Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: Frustrated induced fit in a bent protein-DNA complex

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36787-36807

  Phillips, Nelson B ^a   Racca, Joseph ^a   Chen, Yen Shan ^a   Singh, Rupinder ^a   Jancso Radek, Agnes ^a,c   Radek, James T ^a,d   Wickramasinghe, Nalinda P ^a   Haas, Elisha ^b   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b BAR ILAN UNIVERSITY   (Israel)

^c ILLUMINA INC   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEND ANGLE; BIOPHYSICAL PROPERTIES; CELL LINES; CONFORMATIONAL FLUCTUATIONS; DNA BENDING; DNA BINDING; DNA COMPLEX; DNA-BINDING PROPERTIES; DOWNSTREAM TARGET; GENETIC BACKGROUNDS; HIGH-MOBILITY GROUPS; INDUCED FIT; L-SHAPED DOMAIN; LOCAL PERTURBATION; LONG RANGE; MUTATION SITES; NMR STUDIES; NONLOCAL COUPLING; PARTIAL ACTIVATION; PROTEIN-DNA COMPLEXES; STOPPED FLOW; SUBNANOSECOND; TIME-RESOLVED FLUORESCENCE; TRANSCRIPTIONAL REGULATION; WILD TYPES;

BINDING ENERGY; CELL CULTURE; COMPLEXATION; ENERGY TRANSFER; FLUORESCENCE; MAMMALS; NUCLEAR MAGNETIC RESONANCE; PROTEIN FOLDING; PROTEINS;

DNA;

DNA; TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR 7 LIKE 1; TRANSCRIPTION FACTOR SOX9;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; GONADAL DYSGENESIS; HIGH MOBILITY GROUP BOX DOMAIN; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTON NUCLEAR MAGNETIC RESONANCE; SEX TRANSFORMATION; SPERMATOGENESIS; TESTIS; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; DNA; GONADAL DYSGENESIS, 46,XY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUTATION, MISSENSE; NUCLEIC ACID CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RODENTIA; SEX-DETERMINING REGION Y PROTEIN; SOX9 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EUKARYOTA; MAMMALIA;

EID: 80054714796     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.260091     Document Type: Article

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