Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimo lecular autoproteolytic event for the processing of zymogens belonging to the Papain family

Journal of Biological Chemistry

Volumn 276, Issue 11, 2001, Pages 8118-8124

  Quraishi, Omar ^a,c   Storer, Andrew C ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYST ACTIVITY; CRYSTAL STRUCTURE; IONS; REACTION KINETICS; X RAY ANALYSIS;

AUTOPROTEOLYTIC EVENTS; CLEAVAGE SITES; INTERMOLECULAR PROCESSING;

ENZYMES;

ENZYME PRECURSOR; IMIDAZOLE DERIVATIVE; PAPAIN; PROCATHEPSIN B; PROCATHEPSIN S; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; CATHEPSIN; CATHEPSIN B; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME MODIFICATION; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DEGRADATION; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; PH; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CATHEPSIN B; CATHEPSINS; ENZYME PRECURSORS; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; PAPAIN; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 0035896612     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M005851200     Document Type: Article

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