Silibinin inhibits β-catenin/ZEB1 signaling and suppresses bladder cancer metastasis via dual-blocking epithelial-mesenchymal transition and stemness

Cellular Signalling

Volumn 25, Issue 12, 2013, Pages 2625-2633

  Wu, Kaijie ^a   Ning, Zhongyun ^b   Zeng, Jin ^a   Fan, Jinhai ^a   Zhou, Jiancheng ^b   Zhang, Tingting ^b   Zhang, Linlin ^a   Chen, Yule ^b   Gao, Yang ^b   Wang, Bin ^b   Guo, Peng ^b   Li, Lei ^a   Wang, Xinyang ^b   He, Dalin ^a,b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Bladder cancer; CSC; EMT; Metastasis; Silibinin

Indexed keywords

BETA CATENIN; CYTOKERATIN; DIMETHYL SULFOXIDE; GELATINASE A; GLYCOGEN SYNTHASE KINASE 3BETA; HERMES ANTIGEN; SILIBININ; TRANSCRIPTION FACTOR ZEB1; VIMENTIN; ANTINEOPLASTIC AGENT; HOMEODOMAIN PROTEIN; SILYMARIN; TRANSCRIPTION FACTOR; ZEB1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER METASTASIS; CANCER CELL; CANCER STEM CELL; CANCER SURVIVAL; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE; GENE TARGETING; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; IN VITRO STUDY; LUNG METASTASIS; METASTASIS INHIBITION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR INVASION; TUMOR SPHEROID; TUMOR VOLUME; ZEB1 GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BLADDER; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; NEOPLASM METASTASIS; NUDE MOUSE; PATHOLOGY; SILYBUM MARIANUM; TUMOR CELL LINE; URINARY BLADDER NEOPLASMS;

ANIMALIA;

ANIMALS; ANTICARCINOGENIC AGENTS; BETA CATENIN; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MILK THISTLE; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION; SILYMARIN; TRANSCRIPTION FACTORS; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 84884366170     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.08.028     Document Type: Article

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