The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation

International Immunopharmacology

Volumn 17, Issue 3, 2013, Pages 721-726

  Lee, Won Sik ^a   Lee, Soung Min ^b   Kim, Mi Kyoung ^b   Park, Sae Gwang ^b   Choi, Ii Whan ^b   Choi, Inhak ^b   Joo, Young Don ^a   Park, Sung Jae ^a   Kang, Sun Woo ^a   Seo, Su Kil ^b  

^a Inje University College of Medicine   (South Korea)

^b Inje University   (South Korea)

Author keywords

3 Hydroxyanthranilic acid; Dendritic cells; Indoleamine 2,3 dioxygenase

Indexed keywords

3 HYDROXYANTHRANILIC ACID; B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MATURATION; CELL VIABILITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING;

3-HYDROXYANTHRANILIC ACID; DENDRITIC CELLS; INDOLEAMINE 2,3-DIOXYGENASE;

3-HYDROXYANTHRANILIC ACID; ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; IMMUNOLOGIC FACTORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SPLEEN; T-LYMPHOCYTES; TRYPTOPHAN;

EID: 84884262127     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.08.018     Document Type: Article

References (35)

1. J. Banchereau, F. Briere, C. Caux, J. Davoust, S. Lebecque, and Y.J. Liu Immunobiology of dendritic cells Annu Rev Immunol 18 2000 767 811
2. R. Kushwah, and J. Hu Dendritic cell apoptosis: regulation of tolerance versus immunity J Immunol 185 2010 795 802
3. M.L. Kapsenberg Dendritic-cell control of pathogen-driven T-cell polarization Nat Rev Immunol 3 2003 984 993
4. L. Summers deLuca, and J.L. Gommerman Fine-tuning of dendritic cell biology by the TNF superfamily Nat Rev Immunol 12 2012 339 351
5. S.J. van Vliet, J. den Dunnen, S.I. Gringhuis, T.B. Geijtenbeek, and Y. van Kooyk Innate signaling and regulation of dendritic cell immunity Curr Opin Immunol 19 2007 435 440
6. L. Chen Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity Nat Rev Immunol 4 2004 336 347
7. K.H.G. Mills TLR-dependent T cell activation in autoimmunity Nat Rev Immunol 11 2011 807 822
8. D.M. Briscoe, and M.H. Sayegh A rendezvous before rejection: where do T cells meet transplant antigens? Nat Med 8 2002 220 222
9. U. Grohmann Tolerance, DCs and tryptophan: much ado about IDO Trends Immunol 24 2003 242 248
10. A.L. Mellor, and D.H. Munn IDO expression by dendritic cells: tolerance and tryptophan catabolism Nat Rev Immunol 4 2004 762 774
11. + T cells during Aspergillus fumigatus antigen exposure Am J Respir Cell Mol Biol 44 2011 11 23
12. Y. Li, E.E. Tredget, A. Ghaffari, X. Lin, R.T. Kilani, and A. Ghahary Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute J Invest Dermatol 126 2006 128 136
13. L. Romani, F. Fallarino, A. De Luca, C. Montagnoli, C. D'Angelo, and T. Zelante Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease Nature 451 2008 211 215
14. T. Zelante, F. Fallarino, F. Bistoni, P. Puccetti, and L. Romani Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host Microbes Infect 11 2009 133 141
15. M.L. Belladonna, U. Grohmann, P. Guidetti, C. Volpi, R. Bianchi, and M.C. Fioretti Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO J Immunol 177 2006 130 137
16. M.L. Belladonna, C. Orabona, U. Grohmann, and P. Puccetti TGF-β and kynurenines as the key to infectious tolerance Trends Mol Med 15 2009 41 49
17. G. Frumento, R. Rotondo, M. Tonetti, G. Damonte, U. Benatti, and G.B. Ferrara Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell roliferation induced by indoleamine 2,3-dioxygenase J Exp Med 196 2002 459 468
18. P. Terness, T.M. Bauer, L. Rose, C. Dufter, A. Watzlik, and H. Simon Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites J Exp Med 196 2002 447 457
19. + regulatory T cells J Immunol 174 2005 5181 5186
20. T. Hayashi, J.H. Mo, X. Gong, C. Rossetto, A. Jang, and L. Beck 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis Proc Natl Acad Sci 104 2007 18619 18624
21. + T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival Invest Ophthalmol Vis Sci 52 2011 2640 2648
22. Y. Yan, G.X. Zhang, B. Gran, F. Fallarino, S. Yu, and H. Li IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis J Immunol 185 2010 5953 5961
23. N.T. Nguyen, A. Kimura, T. Nakahama, I. Chinen, K. Masuda, and K. Nohara Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism Proc Natl Acad Sci 107 2010 19961 19966
24. K. Nakayama, Y. Ota, S. Okugawa, N. Ise, T. Kitazawa, and K. Tsukada Raf1 plays a pivotal role in lipopolysaccharide-induced activation of dendritic cells Biochem Biophys Res Commun 308 2003 353 360
25. K. Nagamatsu, A. Kuwae, T. Konaka, S. Nagai, S. Yoshida, and M. Eguchi Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN J Exp Med 206 2009 3073 3088
26. S.M. Lee, Y.S. Lee, J.H. Choi, S.G. Park, I.W. Choi, and Y.D. Joo Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion Immunol Lett 132 2010 53 60
27. M. Moser, and K.M. Murphy Dendritic cell regulation of TH1-TH2 development Nat Immunol 1 2000 199 205
28. L. Zhou, I.I. Ivanov, R. Spolski, R. Min, K. Shenderov, and T. Egawa IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 8 2007 967 974
29. G. Criado, E. Šimelyte, J.J. Inglis, D. Essex, and R.O. Williams Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis Arthritis Rheum 60 2009 1342 1351
30. S. Agrawal, A. Agrawal, B. Doughty, A. Gerwitz, J. Blenis, and T. Van Dyke Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos J Immunol 171 2003 4984 4989
31. S. Dillon, A. Agrawal, T. Van Dyke, G. Landreth, L. McCauley, and A. Koh A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells J Immunol 172 2004 4733 4743
32. B. Pulendran, and R. Ahmed Translating innate immunity into immunological memory: implications for vaccine development Cell 124 2006 849 863
33. G. Huang, Y. Wang, P. Vogel, T.-D. Kanneganti, K. Otsu, and H. Chi Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation Nat Immunol 13 2012 152 161
34. M. Platten Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite Science 310 2005 850 855
35. J.J. Inglis, G. Criado, M. Andrews, M. Feldmann, R.O. Williams, and M.L. Selley The anti-allergic drug, N-(3′,4′-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis Rheumatology 46 2007 1428 1432