로고
    • The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
    • Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., et al. The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation. Cell 2002, 108:17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5
  • 32
    • 79952223324 scopus 로고    scopus 로고
    • An activator of PHD2, KRH102140, decreases angiogenesis via inhibition of HIF-1α
    • Nepal M., Gong Y.-D., Park Y.R., Soh Y. An activator of PHD2, KRH102140, decreases angiogenesis via inhibition of HIF-1α. Cell. Biochem. Funct. 2011, 29:126-134.
    • (2011) Cell. Biochem. Funct. , vol.29 , pp. 126-134
    • Nepal, M.1    Gong, Y.-D.2    Park, Y.R.3    Soh, Y.4
  • 33
    • 84864997227 scopus 로고    scopus 로고
    • Anti-angiogenicandanti-tumoractivityof Bavachinin by targeting hypoxia-inducible factor-1a
    • Nepal M., Choi J.H., Choi B.Y., Kim S.L., Ryu J.H., Kim H.D., Lee Y.H., Soh Y. Anti-angiogenicandanti-tumoractivityof Bavachinin by targeting hypoxia-inducible factor-1a. Eur. J. Pharmacol. 2012, 15(691):28-37.
    • (2012) Eur. J. Pharmacol. , vol.15 , Issue.691 , pp. 28-37
    • Nepal, M.1    Choi, J.H.2    Choi, B.Y.3    Kim, S.L.4    Ryu, J.H.5    Kim, H.D.6    Lee, Y.H.7    Soh, Y.8
  • 34
    • 78951490151 scopus 로고    scopus 로고
    • Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats
    • Nirmala P., Ramanathan M. Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats. Eur. J. Pharmacol. 2011, 654:75-79.
    • (2011) Eur. J. Pharmacol. , vol.654 , pp. 75-79
    • Nirmala, P.1    Ramanathan, M.2
  • 35
    • 65549121723 scopus 로고    scopus 로고
    • Inflammatory cytokines and the GH/IGF-I axis: novel actions on bone growth
    • Pass C., MacRae V.E., Ahmed S.F., Farquharson C. Inflammatory cytokines and the GH/IGF-I axis: novel actions on bone growth. Cell. Biochem. Funct. 2009, 27:119-127.
    • (2009) Cell. Biochem. Funct. , vol.27 , pp. 119-127
    • Pass, C.1    MacRae, V.E.2    Ahmed, S.F.3    Farquharson, C.4
  • 36
    • 0033562850 scopus 로고    scopus 로고
    • Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation
    • Pathi S., Rutenberg J.B., Johnson R.L., Vortkamp A. Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation. Dev. Biol. 1999, 209:239-253.
    • (1999) Dev. Biol. , vol.209 , pp. 239-253
    • Pathi, S.1    Rutenberg, J.B.2    Johnson, R.L.3    Vortkamp, A.4
  • 37
    • 37549048240 scopus 로고    scopus 로고
    • A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes
    • Provot S., Nachtrab G., Paruch J., Chen A.P., Silva A., Kronenberg H.M. A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes. Mol. Cell. Biol. 2008, 28:344-357.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 344-357
    • Provot, S.1    Nachtrab, G.2    Paruch, J.3    Chen, A.P.4    Silva, A.5    Kronenberg, H.M.6
  • 38
    • 0033019034 scopus 로고    scopus 로고
    • Association of matrix acid and alkaline phosphatases with mineralization of cartilage and endochondral bone
    • Roach H.I. Association of matrix acid and alkaline phosphatases with mineralization of cartilage and endochondral bone. Histochem. J. 1999, 31:53-61.
    • (1999) Histochem. J. , vol.31 , pp. 53-61
    • Roach, H.I.1
  • 39
  • 40
    • 0029875398 scopus 로고    scopus 로고
    • Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor
    • Shukunami C., Shigeno C., Atsumi T., Ishizeki K., Suzuki F., Hiraki Y. Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor. J. Cell. Biol. 1996, 133:457-468.
    • (1996) J. Cell. Biol. , vol.133 , pp. 457-468
    • Shukunami, C.1    Shigeno, C.2    Atsumi, T.3    Ishizeki, K.4    Suzuki, F.5    Hiraki, Y.6
  • 41
    • 0030788922 scopus 로고    scopus 로고
    • Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro
    • Shukunami C., Ishizeki K., Atsumi T., Ohta Y., Suzuki F., Hiraki Y. Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro. J. Bone. Miner. Res. 1997, 12:1174-1188.
    • (1997) J. Bone. Miner. Res. , vol.12 , pp. 1174-1188
    • Shukunami, C.1    Ishizeki, K.2    Atsumi, T.3    Ohta, Y.4    Suzuki, F.5    Hiraki, Y.6
  • 42
    • 0036197206 scopus 로고    scopus 로고
    • The life cycle of chondrocytes in the developing skeleton
    • Shum L., Nuckolls G. The life cycle of chondrocytes in the developing skeleton. Arthritis Res. 2002, 4:94-106.
    • (2002) Arthritis Res. , vol.4 , pp. 94-106
    • Shum, L.1    Nuckolls, G.2
  • 43
    • 20544472587 scopus 로고    scopus 로고
    • Tissue engineering strategies for cartilage generation-micromass and three dimensional cultures using human chondrocytes and a continuous cell line
    • Tare R.S., Howard D., Pound J.C., Roach H.I., Oreffo R.O. Tissue engineering strategies for cartilage generation-micromass and three dimensional cultures using human chondrocytes and a continuous cell line. Biochem. Biophys. Res. Commun. 2005, 333:609-621.
    • (2005) Biochem. Biophys. Res. Commun. , vol.333 , pp. 609-621
    • Tare, R.S.1    Howard, D.2    Pound, J.C.3    Roach, H.I.4    Oreffo, R.O.5
  • 44
    • 33845432866 scopus 로고    scopus 로고
    • Regulating insulin signaling and beta-cell function through IRS proteins
    • White M.F. Regulating insulin signaling and beta-cell function through IRS proteins. Can J. Physiol. Pharmacol. 2006, 84:725-737.
    • (2006) Can J. Physiol. Pharmacol. , vol.84 , pp. 725-737
    • White, M.F.1
  • 46
    • 11144354938 scopus 로고    scopus 로고
    • Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    • Yoshida C.A., Yamamoto H., Fujita T., Furuichi T., Ito K., Yamana K., Zanma A., Takada K., Ito Y., Komori T. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004, 18:952-963.
    • (2004) Genes Dev. , vol.18 , pp. 952-963
    • Yoshida, C.A.1    Yamamoto, H.2    Fujita, T.3    Furuichi, T.4    Ito, K.5    Yamana, K.6    Zanma, A.7    Takada, K.8    Ito, Y.9    Komori, T.10
  • 47
    • 45049088538 scopus 로고    scopus 로고
    • Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells
    • Zhang Y., Chen A.Y., Li M., Chen C., Yao Q. Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J. Surg. Res. 2008, 148:17-23.
    • (2008) J. Surg. Res. , vol.148 , pp. 17-23
    • Zhang, Y.1    Chen, A.Y.2    Li, M.3    Chen, C.4    Yao, Q.5


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