Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy

Journal of Cellular Biochemistry

Volumn 114, Issue 11, 2013, Pages 2454-2460

  Miwa, Shinji ^a,b,c   Yano, Shuya ^a,b,d   Tome, Yasunori ^a,b   Sugimoto, Naotoshi ^c   Hiroshima, Yukihiko ^a,b   Uehara, Fuminari ^a,b   Mii, Sumiyuki ^a,b   Kimura, Hiroaki ^c   Hayashi, Katsuhiro ^c   Efimova, Elena V ^e   Fujiwara, Toshiyoshi ^d   Tsuchiya, Hiroyuki ^c   Hoffman, Robert M ^a,b  

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e UNIVERSITY OF CHICAGO   (United States)

Author keywords

Apoptosis; Caffeine; Cell Cycle; Cisplatinum; Fluorescence Imaging; Fucci; Gfp; Mitosis; Modulation; Osteosarcoma; Rfp

Indexed keywords

CAFFEINE; CISPLATIN; GREEN FLUORESCENT PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE PHASE; CELL NUCLEUS; CELL PROLIFERATION; CLONOGENIC ASSAY; CONTROLLED STUDY; CYTOPLASM; FLUORESCENCE IMAGING; HELA CELL; HUMAN; HUMAN CELL; MITOSIS; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UBIQUITINATION;

APOPTOSIS; CAFFEINE; CELL CYCLE; CISPLATINUM; FLUORESCENCE IMAGING; FUCCI; GFP; MITOSIS; MODULATION; OSTEOSARCOMA; RFP;

APOPTOSIS; CAFFEINE; CELL CYCLE; CELL LINE, TUMOR; CISPLATIN; DNA DAMAGE; DRUG INTERACTIONS; HUMANS; MICROSCOPY, CONFOCAL; MITOSIS;

EID: 84884265856     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24593     Document Type: Article

References (34)

1. Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A, Picci P,. 2006. Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy. 15-year experience in 789 patients treated at a single institution. Cancer 106: 1154-1161.
2. Chishima T, Miyagi Y, Wang X, Yamaoka H, Shimada H, Moossa AR, Hoffman RM,. 1997. Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Res 57: 2042-2047.
3. Chung KY, Saltz LB,. 2007. Adjuvant therapy of colon cancer: Current status and future directions. Cancer J 13 (3): 192-197.
4. Efferth T, Fabry U, Glatte P, Osieka R,. 1995. Expression of apoptosis-related oncoproteins and modulation of apoptosis by caffeine in human leukemic cells. J Cancer Res Clin Oncol 121: 648-656.
5. Efimova EV, Mauceri HJ, Golden DW, Labay E, Bindokas VP, Darga TE, Chakraborty C, Barreto-Andrade JC, Crawley C, Sutton HG, Kron SJ, Weichselbaum RR,. 2010. Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. Cancer Res 70: 6277-6282.
6. Hayashi M, Tsuchiya H, Yamamoto N, Karita M, Shirai T, Nishida H, Takeuchi A, Tomita K,. 2005. Caffeine-potentiated chemotherapy for metastatic carcinoma and lymphoma of bone and soft tissue. Anticancer Res 25: 2399-2405.
7. He Z, Ma WY, Hashimoto T, Bode AM, Yang CS, Dong Z,. 2003. Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways. Cancer Res 63: 4396-4401.
8. Hoffman RM,. 2005. The multiple uses of fluorescent proteins to visualize cancer in vivo. Nat Rev Cancer 5: 796-806.
9. Hoffman RM, Yang M,. 2006a. Subcellular imaging in the live mouse. Nat Prot 1: 775-782.
10. Hoffman RM, Yang M,. 2006b. Color-coded fluorescent imaging of tumor host interactions. Nat Prot 1: 928-935.
11. Hoffman RM, Yang M,. 2006c. Whole-body imaging with fluorescent proteins. Nat Prot 1: 1429-1438.
12. Ishihara Y, Matsunaga K, Iijima H, Hasegawa G, Suzuki T, Sato A, Kobayashi T, Yang M, Hoffman RM,. 2010. The combination of 5-FU, leucovorin and CPT-11 (FOLFIRI) prolongs survival through inhibition of metastasis in an orthotopic model of colon cancer. Anticancer Res 30: 403-408.
13. Jiang P, Yamauchi K, Yang M, Tsuji K, Xu M, Maitra A, Bouvet M, Hoffman RM,. 2006. Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle 5: 1198-1201.
14. Kimura H, Tsuchiya H, Shirai T, Nishida H, Hayashi K, Takeuchi A, Ohnari I, Tomita K,. 2009. Caffeine-potentiated chemotherapy for metastatic osteosarcoma. J Orthop Sci 14: 556-565.
15. Marshall JL, Gehan EA,. 2007. The development of novel agents for the treatment of colorectal cancer: A critical review of current practice and some suggestions for the future. Clin Adv Hematol Oncol 5: 167-172.
16. Miwa S, Kitamura S, Shirai T, Hayashi K, Nishida H, Takeuchi A, Nojima T, Tsuchiya H,. 2010. Desmoplastic small round cell tumour successfully treated with caffeine-assisted chemotherapy: A case report and review of the literature. Anticancer Res 30: 3769-3774.
17. Miwa S, Sugimoto N, Shirai T, Nishida H, Hayashi K, Takeuchi A, Yachie A, Tsuchiya H,. 2011. Caffeine activates tumor suppressor PTEN in sarcoma cells. Int J Oncol 39: 465-472.
18. Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H,. 2012. Caffeine induces apoptosis by inhibiting Akt/mTOR/S6K, NF-κB and MAPK pathways in osteosarcoma cell. Anticancer Res 32: 3643-3649.
19. Miwa S, Tome Y, Yano S, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Tsuchiya H, Bouvet M, Efimova EV, Hoffman RM,. 2013. Single cell time-lapse imaging of focus formation by the DNA damage-response protein 53BP1 after UVC irradiation of human pancreatic cancer cells. Anticancer Res 33: 1373-1377.
20. Momiyama M, Suetsugu A, Chishima T, Bouvet M, Endo I, Hoffman RM,. 2013a. Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. Anticancer Res 33: 103-106.
21. Momiyama M, Suetsugu A, Kimura H, Chishima T, Bouvet M, Endo I, Hoffman RM,. 2013b. Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice. Anticancer Res 33: 1367-1371.
22. Nishikawa A, Furukawa F, Imazawa T, Ikezaki S, Hasegawa T, Takahashi M,. 1995. Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N′-nitro-N-nitrosoguanidine and sodium chloride. Food Chem Toxicol 33: 21-26.
23. Sakaue-Sawano A, Kurokawa H, Morimura T, Hanyu A, Hama H, Osawa H, Kashiwagi S, Fukami K, Miyata T, Miyoshi H, Imamura T, Ogawa M, Masai H, Miyawaki A,. 2008. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132: 487-498.
24. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT,. 1999. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 59: 4375-4382.
25. Shinomiya N, Takemura T, Iwamoto K, Rokutanda M,. 1997. Caffeine induces S-phase apoptosis in cis-diamminedichloroplatinum-treated cells, whereas cis-diamminedichloroplatinum induces a block in G2-M. Cytometry 27: 365-373.
26. Takeuchi A, Tsuchiya H, Yamamoto N, Hayashi K, Yamauchi K, Kawahara M, Miyamoto K, Tomita K,. 2007. Caffeine-potentiated chemotherapy for patients with high-grade soft tissue sarcoma: Long-term clinical outcome. Anticancer Res 27: 3489-3495.
27. Tsuchiya H, Tomita K, Mori Y, Asada N, Morinaga T, Kitano S, Yamamoto N,. 1998. Caffeine-assisted chemotherapy and minimized tumor excision for non metastatic osteosarcoma. Anticancer Res 18: 657-666.
28. Uchugonova A, Duong J, Zhang N, König K, Hoffman RM,. 2011. The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle. J Cell Biochem 112: 2046-2050.
29. Valenzuela MT, Mateous S, Ruiz de Almodovar JM, McMillan TJ,. 2000. Variation in sensitizing effect of caffeine in human tumour cell lines after gamma-irradiation. Radiother Oncol 54: 261-271.
30. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR, Hoffman RM,. 2004. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res 64: 4251-4256.
31. Yang M, Baranov E, Jiang P, Sun FX, Li XM, Li L, Hasegawa S, Bouvet M, Al-Tuwaijri M, Chishima T, Shimada H, Moossa AR, Penman S, Hoffman RM,. 2000. Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci USA 97: 1206-1211.
32. Yang M, Li L, Jiang P, Moossa AR, Penman S, Hoffman RM,. 2003. Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc Natl Acad Sci USA 100: 14259-14262.
33. Yang M, Jiang P, Hoffman RM,. 2007. Whole-body subcellular multicolor imaging of tumor-host interaction and drug response in real time. Cancer Res 67: 5195-5200.
34. Zhou BB, Chaturvedi P, Spring K, Scott SP, Johansen RA, Mishra R, Mattern MR, Winkler JD, Khanna KK,. 2000. Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. J Biol Chem 275: 10342-10348.