3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 5, 2011, Pages 2640-2648

  Zaher, Sarah S ^a   Germain, Conrad ^a   Fu, Hongmei ^a   Larkin, Daniel F P ^a,b   George, Andrew J T ^a,b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYANTHRANILIC ACID; 3 HYDROXYKYNURENINE; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DEATH; CELL FUNCTION; CELL MATURATION; CELL VIABILITY; CONTROLLED STUDY; CORNEA ENDOTHELIUM; CORNEA TRANSPLANTATION; DENDRITIC CELL; GRAFT REJECTION; GRAFT SURVIVAL; IN VITRO STUDY; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PATHOGENICITY; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SYSTEMIC THERAPY;

ADMINISTRATION, TOPICAL; ANIMALS; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CORNEAL TRANSPLANTATION; DENDRITIC CELLS; ENDOTHELIUM, CORNEAL; GRAFT REJECTION; GRAFT SURVIVAL; KYNURENINE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, HOMOLOGOUS;

EID: 79956004948     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5793     Document Type: Article

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