Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 38, 2013, Pages

  Chen, Yen Shan ^a   Racca, Joseph D ^a   Phillips, Nelson B ^a   Weiss, Michael A ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Case Western Reserve University   (United States)

Author keywords

Gene regulatory network; Gonadogenesis; Organogenesis; Protein DNA interaction; Sex determination

Indexed keywords

CARRIER PROTEIN; CURVED DNA; EXPORTIN 4; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FATE; DNA BINDING; GENE MUTATION; GENETIC VARIABILITY; HAPLOINSUFFICIENCY; HIGH MOBILITY GROUP BOX DOMAIN; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR IMPORT; NUCLEOCYTOPLASMIC TRANSPORT; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SERTOLI CELL; SEX DETERMINATION; SEX TRANSFORMATION; SRY GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

GENE-REGULATORY NETWORK; GONADOGENESIS; ORGANOGENESIS; PROTEIN-DNA INTERACTION; SEX DETERMINATION;

ACTIVE TRANSPORT, CELL NUCLEUS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GONADAL DYSGENESIS, 46,XY; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MODELS, MOLECULAR; PROTEIN CONFORMATION; SERTOLI CELLS; SEX-DETERMINING REGION Y PROTEIN; SOX9 TRANSCRIPTION FACTOR; TESTIS;

EID: 84884319384     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300828110     Document Type: Article

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