CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans

Current Biology

Volumn 11, Issue 7, 2001, Pages 474-481

  Kay, Amanda J ^a   Hunter, Craig P ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CAENORHABDITIS ELEGANS; INVERTEBRATA; MAMMALIA; RICKETTSIA SP. PAR; VERMES;

EID: 0035799308     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00141-5     Document Type: Article

References (34)

1. Maternal control of pattern formation in early Caenorhabditis elegans embryos
2. Early patterning of the C. elegans embryo
3. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos
4. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos
5. Fertilization and establishment of polarity in the embryo
6. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
7. A human homologue of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signalling and cell transformation
8. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
9. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and αPKC signalling and cell polarity
10. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
11. The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation
12. The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation
13. CYK-4: A Rho family GTPase activating protein (GAP) required for central spindle formation and cytokinesis
14. DNA transformation
15. Identification of genes required for cytoplasmic localization in early C. elegans embryos
16. An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in C. elegans zygotes
17. Brief cytochalasin-induced disruption of microfilaments during a critical interval in 1-cell C. elegans embryos alters the partitioning of developmental instructions to the 2-cell embryo
18. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3
19. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans
20. Par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP binding-motifs
21. Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process
22. Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells
23. Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development
24. CDC-42 controls early cell polarity and spindle orientation in C. elegans
25. Control of cleavage spindle orientation in Caenorhabditis elegans: The role of the genes par-2 and par-3
26. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos
27. The genetics of Caenorhabditis elegans
28. Blastomere culture and analysis
29. The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo
30. The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans
31. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
32. Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
33. Genetic requirements for PIE-1 localization and inhibition of gene expression in the embryonic germ lineage of Caenorhabditis elegans
34. Fluorescence visualization of the distribution of microfilaments in gonads and early embryos in the nematode Caenorhabditis elegans